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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis:First case report in the literature显示文摘Alveolar echinococcosis(AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins(R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for marginnegative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery. | Sami Akbulut Egemen Cicek Mehmet Kolu Tevfik Tolga Sahin Sezai Yilmaz | 2018 | World Journal of Gastrointestinal Surgery2018，10，1： | 10 |
| 3 | Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey显示文摘Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[A.baumannii)isolates obtained from nine different cities in Turkey.Methods:A collection of 281 A.baumannii clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as A.baumannU by conventional biochemical,API testing and bla_(-OXA-51)specific PCR.The isolates were examined by PCR for existence of class I and2 integron gene cassettes.Results:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of A.baumannii strains and no class 2 integron was detected.The gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,TEM-1.AAC(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains.The aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 genes.Conclusions:This is an extensive study on the distribulion of class 1 integron among A.baumannii in Turkey.In addition to these,two new alleles were observed.Their percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3). | Aysegül Copur Cicek Azer Ozad Düzgün Aysegül Saral Tuba Kayman Zeynep Cizmeci Pervin Ozlem Balci Tuba Dal Mehmet Firat Ismail Tosun Yasemin Ay Alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 3 |
| 4 | MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer显示文摘 | Douglas D. Taylor Cicek Gercel-Taylor | 2008 | Gynecologic Oncology2008，，1： | 3 |
| 5 | Biofilter:a promising tool for mitigating methane emission from manure storage显示文摘Liquid manure storage may contribute to methane(CH4) emission and this emission can be greatly reduced if appropriate management practices are applied. Biofiltration has been used in other fields for mitigating greenhouse gas(GHG) emission(e.g.,landfill) and shown promise for mitigation CH4 emission from liquid manure storage. It has been reported that biofilter was capable of reducing 80% of CH4 emissions from manure storage. The CH4 removal efficiency is influenced by many factors,including CH4 and O2 concentrations,temperature,moisture,composition of the filter bed,nutrient,and empty bed residency time(EBRT) . Biological conversion of methane of a biofilter is a slow process due to the low water solubility of methane. The residence times(EBRT) between 5 min and 5 h have been used,whereas a typical EBRT of 25 s is used for common biofilter applications. Temperature at which methanotrophic bacteria are active ranges from 10oC to 45oC. The maximum activity is found at around 30oC. The optimal filter bed water content depends on both the gas flow rate and the type of filter bed(soil,compost,etc.) and ranges from 30%-70% of the water holding capacity. Compost is the best material for filter bed. The optimal pH for methanotrophic bacteria is neutral to slightly acidic. Copper and nitrogen compounds especially nitrate are important nutrients to methanotrophic bacteria but their optimal concentrations have not been founded. Phosphorus and other elements such as potassium and manganese are reported to affect the performance of methanotrophic bacteria but need further confirmation. | Nazim CICEK Danny MANN | 2011 | Journal of Arid Land2011，3，1： | 2 |
| 6 | 土耳其门诊精神分裂症患者性功能障碍的一项横断面研究(英文)显示文摘背景:性功能障碍是影响患者对抗精神病药物服药依从性的因素之一,但尚不清楚这个问题的严重程度。目的:比较服用抗精神病药物且临床症状稳定的精神分裂症患者和健康对照者自我报告的性功能状况。评估工具采用土耳其语版的5个条目的亚利桑那性体验量表(Arizona Sexual Experience Scale,ASEX)。该量表的效度已在土耳其得到验证。量表评估性欲、性唤起、阴道润滑/阴茎勃起、达到高潮的能力以及对高潮的满意度等5个方面的性功能。方法:采用阳性症状量表、阴性症状量表和ASEX分别对101例临床症状稳定的门诊精神分裂症患者(女性38例、男性63例)进行评估。对89例无精神疾病史的对照者(女性41名、男性48名)也进行了ASEX量表评估。如果ASEX总分(范围5-30)>18,或者任一条目得分(范围1-6)≥5,或者至少有3个条目得分都大于4,则被视为存在性功能障碍。结果:自我报告有性功能障碍的男性精神分裂症患者多于健康对照者(46%对8%)。虽然女性患者性功能障碍的患病率显著高于男性患者(68%对46%),但是对照组中健康女性的性功能障碍患病率也非常高(68%),因而女性患者的性功能障碍不能归咎于她们的疾病或是正在服用的药物。患者组中,阳性症状和阴性症状的严重程度与性功能障碍无相关性,服用第一代抗精神病药的患者与服用第二代抗精神病药的患者之间的性功能障碍严重程度无明显差异。结论:在土耳其,不同性别的精神分裂症患者性功能状况的研究结果不同,这凸显了在评估精神障碍和药物对性功能的影响时制定特定区域、特定性别的性行为社会规范的重要性。今后需要采用前瞻性研究来区分文化规范、精神疾病以及使用的抗精神病药物在精神分裂症患者性功能障碍的病因和病程中的相对作用。 | Cicek HOCAOGLU Fatmasul H. CELIK Gokhan KANDEMIR Hulya GUVELI Bulent BAHCECl | 2014 | 上海精神医学2014，26，6： | 2 |
