|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 可持续发展研究方法国际进展——脆弱性分析方法与可持续生计方法比较显示文摘自从以布伦特兰德夫人领导的委员会正式提出可持续发展概念以来,可持续发展受到社会各界的密切关注,可持续发展思想已经深入人心。但由于问题的复杂性,既使是今天,可持续的实现依然困难。因此,围绕可持续发展提出了各式各样的研究工具,其中可持续生计方法和脆弱性分析方法可谓是众多方法中的佼佼者。前者强调贫困的消除,后者强调脆弱性的缓解,可持续发展又是其共同的目的。本文对两种方法在概念和实施方案方面进行了比较分析,在明确它们的差异和相似之处的基础上,认为两种方法通过联合可以在实践中相互加强和相互促进。 | Martha G.Roberts 杨国安 | 2003 | 地理科学进展2003，22，1： | 242 |
| 2 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 3 | 电站锅炉受热面高温积灰的数值模拟(英文)显示文摘针对某电站锅炉的炉内过程进行数值模拟。以加拿大过程仿真公司开发的软件为基础,运用流体、化学、能量和辐射模型仿真炉膛内部的燃烧过程;运用辐射和对流换热模型仿真沿水平烟道的过热器热交换过程。通过对温度场和速度场的模拟计算,揭示锅炉炉内和高温受热面处的实际情况。仿真结果显示,温度场和速度场造成了受热面的高温积灰,仿真结果得到了实验验证。 | 庞力平 孙保民 Martha E Salcudean | 2004 | 中国电机工程学报2004，24，10： | 15 |
| 4 | International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas显示文摘 | Masao Tanaka Carlos Fernández-del Castillo Volkan Adsay Suresh Chari Massimo Falconi Jin-Young Jang Wataru Kimura Philippe Levy Martha Bishop Pitman C. Max Schmidt Michio Shimizu Christopher L. Wolfgang Koji Yamaguchi Kenji Yamao | 2012 | Pancreatology2012，，3： | 13 |
| 5 | 年长男子的生育年龄对生育质量的影响显示文摘最近几十年来,妇女生第一胎的年龄越来越大。同样的趋势在男性群体也逐渐表现出来了。母亲年龄对生育、染色体异常、孕期并发症、先天缺陷以及对后代的整体健康的影响已经得到全面的研究,而且这些研究结果已经应用于临床受孕咨询和产前咨询中。但男性的年龄及其对生育结果的影响相对来说得到的关注度较低。本综述的目的是对最近相关文献中父亲年龄对生育结果的影响做一个综合评述。 | Zofnat Wiener-Megnazi Ron Auslender Martha Dirnfeld | 2012 | Asian Journal of Andrology2012，14，1： | 12 |
| 6 | Adiponectin as a protective factor in hepatic steatosis显示文摘AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. | Nahum Méndez-Sánchez Norberto C.Chávez-Tapia Antonio R.Villa Karla Sánchez-Lara Daniel Zamora-Valdés Martha H.Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，12： | 12 |
| 7 | New gene therapy strategies for hepatic fibrosis显示文摘The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient′s bed-side. | Adriana M Salazar-Montes Luis D Hernández-Ortega Martha S Lucano-Landeros Juan Armendariz-Borunda | 2015 | World Journal of Gastroenterology2015，21，13： | 12 |
| 8 | Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis显示文摘AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver cirrhosis.METHODS: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal hypertension.RESULTS: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood flow.CONCLUSION: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin Ⅲ levels and could be responsible for disturbances of organ pathology. | Sasa-Marcel Maksan Eduard Ryschich Zilfi (U|¨)lger Martha Maria Gebhard Jan Schmidt | 2005 | World Journal of Gastroenterology2005，11，6： | 11 |
