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	题名	作者	年代	出处	被引量
1	HIV-1Gag、Tat、Rev和Nef蛋白特异性的免疫应答显示文摘目的: 探讨中国HIV/AIDS患者HIV-1 Gag、 Tat、 Rev和Nef蛋白特异性CTL应答的特征.方法: 应用覆盖HIV-1B、 C亚型Gag、 Tat、 Rev和Nef蛋白的220个肽段作为抗原, 通过ELISPOT方法检测HIV/AIDS患者HIV特异性CTL应答.结果: 无论HIV-1B亚型还是HIV-1C亚型所构建肽库的应答强度和频率, 主要集中在Gag和Nef蛋白, Tat和Rev蛋白也有不同程度的应答.HIV-1 B、 C亚型间应答比较, 整体应答强度大致相同, 但免疫优势区间存在着一定的差异, B亚型Gagp24亚蛋白的288~313氨基酸区应答最强, 而C亚型Gagp24亚蛋白的155~181氨基酸区应答最强; 两个亚型免疫优势区应答频率最高的都是Nef蛋白106~143氨基酸区(48.1%). 结论: 中国人群CTL应答多集中在Gag和Nef蛋白, B、 C亚型间略有差异且存在交叉识别, 这对设计针对中国人群的HIV疫苗是有重要的意义.	翟嵩康文臻于旭王少扬 Walker BD Altfeld M 孙永涛	2005	细胞与分子免疫学杂志2005，21，2：	3
2	HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes (CTL) in HIV-1-infection显示文摘	Addo M Altfeld M Rathod A	2002	AIDS2002，6，：	1
3	NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection 显示文摘	Alter G Altfeld M	2009	J Imern Med2009，265，1：	1
4	HIV-1 superinfection despite broad CD8+T-cell responses containing replication of the primary virus显示文摘	Altfeld M Allen T M Yu X G	2002	Nature2002，420，：	1
5	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
6	The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infeeted individuals 显示文摘	Addo M M Altfeld M Rosenberg E S	2001	Proc Natl Acad Sci USA2001，98，4：	1
7	Selctive escape from CD8^+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution显示文摘	Allen T M Altfeld M Geer S C	2005	J Virol2005，79，13：	1
8	Rapid definition of five novel HLA-A·3002-restricted human epitopes by Elispot and intracellular cytokine staining assay显示文摘	Goulder PJ Addo M M Altfeld MA	2001	J Virol2001，75，3：	1
9	Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection显示文摘	Altfeld M Addo MM Rosenberg ES	2003	AIDS2003，17，18：	1
10	CD107a as a functional maker for the identification of natural killer cell activity显示文摘	Alter G Malenfant J M Altfeld M		0，，1：	1
11	Innate immunity against HIV-1 infection显示文摘	Altfeld M Gale M Jr	2015	Nat Immunol2015，16，6：	1
12	Immune control of HIV- 1 after early treatment of acute infection显示文摘	Rosenberg ES Altfeld M Poon SH	2000	Nature2000，407，：	1
13	The role of CD4 + T helper cells in thecytotoxic T lymphocyte response to HIV-1显示文摘	Altfeld M Rosenberg ES	2000	Curr Opin Immunol2000，12，4：	1
14	Control of human viral infections by natural killer cells显示文摘	Jost S Altfeld M	2013	Annu Rev Immunol2013，31，11：	1
15	Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection显示文摘	Altfeld M Rosenberg E S Shankarappa R	2001	Exp Med2001，193，：	1
16	Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection 显示文摘	Allen TM Altfeld M Yu XG	2004	J Virol2004，78，13：	1
17	The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxie T lymphocytes derived from HIV- 1-infected individuals 显示文摘	Addo M M Altfeld M Rosenberg E S	2001	Proe Natl Acad Sei USA2001，98，4：	1
18	The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1显示文摘	Altfeld M	2000	Curr Opin Immunol2000，12，4：	1
19	The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals显示文摘	Addo MM Altfeld M Rosenberg ES	2001	Proc Natl Acad Sci USA2001，98，4：	1
20	Innate immunity against HIV-1 infection 显示文摘	Altfeld M Gale Jr M	2015	Nat Immunol2015，16，6：	1

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