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| 1 | RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F显示文摘 | Moritz Leppkes Christoph Becker Ivaylo I. Ivanov Sebastian Hirth Stefan Wirtz Clemens Neufert Sandrine Pouly Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Burkhard Becher Dan R. Littman Markus F. Neurath | 2009 | Gastroenterology2009，，1： | 2 |
| 2 | Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding显示文摘BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent 'touch-free' agents.AIM To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI bleeding.Patients were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. | Francesco Vitali Andreas Naegel Raja Atreya Steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 3 | STAT3 links IL-22 sig- naling in intestinal epithelial cells to mucosal wound healing显示文摘 | Pickert G Neufert C Leppkes M | 2009 | J Exp Med2009，206，7： | 1 |
| 4 | IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1 显示文摘 | Neufert C Becker C Wirtz S | 2007 | Eur J Immunol2007，37，7： | 1 |
| 5 | IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1 显示文摘 | Neufert C Becker C Wirtz S | 2007 | Immunol2007，37，7： | 1 |
| 6 | An inducible mouse model of colon carcinogenesis for the analysis of speradic and inflammation-driven tumor progression显示文摘 | Neufert C Becket C Neurath MF | 2007 | Nat Protoc2007，2，8： | 1 |
| 7 | An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression显示文摘 | Neufert C Becker C Neurath MF | 2007 | Nat Protoc2007，2，8： | 1 |
| 8 | IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STATI 显示文摘 | Neufert C Becker C Wirtz S | 2007 | Eur J Immunol2007，37，7： | 1 |
| 9 | IL-27 controls the development of inducible regulatory T cells and Th17 ceils via differential effects on STATI显示文摘 | Neufert C Becker C Wirtz S | 2007 | Eur J Immunol2007，37，： | 1 |
| 10 | Cutting edge : IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis 显示文摘 | Becker C Dornhoff H Neufert C | 2006 | J Immunol2006，177，5： | 1 |
| 11 | Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial显示文摘BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy.However,adenoma miss rates reach up to 26%and studies have shown that a second inspection of the right colon in retroflected view(RFV)can increase ADR.AIM To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV)can increase ADR.METHODS Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two arms.In RFV arm colonoscopy was initially performed with SFV,followed by a second inspection of the whole colon in RFV.In the SFV arm first withdrawal was performed with SFV,followed by a second inspection of the whole colon again with SFV.Number,size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate containers.RESULTS Two hundred and five patients were randomly assigned to the RFV(n=101)and SFV(n=104)arm.In the RFV arm,both polyp detection rate(PDR)and ADR were increased under second inspection in RFV(PDR 1st SFV:39.8%,PDR 2nd RFV:46.6%;ADR 1st SFV:35.2%,ADR 2nd RFV:42%).Likewise,in the SFV arm,PDR and ADR were increased under second inspection(PDR 1st SFV:37.5%,PDR 2nd SFV:46.6%;ADR 1st SFV:34.1%,ADR 2nd SFV:44.3%)with no significant differences in ADR and PDR between the SFV and RFV arm.Mean number of adenomas per patient(APP)was increased in the RFV and SFV(APP RFV arm:1st SFV:1.71;2nd RFV:2.38;APP SFV arm:1st SFV:1.83,2nd SFV:2.2).The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were>5 mm in size.CONCLUSION Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV.Hence,increased detection is most likely a feature of the second inspection itself but not of the inspection mode. | Timo Rath Lukas Pfeifer Clemens Neufert Andreas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath Steffen Zopf | 2020 | World Journal of Gastroenterology2020，26，16： | 1 |
| 12 | Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK显示文摘 | Neufert Clemens Becker Christoph Türeci ?zlem Waldner Maximilian J Backert Ingo FIoh Katharina Atreya lmke Leppkes Moritz Jefremow Andre Vieth Michael Schneider-Stock Regine Klinger Patricia Greten Florian R Threadgill David W Sahin Ugur Ne | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
| 13 | IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STATl显示文摘 | Neufert C Becker C Wirtz S | 2007 | Eur J Immunol2007，37，7： | 1 |
| 14 | IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1 显示文摘 | Neufert C Becker C Wirtz S | 2007 | Eur J Immunol2007，37，7： | 1 |
| 15 | Chemically induced mouse models of intestinal inflammation显示文摘 | Wirtz S Neufert C Weigmann B | | 0，，： | 1 |
| 16 | STAT3 links IL - 22 sig- naling in intestinal epithelial cells to mucosal wound healing显示文摘 | Pickert G Neufert C Leppkes M | 2009 | J Exp Med2009，206，7： | 1 |
| 17 | STAT3links IL-22signaling in intestinal epithelial cells to mucosal wound healing显示文摘 | Pickert G Neufert C Leppkes M | 2009 | J Exp Med2009，206，7： | 1 |
| 18 | STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing显示文摘 | Pickert G Neufert C Leppkes M | 2009 | J Exp Med2009，206，7： | 1 |
| 19 | In vivo imaging using fluo- rescent antibodies to tumor necrosis factor predicts therapeutic re- sponse in Crohn's disease显示文摘 | Atreya R Neumann H Neufert C | 2014 | Nature Method2014，20，3： | 1 |
| 20 | Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis 显示文摘 | Becker C Domhoff H Neufert C | 2006 | J hnmunol2006，177，5： | 1 |
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