|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 厚环乳牛肝菌(Suillus grevillei)N40与绿木霉(Trichoderma virens)T43复合接种下樟子松苗木的生理响应显示文摘采用植物生理学和生物化学等研究方法,研究了厚环乳牛肝菌(Suillus grevillei)N40与绿木霉(Trichoderma virens)T43复合接种条件下,对樟子松苗木的接种效应。测定不同接种方式下樟子松苗木生长指标、菌根合成率、光合色素含量、可溶性蛋白含量、抗氧化酶活性,根际土壤酶活性和抗病保护酶活性等指标。结果表明:N40和T43既有竞争性,同时又具有良好的兼容性,对苗木的生长指标、生理指标均有明显的提高作用。接种N40 30d后接种T43,3个月后苗木高生长提高43.0%,地径提高55.6%,苗木可溶性蛋白含量提高176.9%,苗木叶绿素a水平提高76.2%,叶绿素b水平提高64.1%,类胡萝卜素水平提高103.6%,苗木CAT和SOD活力分别提高45.5%和43.7%,β-1,3葡聚糖酶和几丁质酶活力提高28.0%和40.0%;苗木根际土壤脲酶和碱性磷酸酶活力分别提高120%和100%。上述结果表明,绿木霉T43能够促进菌根化苗木的生长并能诱导苗木产生抗性。 | 尹大川 邓勋 Ilan Chet 宋瑞清 | 2014 | 生态学杂志2014，33，8： | 43 |
| 2 | 绿木霉对樟子松苗木生长指标及生理生化指标的影响显示文摘樟子松是我国北方的主要造林树种。苗木质量是造林成功与否的关键。木霉菌可以有效促进作物的生长,并能很好地诱导植物产生系统抗性,促进种子萌发和增加根茎生物量。然而,大量研究都是关于农作物,将木霉应用于林木的研究还鲜有报道。为了探明绿木霉菌株T43对樟子松苗木的促生作用及对苗木生理生化指标的影响,采用打孔灌根接种方法对樟子松1年生苗木接种菌株T43,对接种苗木体内过氧化氢酶(CAT)、过氧化物酶(POD)、超氧化物歧化酶(SOD)活性、可溶性蛋白和可溶性糖含量进行动态跟踪测定,在生长季结束时对各处理苗木生物量进行调查。结果表明:与CK相比,经过T43诱导处理后,苗木表现出较高的CAT、POD和SOD活性,其中CAT和POD出现平稳上升的趋势,SOD表现出波动上升的趋势,但这3种酶整体都表现出上升的趋势,且在整个过程中其活性水平均高于CK。与该结果类似,可溶性蛋白和可溶性糖含量也表现出高于CK的现象,不同的是,二者在诱导处理后即出现上升,随着时间的推移,其含量在下降中趋于平稳,但始终高于CK。在生物量方面,T43处理组的苗高、地径、鲜质量和干质量均高于CK,苗木生长质量显著提高。接种3个月后,与对照相比苗高提高了36.7%,地径提高了22.2%,干质量提高了50%,鲜质量提高了21.7%。认为使用绿木霉接种处理苗木促进苗木生长、提高苗木质量是可行的。 | 尹大川 杨立宾 邓勋 Ilan Chet 宋瑞清 | 2015 | 北京林业大学学报2015，37，1： | 27 |
| 3 | 引进木霉菌株T43对立枯病的抑制效果及对苗木的促生作用显示文摘把从以色列引进、室内抑菌试验显示对苗木立枯病菌(立枯丝核菌Rhizoctonia solani、腐霉Pythium sp.和腐皮镰刀菌Fusarium oxysporum)具有显著抑制效果的绿木霉Trichoderma virens菌株T43制成不同浓度菌剂,对落叶松Larix sp.和红松Pinus koraiensis 1年生苗木进行室外灌根处理,30 d后测定苗木生长及病害发生情况。结果表明:引进的绿木霉T43菌剂在显著控制落叶松和红松立枯病发生的同时,还显著提高苗木的生长、土壤微生物种群数量及土壤酶活性,该菌株液体菌剂适合落叶松苗木,孢子悬浮液适合红松苗木。 | 尹大川 邓勋 Ilan Chet 李冲伟 宋瑞清 | 2012 | 中国森林病虫2012，31，4： | 22 |
| 4 | 木霉菌株对金黄壳囊孢菌的抑菌效应及机制显示文摘采用对峙培养法和生长速率法,从29个木霉菌株中筛选出3株对金黄壳囊孢菌具有显著抑制效果的菌株T-33,T-14,T-09,并对3个菌株的抑菌活性成分进行复筛确定T-33菌株培养液的正丁醇浸提物对金黄壳囊孢菌菌丝生长的抑制率最高,达到94%,并能显著抑制分生孢子萌发。该抑菌活性成分可显著提高金黄壳囊孢菌细胞膜的通透性,降低病原菌蛋白质含量和SDH,PK,HK,LDH,MDH与辅酶Ⅰ的活力,同时导致Na+,K+-ATP酶,Mg2+-ATP酶和Ca2+-ATP酶活性急剧下降。结果表明:金黄壳囊孢菌细胞膜脂质过氧化严重,糖酵解途径、TCA循环、电子传递与氧化磷酸化过程等代谢途径均不能正常进行,产能下降。抑菌活性成分通过破坏病原菌的防护系统和代谢途径抑制其生长。 | 李冲伟 杨立宾 邓勋 Ilan Chet 宋瑞清 | 2012 | 林业科学2012，48，9： | 20 |
| 5 | 绿木霉(Trichoderma virens)T43对四种重要林木病原菌的抑制效果及抑菌机理显示文摘通过对峙培养和非挥发性代谢产物对病原菌生长的抑制作用,开展了木霉菌株T43及其抑菌活性物质抑制樟子松枯梢病、杨树烂皮病和苗木立枯病3种病害的4种病原菌效果的研究。从菌株T43发酵液乙酸乙酯提取物对各病原菌的3种保护酶(CAT、POD和SOD)活力影响和对细胞渗透调节物质(可溶性蛋白、可溶性糖和丙二醛)的含量影响,探讨了提取物对病原菌的抑菌机理。结果表明:木霉菌株T43及其代谢产物对供试林木病原菌均有明显的抑制作用,菌株T43发酵液乙酸乙酯提取物对病原菌3种保护酶活性均有不同程度的影响,可导致病原菌3种保护酶活性降低,尤其是SOD活性下降的最为显著。该提取物可以显著降低菌丝体可溶性糖和蛋白含量,提高丙二醛含量,破坏细胞的完整性,这可能是绿木霉T43发酵液乙酸乙酯提取物抑制病原菌生长的机理之一。 | 尹大川 邓勋 Ilan CHET 宋瑞清 | 2014 | 生态学杂志2014，33，7： | 20 |
| 6 | Climate Change’s Role in Disaster Risk Reduction’s Future:Beyond Vulnerability and Resilience显示文摘A seminal policy year for development and sustainability occurs in 2015 due to three parallel processes that seek long-term agreements for climate change, the Sustainable Development Goals, and disaster risk reduction.Little reason exists to separate them, since all three examine and aim to deal with many similar processes, including vulnerability and resilience. This article uses vulnerability and resilience to explore the intersections and overlaps amongst climate change, disaster risk reduction, and sustainability. Critiquing concepts such as 'return to normal'and 'double exposure'demonstrate how separating climate change from wider contexts is counterproductive. Climate change is one contributor to disaster risk and one creeping environmental change amongst many, and not necessarily the most prominent or fundamental