|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Peripheral nerve regeneration and intraneural revascularization显示文摘Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully. | Martial Caillaud Laurence Richard Jean-Michel Vallat Alexis Desmoulière Fabrice Billet | 2019 | Neural Regeneration Research2019，14，1： | 20 |
| 2 | 土源性线虫感染对儿童生长发育影响及相关因素分析显示文摘目的了解中国西南贫困地区儿童土源性线虫感染现状,分析其对儿童生长发育的影响。方法在四川省和贵州省随机选取3个国家级贫困县,采用改良加藤厚涂片法对受检儿童粪便进行病原学检查并进行问卷调查。采用普通最小二乘法(OLS)分析土源性线虫感染情况、个体特征、饮食卫生习惯和家庭特征等相关因素对儿童身体质量指数(BMI)、身高和体重的影响。结果共粪检1 707名儿童,土源性线虫感染率为22.2%。OLS分析显示感染土源性线虫、性别、年龄、母亲受教育程度、饮用生水、饲养畜禽等6个因素差异均有统计学意义,并与儿童身高和体重存在负相关关系。结论中国西南农村贫困地区儿童感染土源性线虫与生长发育存在负相关关系。土源性线虫感染与母亲的文化程度密切相关。应加大力度控制儿童土源性线虫的感染。 | 王晓兵 王国飞 张林秀 罗仁福 王聚君 Alexis Medina Karen Eggleston Scott Rozelle Scott Smith | 2013 | 中国血吸虫病防治杂志2013，25，3： | 18 |
| 3 | On-the-fly active learning of interpretable Bayesian force fields for atomistic rare events显示文摘Machine learned force fields typically require manual construction of training sets consisting of thousands of first principles calculations,which can result in low training efficiency and unpredictable errors when applied to structures not represented in the training set of the model.This severely limits the practical application of these models in systems with dynamics governed by important rare events,such as chemical reactions and diffusion.We present an adaptive Bayesian inference method for automating the training of interpretable,low-dimensional,and multi-element interatomic force fields using structures drawn on the fly from molecular dynamics simulations.Within an active learning framework,the internal uncertainty of a Gaussian process regression model is used to decide whether to accept the model prediction or to perform a first principles calculation to augment the training set of the model.The method is applied to a range of single-and multi-element systems and shown to achieve a favorable balance of accuracy and computational efficiency,while requiring a minimal amount of ab initio training data.We provide a fully opensource implementation of our method,as well as a procedure to map trained models to computationally efficient tabulated force fields. | Jonathan Vandermause Steven B.Torrisi Simon Batzner Yu Xie Lixin Sun Alexie M.Kolpak Boris Kozinsky | 2020 | npj Computational Materials2020，，1： | 17 |
| 4 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 5 | Application of MODIS satellite products to the air pollution research in Beijing显示文摘The direct correlation between NASA MODIS aerosol optical depth (AOD) products and the air pollution index (API) in Beijing was found relatively low based on the long-term comparison analysis. The correlation improved to some extent after taking account of the seasonal variation of scale height and the vertical distribution of aerosols. The correlation coefficient further improved significantly after considering the influencing factor of Relative Humidity (RH). This study concluded that satellite remote-sensing could serve as an efficient tool for monitoring the spatial distribution of particulate pollutants on the ground-level, as long as corrections have been made in the two aforementioned processes. Taking advantage of the MODIS information, we analyzed a pollution episode occurring in