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231篇 您的检索式:作者名="David Lewis"
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1Is there a role for serum endothelin in predicting the severity of acute pancreatitis?显示文摘BACKGROUND: Acute pancreatitis remains a common presentation to acute surgical units and carries significant morbidity and mortality. The progression of the disease to necrotizing pancreatitis and multi-organ dysfunction syndrome (MODS) is associated with a very poor clinical outcome, and persistendy high mortality. Increases in serum endothelin (ET) have been seen in animal models of acute pancreatitis and this study aims to investigate whether there is a change in serum ET-1 in patients with acute pancreatitis and whether any such change is linked to disease severity. METHODS: All patients admitted with acute pancreatitis were prospectively recruited from die emergency admissions at the Norfolk and Norwich University Hospital. Serum ET levels were determined on admission, at 24 hours and 5 days post admission. Healthy adult controls were recruited from dermatology outpatients. RESULTS: A total of 21 patients joined the trial after giving informed consent. There were 3 men and 18 women with a median age of 65 years (range 26-87 years). Serum ET levels were significantly higher in acute pancreatitis patients than in normal controls (P <0. 05). An association was seen between persistendy raised serum ET levels and progression to MODS. CONCLUSIONS: The study does demonstrate a correlation between the circulating levels of ET and acute pancreatitis in humans, although it does not elicit its involvement in the pathogenesis of the disease. The observation that a persistendy high level of circulating ET-1 is associated with progression to MODS may indicate a role for ET in the monitoring of acute pancreatitis patients for recovery or progression to MODS.John Bennett David Cooper Anita Balakrishnan Michael Rhodes Michael Lewis 2006Hepatobiliary & Pancreatic Diseases International2006,5,2:8
2Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets显示文摘Benjamin P. Lewis Christopher B. Burge David P. Bartel 2005Cell2005,,1:8
3美国肺动脉高压治疗指南显示文摘David B.Badesch Steven H.Abman Gerald Simonneau Lewis J.Rubin Vallerie V.McLaughlin 李井泉 2008中国全科医学2008,11,2:7
4Prediction of Mammalian MicroRNA Targets显示文摘Benjamin P. Lewis I-hung Shih Matthew W. Jones-Rhoades David P. Bartel Christopher B. Burge 2003Cell2003,,7:7
5Quantitative Changes in Microtubule Distribution Correlate with Guard Cell Function in Arabidopsis显示文摘放射状地安排的外皮的微导管是警卫房间的一个突出的特征。我们观察了与共焦的显微镜学表示 GFP 导管素(GFP-TUA6 ) 的警卫房间并且当时,在微导管的外观发现了可认识的变化开或靠近的 stomata (Eisinger 等, 2012 ) 。在现在的学习,荧光分发的分析作为 stomata 在警卫房间以内在微导管捆的山峰紧张显示出戏剧的增加开。这增加随能被归因于 polymerized 导管素的全部的荧光的增加被相关。邻近的人行道房间没在山峰紧张或综合荧光看类似的变化有气孔的孔什么时候变化了。标注 RFP 的结束绑定蛋白质 1 的成像(EB1 ) 和在一样的房间表示的标注 YFP 的导管素表明有种结束的微导管的数字仍然保持不变,尽管 polymerized 导管素的全部的数量是更高的在比在关上的警卫房间开。一起拿,这些结果显示在微导管的变化穿被相关与并且为正常要求警卫房间功能被变化在聚类的微导管或捆绑描绘的组织。William R. Eisinger Viktor Kirik Charlotte Lewis David W. Ehrhardt Winslow R. Briggs 2012Molecular Plant2012,5,3:4
6Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets显示文摘Benjamin P. Lewis Christopher B. Burge David P. Bartel 2005Cell2005,,1:4
7Comparison of Standard Forward Viewing Mode Versus Ultra-Wide Viewing Mode of a Novel Colonoscopy Platform: A Prospective, Multicenter Study in the Detection of Simulated Polyps in an in vitro Colon Model显示文摘Ian M. Gralnek David L. Carr-Locke Ori Segol Zamir Halpern Peter D. Siersema Alan Sloyer Jay Fenster Blair S. Lewis Erwin Santo Alain Suissa Meytal Segev 2012Gastrointestinal Endoscopy2012,,:3
8α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma显示文摘Jorge A. Marrero Ziding Feng Yinghui Wang Mindie H. Nguyen Alex S. Befeler Lewis R. Roberts K. Rajender Reddy Denise Harnois Josep M. Llovet Daniel Normolle Jackie Dalhgren David Chia Anna S. Lok Paul D. Wagner Sudhir Srivastava Myron Schwartz 2009Gastroenterology2009,,1:3
9Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species显示文摘This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic range.The new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique morphology.The family is sister to Biatriosporaceae and Roussoellaceae.The new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,A.muriformia,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,C.aureum,C.frutexensis,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,C.sibiraeae,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,D.meiosporum,D.thailandicum,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,K.spartii,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,L.ravennicum,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,N.italica,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,P.thysanolaenae,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,P.dracontomelon,P.italiana,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tamarindi,Pseudotrichia rubriostiolata,P.thailandica,Psiloglonium multiseptatum,Saagaromyces mangrovei,Sarimanas pseudofluviatile,S.shirakamiense,Tothia spartii,Trichomerium siamensis,Wojnowicia dactylidicola,W.dactylidis and W.lonicerae.The Basidiomycota Agaricus flavicentrus,A.hanthanaensis,A.parvibicolor,A.sodalis,Cantharellus luteostipitatus,Lactarius atrobrunneus,L.politus,Phylloporia dependens and Russula cortinarioides are also introduced.Epitypifications or reference specimens are designated for Hapalocystis berkeleyi,Meliola tamarindi,Pallidocercospora acaciigena,Phaeosphaeria musae,Plenodomus agnitus,Psiloglonium colihuae,P.sasicola and Zasmidium musae while notes and/or new sequence data are provided for Annulohypoxylon leptascum,A.nitens,A.stygium,Biscogniauxia marginata,Fasciatispora nypae,Hypoxylon fendleri,H.monticulosum,Leptosphaeria doliolum,Microsphaeropsis olivacea,Neomicrothyrium,Paraleptosphaeria nitschkei,Phoma medicaginis and Saccotheciaceae.A full description of each species is provided with light micrographs(or drawings).Molecular data is provided for 90 taxa and used to generate phylogenetic trees to establish a natural classification for species.Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin Zhao Erio Camporesi 2015Fungal Diversity2015,,3:3
10ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension显示文摘Vallerie V. McLaughlin Stephen L. Archer David B. Badesch Robyn J. Barst Harrison W. Farber Jonathan R. Lindner Michael A. Mathier Michael D. McGoon Myung H. Park Robert S. Rosenson Lewis J. Rubin Victor F. Tapson John Varga 2009Journal of the American College of Cardiology2009,,17:2
11Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin 2008Circulation2008,,23:2
12Skeletal muscle creatine kinase MB alterations in women marathon runners显示文摘Fred S. Apple Marc A. Rogers David C. Casal Linda Lewis John L. Ivy Johanna W. Lampe 1987European Journal of Applied Physiology and Occupational Physiology1987,,1:2
13Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer显示文摘Christopher P. Twine S. Ashley Roberts Wyn G. Lewis B. Vicki Dave Claire E. Rawlinson David Chan Mark Robinson Tom D. Crosby 2010Surgical Endoscopy2010,,4:2
14Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities显示文摘Robert G. Gish Bruce D. Given Ching-Lung Lai Stephen A. Locarnini Johnson Y.N. Lau David L. Lewis Thomas Schluep 2015Antiviral Research2015,,:2
152009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations显示文摘Jacques Genest Ruth McPherson Jiri Frohlich Todd Anderson Norm Campbell André Carpentier Patrick Couture Robert Dufour George Fodor Gordon A. Francis Steven Grover Milan Gupta Robert A. Hegele David C. Lau Lawrence Leiter Gary F. Lewis Eva Lonn G.B. John 2009Canadian Journal of Cardiology2009,,10:2
16Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: The Coronary Artery Risk Development in Young Adults Study显示文摘Lisa B. VanWagner Hongyan Ning Cora E. Lewis Christina M. Shay John Wilkins J. Jeffrey Carr James G. Terry Donald M. Lloyd-Jones David R. Jacobs Mercedes R. Carnethon 2014Atherosclerosis2014,,2:2
17α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis 2014Cellular & Molecular Immunology2014,11,4:2
18Evolution in the Management of Hepatic Trauma: A 25-Year Perspective显示文摘J. David Richardson Glen A. Franklin James K. Lukan Eddy H. Carrillo David A. Spain Frank B. Miller Mark A. Wilson Hiram C. Polk Lewis M. Flint 2000Annals of Surgery2000,,3:2
19Rethinking aquaculture for resource-poor farmers: perspectives from Bangladesh显示文摘David Lewis 1997Food Policy1997,226,:1
20Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow 2012The Lancet . 2012 (9850)2012,,9850:1
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