|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is there a role for serum endothelin in predicting the severity of acute pancreatitis?显示文摘BACKGROUND: Acute pancreatitis remains a common presentation to acute surgical units and carries significant morbidity and mortality. The progression of the disease to necrotizing pancreatitis and multi-organ dysfunction syndrome (MODS) is associated with a very poor clinical outcome, and persistendy high mortality. Increases in serum endothelin (ET) have been seen in animal models of acute pancreatitis and this study aims to investigate whether there is a change in serum ET-1 in patients with acute pancreatitis and whether any such change is linked to disease severity. METHODS: All patients admitted with acute pancreatitis were prospectively recruited from die emergency admissions at the Norfolk and Norwich University Hospital. Serum ET levels were determined on admission, at 24 hours and 5 days post admission. Healthy adult controls were recruited from dermatology outpatients. RESULTS: A total of 21 patients joined the trial after giving informed consent. There were 3 men and 18 women with a median age of 65 years (range 26-87 years). Serum ET levels were significantly higher in acute pancreatitis patients than in normal controls (P <0. 05). An association was seen between persistendy raised serum ET levels and progression to MODS. CONCLUSIONS: The study does demonstrate a correlation between the circulating levels of ET and acute pancreatitis in humans, although it does not elicit its involvement in the pathogenesis of the disease. The observation that a persistendy high level of circulating ET-1 is associated with progression to MODS may indicate a role for ET in the monitoring of acute pancreatitis patients for recovery or progression to MODS. | John Bennett David Cooper Anita Balakrishnan Michael Rhodes Michael Lewis | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 8 |
| 2 | 抗甲状腺药物的副作用显示文摘抗甲状腺药物是治疗甲状腺功能亢进症的主要方法,尤其是由Graves病所致者。尽管一般情况下抗甲状腺药物是安全的,但是它的副作用限制了某些病人的使用。基于致病的严重程度将副作用分为轻度和严重两种。大剂量他巴唑(methimazole,MMI)(400mg或以上)时所有副作用都常见,但是丙基硫氧嘧啶(propyl-thiouracil,PTU)没有明显的剂量相关性。最常见的轻度副作用有皮疹、关节痛、胃肠不适,常规剂量时发生于5%病人;脱发、涎腺炎、肌病、味觉和嗅觉异常亦有发生。常见的严重副作用是粒细胞减少症的症状明显的多关节炎,严重的系统性腺管炎或药物诱发的狼疮(常见于抗中性粒细胞胞浆抗体阳性者)和PTU相关。他巴唑引起的胆汁淤积性肝毒性反应较PTU引起的潜在的致命肝细胞反应为轻。低凝血酶原血症和胰岛素自身免疫综合征是极少见的严重副作用。学习目的:复习抗甲状腺药物少见的副作用和推荐治疗,尤其是否该终止治疗;了解抗甲状腺药物引起的粒细胞缺乏症的可能机制、临床表现和治疗;比较主要抗甲状腺药物的肝毒性。 | David S Cooper,MD 李玉秀 | 2001 | 世界医学杂志2001，5，10： | 7 |
| 3 | Afterword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology显示文摘 | David J. Handelsman Trevor G. Cooper | 2010 | Asian Journal of Andrology2010，12，1： | 6 |
| 4 | A literature survey on smart cities显示文摘Rapid urbanization creates new challenges and issues, and the smart city concept offers opportunities to rise to these challenges, solve urban problems and provide citizens with a better living environment. This paper presents an exhaustive literature survey of smart cities. First, it introduces the origin and main issues facing the smart city concept, and then presents the fundamentals of a smart city by analyzing its definition and application domains. Second, a data-centric view of smart city architectures and key enabling technologies is provided. Finally, a survey of recent smart city research is presented. This paper provides a reference to researchers who intend to contribute to smart city research and implementation. | YIN ChuanTao XIONG Zhang CHEN Hui WANG JingYuan COOPER Daven DAVID Bertrand | 2015 | Science China(Information Sciences)2015，58，10： | 5 |
| 5 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 6 | Foreword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology显示文摘 | David J. Handelsman Trevor G. Cooper | 2010 | Asian Journal of Andrology2010，12，1： | 3 |
| 7 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 8 | Subclinical thyroid disease显示文摘 | David S Cooper Bernadette Biondi | 2012 | 2012 (9821)2012，，9821： | 2 |
| 9 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 10 | Diabetic patients and kidney protection: an attainable target显示文摘 | David Barit Mark E Cooper | 2008 | Journal of Hypertension2008，，： | 2 |
| 11 | Nutritional therapy in patients with acute pancreatitis requiring critical care unit management: A prospective observational study in Australia and New Zealand显示文摘 | Andrew R. Davies Siouxzy S. Morrison Emma J. Ridley Michael Bailey Merrilyn D. Banks David J. Cooper Gil Hardy Kerry McIlroy Andrew Thomson | 2011 | Critical Care Medicine2011，，3： | 2 |
| 12 | Falling sperm counts and global oestrogenic pollution:postscript显示文摘 | Trevor G Cooper David J Handelsman | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 13 | Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study显示文摘 | Daniel Baylis Georgia Ntani Mark H. Edwards Holly E. Syddall David B. Bartlett Elaine M. Dennison Carmen Martin-Ruiz Thomas Zglinicki Diana Kuh Janet M. Lord Avan Aihie Sayer Cyrus Cooper | 2014 | Calcified Tissue International2014，，1： | 1 |
| 14 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 15 | Antithymid Drugs The New England Journal of Medicine显示文摘 | David S Cooper M D | 2005 | 352:915-9172005，352，： | 1 |
| 16 | Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans显示文摘 | Michael C. Jensen Leslie Popplewell Laurence J. Cooper David DiGiusto Michael Kalos Julie R. Ostberg Stephen J. Forman | 2010 | Biology of Blood and Marrow Transplantation2010，，9： | 1 |
| 17 | Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock显示文摘 | Charlie R. Mantel Heather A. O’Leary Brahmananda R. Chitteti XinXin Huang Scott Cooper Giao Hangoc Nickolay Brustovetsky Edward F. Srour Man Ryul Lee Steven Messina-Graham David M. Haas Nadia Falah Reuben Kapur Louis M. Pelus Nabeel Bardeesy Julien Fitama | 2015 | Cell2015，，7： | 1 |
| 18 | Antithyroid drugs显示文摘 | David S Cooper ND | 2005 | New England Journal of Medicine2005，352，2： | 1 |
| 19 | Sinus of Valsalva Aneurysms—47 Years of a Single Center Experience and Systematic Overview of Published Reports显示文摘 | Sherif Moustafa Farouk Mookadam Leslie Cooper Guleid Adam Kenton Zehr John Stulak David Holmes | 2007 | The American Journal of Cardiology2007，，： | 1 |
| 20 | Evaluation of ZnO(Ga) Coatings as Alpha Particle Transducers within a Neutron Generator 显示文摘 | Charles Cooper J Koltick David S Mihalczo John T | 2003 | Nuclear Instruments and Methods in Physics Research2003，505，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员