|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CB-Dock: a web server for cavity detection-guided protein–ligand blind docking显示文摘As the number of elucidated protein structures is rapidly increasing,the growing data call for methods to efficiently exploit the structural information for biological and pharmaceutical purposes.Given the three-dimensional(3D)structure of a protein and a ligand,predicting their binding sites and affinity are a key task for computer-aided drug discovery.To address this task,a variety of docking tools have been developed.Most of them focus on docking in the preset binding sites given by users.To automatically predict binding modes without information about binding sites,we developed a user-friendly blind docking web server,named CB-Dock,which predicts binding sites of a given protein and calculates the centers and sizes with a novel curvature-based cavity detection approach,and performs docking with a popular docking program,Autodock Vina.This method was carefully optimized and achieved^70% success rate for the top-ranking poses whose root mean square deviation(RMSD)were within 2Åfrom the X-ray pose,which outperformed the state-of-the-art blind docking tools in our benchmark tests.CB-Dock offers an interactive 3D visualization of results,and is freely available at http://gffzzdb39119b70414d18hock6wwvun5u96puw.ffgz.tsg.suse.edu.cn/cb-dock/. | Yang Liu Maximilian Grimm Wen-tao Dai Mu-chun Hou Zhi-Xiong Xiao Yang Cao | 2020 | Acta Pharmacologica Sinica2020，41，1： | 36 |
| 2 | Colon cancer and the immune system:The role of tumor invading T cells显示文摘Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune system has been shown to react against tumor cells, mainly through tumor infi ltrating lymphocytes and NK cells, tumor cells may utilize different ways to escape anti-tumor immune response. Tumor infi ltration of CD8+ and CD4+ (T-bet+) effector T cells has been attributed to a beneficial outcome, and the enhancement of T cell activation through T cell receptor stimulation and co-stimulatory signals provides promising strategies for immunotherapy of colon cancer. Growing evidence supports a role for the Fas/FasL system in tumor immunology, although the mechanisms and consequences of FasL activation in colon cancer are not completely understood. In animal models, depletion of regulatory T cells (CD4+ CD25+ T cells) can enhance the anti-tumor immune response under certain conditions. Taken together, recent insights in the immune reaction against colon carcinoma have provided new approaches to immunotherapy, although much remains to be learned about the exact mechanisms. | Maximilian Waldner Carl C Schimanski Markus F Neurath | 2006 | World Journal of Gastroenterology2006，12，45： | 15 |
| 3 | Biliary complications in liver transplantation: Impact of anastomotic technique and ischemic time on short- and long-term outcome显示文摘AIM: To elucidate the impact of various donor recipient and transplant factors on the development of biliary complications after liver transplantation.METHODS: We retrospectively reviewed 200 patients of our newly established liver transplantation(LT) program, who received full size liver graft. Biliary reconstruction was performed by side-to-side(SS), end-to-end(EE) anastomosis or hepeaticojejunostomy(HJ). Biliary complications(BC), anastomotic stenosis, bile leak, papillary stenosis, biliary drain complication, ischemic type biliary lesion(ITBL) were evaluated by studying patient records, corresponding radiologic imaging and reports of interventional procedures [e.g., endoscopic retrograde cholangiopancreatography(ERCP)]. Laboratory results included alanine aminotransferase(ALT), gammaglutamyltransferase and direct/indirect bilirubin with focus