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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Role of cytokines and chemokines in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease (NAFLD) includes a variety of histological conditions (ranging from liver steatosis and steatohepatitis, to fibrosis and hepatocarcinoma) that are characterized by an increased fat content within the liver. The accumulation/deposition of fat within the liver is essential for diagnosis of NAFLD and might be associated with alterations in the hepatic and systemic inflammatory state. Although it is still unclear if each histological entity represents a different disease or rather steps of the same disease, inflammatory processes in NAFLD might influence its pathophysiology and prognosis. In particular, non-alcoholic steatohepatitis (the most inflamed condition in NAFLDs, which more frequently evolves towards chronic and serious liver diseases) is characterized by a marked activation of inflammatory cells and the upregulation of several soluble inflammatory mediators. Among several mediators, cytokines and chemokines might play a pivotal active role in NAFLD and are considered as potential therapeutic targets. In this review, we will update evidence from both basic research and clinical studies on the potential role of cytokines and chemokines in the pathophysiology of NAFLD. | Vincent Braunersreuther Giorgio Luciano Viviani Franois Mach Fabrizio Montecucco | 2012 | World Journal of Gastroenterology2012，18，8： | 40 |
| 3 | 基于MAX30102的穿戴式血氧饱和度检测系统显示文摘本文设计了一种以MAX30102血氧饱和度和心率的集成芯片为传感器,nRF52832为微处理器的穿戴式血氧饱和度检测系统。系统设计过程中充分利用MAX30102光电反射式血氧传感器集光电发射接收、数模转换、数据滤波为一体,nRF52832 Cortex-M4F微处理器集成硬FPU单元和多种无线通信协议的优点,提高了检测模块的抗干扰能力和系统的运行速度及信号处理能力,降低了系统的开发时间和系统功耗,为系统的智能化提供多平台支持。在系统的信号处理算法上,设计了多种滤波算法进行比较,并选择了性能较优适合本系统的Dtrend去趋势算法虑除基线漂移和运动伪差干扰,以实现了更为精准的穿戴式血氧饱和度检测系统的设计。 | 白鹏飞 刘强 段飞波 安琪 Nicolaas Frans de Rooij 李楠 周国富 | 2017 | 激光与红外2017，47，10： | 35 |
| 4 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 5 | Genesis of Daba arcuate structural belt related to adjacent basement upheavals:Constraints from Fission-track and (U-Th)/He thermochronology显示文摘Fission-track, (U-Th)/He thermochronology, and cooling properties indicate that the southern Daba arcuate zone (SDBAZ) underwent a distinctive phase of rapid cooling in 153-100 Ma at a rate of 1.44-1.90°C/Ma. This rapid uplifting strongly contrasts with (1) the previous, rapid foreland subsidence during Early to Middle Jurassic in response to late-orogenic compression from the Qinling belt, (2) the succeeding long, slow cooling phase and relative thermal stability that occurred during the 100-45 Ma period. This rapid cooling event in the SDBAZ parallels those experienced by two adjacent upheavals of Huangling (HLUZ) and Hannan-Micang (HMUZ), with cooling rates of 2.22-3.17°C/Ma for the HLUZ in 160-126 Ma, 4.91°C/Ma for the southern HMUZ in 150-125 Ma, as well as 2.11°C/Ma for the northern HMUZ in 150-105 Ma. Comparing thermal histories among the SDBAZ, the HLUZ, the HMUZ, and the Wudang metamorphic zone (WDMZ), we infer that the Daba arcuate structural belt formed in 153-100 Ma. The combined dating data support a correlation with a low-angle arcuate south-thrusting of the Qinling orogen triggered by northward convergence of the Yangtze Craton, contemporaneously encountering rigid basement obstructions from the HLUZ and the HMUZ, respectively. Both the SDBAZ and neighboring domains additionally underwent a comparatively fast cooling and uplift since about 45 Ma. | GUILLOT Franois | 2010 | Science China Earth Sciences2010，53，11： | 24 |
