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| 1 | 低脂肪饮食模式与浸润型乳腺癌风险的妇女健康初步随机对照饮食改良试验显示文摘Context: The hypothesis that a low- fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial. Objective: To assess the effects of undertaking a low- fat dietary pattern on breast cancer incidence. Design and Setting: A randomized, controlled, primary prevention trial conducted at 40 US clinical centers from 1993 to 2005. Participants: A total of 48 835 postmenopausal women, aged 50 to 79 years, without prior breast cancer, including 18.6% of minority race/ethnicity, were enrolled. Interventions: Women were randomly assigned to the dietary modification intervention group (40% [n = 19 541]) or the comparison group (60% [n = 29 294]). The intervention was designed to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily. Comparison group participants were not asked to make dietary changes. Main Outcome Measure: Invasive breast cancer incidence. Results: Dietary fat intake was significantly lower in the dietary modification intervention group compared with the comparison group. The difference between groups in change from baseline for percentage of energy from fat varied from 10.7% at year 1 to 8.1% at year 6. Vegetable and fruit consumption was higher in the intervention group by at least 1 serving per day and a smaller, more transient difference was found for grain consumption. The number of women who developed invasive breast cancer (annualized incidence rate) over the 8.1- year average follow- up period was 655 (0.42% ) in the intervention group and 1072 (0.45% ) in the comparison group (hazard ratio, 0.91; 95% confidence interval, 0.83- 1.01 for the comparison between the 2 groups). Secondary analyses suggest a lower hazard ratio among adherent women, provide greater evidence of risk reduction among women having a high- fat diet at baseline, and suggest a dietary effect that varies by hormone receptor characteristics of the tumor. Conclusions: Among postmenopausal women, a low- fat dietary pattern did not result in a statistically significant reduction in invasive breast cancer risk over an 8.1- year average follow- up period. However, the nonsignificant trends observed suggesting reduced risk associated with a low- fat dietary pattern indicate that longer, planned, nonintervention follow- up may yield a more definitive comparison. | Prentice R.L. Caan B. Chlebowski R.T. 张旸 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，6： | 4 |
| 2 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 3 | Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial 显示文摘 | Freeman EW Guthrie KA Caan B | 2011 | JAMA2011，305，3： | 1 |
| 4 | <ce:link locator='fx1'/> Changes in food sources of dietary fat in response to an intensive low-fat dietary intervention: Early results from the Women’s Health Initiative显示文摘 | Ruth E. Patterson Alan Kristal Rebecca Rodabough Bette Caan Linda Lillington Yasmin Mossavar-Rahmani Michael S. Simon Linda Snetselaar Linda van Horn | 2003 | Journal of the American Dietetic Association2003，，4： | 1 |
| 5 | Association between alcoholic and caffeinated beverages and premenstrual syndrome显示文摘 | Caan B Duncan D Hiatt R | 1993 | J Reprod Med1993，38，8： | 1 |
| 6 | Decreased cerebellar fiber density in cortical myoclonic tremor but not in essential tremo 显示文摘 | Buijink A W Caan M W Tijssen M A | 2013 | Cerebellum2013，12，： | 1 |
| 7 | Low-Fat Dietary Pattern Risk of Invasive Breast Cancer 显示文摘 | Ross L Bette Caan Rowan T | 2006 | JAMA2006，295，6： | 1 |
| 8 | Efficacy of escitalo- pram for hot flashes in healthy menopausal women: a randomized controlled trial 显示文摘 | Freeman EW Guthrie KA Caan B | 2011 | JAMA2011，305，3： | 1 |
| 9 | Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study显示文摘 | Neela Guha Marilyn L. Kwan Charles P. Quesenberry Erin K. Weltzien Adrienne L. Castillo Bette J. Caan | 2009 | Breast Cancer Research and Treatment2009，，2： | 1 |
| 10 | Hormone replacement therapy, reproductive history, and colon cancer: a multicenter, case-control study in the United States显示文摘 | Ellen Kampman John D. Potter Martha L. Slattery Bette J. Caan Sandra Edwards | 1997 | Cancer Causes and Control1997，，2： | 1 |
| 11 | Rela- tion between structural and functional connectivity in major depressive disorder 显示文摘 | DE KWAASTENIET B RUHE E CAAN M | 2013 | Biol Psychiatry2013，74，1： | 1 |
| 12 | Dietary energy sources and colon cancer risk显示文摘 | SLATTERY M L CAAN B J POTFER J D | 1997 | Am J Epidemiol1997，145，3： | 1 |
| 13 | An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer显示文摘 | Bríd M. Ryan Roger K. Wolff Nicola Valeri Mohammed Khan Dillon Robinson Alessio Paone Elise D. Bowman Abbie Lundgreen Bette Caan John Potter Derek Brown Carlo Croce Martha L. Slattery Curtis C. Harris | 2014 | Cancer Epidemiology2014，，5： | 1 |
| 14 | Renal protective effectsof enalapril in hypertensive NIDDM:role of baseline albuminuria显示文摘 | Lebovitz HE Wiegmann TB Caan A | 1994 | Kidney Int Suppl1994，45，： | 1 |
| 15 | IL6 genotypes and colon and rectal cancer显示文摘 | Martha L. Slattery Roger K. Wolff Jennifer S. Herrick Bette J. Caan John D. Potter | 2007 | Cancer Causes & Control2007，，10： | 1 |
| 16 | Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI显示文摘 | Schouw ML Kaag AM Caan MW | | 0，，： | 1 |
| 17 | Obesity and mortality after breast cancer by race/ethnicity :The California Breast Cancer Survivorship Consortium 显示文摘 | Kwan ML John EM Caan BJ | 2014 | Am J Epidemiol2014，179，1： | 1 |
| 18 | Prognostic Impact of Comorbidity among Long-Term Breast Cancer Survivors: Results from the LACE Study显示文摘 | Dejana Braithwaite Dan H. Moore William A. Satariano Marilyn L. Kwan Robert A. Hiatt Candyce Kroenke Bette J. Caan | 2012 | Cancer Epidemiology Biomarkers & Prevention2012，，： | 1 |
| 19 | Feasibility of ASLbased phMRI with a single dose of oral citalopram for repeated assessment of serotonin function显示文摘 | Klomp A Caan MW Denys D | | 0，，03： | 1 |
| 20 | Ran- domized controlled trial of a low animal protein, high fiber diet in the prevention of recurrent calcium ox- alate kidney stones显示文摘 | HIATT R A ETTINGER B CAAN B | 1996 | Am J Epidemiol1996，144，： | 1 |
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