contributor. Yet climate change has become politically important, yielding an opportunity to highlight and tackle the deep-rooted vulnerability processes that cause 'multiple exposure'to multiple threats. To enhance resilience processes that deal with the challenges, a prudent place for climate changewould be as a subset within disaster risk reduction. Climate change adaptation therefore becomes one of many processes within disaster risk reduction. In turn, disaster risk reduction should sit within development and sustainability to avoid isolation from topics wider than disaster risk. Integration of the topics in this way moves beyond expressions of vulnerability and resilience towards a vision of disaster risk reduction’s future that ends tribalism and separation in order to work together to achieve common goals for humanity. | Ilan Kelman JC Gaillard Jessica Mercer | 2015 | International Journal of Disaster Risk Science2015，6，1： | 19 |
| 7 | Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis显示文摘Gut flora and bacterial translocation (BT) play important roles in the pathogenesis of chronic liver disease, including cirrhosis and its complications. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen predispose patients to bacterial infections, major complications and also play a role in the pathogenesis of chronic liver disorders. Levels of bacterial lipopolysaccharide, a component of gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver disease. Impaired gut epithelial integrity due to alterations in tight junction proteins may be the pathological mechanism underlying bacterial translocation. Preclinical and clinical studies over the last decade have suggested a role for BT in the pathogenesis of nonalcoholic steatohepatitis (NASH). Bacterial overgrowth, immune dysfunction, alteration of the luminal factors, and altered intestinal permeability are all involved in the pathogenesis of NASH and its complications. A better understanding of the cell-specific recognition and intracellular signaling events involved in sensing gut-derived microbes will help in the development of means to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases. These may suggest new targets for potential therapeutic interventions for the treatment of NASH. Here, we review some of the mechanisms connecting BT and NASH and potential therapeutic developments. | Yaron Ilan | 2012 | World Journal of Gastroenterology2012，18，21： | 17 |
| 8 | Climate Change and the Sendai Framework for Disaster Risk Reduction显示文摘This article reviews climate change within the Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR), analyzing how climate change is mentioned in the framework’s text and the potential implications for dealing with climate change within the context of disaster risk reduction. Three main categories are examined. First,climate change affecting disaster risk and disasters,demonstrating too much emphasis on the single hazard driver and diminisher of climate change. Second, crosssectoral approaches, for which the SFDRR treads carefully,thereby unfortunately entrenching artificial differences and divisions, although appropriately offering plenty of support to other sectors from disaster risk reduction. Third,implementation, for which climate change plays a suitable role without being overbearing, but for which other hazard influencers should have been treated similarly. Overall, the mentions of climate change within the SFDRR put too much emphasis on the hazard part of disaster risk. Instead,within the context of the three global sustainable development processes that seek agreements in 2015, climate change could have been used to further support an allvulnerabilities and all-resiliences approach. That could be achieved by placing climate change adaptation as one subset within disaster risk reduction and climate change mitigation as one subset within sustainable development. | Ilan Kelman | 2015 | International Journal of Disaster Risk Science2015，6，2： | 16 |