| 9 | 中年体重指数与老年住院、死亡的关系显示文摘背景:大量证据显示,超重和肥胖有损健康。它们与高血压、高血脂等已知冠心病危险因素密切相关。但是,除此之外。它们是否对心血管疾病还有其他影响?人们对此争论不休。
目的:在人群中(无论其在基线时是否存在其他主要危险因素)评价中年时期体重指数与老年后发病率、死亡率之间的关系。
设计:“芝加哥心脏学会工业检查项目研究”(Chicago Heart Association Detection Projectin Industry)是一项前瞻性研究,研究将基线时(1967—1973年)心血管患病风险分为低危(血压≤120/≤80mm Hg,血清总胆固醇水平〈200mg/dL[5.2mmol/L],不吸烟)、中危(不吸烟,收缩压121—139mm Hg。舒张压81—89mm Hg,和/或血清总胆固醇水平200—239mg/dL[5.2—6.2mmol/L])以及存在下列危险因素中的1项、2项或全部3项:血压≥140/90mm Hg,血清总胆固醇水平≥240mg/dL(6.2 mmol/L),吸烟。体重指数分为正常(18.5—24.9)、超重(25.0—29.9)和肥胖(≥30)。平均随访时间为32年。
地点及参试者:共有17643人参加研究,其中既有男性也有女性,年龄为31—64岁。他们均来自芝加哥地区的公司或机构。基线时无冠心病(coronary heart disease,CHD)和糖尿病,心电图也未见重大异常。
主要观测指标:65岁以后因CHD、心血管疾病或糖尿病住院、死亡的情况。
结果:在多变量分析中,对收缩压和血清总胆固醇水平进行校正。研究发现,在低危组和中危组中,与体重正常者相比,超重者死于CHD的比值比(95%可信区间)分别为1.43(0.33—6.25)和2.07(1.29—3.31),而因CHD住院的比值比(95%可信区间)分别为4.25(1.57—11.5)和2.04(1.29—3.24)。其他风险组结果类似,心血管疾病的情况也大致如此,但糖尿病的情形则更为严重(低危组:死于糖尿病的比值比[95%可信区间]为11.0[2.21—54.5],因糖尿病住院的比值比[95%可信区间]为7.84[3.95—15.6])。
结论:对没有心血管危险因素的人群和有1个或1个以上危险因素的人群而言,中年时肥胖者老年后因CHD、心血管疾病或糖尿病住院、死亡的风险高于中年时体重正常者。 | Lijing L. Yan Martha L Daviglus Kiang Liu 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 11 |
| 10 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 11 | Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy显示文摘生来的杀手(NK ) 房间是天生的免疫系统的部分并且由于他们没有优先的促进感受性,杀死感染的房间或癌症房间的能力是为免疫疗法的一种诱惑选择。在整个过去的 20 年,不同的组能在 vitro 复制 NK 房间开发,并且 NK 房间个体发生学习提供了基础让协议的建立为免疫疗法在 vitro 生产 NK 房间。这里,我们简短讨论 NK 房间开发和 NK 房间免疫疗法途径。我们考察为在 vitro 的房间区别,干细胞采购被使用的、出版协议,质问的 NK 需要的因素,为好生产的未来方向练习协议。 | Martha Luevano Alejandro Madrigal Aurore Saudemont | 2012 | Cellular & Molecular Immunology2012，9，4： | 10 |
| 12 | 欧美国家休闲体育发展现状及其对中国的启示(英文)显示文摘(1)欧美国家休闲体育发展现状。休闲体育引领健康世界。面对汹涌而来的世界性的现代健康危机,各国纷纷出台国民健康的政策和办法,通过开展调查研究为民众的体育参与提供数据和支撑,还通过体育设施设备供给为社会大众参与体育运动锻炼创造条件。随着经济社会发展、个人拥有物质财富和自由时间的增多,休闲体育作为一种促进人类健康的时代力量和新的生活方式、文化现象被社会大众广泛关注和接受。社会大众逐渐崇尚生命价值的真实和品质;大众积极休闲观念的养成、对体验型运动休闲方式青睐等也助推了休闲体育的发展。休闲健身的理念和实施成了推动休闲体育、进一步发展的关键一环;同时我们还要把加快形成有利于健康的生活方式、生态环境和经济社会发展模式,实现健康与经济社会良性协调发展作为基本准则。大众化、多样化和差异化是法国休闲体育发展主要趋势。运动休闲在法国的普及程度较高,截至2010年,有89%14周岁以上的法国人至少参加一项休闲体育运动。休闲体育运动参与人数的增加,还拓展了休闲体育活动的内容和类型。研究(Lefèvre&Thierry,2010)表明:法国人不但可以同时参与多项体育运动,他们还对一些传统的项目加以创新和发展;所以,法国人经常参与的休闲体育运动项目有300余项。法国大众的休闲体育运动参与还呈现出多样化特点,参与者呈现出巨大的性别、年龄、职业、形式、规模等方面的差别;社会大众参与休闲体育运动的目的也是多种多样,除了竞技和表演外,人们赋予休闲体育运动保持健康、愉悦身心、形体塑造等多重意义和价值。加拿大休闲体育发展主要趋势。根据加拿大统计局(Statistics Canada)的数据,2012年12岁及以上加拿大人口中,有53.9%(1 560万)的人经常运动。2001年-2012年间,加拿大经常参与休闲体育运动活动的人数呈现出上升态势,其中男性经常参与体育锻炼的比例高于女性。