on the first and fifth postoperative day, six weeks after LT. The routinely employed external bile drain was examined by a routine cholangiography on the fifth postoperative day and six weeks after transplantation as a standard procedure, but also whenever clinically indicated. If necessary, interventional(e.g., ERCP) or surgical therapy was performed. In case of biliary complication, patients were selected, assigned to different complication-groups and subsequently reviewed in detail. To evaluate the patients outcome, we focussed on appearance of postoperative/post-interventional cholangitis, need for rehospitalisation, retransplantation, ITBL or death caused by BC.RESULTS: A total of 200 patients [age: 56(19-72), alcoholic cirrhosis: n = 64(32%), hepatocellular carcinoma: n = 40(20%), acute liver failure: n = 23(11.5%), cryptogenic cirrhosis: n = 22(11%), hepatitis B virus /hepatitis C virus cirrhosis: n = 13(6.5%), primary sclerosing cholangitis: n = 13(6.5%), others: n = 25(12.5%) were included. The median follow-up was 27 mo until June 2015. The overall biliary complication rate was 37.5%(n = 75) with anastomotic strictures(AS): n = 38(19%), bile leak(BL): n = 12(6%), biliary drain complication: n = 12(6%); papillary stenosis(PS): n = 7(3.5%), ITBL: n = 6(3%). Clinically relevant were only 19%(n = 38). We established a comprehensive classification for AS with four grades according to clinical relevance. The reconstruction techniques [SS: n = 164, EE: n = 18, HJ: n = 18] showed no significant impact on the development of BCs in general(all n < 0.05), whereas in the HJ group significantly less AS were found(P = 0.031). The length of donor intensive care unit stay over 6 d had a significant influence on BC development(P = 0.007, HR = 2.85; 95%CI: 1.33-6.08) in the binary logistic regression model, whereas other reviewed variables had not [warm ischemic time > 45 min(P = 0.543), cold ischemic time > 10 h(P = 0.114), ALT init > 1500 U/L(P = 0.631), bilirubin init > 5 mg/d L(P = 0.595), donor age > 65(P = 0.244), donor sex(P = 0.068), rescue organ(P = 0.971)]. 13%(n = 10) of BCs had no therapeutic consequences, 36%(n = 27) resulted in repeated lab control, 40%(n = 30) received ERCP and 11%(n = 8) surgical therapy. Fifteen(7.5%) patients developed cholangitis [AS(n = 6), ITBL(n = 5), PS(n = 3), biliary lesion BL(n = 1)]. One patient developed ITBL twelve months after LT and subsequently needed retransplantation. Rehospitalisation rate was 10.5 %(n = 21) [AS(n = 11), ITBL(n = 5), PS(n = 3), BL(n = 1)] with intervention or reinterventional therapy as main reasons. Retransplantation was performed in 5(2.5%) patients [ITBL(n = 1), acute liver injury(ALI) by organ rejection(n = 3), ALI by occlusion of hepatic artery(n = 1)]. In total 21(10.5%) patients died within the follow-up period. Out of these, one patient with AS developed severe fatal chologenic sepsis after ERCP.CONCLUSION: In our data biliary reconstruction technique and ischemic times seem to have little impact on the development of BCs. | Stefan Kienlein Wenzel Schoening Anne Andert Daniela Kroy Ulf Peter Neumann Maximilian Schmeding | 2015 | World Journal of Transplantation2015，5，4： | 14 |
| 4 | EMT and Dissemination Precede Pancreatic Tumor Formation显示文摘 | Andrew D. Rhim Emily T. Mirek Nicole M. Aiello Anirban Maitra Jennifer M. Bailey Florencia McAllister Maximilian Reichert Gregory L. Beatty Anil K. Rustgi Robert H. Vonderheide Steven D. Leach Ben Z. Stanger | 2012 | Cell2012，，1： | 13 |
| 5 | 单一端元岩浆流体的减压沸腾作用是钨-锡矿形成的一种重要机制显示文摘全球范围内的锡(Sn)和钨(W)矿化普遍与高演化花岗岩有关,但是达到经济品位的矿床较少,且矿化的类型也各有不同,其矿床成因机制一直存在较大争议。近日,《地质学》杂志报道了德国地球科学研究中心的Maximilian Korges等人关于上述问题的研究成果。该团队以位于德国和捷克的Erzgebirge山脉的ZinnwaldS n-W矿床为研究对象,进行了系统的流体包裹体地球化学研究。 | Maximilian Korges Philipp Weis Volker Lüders Oscar Laurent 袁超 | 2018 | 矿物岩石地球化学通报2018，37，2： | 10 |
