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| 1 | Metal-organic framework coated titanium dioxide nanorod array p-n heterojunction photoanode for solar water-splitting显示文摘This paper presents a p-n heterojunction photoanode based on a p-type porphyrin metal-organic framework (MOF) thin film and an n-type rutile titanium dioxide nanorod array for photoelectrochemical water splitting. The TiO2@MOF core-shell n anorod array is formed by coati ng an 8 nm thick MOF layer on a vertically aligned TiO2 nanorod array scaffold via a layer-by-layer self-assembly method. This vertically aligned core-shell nanorod array enables a long optical path length but a short path length for extraction of photogenerated minority charge carriers (holes) from TiO2 to the electrolyte. A p-n junction is formed between TiO2 and MOF, which improves the extraction of photogenerated electr ons and holes out of the TiO2 nano rods. In additi on, the MOF coati ng sign ificantly improves the efficie ncy of charge in jecti on at the photoanode/electrolyte interface. Introduction of Co(lll) into the MOF layer further enhances the charge extraction in the photoanode and improves the charge injection efficiency. As a result, the photoelectrochemical cell with the TiO2@Co-MOF nanorod array photoanode exhibits a photocurrent density of 2.93 mA/cm^2 at 1.23 V (vs. RHE), which is ~ 2.7 times the photocurrent achieved with bare T1O2 nanorod array under irradiation of an unfiltered 300 W Xe lamp with an output power density of 100 mW/cm^2. | Hui Yang Joeseph Bright Sujan Kasani Peng Zheng Terence Musho Banglin Chen Ling Huang Nianqiang Wu | 2019 | Nano Research2019，12，3： | 14 |
| 2 | Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome显示文摘BackgroundObstructive 睡觉呼吸暂停(OSA ) 是在有急性冠的症候群(交流) 的病人的普通疾病并且与致命、非致命的心血管的事件的增加的风险联系。然而,在以前的学习的大多数病人与赤裸的金属 stents 被对待,样品尺寸是相对低的。学习是在病人的严厉和预后上评估 OSA 的影响的这的目标为 ACS.MethodsIn 承认了这未来的队研究,我们与交流注册了病人为冠的 angiogram/percutaneous 被就医冠的干预和经历的 polysomnography。我们把病人划分了成二个组:对严重 OSA 组中等[呼吸暂停呼吸过慢过浅索引(AHI )> 15 events/h ] 并且控制组(AHI 15 events/h ) 。他们被跟随在上面为在 32 个月上面。然后,我们在病人把 ACS 严厉和长期的主要不利心血管的事件(向) 与 OSA.ResultsFive 的不同严厉作比较百和 29 个病人总之被包括,与他们中的 76% 个一起是人和一般水准 59 | Shuo JIA Yu-Jie ZHOU Yi YU Si-Jing WU Yan SUN Zhi-Jian WANG Xiao-Li LIU Bright Eric King Ying-Xin ZHAO Dong-Mei SHI Yu-Yang LIU Zhi-Ming ZHOU | 2018 | Journal of Geriatric Cardiology2018，15，2： | 13 |
| 3 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 4 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 5 | A conceptual framework for characterizing mineralized waste rocks as future resource显示文摘Conventional mining practices do not extract all mineralized rocks due to prevailing economics.Improvement in mineral prices and processing recovery(technology)could potentially make mineralized waste rocks profitable.A well-integrated mining strategy that focuses on both economic and physical resource depletion is vital to the management of non-renewable mineral resources.In this paper,a conceptual framework that maximizes the benefits of mining and processing mineralized waste rocks as future resource is proposed.Governmental policy and technical reforms that ensure mining companies incorporate the proposed mineralized waste rocks management framework in their long-term strategic mine plans have been recommended. | Bright Oppong Afum Dylan Caverson Eugene Ben-Awuah | 2019 | International Journal of Mining Science and Technology2019，29，3： | 3 |
| 6 | A new method to determine the synergistic effects of area ratio and microstructure on the galvanic corrosion of LAS A508/309 L/308 L SS dissimilar metals weld显示文摘The synergistic effects of area ratio and microstructure on the galvanic corrosion of A508/309 L/308 L dissimilar metals weld(DMW)are studied by a multi-analytical approach.It was demonstrated that decreasing the anode/cathode surface area ratio obviously enhances the corrosion rate of A508,both locally and globally.Deeper analyses of the AFM results enabled quantitative comparison of the corrosion behaviour of the different surface constituents.It was revealed that in the galvanic interaction of the DMW,the grain refined region corrodes most,followed by the partial grain refined region and base metal matrix of the A508,respectively.The electrochemical localization index(LI)estimation method and AFM analysis both confirmed the presence of a mixed(localized and uniform)corrosion phenomenon occurring on the surface of the A508 anode metal in the galvanic interaction of the dissimilar metals.Finally,the degree of synergism equation was utilized to describe the synergistic effects of anode/cathode area ratio and the microstructure of the samples on the galvanic corrosion of LAS A508/309 L/308 L SS DMW. | Bright O.Okonkwo Hongliang Ming Jianqiu Wang En-Hou Han Ehsan Rahimi Ali Davoodi Saman Hosseinpour | 2021 | Journal of Materials Science & Technology2021，，19： | 3 |