October 2004 in Beijing. It indicated that satellite remote-sensing could describe the formation process of the ground-level pollution episode in detail, and showed that regional transport and the topography were crucial factors to air quality in Beijing. The annual averaged distribution in the urban area of Beijing and its surroundings could be also obtained from the high-resolution retrieval results, implicating that high-resolution satellite remote-sensing might be potential in monitoring the source distribution of particulate pollutants. | Alexis K.H.Lau | 2005 | Science China Earth Sciences2005，48，z2： | 12 |
| 6 | Current Controversies and the State of the Art in Endovascular Treatment of Vascular Malformations显示文摘Vascular anomalies constitute some of the most difficult diagnostic and therapeutic enigmas that can be encountered in the practice of medicine. The clinical presentations are extremely protean and can range from an asymptomatic birthmark to fulminant。 | Wayne Yakes Alexis Yakes Fiona Rohlffs Krasnodar Ivancev | 2018 | Journal of Interventional Medicine2018，1，2： | 12 |
| 7 | 探讨美国CCRC养老模式及其在中国的前景显示文摘在美国,养老产业有很悠久的历史。1860年出现的专业护理(NursingHome)标志着美国养老产业的诞生,在之后漫长的120年中,专业护理都占据着主导地位。从上世纪80年代开始,美国的养老产业进入了多元化的发展阶段,直到现在。形成了一个完整的养老产业,包括投资、物业、运营管理、建筑设计等。 | Alexis Denton Joyce Polhamus SmithGroupJJR 陈鸥翔 | 2014 | 建筑技艺2014，20，3： | 11 |
| 8 | 中国农村医生医疗服务质量的测量——基于标准化病人法的实验研究显示文摘过去十年中,中国政府在农村地区进行了一系列的医疗改革,这些改革极大地提高了医疗服务的可及性,但却很少关注医疗服务的质量。本文采用标准化病人法,测量和评估中国农村基层医疗服务的质量。我们招募样本地区的农民作为'标准化病人',培训他们稳定地展示小儿痢疾和心绞痛这两种常见疾病的症状。基于标准化病人在村卫生室的就诊案例,我们发现作为基层医疗服务第一线的村医可能无法给患者提供高质量的医疗服务。村医在诊断过程中仅完成了18%的建议问诊条目,诊断正确率仅为26%;在所有开具处方的病例中,有64%的药物是不必要的,甚至是有害的。进一步分析表明,医疗服务质量与医生的受教育水平和是否获得医疗资格证书密切相关。此外,我们发现农民患者并不能很好地识别出哪些医生是相对好的医生,这样的医患信息不对称的情况可能使村医更加缺乏提高医疗服务质量的激励。研究结果建议政府在投资硬件改善基层医疗服务设施的同时,应更加注重提高农村医生的诊断和治疗水平。 | 史耀疆 薛浩 王欢 Sean Sylvia Alexis Medina Scott Rozelle | 2016 | 劳动经济研究2016，4，2： | 10 |
| 9 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 10 | To Board or Not to Board: Evidence from Nutrition, Health and Education Outcomes of Students in Rural China显示文摘寄宿学校是否为学生是有益的争论仍然在发展和发达国家存在。在农村中国,由于在 2001 开始了的一个国家学校兼并节目,上学生的数字戏剧性地增加了。然而,很少研究都没被做测量登机地位怎么可以与营养,健康和教育结果被相关。在这篇论文,我们比较不搭伙的学生登机到那些用的结果一大,在中国越过五个省包括 59 个农村县的总数数据集。我们发现为登机的所有结果,学生们表演比不搭伙的学生更坏。尽管有这些差别,所有结果的绝对层次为登机和不搭伙的学生是低的,显示对将指向不管他们的登机地位的所有农村学生的新政策的需要。 | Aiqin Wang Alexis Medina Renfu Luo Yaojiang Shi Ai Yue | 2016 | China & World Economy2016，24，3： | 10 |
| 11 | 中国西南地区儿童土源性线虫感染及影响因素调查显示文摘目的了解中国西南贫困地区儿童土源性线虫感染情况和主要影响因素,为制定土源性线虫病防治措施提供依据。方法采用改良加藤厚涂片法对受检儿童粪便进行病原学检查,其中部分儿童进行透明胶纸肛拭法检查蛲虫卵。采用问卷调查和Probit估计多元统计方法,分析儿童服药驱虫、个体特征、饮食卫生习惯和家庭特征等16个相关因素对土源性线虫感染的影响。结果共粪检1 707名儿童,土源性线虫感染率为22.2%,其中蛔虫、钩虫、鞭虫感染率分别为16.9%、3.8%和6.6%,且以蛔虫感染率和感染度为最高;蛲虫检查495名,感染率为5.1%。Probit估计多元统计显示,兄弟姐妹数量、母亲受教育程度、饮用生水、饲养畜禽等4个因素差异均有统计学意义(P均<0.05)。其中,母亲受教育程度能降低土源性线虫感染率,边际效应为-0.074;兄弟姐妹数量、饮用生水和饲养畜禽均能提高土源性线虫感染率,边际效应分别为0.028、-0.112和0.080。结论我国西南贫困地区儿童土源性线虫感染率仍然较高,且以蛔虫感染为主;改变儿童饮用生水的不良卫生习惯、家庭饲养畜禽习惯和针对其母亲开展寄生虫病防治知识的健康教育,对儿童土源性线虫病的预防和控制具有重要意义。 | 王晓兵 王国飞 张林秀 罗仁福 田洪春 唐丽娜 王聚君 Alexis Medina Paul Wise Scott Rozelle | 2012 | 中国血吸虫病防治杂志2012，24，3： | 10 |