| 6 | Laser additive manufacturing of Zn porous scaffolds: Shielding gas flow, surface quality and densification显示文摘Zn based metals have exhibited promising prospects as a structural material for biodegradable applications. Pure Zn porous scaffolds were produced by laser powder bed fusion(LPBF) based on data files of designing and CT scanning. Massive Zn evaporation during laser melting largely influenced the formation quality during LPBF of Zn metal. The metal vapor in processing chamber was blown off and suctioned out efficiently by an optimized gas circulation system. Numerical analysis was used to design and testify the performance of gas flow. The surface of scaffolds was covered with numerous particles in different sizes. Processing pores occurred near the outline contour of struts. The average grain size in width was8.5m, and the hardness was 43.8 HV. Chemical plus electrochemical polishing obtained uniform and smooth surface without processing pores, but the diameter of struts reduced to 250 αm from the design value 300 m. The poor surface quality and processing pores were resulted by the splashing particles included spatters and powders due to the recoil force of evaporation, and the horizontal movement of liquid metal due to overheating and wetting. The insufficient melting at the outline contour combined with good wetting of Zn liquid metal further increased the surface roughness and processing pores. | Peng Wen Yu Qin Yanzhe Chen Maximilian Voshage Lucas Jauer Reinhart Poprawe Johannes Henrich Schleifenbaum | 2019 | Journal of Materials Science & Technology2019，35，2： | 9 |
| 7 | Let’s talk about Secs: Sec61, Sec62 and Sec63 in signaltransduction, oncology and personalized medicine显示文摘The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER.This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation.Apart from this central role in the intracellular transport of polypeptides,several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling:Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel.Furthermore,mutations,amplifications and an overexpression of the SEC genes were linked to various diseases including kidney and liver diseases,diabetes and human cancer.Studies of the last decade could not only elucidate the functional role of Sec proteins in the pathogenesis of these diseases,but also demonstrate a relevance of Sec62 as a prognostic and predictive biomarker in head and neck cancer,prostate and lung cancer including a basis for new therapeutic strategies.In this article,we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61,Sec62 and Sec63 in human diseases. | Maximilian Linxweiler Bernhard Schick Richard Zimmermann | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 8 |
| 8 | Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation显示文摘BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver transplantation.METHODS:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS <30%(n=27), MiS 30%-60%(n=41) and MiS >60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PNF). RESULTS:The incidences of EAD and PNF did not differ significantly between the groups. We observed 5 cases of PNF,one occurred in the MiS <30% group and 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS <30% group, 87.9% in the MiS 30%-60% group and 90.9% in the MiS >60% group.CONCLUSION:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation. | Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai Christoph Heidenhain Ulf Neumann Maximilian Schmeding | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 7 |