| 6 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 7 | Association of smoking, alcohol drinking and dietary factors with esophageal cancer in high- and low-risk areas of Jiangsu Province, China显示文摘瞄准:到环境的 main 和在食道的癌症(EC ) 说明地区性的差别的生活方式因素在江苏省的低风险、高风险的区域冒的风险的学习,中国。方法:自从 2003,基于人口的盒子控制研究同时被进行了在低风险(Ganyu 县) 并且高风险(Dafeng 县) 江苏省的区域,中国。使用相同协议和 pre-tested 标准化了问询表,跟随写的知情同意,合格题目被询问他们 EC 的潜在的决定因素的详细信息包括人口统计的信息,社会经济的地位,生活条件,疾病历史,家庭癌症历史,吸烟,酒精喝酒,饮食的习惯,频率,食物摄取的数量,等等。有最大的可能性评价的有条件的逻辑回归被用来获得机会比率(或) 并且 95 % 信心间隔(95% CI ) ,在为潜力的调整以后,反对失败。结果:在进行中的学习的初步的分析,我们招募了在 Ganyu 的在 Dafeng 的 291 个盒子和 240 个盒子和控制分别地。在低风险、高风险的区域, EC 相反地与社会经济的地位被联系,例如教育的水平,经过经济地位和身体团索引。然而,这疾病在有癌症的家庭历史或在过去的 10 年里遇到了不幸的那些之中是更经常的。EC 在吸烟者,白酒喝酒者和快食客之中也是更经常的。而且,有在吸烟,酒精喝酒和尽管有在低风险、高风险的区域的这些风险因素的类似的流行的 EC 风险之间的协会的一个地理变化。吸烟并且吸烟的剂量反应关系联系了变量,例如首先吸烟,持续时间和数量的年龄在高风险的区域仅仅是明显的。相反,在 EC 上喝的酒精的效果上的一种剂量反应关系仅仅在低风险的区域被观察。结论:环境风险因素,可能和基因因素和基因环境的相互作用是为在江苏省的这个高风险的坡度的主要原因,中国。 | Ming Wu Jin-Kou Zhao Xiao-Shu Hu Pei-Hua Wang Yu Qin Yin-Chang Lu Jie Yang Ai-Min Liu De-Lin Wu Zuo-Feng Zhang Kok J Frans Pieter van't Veer | 2006 | World Journal of Gastroenterology2006，12，11： | 18 |
| 8 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 9 | Potential pathophysiological role for the vitamin D deficiency in essential hypertension显示文摘Vitamin D deficiency has been indicated as a pandemicemerging public health problem. In addition to the well-known role on calcium-phosphorus homeostasis in thebone, vitamin D-mediated processes have been recentlyinvestigated on other diseases, such as infections, can-cer and cardiovascular diseases. Recently, both the dis-covery of paracrine actions of vitamin D(recognized as'local vitamin D system') and the link of vitamin D with renin-angiotensin-aldosterone system and the fibroblast growth factor 23/klotho pathways highlighted its ac-tive cardiovascular activity. Focusing on hypertension, this review summarizes the more recent experimental evidence involving the vitamin D system and deficiency in the cardiovascular pathophysiology. In particular, we updated the vascular synthesis/catabolism of vitamin D and its complex interactions between the various endocrine networks involved in the regulation of blood pressure in humans. On the other hand, the conflicting results emerged from the comparison between obser-vational and interventional studies emphasize the frag-mentary nature of our knowledge in the field of vitamin D and hypertension, strongly suggesting the need of further researches in this field. | Federico Carbone Fran?ois Mach Nicolas Vuilleumier Fabrizio Montecucco | 2014 | World Journal of Cardiology2014，6，5： | 17 |
| 10 | Rise of China and India in International Trade:From Textiles to New Technology显示文摘中国和印度是变得大开发经济力量的二个人口统计的巨人。他们坚持说他们在纺织品和发达向外面向的部门的专门化连接了到新技术,利用 offshoring 并且采购。他们对国际贸易的增加的贡献正在改变世界供应和生产商品,主要商品和服务的需求。他们是在劳动的国际部门的新领导人,但是在技术追上来以外,他们的挑战是优秀的升级。国家逐渐地正在贡献全球经济生长,但是他们还不能自己触发世界的其余部分的生长。 | Franoise Lemoine Deniz nal-Kesenci | 2008 | China & World Economy2008，16，5： | 17 |
| 11 | The burden of liver disease in Europe: A review of available epidemiological data显示文摘 | Martin Blachier Henri Leleu Markus Peck-Radosavljevic Dominique-Charles Valla Fran?oise Roudot-Thoraval | 2013 | Journal of Hepatology2013，，3： | 16 |
| 12 | Endoscopic and histologic characteristics of serrated lesions显示文摘In recent years , a second pathway for colonic carcinogenesis , distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp,characterised by a serrated appearance of the crypts:hyperplastic polyps(HP),sessile serrated adenomas(SSA)or lesions,and traditional serrated adenomas.Each lesion has its own genetic,as well as macroscopic and microscopic morphological features.Because of their flat aspect,their detection is easier with chromoendoscopy(carmin indigo or narrow-band imaging).However,as we show in this review,the distinction between SSA and HP is quite difficult.It is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of dysplasia.These different types of lesion are described in detail in the present review in general population,in polyposis and in inflammatory bowel diseases patients.This review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis. | Driffa Moussata Gilles Boschetti Marion Chauvenet Karine Stroeymeyt Stéphane Nancey Franoise Berger Thierry Lecomte Bernard Flourié | 2015 | World Journal of Gastroenterology2015，21，10： | 14 |