| 7 | Response of nephelometric turbidity to hydrodynamic particle size of fine suspended sediment显示文摘Turbidity is used as a surrogate for suspended sediment concentration(SSC),and as a regulatory tool for indicating land use disturbance and environmental protection.Turbidity relates linearly to suspended material,however,can show non-linear responses to particulate organic matter(POM),concomitant with changes in particle size distribution(PSD).In the paper the influence of ultra-fine particulate matter(UFPM)on specific turbidity and its association with POM in suspended sediment are shown for alpine rivers in the Southern Alps of New Zealand.The approach was two-fold:a field-based investigation of the relations between SSC,POM,and turbidity sampled during event flow;and experimental work on hydrodynamic particle size effects on SSC,POM,PSD,and turbidity.Specific turbidity changes over event flow and are sensitive to increasing proportional amounts of sand,UFPM,and POM in suspension.Furthermore,the UFPM is the size fraction(<6 mm)where POM increases.The implications of the current study are that the slopes of turbidity-SSC relations are undesirable in locations that may be dominated by cyclic release of POM or distinct pulses of fine-grained material.At locations where the turbidity-SSC slopes approximate 2,the POM proportion is usually<10%of the total suspended load.However,when turbidity-SSC slopes are<1 this is likely caused by high amounts of side-scatter from UFPM concomitant with higher proportions of POM.Thus,the use of turbidity as a proxy for determining SSC may have serious consequences for the measurement of representative suspended sediment data,particularly in locations where POM may be a significant contributor to overall suspended load. | Christina Bright Sarah Mager Sophie Horton | 2020 | International Journal of Sediment Research2020，35，5： | 3 |
| 8 | Application of Excimer Laser Coronary Atherectomy Guided by Optical Coherence Tomography in the Treatment of a Severe Calcified Coronary Lesion显示文摘 | Fang-Jie Hou Yu-Jie Zhou Wei Liu Yong-He Guo Shi-Wei Yang Bright Eric Ohene Zheng-Zhong Wang Jun Guan | 2018 | Chinese Medical Journal2018，，8： | 2 |
| 9 | NOTUM inhibition increases endocortical bone formation and bone strength显示文摘The disability,mortality and costs caused by non-vertebral osteoporotic fractures are enormous.Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures.Cortical bone is a major determinant of non-vertebral bone strength.To identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes.Cortical bone thickness was substantially elevated in Notum?/?mice.NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts.Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed.They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation.Thus,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures. | Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu | 2019 | Bone Research2019，7，1： | 2 |
| 10 | Modeling and implementation of tandem polymer solar cells using wide-bandgap front cells显示文摘Tandem device architectures offer a route to greatly increase the maximum possible power conversion efficiencies(PCEs)of polymer solar cells,however,the complexity of tandem cell device fabrication(such as selecting bandgaps of the front and back cells,current matching,thickness,and recombination layer optimization)often result in lower PCEs than are observed in single-junction devices.In this study,we analyze the influence of front cell and back cell bandgaps and use transfer matrix modeling to rationally design and optimize effective tandem solar cell structures before actual device