他们把体育参与分为3种类型:体育运动(Sport,有规则、有对手、竞争性)、体力活动(Physical Activity,需要一切的能量消耗及休闲体育锻炼(Exercise,有计划、有组织、重复性的旨在改善或维持身体健康)。调查表明:(1)最受加拿大男性欢迎的3项体育运动是冰球、高尔夫球和足球,最受加拿大女性欢迎的项目则是高尔夫、足球和游泳。(2)2010年以前步行或慢跑是加拿大人最常参与的休闲活动项目,是加拿大人最常用的休闲体育锻炼项目。(3)由加拿大健身和生活方式研究所(Canadian Fitness and Lifestyle Research Institute)完成的研究报告表明:2014年-2015年18岁及以上加拿大人经常参加的体力活动的类型有:步行(84%)、园艺或庭院工作(74%)、在家锻炼(65%)和游泳(58%)等。澳大利亚体育发展概况。澳大利亚一直被公认为是一个热爱体育运动的国家。澳政府出台了各种促进体育发展的政策以期增加参与体育运动人口数量、提升精英运动员成绩、增进社会包容度、改善大众心理健康、帮助老年人保持独立并提升他们的生活质量、推动社会变革。2015年澳大利亚人仅在体育馆、健身房、休闲中心的体育和休闲活动花费就超过107亿美元。澳大利亚90%以上的体育和体育娱乐从业人员都在私营部门就业。但令人担忧的是:近年来久坐的成年人和儿童数量大幅增加,肥胖和其他与不运动相关的健康问题日益增多。澳大利亚统计局的数据(Australian Bureau of Statistics,2014)表明,参加体育运动和休闲体育娱乐活动的澳大利亚人数量有所减少,会员制体育和休闲俱乐部的会员人数有所下降。究其根源:社会变化、政治决定、经济条件和人口变化等相互作用导致体育志愿者工作时间减少。志愿者一直是澳大利亚非营利性社区体育和娱乐团体运营的关键因素,但受人口结构的变化、就业模式和利益相关者的期望等因素影响,体育志愿者工作时间正在减少。随着休闲方式变革、人口结构变化、体育发展商业化和全球化对澳大利亚的休闲娱乐和体育运动发展的影响逐渐深入,体育发展既要积极变革以适应青少年休闲体育运动偏好,又要主动寻求非政府组织的资助,还要努力探索'商业化'背景下体育组织的运营模式。气候变化对休闲体育高尔夫旅游的影响。据估计,全世界有34 011个高尔夫球场;全球高尔夫旅游市场每年的产值超过200亿美元,许多国家已将高尔夫作为重要的旅游产品来开发。加勒比海地区的高尔夫球场数量较少,占全球高尔夫球场总数的不到1%(121个,截至2014年);球场运营的模式有4种:单独运营的球场、与酒店共同运营、与住宅房地产和/或酒店合作运营、只与主要的住宅房地产合作运营。加勒比地区的高尔夫市场曾主要依赖美国和加拿大的游客。然而,比起打高尔夫(14%),北美的游客现在更喜欢钓鱼(30%)、赏鸟(15%)、在沙滩上漫步(77%)或放松休憩(71%)。高尔夫球场经营和高尔夫球旅游发展与气候密切相关。一方面,全球气候变化也延长了全球北部地区的高尔夫球季。另一方面,高尔夫球场项目建设也可能会因砍伐树木、植被和红树林等导致气候变化;投入运营的高尔夫球场会通过增加温室气体排放及其对淡水的大量需求等形式影响气候变化。所以,高尔夫球场建设与运营应更加注重对环境的保护。除了研究草坪管理、培育草种外,我们更应该关注高尔夫球场如何适应气候变化的客观现实。加勒比和其他地区的新高尔夫球场建设除了必须符合国际公认项目标准,还要积极探索冷却大气、防止侵蚀、给地下水补给和应对气候变化的最佳做法。(2)欧美国家休闲体育发展对中国的启示。观念的转变,让理念主导休闲体育发展方式变迁。体育及休闲体育既是提高人民健康水平,又是推动体育消费结构升级和体育产业发展的重要力量。另外,社会大众对体育及休闲的认识是推进休闲体育及体育发展方式大变革关键:休闲体育发展既需要社会大众重视,又需要全社会积极参与。方式的创新,让社会和市场成为推动休闲体育发展的核心力量。一方面发挥协会、高校、俱乐部、企业等在提供和生产多元化休闲体育产品及服务方面的职能和职责,以缓解当前休闲体育产品和服务供给总体不足与需求不断增长之间的矛盾。另一方面,发挥市场机制配置休闲体育资源的决定性作用,让市场逻辑和效率逻辑主导休闲体育的发展。文化培育,让浓厚的文化氛围为休闲体育发展提供滋养。政府部门主导休闲体育设施设备供给和制度供给,为休闲体育发展提供物质和制度文化层面的保障和支持;加强宣传和引导,推动休闲体育产品和服务供给者、各类参与者的休闲体育文化自觉,并落实到休闲体育发展、休闲体育参与和休闲体育消费的实践中。 | 李相如 宝帝.古若米 凯伦.丹尼贾克 特雷西.泰勒 约翰.诺莱特 Anand Rampersad Martha Honey 陈林会 | 2017 | 成都体育学院学报2017，43，4： | 10 |
| 13 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 14 | Genetic variants involved in gallstone formation and capsaicin metabolism,and the risk of gallbladder cancer in Chilean women显示文摘AIM:To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffi n block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman SNP Genotyping Assays or Custom Taqman SNP Genotyping Assays.RESULTS:The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR:0.14,95% CI:0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR:5.04,95% CI:1.43-17.8).CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs 708272 polymorphisms may be related to the risk of developing GBC in Chilean women. | Sergio Báez Yasuo Tsuchiya Alfonso Calvo Martha Pruyas Kazutoshi Nakamura Chikako Kiyohara Mari Oyama Masaharu Yamamoto | 2010 | World Journal of Gastroenterology2010，16，3： | 8 |