| 9 | 北京城市交通发展政策述评及对拥挤收费的讨论显示文摘中国城市交通发展政策承载了很多共同利益,包括减少空气污染与交通拥堵、提高骑车者与行人的交通安全以及改善公共汽车服务的可靠性。逐一评述北京市为达成上述事项而实施的包括公共交通、限行措施、小汽车数量调控和停车管理在内的一系列城市交通发展政策。指出北京市已实施的一系列政策还无法实现缓解交通拥堵的目标,未来可以考虑采取更加行之有效的措施,如交通拥挤收费。由此定量论证了北京市实施拥挤收费的前景及其综合效益,并探讨了实施拥挤收费的重要保障因素:决策与公平、综合配套措施、政府支持、国际经验。 | Felix Creutzig Maximilian Thess 周江评 Michael Replogle 韩慧敏 耿雪 张绍滨 | 2011 | 城市交通2011，9，4： | 7 |
| 10 | Genome Editing with CRISPR-Cas9:Can It Get Any Better?显示文摘The CRISPR-Cas revolution is taking place in virtually all fields of life sciences.Harnessing DNA cleavage with the CRISPR-Cas9 system of Streptococcus pyogenes has proven to be extraordinarily simple and efficient,relying only on the design of a synthetic single guide RNA(sgRNA) and its co-expression with Cas9.Here,we review the progress in the design of sgRNA from the original dual RNA guide for S.pyogenes and Staphylococcus aureus Cas9(SpCas9 and SaCas9).New assays for genome-wide identification of offtargets have provided important insights into the issue of cleavage specificity in vivo.At the same time,the on-target activity of thousands of guides has been determined.These data have led to numerous online tools that facilitate the selection of guide RNAs in target sequences.It appears that for most basic research applications,cleavage activity can be maximized and off-targets minimized by carefully choosing guide RNAs based on computational predictions.Moreover,recent studies of Cas proteins have further improved the flexibility and precision of the CRISPR-Cas toolkit for genome editing.Inspired by the crystal structure of the complex of sgRNA-SpCas9 bound to target DNA,several variants of SpCas9 have recently been engineered,either with novel protospacer adjacent motifs(PAMs) or with drastically reduced off-targets.Novel Cas9 and Cas9-like proteins called Cpf 1 have also been characterized from other bacteria and will benefit from die insights obtained from SpCas9.Genome editing with CRISPR-Cas9 may also progress with better understanding and control of cellular DNA repair pathways activated after Cas9-induced DNA cleavage. | Maximilian Haeussler Jean-Paul Concordet | 2016 | Journal of Genetics and Genomics2016，43，5： | 5 |
| 11 | Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS. | Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens | 2019 | Acta Pharmacologica Sinica2019，40，4： | 5 |
| 12 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 13 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 4 |
| 14 | Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit显示文摘Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbidity. We developed a rat model which allows the testing of different cell applications, i.e., mesenchymal stem cells, to improve nerve regeneration in vivo. To mimic inaccurate alignment of autologous nerve grafts with the injured nerve, a 20 mm portion of the sciatic nerve was excised, and sutured back in place in reversed direction. To validate the feasibility of our novel model, a fibrin gel conduit containing autologous undifferentiated adipose-derived stem cells was applied around the coaptation sites and compared to autologous nerve grafts. After evaluating sciatic nerve function for 16 weeks postoperatively, animals were sacrificed, and gastrocnemius muscle weight was determined along with morphological parameters(g-ratio, axon density & diameter) of regenerating axons. Interestingly, the addition of undifferentiated adipose-derived stem cells resulted in a significantly improved re-myelination, axon ingrowth and functional outcome, when compared to animals without a cell seeded conduit. The presented model thus displays several intriguing features: it imitates a certain mismatch in size, distribution and orientation of axons within the nerve coaptation site. The fibrin conduit itself allows for an easy application of cells and, as a true critical-size defect model, any observed improvement relates directly to the performed intervention. Since fibrin and adipose-derived stem cells have been approved for human applications, the technique can theoretically be performed on humans. Thus, we suggest that the model is a powerful tool to investigate cell mediated assistance of peripheral nerve regeneration. | Maximilian M.Saller Rosa-Eva Huettl Julius M.Mayer Annette Feuchtinger Christian Krug Thomas Holzbach Elias Volkmer | 2018 | Neural Regeneration Research2018，13，5： | 4 |
