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| 1 | 中国人群遗传性耳聋研究进展显示文摘耳聋有着复杂的病因学特点,遗传和/或环境因素均可致聋。120多个耳聋相关基因的发现为我们了解听觉的病理生理机制提供了新的视点。然而,最近的研究表明在中国相当一部分综合征性和非综合征性耳聋仅由为数不多的几个基因突变引起。本文旨在综述综合征性、非综合征性及线粒体遗传性聋在中国人群感音神经性聋致病机制方面的最新进展。深入了解中国人群耳聋分子病因学特点,对获得准确的耳聋早期诊断和遗传咨询,以便及时干预和治疗至关重要。 | 刘学忠 欧阳小梅 Denise Yan 袁永一 袁慧军 | 2006 | 中华耳科学杂志2006，4，2： | 81 |
| 2 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 3 | 由高级实践护士主导的延续护理现状与展望显示文摘在未来的十年里,高级实践护理角色的成长和使用将得到飞速发展。当今医疗卫生服务模式旨在改善患者和医疗体系的临床结局,明确高级实践护理角色在该模式中的临床职责对确保其成功实施以及发挥影响有着重要作用。延续护理模式是借助于护士的临床经验和专业知识从而发挥其高级角色功能的一种方法。本文旨在描述目前延续护理的需求和定义,总结由高级实践护士引导的延续护理的目标患者群体、特点和效果,同时提出高层护理管理者和领导者可用于发展和评估加入高级实践护理角色的延续护理新模式的策略。 | Denise Bryant-Lukosiu 刘晓航 张俊娥 | 2017 | 中国护理管理2017，17，4： | 22 |
| 4 | 农村基础设施投资与农民投资需求的关系--来自5省的实证分析显示文摘近年来,随着对农村基础设施建设的加强,大量的资金用于投资道路、灌溉和饮用水等设施,至于这些投资是否是当地居民迫切需要的仍然是一个有待回答的问题。本文利用5省101个村的村级和农户的追踪调查资料,描述了2005年初样本村的普通村民和村干部对基础设施建设的投资需求以及2005-2006年期间这些村的村级公共投资水平和投资结构,并以道路、灌溉设施、饮用水设施为例,详细分析了当地居民对这3类基础设施的投资需求排序与各村对这些项目的实际投资行为之间的关系。结果表明,农村村级饮用水设施和灌溉设施的项目实施与当地村民对这两类基础设施的投资需求呈现出高度的正相关关系;但是,虽然过去两年中样本村实施的道路项目最多,但并不是所有的道路投资都是村民最需要的。 | 易红梅 张林秀 Denise Hare 刘承芳 | 2008 | 中国软科学2008，，11： | 20 |
| 5 | 超越领导力:卫生政策协调的政治策略显示文摘'将健康融入所有政策'是指通过发挥不同部门的优势和积极性以改善人群健康状况。然而,在具体实施的过程中会面临各种官僚制度障碍,需要进行跨部门治理,而其中涉及的基本问题已经在公共管理学和政治学领域做过阐述。通过查阅文献发现,建立'将健康融入所有政策'跨部门治理的难点被分解为两大类问题:一是在所有部门中开展协调性行动(协调性),二是确保这些部门可以适应不同的政治环境(持续性)。本文还发现,决策者的应对策略也可以归纳为三种类型:明显的政治意愿(如各种计划和目标)、官僚制度改革(如引进卫生影响力评估或机构重组)以及各种间接策略(如各种数据发布以及从外部组织获得支持以向政府施加压力)。由此可以看出,与众多公共卫生政策一样,'将健康融入所有政策'也要依赖于可以做出并有效履行承诺的决策者,但这在不断变换的政治环境中往往不堪一击。三种应对策略则暗示了决策者该如何建立一种跨部门的治理制度,以扩大有效政策建议的范围。 | Scott L.Greer Denise F.Lillvis | 2014 | 中国卫生政策研究2014，7，9： | 15 |
| 6 | 树实验种群的繁育显示文摘探讨了树实验种群的繁育。结果是 5对成年树在 7个月内共产 1 1窝 3 1只仔树。 2 7只出生后即人工喂养的仔树中 ,2 5只健康存活至进入动物实验。成年树平均产仔周期为 (52± 8.9)d ;仔树的人工喂养成活率为 92 .6%。可以认为树实验种群的人工繁育是可行的。人工繁育的树有望取代野外捕获的树用于有关的动物实验研究。 | 李瑗 Karen Baumgartner Denise MacMillan Bill D.Roebuck | 2001 | 动物学杂志2001，36，3： | 10 |
| 7 | Current concepts in the management of radial head fractures显示文摘Fracture of the radial head is a common injury. Over the last decades, the radial head is increasingly recognized as an important stabilizer of the elbow. In order to maintain stability of the injured elbow, goals of treatment of radial head fractures have become more and more towards restoring function and stability of the elbow. As treatment strategies have changed over the years, with an increasing amount of literature on this subject, the purpose of this article was to provide an overview of current concepts of the management of radial head fractures. | Iza?k F Kodde Laurens Kaas Mark Flipsen Michel PJ van den Bekerom Denise Eygendaal | 2015 | World Journal of Orthopedics2015，6，11： | 9 |
| 8 | Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials显示文摘Millions of people worldwide suffer from a toothache due to tooth cavity,and often permanent tooth loss.Dental caries,also known as tooth decay,is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings(tooth colored fillings).Until now,restorative polymeric fillings present no bioactivity.The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials.Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria.Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials.The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against caries-related pathogens.It has been suggested that this bioactivity could minimize the incidence of caries around restorations(CARS)and increase the longevity of such filling materials.The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials.Herein,the caries disease process and the role of pathogenic caries-related biofilm,the increasing incidence of CARS,and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed.We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality. | Abdulrahman A.Balhaddad Anmar A.Kansara Denise Hidan Michael D.Weir Hockin H.K.Xu Mary Anne S.Melo | 2019 | Bioactive Materials2019，4，1： | 9 |
| 9 | 广东徐闻县西部沿岸海域的珊瑚虫纲物种显示文摘广东省徐闻县西部沿岸海域分布着珊瑚礁,现生珊瑚虫纲物种较丰富,本文将2004年调查研究的结果,结合文献记录的资料,综合整理,统计有石珊瑚目12科29属56种和5未定种,其它珊瑚虫纲物种有6目15科31种和12未定种.如进一步深入调查研究,还会有本区新的记录.本区石珊瑚目比处于更低纬度的海南岛种属少,但比处于更高纬度的涠洲岛种属多,符合喜热的物种依自然带分布的规律. | 赵焕庭 王丽荣 宋朝景 方静威 Denise McCorry 黄志俊 | 2009 | 台湾海峡2009，28，3： | 9 |
| 10 | Psychological and implied contracts in organizations显示文摘 | Denise M. Rousseau | 1989 | Employee Responsibilities and Rights Journal1989，，2： | 8 |
| 11 | Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach显示文摘Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients. This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods. The target audience includes clinicians involved in pre- and posttransplant patient care and rehabilitation researchers. | Lisa Wickerson Dmitry Rozenberg Tania Janaudis-Ferreira Robin Deliva Vincent Lo Gary Beauchamp Denise Helm Chaya Gottesman Polyana Mendes Luciana Vieira Margaret Herridge Lianne G Singer Sunita Mathur | 2016 | World Journal of Transplantation2016，6，3： | 8 |
| 12 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 13 | Serrated pathway in colorectal carcinogenesis显示文摘Serrated adenocarcinoma is a recently described subset of colorectal cancer(CRC),which account for about10%of all CRCs and follows an alternative pathway in which serrated polyps replace the traditional adenoma as the precursor lesion to CRC.Serrated polyps form a heterogeneous group of colorectal lesions that includes hyperplastic polyps(HPs),sessile serrated adenoma(SSA),traditional serrated adenoma(TSA)and mixed polyps.HPs are the most common serrated polyp followed by SSA and TSA.This distinct histogenesis is believed to have a major influence in prevention strategies,patient prognosis and therapeutic impact.Genetically,serrated polyps exhibited also a distinct pattern,with KRAS and BRAF having an important contribution to its development.Two other molecular changes that have been implicated in the serrated pathway include microsatellite instability and the CpG island methylator phenotype.In the present review we will address the current knowledge of serrated polyps,clinical pathological features and will update the most recent findings of its molecular pathways.The understanding of their biology and malignancy potential is imperative to implement a surveillance approach in order to prevent colorectal cancer development. | Letícia Yamane Cristovam Scapulatempo-Neto Rui Manuel Reis Denise Peixoto Guimares | 2014 | World Journal of Gastroenterology2014，20，10： | 8 |