| 15 | Lymphomatous involvement of gastrointestinal tract: Evaluation by positron emission tomography with ^(18)F-fluorodeoxyglucose显示文摘AIM: To demonstrate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) findings in patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI tract.METHODS: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUVmax) of the lesions was measured before and after the treatment,if data were available and compared with histologic diagnoses.RESULTS: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUVmax±SD was 11.58±5.83. After the therapy,the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal lesions.The SUVmax±SD decreased from 11.58±5.83 to 2.21±0.78. In patients whose post-treatment biopsies showed lymphoma, the SUVmax±SD was 9.42±6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUVmax 8.2 and 10.3, respectively). The SUVmax was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT lymphoma.CONCLUSION: 18F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma,even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL. | Sith Phongkitkarun Vithya Varavithya Toshiki Kazama Silvana C Faria Martha V Mar Donald A Podoloff Homer A Macapinlac | 2005 | World Journal of Gastroenterology2005，11，46： | 6 |
| 16 | STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer显示文摘 | Dimitrios Iliopoulos Savina A. Jaeger Heather A. Hirsch Martha L. Bulyk Kevin Struhl | 2010 | Molecular Cell2010，，4： | 5 |
| 17 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 18 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 19 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 20 | 开放参观对莫高窟洞窟微环境的影响显示文摘洞窟微环境相对湿度是影响壁画保存的关键因素,为了解开放参观对莫高窟洞窟相对湿度的影响,本研究选择莫高窟南区四个相似洞窟进行长达10年(2004~2013年)的定期监测,对比分析了开放洞窟和关闭洞窟其相对湿度的变化情况。结果表明:开放洞窟相对湿度在开放时段波动频率与游客参观频次正相关,发生降雨时开放洞窟相对湿度迅速上升,关闭洞窟可有效阻隔窟外相对湿度波动的影响。开放洞窟在参观量大的旅游旺季,其相对湿度月极大值、日较差月均值以及日极大值超过60%的频次均明显高于关闭洞窟。将开放洞窟关闭,关闭洞窟开放后,其相对湿度呈相反规律变化。开放参观会导致洞窟相对湿度水平显著升高,日波动幅度明显增大,从而增加壁画劣化风险。这些结论可为洞窟的预防性管理和风险评估提供科学依据。 | 陈海玲 陈港泉 Neville Agnew Martha Demas 薛平 侯文芳 苏伯民 前川信 王旭东 | 2017 | 文物保护与考古科学2017，29，6： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员