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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | 2018年急性缺血性卒中患者早期管理指南美国心脏协会/美国卒中协会为医疗专业人员制定的指南显示文摘背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员任命,代表各领域的医学专家。严格遵循美国心脏协会的利益冲突原则。不允许写作组成员对存在企业利益关系的相关议题进行讨论或投票。所有推荐意见必须得到写作组成员的一致通过,除非企业利益关系妨碍了成员投票。由4名同行评议专家以及卒中委员会的科学声明监督委员会和领导委员会成员对指南草案进行发布前评审。本指南采用了美国心脏病学学会/美国心脏协会2015年推荐意见分类和证据级别标准以及新版美国心脏协会指南格式。结果本指南详细介绍了院前医疗、紧急和急诊评估、静脉和血管内治疗以及院内管理,包括在发病后最初2周内启用的二级预防措施。本指南支持院前和院内卒中医疗系统的一体化概念。结论本指南基于目前可获得的最佳证据。然而,许多情况资料有限,迫切需要对急性缺血性卒中的治疗进行持续研究。 | William J. Powers Alejandro A. Rabinstein Teri Ackerson Opeolu M. Adeoye Nicholas C. Bambakidis Kyra Becker José Biller Michael Brown Bart M. Demaerschalk Brian Hoh Edward C. Jauch Chelsea S. Kidwell Thabele M. Leslie-Mazwi Bruce Ovbiagele Phillip A. Scott Kevin N. Sheth Andrew M. Southerland Deborah V. Summers David L. Tirschwell 徐加平 刘慧慧 张霞 石际俊 黄志超 尤寿江 郭志良 肖国栋 杜万良 曹勇军 | 2018 | 国际脑血管病杂志2018，26，2： | 19 |
| 3 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 4 | ECG stress test induced atrial ischemia in a patient with old inferior myocardial infarction due to a distal coronary artery lesion显示文摘 | Andras Vereckei Gabor Katona Zsuzsanna Szelenyi Edit Takacs Pal Maurovich-Horvat David Becker | 2017 | Journal of Geriatric Cardiology2017，14，1： | 3 |
| 5 | RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F显示文摘 | Moritz Leppkes Christoph Becker Ivaylo I. Ivanov Sebastian Hirth Stefan Wirtz Clemens Neufert Sandrine Pouly Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Burkhard Becher Dan R. Littman Markus F. Neurath | 2009 | Gastroenterology2009，，1： | 2 |
| 6 | Molecular genetics of attention-deficit/hyperactivity disorder: an overview显示文摘 | Tobias Banaschewski Katja Becker Susann Scherag Barbara Franke David Coghill | 2010 | European Child & Adolescent Psychiatry2010，，3： | 2 |
| 7 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 8 | Management of bile leaks following laparoscopic cholecystectomy显示文摘 | David C. Brooks James M. Becker Pamela J. Connors David L. Carr-Locke | 1993 | Surgical Endoscopy1993，，4： | 2 |
| 9 | How People Use Earthquake Information and Its Influence on Household Preparedness in New Zealand显示文摘 | Julia Susan Becker David Moore Johnsto~ Douglas Paton Kevin Ronan | 2012 | Journal of Civil Engineering and Architecture2012，6，6： | 1 |
| 10 | Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis显示文摘 | Jeffrey S. Berger David L. Brown Richard C. Becker | 2008 | The American Journal of Medicine2008，，1： | 1 |
| 11 | Identifying optimal spectral bands from in situ measurements of Great Lakes coastal wetlands using second-derivative analysis显示文摘 | BECKER B L DAVID P L QI J G | 2005 | Remote Sensing of Environment2005，97，2： | 1 |
| 12 | Spiritual Well-Being and Depression in Patients with Heart Failure显示文摘 | David B. Bekelman Sydney M. Dy Diane M. Becker Ilan S. Wittstein Danetta E. Hendricks Traci E. Yamashita Sheldon H. Gottlieb | 2007 | Journal of General Internal Medicine2007，，7： | 1 |
| 13 | Primary Prevention of Ischemic Stroke: A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association显示文摘 | Larry B. Goldstein Robert Adams Kyra Becker Curt D. Furberg Philip B. Gorelick George Hademenos Martha Hill George Howard Virginia J. Howard Bradley Jacobs Steven R. Levine Lori Mosca Ralph L. Sacco David G. Sherman Philip A. Wolf Gregory J. del Zoppo | 2001 | Stroke: Journal of the American Heart Association2001，，1： | 1 |
| 14 | Identifying optimal spec- tral bands from in situ measurements of Great Lakes coastal wetlands using second - derivative analysis 显示文摘 | Brian L Becker David P Lusch Jiaguo Qi | 2005 | Remote Sensing of Environment2005，97，2： | 1 |
| 15 | Synergetic effect of poly(vinyl butyral) and calcium carbonate on thermal stability of poly(vinyl chloride) nanocomposites investigated by TG-FTIR-MS显示文摘 | Stephanie Etienne Claude Becker David Ruch | 2010 | J Thermal Anal Calorimetry2010，100，2： | 1 |
| 16 | Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure显示文摘 | Vairappan Balasubramaniyan Dipok Kumar Dhar Anne E. Warner Wai-Yin Vivien Li Azin Farzan Amiri Beverley Bright Rajeshwar P. Mookerjee Nathan A. Davies David L. Becker Rajiv Jalan | 2013 | Journal of Hepatology2013，，： | 1 |
| 17 | Post-Stroke Depression: Relationships to Functional Impairment, Coping Strategies, and Rehabilitation Outcome显示文摘 | DAVID SINYOR PHYLLIS AMATO DANNY G. KALOUPEK RUBIN BECKER MARVIN GOLDENBERG HENRY COOPERSMITH | 1986 | Stroke1986，，： | 1 |
| 18 | Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers显示文摘 | Neil E. Alexis John C. Lay Kirby Zeman William E. Bennett David B. Peden Joleen M. Soukup Robert B. Devlin Susanne Becker | 2006 | The Journal of Allergy and Clinical Immunology2006，，6： | 1 |
| 19 | Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK显示文摘 | Neufert Clemens Becker Christoph Türeci ?zlem Waldner Maximilian J Backert Ingo FIoh Katharina Atreya lmke Leppkes Moritz Jefremow Andre Vieth Michael Schneider-Stock Regine Klinger Patricia Greten Florian R Threadgill David W Sahin Ugur Ne | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
| 20 | Response to Psychosocial Treatment in Poststroke Depression Is Associated With Serotonin Transporter Polymorphisms显示文摘 | Ruth Kohen Kevin C. Cain Ann Buzaitis Vicki Johnson Kyra J. Becker Linda Teri David L. Tirschwell Richard C. Veith Pamela H. Mitchell | 2011 | Stroke2011，，7： | 1 |
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