| 12 | Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation显示文摘Spinal cord injury (SCI) in mammals results in functional deficits that are mostly permanent due in part to the inability of severed axons to regenerate. Several types of growth-inhibitory molecules expressed at the injury site contribute to this regeneration failure. The responses of axons to these inhibitors vary greatly within and between organisms, reflecting axons' characteristic intrinsic propensity for regeneration. In the zebrafish (Danio rerio) many but not all axons exhibit successful regeneration after SCi. This review presents and compares the intrinsic and extrinsic determinants of axonal regeneration in the injured spinal cord in mammals and zebrafish. A better understanding of the molecules and molecular pathways underlying the remarkable individualism among neurons in mature zebrafish may support the development of therapies for SCI and their translation to the clinic. | Katarina Vajn Jeffery A Plunkett Alexis Tapanes-Castillo Martin oudega | 2013 | Neuroscience Bulletin2013，29，4： | 9 |
| 13 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 14 | 两种乳菇菌丝生长的最适培养基与菌根合成显示文摘通过测量菌丝直径和干重对松乳菇(rcb-74)和靓丽乳菇(rll-107,rmsh-118)进行最适菌丝生长培养基的筛选。结果表明所有菌株均在改良的biotin-aneurine-folic acid(BAF)培养基上表现出较大的菌丝直径以及最大菌丝干重。用改良的BAF培养基制备乳菇液体菌丝,接种云南松、马尾松和油松,并在13–30d后发现rcb-74与云南松和油松形成菌根,rll-107与马尾松形成菌根,rmsh-118与云南松形成菌根。 | 王冉 Guerin-Laguette Alexis 于富强 | 2020 | 菌物学报2020，39，7： | 8 |
| 15 | 西南两省贫困地区儿童土源性线虫感染状况及影响因素分析显示文摘目的:了解四川和贵州省贫困地区儿童土源性线虫感染情况及其主要影响因素,为制定土源性线虫病防治策略提供依据。方法采用分层随机抽样,选择贵州和四川两省6个贫困县的95个行政村及46所小学为调查点,每个样本村各选择11名3~5岁学龄前儿童及8~10岁就读于样本学校的儿童作为调查对象,收集其粪便,采用改良加藤厚涂片法进行检查。同时对各村村医和村干部进行问卷调查,了解该村2009年儿童驱虫情况及社会经济和卫生状况;采用Tobit估计多元统计方法分析儿童土源性线虫感染的影响因素。结果两省共粪检1707名儿童,贵州省样本村儿童土源性线虫感染率为46.1%,蛔虫、钩虫、鞭虫感染率分别为31.1%、4.1%、10.8%;四川省样本村儿童土源性线虫感染率为9.8%,上述3种寄生虫感染率分别为3.6%、3.5%、2.7%。两省共粪检890名学龄儿童,贵州省样本学校儿童土源性线虫和蛔虫、钩虫、鞭虫感染率分别为53.8%、32.7%、6.6%、14.4%,四川省分别为7.3%、2.2%、2.9%、2.2%。Tobit估计分析显示,儿童驱虫治疗和村水田比例是儿童土源性线虫感染的影响因素(P均<0.05)。结论我国西南贫困地区儿童土源性线虫感染率仍然较高。为有效降低贫困地区儿童的土源性线虫感染率,除构建长效驱虫工作机制和采取改水、改厕等措施外,还应加强健康教育,并将驱虫防治纳入新型农村合作医疗体系。 | 王晓兵 张林秀 王国飞 罗仁福 Alexis Medina Scott Rozelle | 2014 | 中国血吸虫病防治杂志2014，26，3： | 7 |
| 16 | 中国旅游发展笔谈——旅游与社会文化变迁(二)显示文摘制订旅行和度假计划往往牵涉到人类的想象能力或对他者的想象。关于异国他乡群体与地方的诱人形象与话语是如此重要, 以至于一旦没有它们, 旅游将变得稀少——如果并非全部没有的话。旅游者往往被鼓励把自己想象成身处天堂般美境之中, 在那里, 地方景观与人群通过被观察、被感知、被想象, 从而被旅游者所消费。然而, 由于想象总是置身于更广泛的社会文化架构中, 目的地市场营销人员根本无法对其完全掌控。因此, 我把想象界定为能够与人们的个体想象互动、并能被用于意义制造与世界塑造的社会传播的代表性组合体. | Noel B. Salazar 张进福 Alexis Celeste Bunten Jennifer Devine K. Thirumaran 黄宜瑜 谢素卿 林宛儒 秦宇 高科 | 2013 | 旅游学刊2013，28，12： | 7 |
| 17 | IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer显示文摘In secondary lymphoid organs,mature B cells express membrane immunoglobulin(Ig)of M and D isotypes(IgM and IgD,respectively)of the same specificity through alternative splicing of a pre-mRNA encompassing the VDJ variable region and Cμand Cδheavy chain constant exons.1 After encountering antigen,B cells undergo class switch recombination(CSR)by which the Cμgene is substituted with Cγ,Cεor Cα,thereby generating IgG,IgE and IgA antibodies of the same antigenic specificity but with new effector functions.CSR requires the DNA-editing enzyme activation-induced deaminase(AID). | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2017 | Cellular & Molecular Immunology2017，14，10： | 6 |