| 14 | Screening pre-bariatric surgery patients for esophageal disease with esophageal capsule endoscopy显示文摘AIM:To determine if esophageal capsule endoscopy(ECE)is an adequate diagnostic alternative to esophagogastroduodenoscopy(EGD)in pre-bariatric surgery patients.METHODS:We conducted a prospective pilot study to assess the diagnostic accuracy of ECE(PillCam ESO2,Given Imaging)vs conventional EGD in pre-bariatric surgery patients.Patients who were scheduled for bariatric surgery and referred for pre-operative EGD were prospectively enrolled.All patients underwent ECE followed by standard EGD.Two experienced gastroenterologists blinded to the patient’s history and the findings of the EGD reviewed the ECE and documented their findings.The gold standard was the findings on EGD.RESULTS:Ten patients with an average body mass index of 50 kg/m2were enrolled and completed the study.ECE identified 11 of 14(79%)positive esophageal/gastroesophageal junction(GEJ)findings and 14of 17(82%)combined esophageal and gastric findings identified on EGD.Fisher’s exact test was used to compare the findings and no significant difference was found between ECE and EGD(P=0.64 for esophageal/GEJ and P=0.66 for combined esophageal and gastric findings respectively).Of the positive esophageal/GEJ findings,ECE failed to identify the following:hiatal hernia in two patients,mild esophagitis in two patients,and mild Schatzki ring in two patients.ECE was able to identify the entire esophagus in 100%,gastric cardia in0%,gastric body in 100%,gastric antrum in 70%,pylorus in 60%,and duodenum in 0%.CONCLUSION:There were no significant differences in the likelihood of identifying a positive finding using ECE compared with EGD in preoperative evaluation of bariatric patients. | Ashish Shah Erica Boettcher Marianne Fahmy Thomas Savides Santiago Horgan Garth R Jacobsen Bryan J Sandler Michael Sedrak Denise Kalmaz | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 15 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 16 | 华南昭通古猿产地的晚中新世麂属新材料(英文)显示文摘2007~2010年在云南昭通水塘坝砖厂采煤场进行的抢救性采掘中不仅出土了禄丰古猿新材料,使得云南的禄丰古猿产地新增了一处,而且还出土了一种麂的新材料。这种麂具有鹿角眉枝较低、主枝先向外侧偏上方向生长然后再向内侧弯曲,上臼齿具有发育的新棱和内齿带,四肢较短等特征。根据支序分析这种麂与元谋晚中新世雷老麂不是姐妹群关系,而是一个独立的支序,因此将新材料订立为一个新种:昭通麂(Muntiacuszhaotongensissp.nov.)。1978年在昭通“永乐煤场”出土的“后麂(Metacervulussp.)”也当归为昭通麂,而“永乐煤场”即为水塘坝煤场。根据古地磁地层对比的结果,昭通麂的出土层位均相当于C3An.In,绝对年龄在6.1~5.9Ma,为最晚中新世。 | 董为 吉学平 Nina G.JABLONSKI Denise F.SU 李文奇 | 2014 | 古脊椎动物学报2014，52，3： | 7 |
| 17 | 手足口病急诊留观患儿转归的相关因素分析显示文摘目的探讨儿科手足口病患儿的临床特点及急诊留观患儿转归的危险因素,为手足口病患儿的护理提供依据。方法对2012年8月至2013年3月儿科急诊留观室收治的471例手足口病患儿及同期住院的40例患儿一般资料、临床症状及实验室检查结果进行比较,分析急诊留观患儿转归的危险因素。结果 3岁以下、高热、肢体抖动、血糖大于7.0 mmol/L、白细胞增高的手足口病患儿作为独立的危险因素使患儿转入住院的机会增多(P<0.01或P<0.05)。结论关注高危急诊留观患儿,有助于及时发现手足口病患儿的病情变化,提高其治愈率。存在病情加重危险的患儿,必要时住院进一步治疗。 | 张丽月 Denise Kudirka Colleen Church 肖玉娟 吴闯 孙玉贝 林刚曦 | 2014 | 护理管理杂志2014，14，4： | 7 |
| 18 | Implementation of a Pediatric Emergency Triage System in Xiamen, China显示文摘 | Gang-Xi Lin Yin-Ling Yang Denise Kudirka Colleen Church Collin K K Yong Fiona Reilly Qi-Yi Zeng | 2016 | Chinese Medical Journal2016，，20： | 7 |