| 13 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 14 | Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum显示文摘AIM: To evaluate the results of segmental duodenectomy (SD) and pancreaticoduodenectomy (PD) for duodenal gastrointestinal stromal tumor (GIST) and help clinicians with surgical management. METHODS: All patients who underwent surgery for non-metastatic GIST of the duodenum in a single institution since 2000 were prospectively followed up. Seven patients (median age 51 years, range: 41-73 years) were enrolled: five underwent SD and two underwent PD. RESULTS: All the patients had a complete resection (R0), with no postoperative morbidity and mortality. Among the SD group, GIST was classified as low risk in two patients, intermediate risk in two, and high risk in one, according to the Fletcher scale, (vs two high risk patients in the PD group). With a median followup of 41 (18-85) mo, disease-free survival (DFS) rateswere 100% after SD and 0% after PD (P < 0.05). The median DFS was 13 mo in the PD group. CONCLUSION: Whenever associated with clear surgical margins, SD is a reliable and curative option for most duodenal GISTs, and is compatible with longterm DFS. | Nicolas Christian Buchs Pascal Bucher Pascal Gervaz Sandrine Ostermann Franois Pugin Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，22： | 13 |
| 15 | Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks显示文摘Hepatocyte nuclear factor 4-alpha(HNF4-α)is a nuclear receptor regulating metabolism,cell junctions,differentiation and proliferation in liver and intestinal epithelial cells.Mutations within the HNF4A gene are associated with human diseases such as maturityonset diabetes of the young.Recently,HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies.In addition,specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease.Results obtained from knockout mice supported that HNF4-αcan protect the intestinal mucosae against inflammation.However,the exact molecular links behind HNF4-αand inflammatory bowel diseases remains elusive.In this review,we will summarize the current knowledge about the role of HNF4-αand its isoforms in inflammation.Specific nature of HNF4-αP1 and P2 classes of isoforms will be summarized.HNF4-αrole as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature.Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation.Finally,potential functional roles for HNF4-αisoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented. | Jean-Philippe Babeu Franois Boudreau | 2014 | World Journal of Gastroenterology2014，20，1： | 12 |
| 16 | 泻阴补阳合巨刺针刺法治疗脑卒中后肌张力障碍Ashworth痉挛量表的临床疗效观察显示文摘目的:观察泻阴补阳合巨刺法治疗脑卒中后肌张力障碍Ashworth痉挛量表的临床疗效。方法:120例脑卒中后肌张力障碍患者采用随机分组法分为治疗组A组和对照组B、C、D组,治疗组采用泻阴补阳合巨刺针刺法,对照组B组采用传统针刺法合巨刺法,C组采用泻阴补阳针刺法,D组采用传统针刺法,每组各30例患者,每位患者均在脑卒中的西医常规治疗方法的基础上进行治疗。治疗前后采用Ashworth痉挛量表进行评定。结果:泻阴补阳合巨刺法对脑卒中后肌张力障碍的治疗效果明显优于对照组。结论:泻阴补阳合巨刺法对脑卒中后肌张力障碍的疗效显著,能有效改善患者的运动功能和生活能力。 | 李作伟 李平 Eudes Saturnin Régis ITOUA Franoise NDINGAANDELY Donatien MOUKASSA | 2016 | 世界中医药2016，11，2： | 11 |
| 17 | A^200 ka pollen record from Okinawa Trough:Paleoenvironment reconstruction of glacial-interglacial cycles显示文摘Pollen analysis was carried out on the Core MD982194 of 29.78 m retrieved from the Middle Okinawa Trough which was dated as old as^200 ka BP.The results revealed that pollen assemblages mainly presented an alternation of coniferous and herb pollen.The coniferous saccate pollen,principally Pinus and Tsuga,predominated in most parts of the core,especially highlighted in the interstadial stages including MIS 1,3,5 and MIS7,whereas the herb pollen significantly increased in the glacial periods.Thus the pollen flora and their percentages showed the sensitive changes under the influence of ice volume during the glacial and interglacial periods.Our record from this core has first documented that the percentage of Cyperaceae was extremely high in the glacial stages with a notable increase in