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    题名 作者 年代 出处 被引量
1L3T4 CD4+ cells that mediate contact sensitivity to trinitrochlorobenzene express I-A determinants显示文摘Gautam SC Matriano JA Chikkala NF Edinger MG Tubbs R 1991Cell Immunol1991,135,1:2
2Cylindrical implosion experiments using laser direct drive显示文摘Tubbs D L Boehly T Barnes C W 1999Phys of Plasmas1999,6,5:2
3Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver显示文摘Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin action.Whereas mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are unknown.In this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse liver.Screening of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in vivo.Glucose reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired respiration.Blocking MAM reduction counteracted glucose-induced mitochondrial alterations.Furthermore,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and function.This glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial respiration.These data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional transition.Chronic disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset 2016Journal of Molecular Cell Biology2016,8,2:2
4Bipolar supernumerary renal artery显示文摘Shakeri AB Tubbs RS Shoja MM 2007Surg Radiot Anat2007,29,1:1
5Out of the darkness and into the light: bright field in situ hybridisation for delineation of ERBB2 (HER2) status in breast carcinoma显示文摘Graver AM Peerwani Z Tubbs RR 2010J Clin Pathol2010,63,3:1
6Surface landmarks for the junction between the transverse and sigmoid sinuses : appli-cation of the 'strategic' burr hole for suboccipital craniotomy显示文摘TUBBS R S LOUKAS M SHOJA M M 2009Neurosurgery2009,65,6:1
7Conversion of tumor specific CD4+ T cell tolerance to T cell priming through in vivo ligation of CD40显示文摘Sotomayor EM Borrello I Tubb E 1999Nat Med1999,5,:1
8Molecular diagnostic techniques for the clinical evaluation of gliomas显示文摘Kelley TW Tubbs RR Prayson RA 2005Diagn Mol Pathol2005,14,1:1
9HER-2 testing in breast cancer显示文摘Tubbs RR Hicks DG 2004JAMA2004,292,:1
10An unusual union of the inter- costobrachial nerve and the medial pectoral nerve 显示文摘Loukas M Grabska J Tubbs RS 2007Folia Morphol (Warsz)2007,66,4:1
11Vertebral spinal osteophytes 显示文摘Klaassen Z Tubbs RS Apaydin N 2011Anat Sci Int2011,86,1:1
12Institutional experience with 500 cases of surgically treated pediatric Chiari malformation type I显示文摘Tubbs RS Beckman J Naftel RP 2011J Neurosurg Pediatr2011,7,3:1
13Experimen- tal reproduction of canine influenza virus H3N8 infection in young puppies显示文摘DESHPANDE M ABDELMAGID O TUBBS A 2009Vet Ther2009,10,12:1
14Surgical experience in 130 pediatic patients with Chiari I malformation 显示文摘Tubbs TS Mcgirt M J Oakes WJ 2003Neurosurgery2003,99,2:1
15Phrenic nerve neurotization utilizing the spinal accessory nerve:technical note with potential application in patients with high cervical quadriplegia显示文摘Tubbs RS Pearson B Loukas M 2008Childs Nerv Syst2008,24,11:1
16Unusual Finding of the Craniocervical Junction 显示文摘Tubbs RS Tyler-kabara EC Salter EG 2005Clinical Anatomy2005,18,6:1
17Biosensor chip mass spectrometry:a chip-based proteomics approach显示文摘Nelsson RW Nedelkov D Tubbs KA 2000Electrophoresis2000,21,6:1
18Molecular diagnostietechniques for the clinical evaluation of gliomas显示文摘 Tubbe RR Prayson RA 2005Diagn Mol Pathol2005,14,1:1
19Surgical experience in 130 pediatric patients with Chiari I malformations 显示文摘Tubbs RS McGirt M J Oakes WJ 2003J Neurosurg2003,99,2:1
20Polymerase chain reaction for the rapid detection of cerebrospinal fluid shunt or ventriculostomy in- fections 显示文摘Banks JT Bharara S Tubbs RS 2005Neurosurgery2005,57,6:1
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