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| 1 | 针刺治疗神经根型颈椎病选经取穴规律探讨显示文摘目的 分析总结针刺治疗神经根型颈椎病的选经取穴规律。方法 以'针刺''神经根型颈椎病'等为主题词,检索6个中英文数据库,检索期限为2009~2018年,筛选出符合纳入标准的针刺治疗神经根型颈椎病的临床随机对照研究,以Microsoft Excel软件对其选经取穴规律进行总结分析。结果 最终纳入文献99篇,针刺治疗神经根型颈椎病:颈夹脊(79篇)、后溪(34篇)、风池(30篇)、肩井(25篇)、大椎(23篇)、外关(22篇)此6穴最为常用;常用穴主要集中在足少阳胆经(55篇)、手阳明大肠经(36篇)、手太阳小肠经(34篇)3条经脉;主穴主要集中于颈项部及上肢(161篇、92篇),交会穴的应用最多(78篇),其次是八脉交会穴(56篇)。结论 针刺治疗神经根型颈椎病取穴以相应节段颈夹脊结合足少阳胆经腧穴为主,注重颈部及上肢部相结合的远近配穴法,重视颈部交会穴与上肢八脉交会穴的应用。 | Ezzat Rowshan zamir 杨超 于天源 沈熠 吕桃桃 李易真 | 2019 | 环球中医药2019，12，5： | 23 |
| 2 | Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial显示文摘AIM:To evaluate the effect of resistance training(RT)on non alcoholic liver disease(NAFLD)patients.METHODS:A randomized clinical trial enrolling NAFLD patients without secondary liver disease(e.g.,without hepatitis B virus,hepatitis C virus or excessive alcohol consumption).Patients were randomly allocated either to RT,three times weekly,for 3 mo or a control arm consisting of home stretching.The RT included leg press,chest press,seated rowing,latissimus pull down etc.with 8-12 repetitions,3 sets for each exercise,for a total duration of 40 min.Hepatic ultrasound,fasting blood tests,anthropometrics and body composition by dual energy X-ray absorptiometry were assessed.At baseline and follow-up,patients filled out a detailed semi-quantitative food frequency questionnaire reporting their habitual nutritional intake.Steatosis was quantified by the hepatorenal-ultrasound index(HRI)representing the ratio between the brightness level of the liver and the right kidney.The HRI has been previously demonstrated to be highly reproducible and was validated against liver biopsy and proton magnetic resonance spectroscopy.RESULTS:Eighty two patients with primary NAFLD were randomized to receive 3 mo of either RT or stretching.After dropout or exclusion from analysis because of protocol violation(weight change>3 kg),thirty three patients in the RT arm and 31 in the stretching arm completed the study per protocol.All baseline characteristics were similar for the two treatment groups with respect to demographics,anthropometrics and body composition,blood tests and liver steatosis on imaging.HRI score was reduced significantly in the RT arm as compared to the stretching arm(-0.25±0.37 vs-0.05±0.28,P=0.017).The RT arm had a significantly higher reduction in total,trunk and android fat with increase in lean body mass.There was no correlation between the reduction in HRI in the RT arm and weight change during the study,but it was positively correlated with the change in trunk fat(r=0.37,P=0.048).The RT arm had a significant reduction in serum ferritin and total cholesterol.There was no significant difference between arms in dietary changes and these did not correlate with HRI change.CONCLUSION:Three months RT improves hepatic fat content accompanied by favorable changes in body composition and ferritin.RT may serve as a complement to treatment of NAFLD. | Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet | 2014 | World Journal of Gastroenterology2014，20，15： | 17 |
| 3 | Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study显示文摘AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B). Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). SB transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37). Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time. | Eva Niv Ido Bogner Olga Barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman | 2008 | World Journal of Gastroenterology2008，14，16： | 10 |
| 4 | Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification显示文摘AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. | Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 5 | 基因组分析揭示番茄育种的历史显示文摘番茄(Solanum lycopersicum)适应性广,产量高,营养丰富,风味独特,栽培方式多样,是世界范围内广泛种植的第一大蔬菜作物。2012年全球产量达到1.62亿吨(联合国粮农组织(FAO)统计),产值超过550亿美元。番茄也是植物遗传、发育和生理研究的重要模式系统。番茄起源于南美洲的安第斯山脉,随着人类迁移和驯化逐渐传到中美洲和墨西哥一代,16世纪传到欧洲,在随后的几百年中番茄被传播到世界各地,在这一过程中受到不同的人工选择,产生了丰富的变异类型。番茄果实大小的变化是驯化的一个重要特征,今天人们食用的大果栽培番茄是由野生醋栗番茄(Solanum pimpinellifolium)驯化而来,野生番茄果实非常小,只有1~2g 重,经过人工的长期驯化,现代栽培番茄的果重是其祖先的100多倍。然而,番茄果实变大的人工驯化过程一直未有全面的研究,人类选择如何改变番茄基因组仍是知之甚少。 | 林涛 祝光涛 张俊红 许向阳 余庆辉 郑铮 张忠华 伦尧尧 李帅 王孝宣 黄泽军 李君明 张春芝 王涛涛 张余洋 王傲雪 张艳聪 林魁 李传友 熊国胜 薛勇彪 Andrea Mazzucato Mathilde Causse Zhangjun Fei James J.Giovannoni Roger T.Chetelat Dani Zamir Thomas Stadler 李景富 叶志彪 杜永臣 黄三文 | 2014 | 遗传2014，36，12： | 7 |