fabrication.Our approach allows us to estimate tandem device parameters based on known absorption coefficients and open-circuit voltages of different active layer materials and design devices without wasting valuable time and materials.Using this approach,we have investigated a series of wide bandgap,high voltage photovoltaic polymers as front cells in tandem devices with PTB7-Th as a back cell.In this way,we have been able to demonstrate tandem devices with PCE of up to 12.8%with minimal consumption of valuable photoactive materials in tandem device optimization.This value represents one of the highest PCE values to date for fullerene-based tandem solar cells. | Seo-Jin Ko Hyosung Choi Quoc Viet Hoang Chang Eun Song Pierre-Olivier Morin Jungwoo Heo Mario Leclerc Sung Cheol Yoon Han Young Woo Won Suk Shin Bright Walker Jin Young Kim | 2020 | Carbon Energy2020，2，1： | 2 |
| 11 | Effects of cutting parameter on microstructure and corrosion behavior of 304 stainless steel in simulated primary water显示文摘The influence of surface conditions on the corrosion behavior of engineering structures has been paid more attention.However,there is still a lack of systematic research on the effect of cutting parameters on material’s microstructure and performance in service.In this paper,the effect of cutting parameters on microstructure and corrosion behaviors of 304 stainless steel in simulated primary water is well investigated.The results show that different cutting parameters can cause the superficial layer a gradient microstructure with nanocrystalized layer on top and deformation band structures underneath.With the similar surface roughness,the deformation microstructure can be very different due to the different cutting parameters.The effect degree on the depth of deformation zone is feed rate>cutting depth>cutting speed.The larger feed rate,lower cutting depth,lower cutting rate may induce a deeper deformation zone.With the increasing depth away from the machined surface,the localized corrosion rate is decreased,and at the same depth the localized corrosion rate along the deformation bands is higher than that along the grain boundaries(GBs).The nanocrystalized surface has a smallest general corrosion rate due to the quick formation of Cr rich oxide film.However,once the corrosion penetrates through this nanocrystalized layer,subsequent preferential corrosion at deformation bands and GBs will dominate and may lead to the significant increase of corrosion rate of the component in high temperature pressurized water. | Honglin Yan Jianqiu Wang Zhiming Zhang Bright O.Okonkwo | 2022 | Journal of Materials Science & Technology2022，，27： | 2 |
| 12 | C3d enhancement of antibodies to Hemagglutinin accelerates protection against influenza virus challenge显示文摘 | Ross T M Xu Y Bright R A | 2000 | Nat Immunol2000，1，2： | 2 |
| 13 | Synthesis,in vivo activity of novel 9-deoxo-9a-aza-homoerythromycin A derivatives; A new class of macrolide antibiotics,the azalides显示文摘 | Nagel A A Bordnor J | 1988 | J Antibiot1988，41，8： | 1 |
| 14 | β-blockers and depression evidence against an association显示文摘 | BRIGHT R A EVERITT D E | 1992 | JAMA1992，267，： | 1 |
| 15 | Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum antigen diversity in the parasitic bacterium Anap/asma显示文摘 | Bright AT Winzeler EA | 2011 | BMC Biol2011，9，： | 1 |
| 16 | Why Are Public Values toward Wildlife Changing? 显示文摘 | Manfredo M Teel T Bright A | 2003 | Human Dimensions of Wildlife2003，8，4： | 1 |
| 17 | Applicationofthecon cepts of values and attitudes in human dimensions of natura resources research显示文摘 | ManfredoMJ TeelTL Bright AD | 2004 | Society and natural resources: A sum mary of knowledge2004，，： | 1 |
| 18 | American Academy of Audiology Childhood Hearing Screening Guidelines显示文摘 | Bright K Eichwald J Loveland CO | 2011 | 2011，，： | 1 |
| 19 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure显示文摘 | Thornton C Bright N J Sastre M | 2011 | Biochem J2011，434，3： | 1 |
| 20 | Prospective randomized trial of argon plasma coagulation ablation versus endoscopic surveillance of Barrett's esophagus in patients treated with antisecretory medication显示文摘 | BRIGHT T WATSON D TAM W | 2009 | Dig Dis Sci2009，54，12： | 1 |
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