| 15 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 16 | TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants显示文摘Protein abundance and localization at the plasma membrane(PM)shapes plant development and mediates adaptation to changing environmental conditions.It is regulated by ubiquitination,a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation.To understand the significance and the variety of roles played by this reversible modification,the function of ubiquitin receptors,which translate the ubiquitin signature into a cellular response,needs to be elucidated.In this study,we show that TOL(TOM1-like)proteins function in plants as multivalent ubiquitin receptors,governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport(ESCRT)pathway.TOL2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding domains.Mutation of these domains results not only in a loss of ubiquitin binding but also altered localization,abolishing TOL6 ubiquitin receptor activity.Function and localization of TOL6 is itself regulated by ubiquitination,whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes,assisting in the fine-tuning of the delicate interplay between protein recycling and downregulation.Taken together,our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants. | Jeanette Moulinier-Anzola Maximilian Schwihla Lucinda De-Araujo Christina Artner Lisa Jorg Nataliia Konstantinova Christian Luschnig Barbara Korbei | 2020 | Molecular Plant2020，13，5： | 3 |
| 17 | Dual Energy CT Characterization of Urinary Calculi: Initial In Vitro and Clinical Experience显示文摘 | Anno Graser Thorsten R. C. Johnson Markus Bader Michael Staehler Nicolas Haseke Konstantin Nikolaou Maximilian F. Reiser Christian G. Stief Christoph R. Becker | 2008 | Investigative Radiology2008，，2： | 3 |
| 18 | Role of contrast enhanced ultrasound in detection of abdominal aortic abnormalities in comparison with multislice computed tomography显示文摘 | Dirk-André Clevert Kerstin Schick CHEN Min-hua ZHU Qing-li Maximilian Reiser | 2009 | Chinese Medical Journal2009，，7： | 3 |
| 19 | 天才筛选与运动导向:德国二年级儿童运动表现能力对青少年足球运动员早期成功的影响显示文摘足球是世界第一运动,在德国拥有广泛的群众基础,那么如何有效地对足球运动员进行科学合理的筛选就成为了一项重要的课题。本文由德国拜罗伊特大学体育系运动训练科学小组完成,目的是为了揭示足球人才在一般运动测试中所表现的中期预后有效性以及从实验结果计算出的足球特定表现分数。在此之前已经对包括体操、滑雪和网球在内的几项人才筛选计划实施了运动诊断分析。然而,与大多数其他运动相比,足球运动对这种早期测试的预测价值尚不清楚。测试对象由参与德国富尔达地区运动表现能力测试(FMC)的U9二年级儿童组成(N=2965)。FMC是一个对测试者基础运动表现能力的筛查,由两个人体测量学特征参数和德国运动能力表现测试(GMT6-18)的8个测试项目组成,并增加了一个投掷球测试。测试数据来自2011-2014年在德国富尔达地区参与测试的所有儿童,并记录了至2016-2017赛季结束时(2017年9月30日)选择足球(N=316)的儿童的足球比赛表现水平。然后依据比赛表现水平的高低将球员分别分配到4个不同的表现级别中,并使用ANOVA,比值比和判别分析法确定运动测试的预后有效性,并将测试结果与测试儿童在U12~U15年龄段所表现出的足球运动表现水平进行分析,最终得出9项基础运动测试的预后相关性。 | Andreas Hohmann 何人也 Maximilian Siener 梁亚普 | 2019 | 体育科研2019，40，4： | 3 |
| 20 | 采用椭圆形非骨水泥压配固定髋臼杯行全髋关节置换术治疗髋关节发育不良显示文摘对继发于髋关节发育不良的晚期骨性关节炎患者来说,全髋关节置换术是较好的治疗选择,但由于此类患者存在的解剖结构异常,手术变得较为复杂。在分型为HartofilakidisⅡ型的患者中,股骨头的半脱位造成髋臼顶部外上方的骨缺损,往往需要某种形式的支撑来使髋臼杯获得稳定的固定。处理这种类型的骨缺损可以采用多种不同的方法,孰优孰劣尚有争议。本文的目的是通过回顾性分析比较两种不同的骨缺损处理方法,来探讨椭圆形非骨水泥髋臼杯是否可以作为传统处理方法的替代方法。 | 王俏杰 张先龙 Boris M.Holzapfel Felix Greimel Peter M.Prodinger Hakan Pilge Ulrich Nth Hans Gollwitzer Maximilian Rudert | 2012 | 中国矫形外科杂志2012，20，17： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员