| 9 | 抑郁症、焦虑症与冠状动脉粥样硬化性心脏病患者血小板活性的关系显示文摘 | Ilan S.Wittstein 陈明 谢良地 | 2010 | 中华高血压杂志2010，18，10： | 16 |
| 10 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 11 | 引进木霉菌株对药用植物刺五加和五味子苗木的抗病促生作用显示文摘通过与立枯丝核菌(Rhizoctonia solani)进行对峙培养,同时测定木霉菌非挥发性和挥发性次生代谢产物对丝核菌菌丝生长的影响,对8株木霉菌进行了室内筛选;制备T-43木霉菌剂,对刺五加和五味子苗木立枯病进行室外防治试验,并测定了木霉菌对苗木的促生抗逆作用。试验结果表明:在对峙培养及发酵液抑菌试验中,各菌株及其次生代谢产物对立枯丝核菌均有不同程度的抑制作用,对峙培养中,T-43对丝核菌的相对抑制系数为2.5;T-43发酵液对丝核菌的抑制率为71.15%,可以强烈抑制丝核菌的生长并具有热稳定性;绿木霉菌株T-43在显著控制刺五加和五味子立枯病发生的同时,可以显著促进苗木的生长、增加生物量和抗逆性,并提高土壤微生物种群数量和稳定性。 | 邓勋 宋小双 尹大川 宋瑞清 Ilan Chet 马晓乾 遇文婧 | 2014 | 吉林农业大学学报2014，36，2： | 9 |
| 12 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 13 | 干旱和NaCl胁迫下哈茨木霉的响应显示文摘[目的]探究哈茨木霉T28在干旱和NaCl胁迫条件下的响应,为开发耐旱、耐盐的木霉菌剂提供理论基础。[方法]采用林木病理学、菌物学、生物化学等方法,对从以色列引进的哈茨木霉菌株T28进行干旱和盐胁迫试验,从生长和营养代谢的角度对其抗逆性进行一系列研究。[结果]T28具有较强的抗旱性,在聚乙二醇(PEG-6000)模拟干旱的环境中,其生长速率几乎不受影响。在NaCl胁迫条件下,木霉菌株生长和营养代谢与盐的浓度呈明显的相关性,当NaCl浓度≤0.4 mol/L时,木霉菌株生长和碳、磷利用率受抑制程度均较低,表现为较强的耐盐性。[结论]可为适合干旱和高盐环境的木霉菌剂开发提供理论依据。 | 尹大川 邓勋 Ilan Chet 宋瑞清 | 2013 | 安徽农业科学2013，41，30： | 7 |
| 14 | Preoperative imaging in staghorn calculi, planning and decision making in management of staghorn calculi显示文摘Objective:Staghorn calculi present a particular and challenging entity of stone morphology.Treatment is associated with lower stone-free rates and higher complication rates compared to non-staghorn stones.In this review we looked for the most relevant data on preoperative imaging and access planning to help decision making for percutaneous surgery with this complex condition.Methods:We conducted a PubMed search of publications in the past 2 decades that include relevant information on the planning for management of staghorn stones.Non-contrast computerized tomography(NCCT)is indeed the standard imaging tool for percutaneous nephrolithotomy(PCNL);additional tools such as three-dimensional computed tomography(CT)reconstruction of the staghorn calculus may help plan access in complex cases.Ultrasound guided percutaneous access may be considered for staghorn stones when planning upper pole access in kidney malposition or complex intrarenal anatomy or with complex body habitus.Wideband doppler ultrasound and real-time virtual sonography can assist.New technologies to improve kidney access such as Uro Dyna-CT or electromagnetic sensor have been reported,but have not shown utilization in staghorn cases.Staghorn morphometry-based prediction algorithms may predict the number of tract(s)and stage(s)for PCNL monotherapy.Lower pole access can be equally effective as upper pole when planning for staghorn and complex stones,with significantly less complications rate;Stone-Tract length-Obstruction-Number of involved calyces-Essence of stone density(STONE)nephrolithometry seems to be the best system to predict outcomes of PCNL in staghorn cases.There is a growing trend of endoscopic combined intrarenal surgery(ECIRS)in concordance with PCNL to treat larger stones.Conservative management of staghorn calculi is an undesired option,but can be an alternative for a carefully selected group of high-risk patients.Conclusion:Staghorn stones may lead to deterioration of renal function and life-threatening urosepsis.This entity should be managed aggressively with planning ahead for surgery using the different tools available as the cornerstone for a successful outcome. | Ilan Klein Jorge Gutierrez-Aceves | 2020 | Asian Journal of Urology2020，7，2： | 7 |