| 18 | The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature显示文摘Objective:Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia(BPH).Methods:A retrospective analysis was performed for all patients who underwent 180 W XPSlaser photoselective vaporization of the prostate(PVP)vaporization of the prostate between 2012 and 2016 at two-tertiary medical centers.Data collection included baseline comorbidities,disease-specific quality of life scores,maximum urinary flow rate(Qmax),postvoid residual(PVR),complications,prostate volume and prostate-specific antigen(PSA).The secondary endpoints were the incidence of intraoperative and postoperative adverse events.Complications were stratified using the Clavien-Dindo grading system up to 90 days after surgery.Results:Mean age of men was 67.8 years old,with a mean body mass index of 29.7 kg/m2.Mean prostate volume as measured by transrectal ultrasound was 29 mL.Anticoagulation use was 47%and urinary retention with catheter at time of surgery was 17%.Mean hospital stay and catheter time were 0.5 days.Median follow-up time was 6 months with the longest duration of follow-up being 22.5 months(interquartile range,3-22.5 months).The International Prostate Symptom Score improved from 22.8±7.0 at baseline to 10.7±7.4(p<0.01)and 6.3±4.4(p<0.01)at 1 and 6 months,respectively.The Qmax improved from 7.70±4.46 mL/s at baseline to 17.25±9.30 mL/s(p<0.01)and 19.14±7.19 mL/s(p<0.001)at 1 and 6 months,respectively,while the PVR improved from 216.0±271.0 mL preoperatively to 32.8±45.3 mL(p<0.01)and 26.2±46.0 mL(p<0.01)at 1 and 6 months,respectively.The PSA dropped from 1.97±1.76 ng/mL preoperatively to 0.71±0.61 ng/mL(p<0.01)and 0.74±0.63 ng/mL at 1 and 6 months,respectively.No patient had a bladder neck contracture postoperatively and no capsular perforations were noted intraoperatively.Conclusion:The 180 W GreenLight XPS system is safe and effective for men with small volume BPH.PVP produced improvements in symptomatic and clinical parameters without any safety concern.It represents a safe surgical option in this under studied population. | Dominique Thomas Kevin C.Zorn Malek Meskawi Ramy Goueli Pierre-Alain Hueber Lesa Deonarine Vincent Misrai Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，4： | 6 |
| 19 | Numerical modeling of dam-break flood through intricate city layouts including underground spaces using GPU-based SPH method显示文摘This paper applies the meshfree Smoothed Particle Hydrodynamics(SPH)method with Graphical Processing Unit(GPU)parallel computing technique to investigate the highly complex 3-D dam-break flow in urban areas including underground spaces.Taking the advantage of GPUs parallel computing techniques,simulations involving more than 107particles can be achieved.We use a virtual geometric plane boundary to handle the outermost solid wall in order to save considerable video card memory for the GPU computing.To evaluate the accuracy of the new GPU-based SPH model,qualitative and quantitative comparison to a real flooding experiment is performed and the results of a numerical model based on Shallow Water Equations(SWEs)is given with good accuracy.With the new GPU-based SPH model,the effects of the building layouts and underground spaces on the propagation of dambreak flood through an intricate city layout are examined. | 吴建松 张辉 杨锐 DALRYMPLE Robert A. HéRAULT Alexis | 2013 | Journal of Hydrodynamics2013，25，6： | 5 |
| 20 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员