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| 1 | 乳腺单纯型大汗腺癌代表一种独特的雄激素受体阳性的三阴型乳腺癌亚型显示文摘乳腺单纯型大汗腺癌在所有乳腺癌中不足1%,是一种胞质内富含嗜酸性颗粒,核圆形,核仁明显的乳腺癌,肿瘤ER、PR及HER-2均阴性,对基于激素和HER-2方案的化疗无效,因此通常被归为三阴型乳腺癌进行治疗,甚至部分病例接受强化化疗。但与其他类型三阴型乳腺癌不同的是,该亚型乳腺癌表达雄激素受体(AR)是大部分非大汗腺分化的三阴型乳腺癌(NA—TNC)所不具有的特征。因此AR可作为乳腺大汗腺癌的一个关键诊断标记及治疗靶点。 | Mills A M E Gottlieb C M Wendorth S 王婷 余英豪 | 2016 | 临床与实验病理学杂志2016，32，11： | 10 |
| 2 | 21世纪治愈法案:医药创新的进展与发展路径显示文摘2016年12月,美国国会表决通过《21世纪治愈法案》(21st Century Cures Act),旨在以"discovery,development and delivery"为方针,通过增加投入鼓励医学研究与创新,改革美国药品注册审评机制与监管法规,以加快创新药物研发与临床使用。一年多来,法案中提出的精准医疗计划、癌症登月计划等,为医学界研究注入了大量的资金支持。同时,在其推动下的审评标准改革也在业界引起了高度关注与争议。2017年12月7日,美国食品药品监督管理局局长Scott Gottlieb就法案实施情况向参议院卫生、教育、劳工和养老金委员会进行总结陈词。 | Scott Gottlieb 蒋蓉 | 2018 | 中国食品药品监管2018，，2： | 9 |
| 3 | 良性乳腺疾病的女性面临更高的癌变风险显示文摘 | Scott Gottlieb 曾敏 | 2006 | 英国医学杂志中文版2006，9，3： | 5 |
| 4 | 依那西普对银屑病患者疲劳和抑郁症状的临床疗效:一项双盲、随机、安慰剂对照、III期试验显示文摘Background: Psoriasis has substantial psychological and emotional effects. We assessed the effect of etanercept, an effective treatment for the clinical symptoms of psoriasis, on fatigue and symptoms of depression associated with the condition. Methods: 618 patients with moderate to severe psoriasis received double-blind treatment with placebo or 50 mg twice-weekly etanercept. The primary efficacy endpoint was a 75% or greater improvement from baseline in psoriasis area and severity index score (PASI 75) at week 12. Secondary and other endpoints included the functional assessment of chronic illness therapy fatigue (FACIT-F) scale, the Hamilton rating scale for depression (Ham-D), the Beck depression inventory (BDI), and adverse events. Efficacy analyses were based on the allocated treatment. Analyses and summaries of safety data were based on the actual treatment received. This study is registered with ClinicalTrials.gov with the identifier NCT00111449. Findings: 47% (147 of 311) of patients achieved PASI 75 at week 12, compared with 5% (15 of 306) of those receiving placebo (p< 0.0001; difference 42% , 95% CI 36- 48). Greater proportions of patients receiving etanercept had at least a 50% improvement in Ham-D or BDI at week 12 compared with the placebo group; patients treated with etanercept also had significant and clinically meaningful improvements in fatigue (mean FACIT-F improvement 5.0 vs 1.9; p< 0.0001, difference 3.0, 95% CI 1.6- 4.5). Improvements in fatigue were correlated with decreasing joint pain, whereas improvements in symptoms of depression were less correlated with objective measures of skin clearance or joint pain. Interpretation: Etanercept treatment might relieve fatigue and symptoms of depression associated with this chronic disease. | Tyring S. Gottlieb A. Papp K. R. Krishnan 王琼(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 4 |
| 5 | The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery显示文摘 | Pekka Talke Richard Chen Brian Thomas Anil Aggarwall Alexandru Gottlieb Per Thorborg Stephen Heard Albert Cheung Stanley Lee Son Antero Kallio | 2000 | Anesthesia & Analgesia2000，，4： | 3 |
| 6 | TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis显示文摘 | Karim Bensaad Atsushi Tsuruta Mary A. Selak M. Nieves Calvo Vidal Katsunori Nakano Ramon Bartrons Eyal Gottlieb Karen H. Vousden | 2006 | Cell2006，，1： | 3 |
| 7 | Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the Southwest Region of Cameroon显示文摘Background:Tuberculosis(TB)remains a global health challenge and depression is a significant contributor to the global burden of disease.Current evidence suggests that there is an association between depressive symptoms and TB,lower adherence to treatment,and increased morbidity and mortality.However,there is paucity of data regarding these associations in Cameroon.This study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB(PTB)in the Southwest Region of Cameroon.Methods:A hospital-based