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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | 搅拌磨湿法粉碎显示文摘精细的颗粒或颗粒尺寸的窄分布是获取特定产品性能的保证。在此方面,除了结晶过程和沉淀过程之外当首推研磨过程,如用搅拌磨。要在最经济的前提下获得所希望的细度和分布范围,必须掌握诸如应力强度、应力分布、滞留时间分布、研磨介质尺寸、液体粘度和固体含量对研磨结果的影响程度。本文以实例指出了最主要的影响尺寸和其结果。以数学模型进行了研讨并给出了搅拌磨操作方式。例如在相同的能耗下。 | Reinhold Stadler Reinhard Polke Joerd Schwedes Friedrich Vock 史久华 | 1991 | 化工装备技术1991，12，6： | 4 |
| 3 | Unintentional perioperative hypothermia is associated with severe complications and high mortality in elective operations显示文摘 | Adrian T. Billeter Samuel F. Hohmann Devin Druen Robert Cannon Hiram C. Polk | 2014 | Surgery2014，，： | 2 |
| 4 | Metabolic and Nutritional Support of the Enterocutaneous Fistula Patient: A Three-Phase Approach显示文摘 | Travis M. Polk C. William Schwab | 2012 | World Journal of Surgery2012，，3： | 2 |
| 5 | Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth显示文摘 | Fang Yan Hanwei Cao Timothy L. Cover Robert Whitehead M. Kay Washington D. Brent Polk | 2007 | Gastroenterology2007，，2： | 2 |
| 6 | Clarification of Risk Factors for Abdominal Operations in Patients with Hepatic Cirrhosis显示文摘 | R. NEAL GARRISON HENRY M. CRYER HIRAM C. POLK DANIEL A. HOWARD | 1984 | Annals of Surgery1984，，6： | 2 |
| 7 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 8 | Evolution in the Management of Hepatic Trauma: A 25-Year Perspective显示文摘 | J. David Richardson Glen A. Franklin James K. Lukan Eddy H. Carrillo David A. Spain Frank B. Miller Mark A. Wilson Hiram C. Polk Lewis M. Flint | 2000 | Annals of Surgery2000，，3： | 2 |
| 9 | Understanding patent - quality mechanisms 显示文摘 | R POLK WAGNER | 2009 | University of Pennsylvania Law Review2009，，157： | 1 |
| 10 | Preterm lung function after retreatment with antenatal beta - methasone in preterm lambs显示文摘 | Polk DH Ikegami M Jobe AH | 1997 | Am J Obstet Gynecol1997，176，2： | 1 |
| 11 | Probiotics as functional food in the treatment of diarrhea 显示文摘 | Yan F Polk DB | 2006 | Curr Opin Clin Nutr Metab Care2006，9，6： | 1 |
| 12 | Deep space 1 measurements of ion propulsion contamination显示文摘 | Brinza D Wang J Polk J | 2001 | Journal of Spacecraft and Rockets2001，38，3： | 1 |
| 13 | Evolution in the treatment of complex blunt liver injuries显示文摘 | Eddy H Carrillo Christopher Wohltmann J.David Richardson Hiram C Polk | 2001 | Current Problems in Surgery2001，，1： | 1 |
| 14 | The stock market and corporate in- vestment: a test of catering theory显示文摘 | Polk C Sapienza P | 2009 | Review of Finan- cial Studies2009，22，1： | 1 |
| 15 | Remote organ failure:a valid sign of occult intra-abdominal infection显示文摘 | Polk HC Jr Shields CL | 1977 | Surgery1977，81，3： | 1 |
| 16 | The Stock Market and Corporate Investment : A Test of Catering Theory 显示文摘 | POLK C SAPIENZA P | 2009 | Review of Financial Studies2009，22，1： | 1 |
| 17 | Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor κB activation in mouse colonocytes显示文摘 | Kaiser CG Yan F Polk B | | 0，，： | 1 |
| 18 | Probiotics and immune health显示文摘 | Fang Y N Polk D B | 2011 | Wolters Kluwer Health2011，，27： | 1 |
| 19 | Financial Constraints and Stock Returns显示文摘 | Lamont O Polk C Saa-Requejo J | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 20 | Estimating yield and economic loss from constriction canker of peach显示文摘 | LALANCETTE N POLK D F | 2000 | Plant disease2000，84，9： | 1 |
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