| 6 | Isolation, characterization and culture of Thy1-positive cells from fetal rat livers显示文摘瞄准:为了调查 Thy1 是否在胎儿的肝认出卵形的房间并且描绘,有教养的 Thy1- 从 E14 老鼠肝选择了房间。方法:Thy1 人口被荧光分析激活的房间 sorter 分析。Thy1 积极房间用磁性的祷告被孤立。肝的标记被西方的弄污,免疫细胞化学和 RT-PCR 检测。结果:Thy1 积极的房间的百分比在胎儿的老鼠肝(E13-E16 ) 的早开发期间减少了。E14 胎儿的肝包含了 7.8% Thy1 积极房间, 61% 为 alpha-fetoprotein (法新社) 和 25% 表示白朊是积极的。Thy1+ 人口表示了卵形的房间标记 c 工具包和 CXCR4,肝充实抄写的因素 HNF1alpha 和 HNF6, hepatocytic 标记白朊,法新社和 cytokeratin 18,并且胆汁的标记 cytokeratin 19。Thy1- 选择了房间形成的仅仅间充质的殖民地什么时候骨胶原上并且在包含浆液的媒介的 plated。选择房间能形成为 HNF1alpha 积极的肝的殖民地的 Thy1, HNF6,白朊,法新社, cytokeratin 18, cytokeratin 19 并且肝糖,当在浆液在 STO 喂食器层上成长时免费媒介。结论:为 Thy1 积极的卵形的房间在早肝是在场的胚胎的阶段。 | Zvibel Isabel Bronstein Miri Hubel Einav Bar-Lev Ella Halpern Zamir Oren Ran | 2006 | World Journal of Gastroenterology2006，12，24： | 7 |
| 7 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 8 | Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up显示文摘 | Shira Zelber-Sagi Roni Lotan Amir Shlomai Muriel Webb Gil Harrari Assaf Buch Dorit Nitzan Kaluski Zamir Halpern Ran Oren | 2012 | Journal of Hepatology2012，，5： | 4 |
| 9 | Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients显示文摘AIM: To verify whether there is a gender difference in the 13C-urea breath test results in a large cohort. METHODS: The test results of dyspeptic patients referred for 13C-urea breath testing between January and December, 2007 were evaluated. Testing was carried out at the health insurance organization branches and evaluated at a central laboratory in Israel. RESULTS: Of a total of 28 746 test results, 18 122 (63.04%) were from females and 10 624 (36.95%) from males. Overall, 10 188 (35.4%) results [expressed as delta over baseline (DOB)] were positive (DOB 13C > 5), 18,326 (63.7%) were negative (DOB 13C < 3.5) and 232 (0.8%) were borderline (DOB 13C 3.5-5). There was a significant difference between the total positive rate among females and males (34.8% vs 37.2%, respectively, P = 0.0003). The mean test value was increased by approximately 10 units for females compared to males (P < 0.01) and this difference was consistent for all age groups (i.e., between 10-80 years of age, P < 0.01). CONCLUSION: More females were referred to 13C-urea breath testing. More males had positive results. The mean test values were significantly higher among females of all age groups, possibly representing an increased bacterial load among females and suggesting gender-associated differences in Helicobacter pylori host interactions. | Menachem Moshkowitz Noya Horowitz Anat Beit-Or Zamir Halpern Erwin Santo | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 4 |
| 10 | Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase显示文摘 | Shani Ben-Shlomo Isabel Zvibel Mati Shnell Amir Shlomai Elena Chepurko Zamir Halpern Nir Barzilai Ran Oren Sigal Fishman | 2010 | Journal of Hepatology2010，，6： | 3 |
| 11 | Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study显示文摘 | Shira Zelber-Sagi Dorit Nitzan-Kaluski Rebecca Goldsmith Muriel Webb Laurie Blendis Zamir Halpern Ran Oren | 2007 | Journal of Hepatology2007，，5： | 3 |
| 12 | Comparison of Standard Forward Viewing Mode Versus Ultra-Wide Viewing Mode of a Novel Colonoscopy Platform: A Prospective, Multicenter Study in the Detection of Simulated Polyps in an in vitro Colon Model显示文摘 | Ian M. Gralnek David L. Carr-Locke Ori Segol Zamir Halpern Peter D. Siersema Alan Sloyer Jay Fenster Blair S. Lewis Erwin Santo Alain Suissa Meytal Segev | 2012 | Gastrointestinal Endoscopy2012，，： | 3 |
| 13 | Non‐alcoholic fatty liver disease independently predicts prediabetes during a 7‐year prospective follow‐up显示文摘 | Shira Zelber‐Sagi Roni Lotan Oren Shibolet Muriel Webb Assaf Buch Dorit Nitzan‐Kaluski Zamir Halpern Erwin Santo Ran Oren | 2013 | Liver Int2013，，9： | 3 |