| 19 | The genetic basis of deafness in populations of African descent显示文摘Hearing loss is the most common sensorineural disorder worldwide and is associated with more than1000 mutations in more than 90 genes. While mutations in genes such as GJB2(gap-junction protein β 2)and GJB6(gap-junction protein β 6) are highly prevalent in Caucasian, Asian, and Middle Eastern populations, they are rare in both native African populations and those of African descent. The objective of this paper is to review the current knowledge regarding the epidemiology and genetics of hearing loss in African populations with a focus on native sub-Saharan African populations. Environmental etiologies related to poor access to healthcare and perinatal care account for the majority of cases. Syndromic etiologies including Waardenburg, Pendred and Usher syndromes are uncommon causes of hearing loss in these populations. Of the non-syndromic causes, common mutations in GJB2 and GJB6 are rarely implicated in populations of African descent. Recent use of next-generation sequencing(NGS) has identified several candidate deafness genes in African populations from Nigeria and South Africa that are unique when compared to common causative mutations worldwide. Researchers also recently described a dominant mutation in MYO3α in an African American family with non-syndromic hearing loss. The use of NGS and specialized panels will aid in identifying rare and novel mutations in a more cost-and timeeffective manner. The identification of common hearing loss mutations in indigenous African populations will pave the way for translation into genetic deafness research in populations of African descent worldwide. | Jason R.Rudman Rosemary I.Kabahuma Sara E.Bressler Yong Feng Susan H.Blanton Denise Yan Xue-Zhong Liu | 2017 | Journal of Genetics and Genomics2017，44，6： | 7 |
| 20 | The role of statins in both cognitive impairment and protection against dementia:a tale of two mechanisms显示文摘Nearly 30% of adults 40 years and older in the United States are on a statin.Their widespread use heightens the importance of careful consideration of their varied effects on the body.Although randomized controlled trials have not confirmed cognitive impairing effects with statins,continuing evidence suggests statins have the ability to cause reversible cognitive impairment in some patients.Paradoxically,statins have also been shown to decrease the risk of dementia,Alzheimer’s disease,and improve cognitive impairment in some cases.However,randomized controlled trials have similarly failed to find the beneficial effect.Supporting evidence for both claims is compelling whereas known limitations of the clinical trials may explain the lack of findings.This narrative review aims to explain why there is still controversy and how both effects can,and may,be possible.The mechanisms that have been hypothesized for each effect are seemingly independent from one another and may explain the contradicting results.Being mindful of the complex effects of statins,health care providers need to be able to identify patients who are at risk for or already experiencing cognitive impairment from statin use while also identifying those who could potentially decrease their risk of dementia with statins. | Bob G.Schultz Denise K.Patten Daniel J.Berlau | 2018 | Translational Neurodegeneration2018，7，1： | 6 |
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