Artemisia,Gramineae,Asteraceae,Chenopodiaceae,and freshwater algae,which can be used as a proxy for sea-level change at the study site because of their close negative correlation of the orbital-scale changes in sea level.The distance between the continental coastline and the Okinawa Trough has deeply shortened due to the sea-level drop in the LGM.As a result,the sediment materials from Yangtze River were extensively deposited on the flat,exposed continental shelf owing to the rapid decline of river flow speed,leading to that pollen grains from Okinawa Trough are derived mainly from the flat coastal vegetation of exposed continental shelf at glacial stages.Changes of pollen assemblage were consistent with the variation of temperature and humidity,which showed that the percentage of arboreal pollen was highly augmented at MIS 7,5 and MIS 1,corresponding to the strengthening of the East Asian summer monsoon and increasing of rainfall.Moreover,the peak of Pinus percentage in MIS 5.3,5.1 and MIS 3.3 may be closely linked by orbital and sub-orbital cycles of solar radiation and monsoonal variability.The present study of core MD981294 implied lower temperature and precipitation during the lowest sea-level stage(LGM),and more visibly testified that the vegetation of the flat plain on the exposed continental shelf was dominated by intrazonal communities such as halophyte grasslands and freshwater wetlands instead of zonal steppe or semi-arid desert.All above evidence demonstrated that the fundamental changes of pollen assemblage and their origins in Okinawa Trough since^200 ka BP were affected by combine factors including the coastline position and climate fluctuation.Moreover,the substantial shortening of distance between shoreline and the Okinawa Trough driven by orbital insolation cycles was clearly indicated by the pollen spectra,whereas the source-area climate signal of the pollen record was largely weakened. | ZHENG Zhuo HUANG KangYou DENG Yun CAO LingLong YU ShaoHua Jean-Pierre SUC Serge BERNE Franois GUICHARD | 2013 | Science China Earth Sciences2013，56，10： | 11 |
| 18 | 核废料地质贮存介质黏土岩的三维各向异性热-水-力耦合数值模拟显示文摘为了解黏土岩在放射性废料长期贮存中的热-水-力耦合过程,结合MontTerri核废料贮存地下岩石试验工程中黏土岩各种物理量的各向异性特点,应用多孔介质力学耦合理论研究了该黏土岩在加热和冷却全过程中由于热荷载引起的耦合效应场。研究过程考虑温度升高引起的孔隙水黏滞性改变对渗透系数的影响。研究结果表明,岩体力学参数、水力学参数和热传导参数的各向异性特性是影响岩体的温度场、孔隙压力场和应力场分布的最主要因素。各向异性耦合模型与各向同性耦合模型的数值模拟对比研究结果表明:各向异性模型数值结果能更加客观地反映该地下岩石试验工程中黏土岩在受热状态下的热-水-力耦合效应;同时,也表明岩体在加热过程中一直处于受压状态,而在冷却过程中局部会出现拉应力,从而有可能导致拉裂缝的产生。 | 蒋中明 Dashnor Hoxha Franoise Homand | 2007 | 岩石力学与工程学报2007，26，3： | 11 |
| 19 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 20 | Carbon/carbon supercapacitors显示文摘Supercapacitors, or electrochemical capacitors, are a power storage system applied for harvesting energy and delivering pulses during short periods of time. The commercially available technology is based on charging an electrical double-layer (EDL), and using high surface area carbon electrodes in an organic electrolyte. This review first presents the state-of-the-art on EDL capacitors, with the objective to better understand their operating principles and to improve their performance. In particular, it is shown that capacitance might be enhanced for carbons having subnanometric pores where ions of the electrolyte are distorted and partly desolvated. Then, strategies for using environment friendly aqueous electrolytes are presented. In this case, the capacitance can be enhanced through pseudo-faradaic contributions involving i) surface functional groups on carbons, ii) hydrogen electrosorption, and iii) redox reactions at the electrode/electrolyte interface. The most promising system is based on the use of aqueous alkali sulfate as electrolyte allowing voltages as high as 2 V to be reached, due to the high overpotential for di-hydrogen evolution at the negative electrode. | Elzbieta Frackowiak Qamar Abbas Franois Bguin | 2013 | Journal of Energy Chemistry2013，22，2： | 10 |
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