| 7 | A Computational Investigation of the Thermohydraulics of an EGS Project显示文摘A numerical analysis of the thermohydraulics of an enhanced geothermal system project is presented. The rock structures are modelled as porous medium, based on the computationally obtained hydraulic fracturing data of other authors. The influence of the domain size, grid resolution, temporal resolution and the discretization scheme is assessed to obtain a highly accurate numerical solution under the prevailing modelling assumptions. Based on the numerical model, different production scenarios are investigated and discussed. The relative positioning of the injection and production ports is also analyzed. It is shown that there is a considerable potential for optimizing the production rate and the port configuration to obtain the most favorable results for the production temperature, investment costs and operation costs. | BENIM Ali Cemal CICEK Aydin EKER Arif Mert | 2018 | Journal of Thermal Science2018，27，5： | 2 |
| 8 | Breast cancer bone metastasis and current small therapeutics 显示文摘 | Cicek M Oursler MJ | 2006 | Cancer Metastasis Rev2006，25，4： | 1 |
| 9 | State-of-the-art of membrane bioreactors: Worldwide research and commercial applications in North America 显示文摘 | Yang W Cicek N Ilg J | 2006 | Journal of Membrane Science2006，270，12： | 1 |
| 10 | State of the art of membrane bioreactors: worldwide research and commercial applications in North Ameirca显示文摘 | Yang W B Cicek N Ilg J | 2006 | Journal of Mebmrane Science2006，270，12： | 1 |
| 11 | Comparison of propofol- alfentanil and propofol -remifentanil anaesthesia in percutaneous nephrol thotripsy 显示文摘 | Cicek M Koroglu A Demirbilek S | 2005 | Eur J Anaesthesiol2005，22，9： | 1 |
| 12 | Lime Based Steam Autoclaved Fly Ash Bricks 显示文摘 | CICEK T TANRIVERDIM | 2007 | Construction and Building Materials2007，21，6： | 1 |
| 13 | Hydrogen production by Clostridium thermocellum 27405 from cellulosic biomass substrates 显示文摘 | David B Levin Rumana Islam Nazim Cicek | 2006 | Int J Hydrogen Energy2006，31，11： | 1 |
| 14 | Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity显示文摘 | Cicek M Fukuyama R Welch D R | 2005 | Cancer Res2005，65，9： | 1 |
| 15 | Treatment of swine wastewater by submerged membrane bioreactors with consideration of estrogenic activity removal显示文摘 | Yang W Cicek N | 2008 | Desalination2008，231，： | 1 |
| 16 | Ensuring location diversity in privacy-preserving spatio-temporal data publishing显示文摘 | CICEK A E NERGIZ M E SAYGIN Y | 2014 | The VLDB Journal2014，23，4： | 1 |
| 17 | Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis显示文摘Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved.Adipose-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and pluripotency.AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics.They are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells.It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression.These advantages have popularized its use in many fields including plastic reconstructive surgery.However,in the field of hepatology and liver transplantation,the progress is slower.AD-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract regeneration.These are very important for the treatment of various hepatobiliary diseases.Furthermore,the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis.We need alternative therapeutic approaches to treat end-stage liver failure.AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation.Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis. | Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz | 2022 | World Journal of Clinical Cases2022，10，14： | 1 |
| 18 | Diagnostic value of bilirubin concentrations compared with novel and traditional biomarkers in atherosclerosis with coronary artery disease 显示文摘 | Yilmaz N Cicek HK Celik A | 2006 | Saudi Med J2006，27，： | 1 |
| 19 | The effects of irrigafion fluid volume and irrigation time on fluid electrolyte balance and her ynamics in percutaneous nephrolithotipsy显示文摘 | Koroglu A Togal T Cicek M | 2003 | 1nt Urol Nephrol2003，35，1： | 1 |
| 20 | Podocalyxin increases the aggressive phenotype of breast and prostate cancer ceils in vitro through its interaction with Ezrin显示文摘 | Sizemore S Cicek M Sizemore N | 2007 | Cancer Res2007，67，13： | 1 |
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