| 14 | Synthesis and antibacterial studies of ciprofloxacin-metal complexes显示文摘Metal complexes of ciprofloxacin were synthesized to study the effect of the drug on the metals present in the body or metals co-administered as multivitamin therapy. These complexes were then characterized by IR, UV, 1 H NMR, CHN and AA analyses. It was found that the metals coordinated through the β-keto carboxylic group, forming four coordinated complexes having square planar geometry. The effect of the antibacterial activity of these complexes with respect to parent drug was also studied against 14 different Gram + ve and Gram – ve organisms by the disk susceptibility technique. Some complexes showed improve activity as compared with the stated drug. | Najma Sultana M.Saeed Arayne Ahsan Zamir Siddiqi Agha Zeeshan Mirza | 2019 | Journal of Chinese Pharmaceutical Sciences2019，28，6： | 2 |
| 15 | Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development显示文摘 | Assaf C. Bester Maayan Roniger Yifat S. Oren Michael M. Im Dan Sarni Malka Chaoat Aaron Bensimon Gideon Zamir Donna S. Shewach Batsheva Kerem | 2011 | Cell2011，，3： | 2 |
| 16 | Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato显示文摘到进在西红柿的类脂化合物新陈代谢的基因规定的获得卓见,我们进行了跟随水果果皮和茄属 pennellii 基因渗入的叶织物介绍的 lipidomic 的分析衬里的新陈代谢的特点 loci (mQTL )(IL ) 。提高为选择水果特定的 mQTL 印射分辨率,我们在独立地导出的 S 的一个子集介绍了类脂化合物。pennellii 回交生来的线,以及在 near-isogenic sub-IL ? 人口。我们识别了控制班 III 脂肪分解酵素家庭, LIP1 和 LIP2 的几类脂化合物,和二个成员的层次的通常认为的 lecithin:cholesterol acyltransferase,那与 diacylglycerols (DAG ) 和 triacylglycerols (标签) 的减少的层次被联系。这个班的脂肪分解酵素从 acylglycerols 的甘油脊梁劈开丰满的酸。释放的丰满的酸用作风味 volatiles 的先锋。我们证明那 LIP1 表情与丰满的导出酸的不稳定的层次相关。我们进一步用转基因的植物在标签和 DAG 故障和不稳定的合成证实 LIP1 的功能。一起拿,我们的学习广泛地在西红柿描绘了脂性的混合物的基因建筑学并且在分子的水平证明从甘油脊梁的免费的丰满的酸的版本能在下游地不稳定的合成上有主要影响。 | Karolina Garbowicz Zhongyuan Liu Saleh Alseekh Denise Tieman Mark Taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir Harry J. Klee Alisdair R. Fernie Yariv Brotman | 2018 | Molecular Plant2018，11，9： | 2 |
| 17 | Gastroesophageal reflux disease symptoms:Prevalence,sociodemographics and treatment patterns in the adult Israeli population显示文摘AIM: To evaluate the prevalence and sociodemographics of gastroesophageal reflux disease (GERD) symptoms and to identify treatment patterns among GERD patients. METHODS: A telephone survey of a representative sample of the adult Israeli population was conducted. The questionnaire included detailed sociodemographics, history of GERD symptoms and the various treatments used. RESULTS: The survey included 2027 subjects. Twice weekly, once weekly and monthly GERD symptoms were reported by 8.4%, 12.5% and 21.5% of subjects, respectively. There was no difference in prevalence between men and woman; however, GERD symptoms were significantly more prevalent within the older age group and lower socioeconomic status. Among those reporting weekly symptoms, a quarter did not use any kind of therapy and another quarter used various traditional remedies (e.g. soda, milk, almonds, etc.). Antacids were used by 35.1%, H2 blockers by 13.2% and PPIs by 17.5%. CONCLUSION: We found that 12.5% of the adult Israeli population experience weekly GERD symptoms. GERD prevalence and sociodemographics are similar to those described in other Western countries, and treatment is still suboptimal. | Menachem Moshkowitz Noya Horowitz Zamir Halpern Erwin Santo | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 18 | A prospective cohort study evaluating a novel colonoscopy platform featuring full-spectrum endoscopy显示文摘 | Ian Gralnek Ori Segol Alain Suissa Peter Siersema David Carr-Locke Zamir Halpern Erwin Santo Svetlana Domanov | 2013 | Endoscopy2013，，： | 2 |
| 19 | Congenital toxoplasmosis—prenatal aspects of Toxoplasma gondii infection显示文摘 | Efrat Rorman Chen Stein Zamir Irena Rilkis Hilla Ben-David | 2005 | Reproductive Toxicology2005，，4： | 2 |
| 20 | Linkage relationships of genes affecting bitterness and flesh color in watermelon显示文摘 | NAVOT N SARFATTI M ZAMIR D | 1990 | J Hered1990，81，： | 1 |
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