cross-sectional study involving 265 patients with PTB was conducted from 2nd January to 31st March 2015 in the Limbe Regional Hospital and the Kumba District Hospital.Depression was diagnosed using the standard nine-item Patient Health Questionnaire,and classified as none,mild or moderate.Logistic regressions were used to investigate correlates of depression in these patients.Results:Of the 265 patients(mean age 36.9±10 years)studied,136(51.3%)were female.The prevalence of depression was 61.1%(95%CI:55.1–66.8),with a significant proportion(36.6%)having mild depression.Multivariable logistic regression analysis showed that being female(aOR=3.0,95%CI(1.7–5.5),P<0.001),having a family history of mental illness(aOR=2.5,95%CI:1.3–5.4,P>0.05),being on retreatment for TB(aOR=11.2,95%CI:5.2–31.1,P<0.001),having discontinued treatment(aOR=8.2,95%CI:1.1–23.3,P<0.05)and having a HIV/TB co-infection(aOR=2.5,95%CI:1.2–6.5,P<0.001)were factors associated with having a higher chance of being depressed.Conclusion:Our study suggests that there is a high prevalence of depression among PTB patients,with more than one in two patients affected.Multidisciplinary care for TB patients involving mental health practitioners is highly encouraged,especially for high-risk groups. | Jules Kehbila Cyril Jabea Ekabe Leopold Ndemnge Aminde Jean Jacques NNoubiap Peter Nde Fon Gottlieb Lobe Monekosso | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 8 | Social support concepts and measures显示文摘 | Benjamin H. Gottlieb Anne E. Bergen | 2010 | Journal of Psychosomatic Research2010，，5： | 2 |
| 9 | Evidence for a Role of Second Pathophysiological Stress in Prevention of Delayed Neuronal Death in the Hippocampal CA1 Region显示文摘 | Jozef Burda Milina Matia?ová Miroslav Gottlieb Viera Danielisová Miroslava Némethová Lidia Garcia Matilde Salinas Rastislav Burda | 2005 | Neurochemical Research2005，，11： | 2 |
| 10 | Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure显示文摘 | Daniel E. Forman Javed Butler Yongfei Wang William T. Abraham Christopher M. O’Connor Stephen S. Gottlieb Evan Loh Barry M. Massie Michael W. Rich Lynne Warner Stevenson James B. Young Harlan M. Krumholz | 2004 | Journal of the American College of Cardiology2004，，1： | 2 |
| 11 | A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation显示文摘 | Stacey J. Wieczorek Alan H.B. Wu Robert Christenson Padma Krishnaswamy Stephen Gottlieb Thomas Rosano David Hager Nancy Gardetto Albert Chiu Kathryn R. Ba illy Alan Maisel | 2002 | American Heart Journal2002，，5： | 2 |
| 12 | 研究表明阿司匹林可预防60岁以上老年男性患前列腺癌显示文摘 | Scott Gottlieb 冯凯 | 2002 | 英国医学杂志中文版2002，5，4： | 2 |
| 13 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 14 | Treatment with anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody dramat ically decreases the clinical activity of pso riasis lesions显示文摘 | Oh C J Das KM Gottlieb AB | | 0，，： | 2 |
| 15 | Identification of hypometabolic areas in the brain using brain imaging and hyperbaric oxygen显示文摘 | Neubauer RA Gottlieb SF Miale A | 1992 | Clin Nucl Med1992，17，6： | 2 |
| 16 | Intravitreal injection of corticosteroid for the treatment of macular edema asscociated with central retinal vein occlusion 显示文摘 | Ip MS Gottlieb JI Kahana A | 2004 | Arch Ophthalmol2004，122，8： | 1 |
| 17 | Modelling ecological and economic systems with STELLA: Part II显示文摘 | Costazzar H Gottlieb S | 1998 | Ecological Modelling1998，112，2： | 1 |
| 18 | Effect of beta-blockade on mortality a- mong high-risk and low-risk patients after myocardial infarction 显示文摘 | Gottlieb SS McCarter R J Vogel RA | 1998 | N Engl J Med1998，339，8： | 1 |
| 19 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009，115，4： | 1 |
| 20 | Repeffusion injury induces apoptosis in rabbit cardiomyocytes 显示文摘 | Gottlieb RA Burleson KO Kloner RA | 1994 | J Clin Invest1994，94，4： | 1 |
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