| 15 | Point-of-care continuous ^(13)C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial显示文摘AIM: To assess the role of the 13C-methacetin breath test (MBT) in patients with acute liver disease. METHODS: Fifteen patients with severe acute liver disease from diverse etiologies were followed-up with 13C-MBT during the acute phase of their illnesses (range 3-116 d after treatment). Patients fasted for 8 h and ingested 75 mg of methacetin prior to the MBT. We compared results from standard clinical assessment, serum liver enzymes, synthetic function, and breath test scores. RESULTS: Thirteen patients recovered and two patients died. In patients that recovered, MBT parameters improved in parallel with improvements in lab results. Evidence of consistent improvement began on day 3 for MBT parameters and between days 7 and 9 for blood tests. Later convergence to normality occurred at an average of 9 d for MBT parameters and from 13 to 28 d for blood tests. In both patients that died, MBT parameters remained low despite fluctuating laboratory values. CONCLUSION: The 13C-MBT provides a rapid, noninvasive assessment of liver function in acute severe liver disease of diverse etiologies. The results of this pilot clinical trial suggest that the MBT may offer greater sensitivity than standard clinical tests for managing patients with severe acute liver disease. | Gadi Lalazar Tomer Adar Yaron Ilan | 2009 | World Journal of Gastroenterology2009，15，8： | 6 |
| 16 | The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants显示文摘到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因,知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度,重金属的压力,和 Botrytis cinerea 感染。抵抗的线, overexpressing 在不同层次的真菌的 chitinases,是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力,尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些,揭示经常的起来规定(至少双重) 10 ,在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。 | Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein Lothar Willmitzer Ilan Chet Ada Viterbo | 2012 | Molecular Plant2012，5，5： | 5 |
| 17 | 素质教育政策、新自由主义与影子教育在中国的兴起显示文摘当前,我国影子教育治理正从“治标”向“治本”迈进。在此背景下,该文重新考察了素质教育政策对义务教育阶段影子教育兴起的影响机制,并就新自由主义是否在其中发挥作用的问题进行了重点探讨。该文通过对政策设计文本以及对政策执行典型案例的考察,发现该政策在设计时就忽视了影子教育,在执行中又通过减少在校备考时间,对正式教育进行了限制,使得学生难以仅通过在校上学就能满足不变的升学需求。供求失衡为影子教育市场创造了扩张空间。因此,素质教育政策是我国影子教育兴起的一项必要条件。过去的研究常将教育领域内的“公退民进”与新自由主义联系起来。然而,该文考察了素质教育政策出台前后的文本材料和财政数据,发现这些政策的主体内容可追溯到计划经济时代,且从未明显出现批判的马克思主义视角中的国家财政从公共教育中“大撤退”。因此,该文的结论是,作为民办教育的影子教育并非源于“新自由主义”治理策略。但基于研究发现,该文认为,“治本”仍须反“新自由主义”之道而行,配合最新的教育评价改革,以已有或新增的独立高考录取区为单位试点统一大幅增加在校时间以开展素质教育,从而缩减应试型影子教育的生存空间。 | 王捷 Ilan Katz 岳经纶 | 2021 | 中国青年研究2021，，7： | 5 |
| 18 | Gastric stimulation for weight loss显示文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity. | Meir Mizrahi Ami Ben Ya'acov Yaron Ilan | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 19 | The diagnosis, treatment, and follow-up of cesarean scar pregnancy显示文摘 | Ilan E. Timor-Tritsch Ana Monteagudo Rosalba Santos Tanya Tsymbal Grace Pineda Alan A. Arslan | 2012 | American Journal of Obstetrics and Gynecology2012，，1： | 3 |
| 20 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员