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| 1 | Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment显示文摘Helicobacter pylori(H. pylori) is an extremely common, yet underappreciated, pathogen that is able to alter host physiology and subvert the host immune response, allowing it to persist for the life of the host. H. pylori is the primary cause of peptic ulcers and gastric cancer. In the United States, the annual cost associated with peptic ulcer disease is estimated to be $6 billion and gastric cancer kills over 700000 people per year globally. The prevalence of H. pylori infection remains high(> 50%) in much of the world, although the infection rates are dropping in some developed nations. The drop in H. pylori prevalence could be a double-edged sword, reducing the incidence of gastric diseases while increasing the risk of allergies and esophageal diseases. The list of diseases potentially caused by H. pylori continues to grow; however, mechanistic explanations of how H. pylori could contribute to extragastric diseases lag far behind clinical studies. A number of host factors and H. pylori virulence factors act in concert to determine which individuals are at the highest risk of disease. These include bacterial cytotoxins and polymorphisms in host genes responsible for directing the immune response. This review discusses the latest advances in H. pylori pathogenesis, diagnosis, and treatment. Up-todate information on correlations between H. pylori and extragastric diseases is also provided. | Traci L Testerman James Morris | 2014 | World Journal of Gastroenterology2014，20，36： | 47 |
| 2 | 我国部分地区丙型肝炎病毒基因分型研究显示文摘目的 研究中国丙型肝炎病毒 (HCV)基因型分布。方法 应用AmplicorPCR试剂盒检测北京、青岛、固安和周口等地 2 7例抗 HCV阳性的单采浆供血员和 36例慢性丙型肝炎病人血清HCVRNA ,并对其中 36例HCVRNA阳性者用INNO LiPATM HCVⅡ试剂盒进行HCV基因分型。结果 抗 HCV阳性的单采浆供血员和慢性丙型肝炎病人HCVRNA检出率分别为 48.15 % (13/ 2 7)和 6 9.44 % (2 5 / 36 ) ,平均为 6 0 .32 % (38/ 6 3)。对 13例HCVRNA阳性的单采浆供血员和 2 3例慢性丙型肝炎病人HCV基因分型结果表明 ,2 9例 (80 .5 5 % )为 1b型 ,5例 (13.89% )为 2型 ,另 2例(5 .5 6 % )不能被分型。结论 上述调查地区流行的HCV基因型以 | 庄辉 Tracy L 崔怡辉 凌斌华 张玲霞 Bowden S | 2001 | 中华流行病学杂志2001，22，2： | 29 |
| 3 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 4 | 高含硫气井安全高效钻完井配套技术--以川东北罗家寨气田为例显示文摘四川盆地东北部罗家寨气田具有高含H_2S、高压、高产等特点,钻井过程中面临喷、漏、塌、卡、斜、硬、毒等难题。为此,以高含硫气井安全高效钻完井为目标,将目前先进的钻完井工艺技术进行了技术集成应用;按照国际一流水准的HSE管理体系要求,充分利用JSA、BBS卡、PTW、SWA、上锁挂签等安全工具.对各个专业化施工单位进行安全、环境及质量的全过程受控管理,真正做到界面清晰、衔接有序、高效运作。现场应用效果表明:①合成基钻井液完全满足本区域高含硫气井钻井要求;②PDC+旋转导向+随钻测井测斜+循环堵漏短节配套井下工具能满足高钻速、井眼轨迹优质、精控钻井液密度、及时应对堵漏等要求,且能钻达固井井深即可下套管;③采用封隔式尾管悬挂器为主体的防气窜配套工艺技术,配合使用弹性水泥浆体系,成功解决了喇叭口窜气问题,完全满足了后续作业对井筒完整性的要求;④LJ20井钻井周期较该气田平均钻井周期缩短了20%,平均机械钻速提高了41%.创造了该地区钻井的新纪录。所形成的钻完井配套技术可以有效地指导类似地区高含硫气田的安全高效开发。 | 张俊良 文绍牧 邵勇 雷震中 Tracy Love | 2015 | 天然气工业2015，35，4： | 10 |
| 5 | TKA术中股骨假体悬突的危险因素与临床后果显示文摘背景:近年来,全膝关节置换(total knee arthroplasty,TKA)术中的股骨假体悬突现象日益引起骨科医生的重视。本文目的为研究男性与女性患者TKA术后股骨假体悬突的发生率、确定预测悬突发生的危险因素以及假体悬突是否与术后疼痛或膝关节活动度的降低有关。方法:对437例使用同一假体系统的TKA术中的股骨假体悬突进行测量。假体牢固固定后,分别在10个分区的中点以mm刻度测量其超出截骨面边缘的悬突程度。寻找假体悬突的预测因素,并研究假体悬突对术后疼痛及膝关节屈曲度的影响。结果:男性患者176膝中的40%(71膝)、女性患者261膝中的68%(177膝)至少在1个分区内发生≥3mm悬突,且常见于外侧2区(前远侧区)和3区(远侧区)。多因素分析模型中,女性、身材矮小以及使用大号股骨假体是发生明显悬突的强预测因素。1个或1个以上分区存在≥3mm股骨假体悬突几乎可使术后2年发生明显膝关节疼痛的风险加倍[比数比1.9,95%可信区间为(1.1,3.3)]。结论:本组病例中股骨假体悬突的发生率高,女性患者更常见且更严重;不论男性患者还是女性患者,使用的股骨假体越大,假体悬突的发生率和严重程度越高。≥3mm股骨假体悬突可使TKA术后2年有临床意义的疼痛发生率加倍。 | OrmondeM. Mahoney Tracy Kinsey 张宇(译) 刘军(译) | 2010 | 中华骨科杂志2010，30，12： | 9 |
| 6 | Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events显示文摘AIM: To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS: Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS: Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have signifi cantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer.CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. | Jennifer Y Wang Jonathan P Terdiman Eric Vittinghoff Tracy Minichiello Madhulika G Varma | 2009 | World Journal of Gastroenterology2009，15，8： | 8 |
| 7 | Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling显示文摘作为我们在 theepididymis 识别新奇避孕目标的努力的部分,我们执行了分别地,用 Affymetrix 全部染色体在每老鼠的 10 和 19 个片断上介绍 drat epididymidis 的 transcriptional 微数组。当在分割的老鼠和老鼠附睾被表示,代表抄本的 17 096 和 16360 个探查集合的一个总数被识别 transcriptomes 分别地。对 transcriptional 介绍数据库从 22 另外的鼠标纸巾导出的一个鼠标的表示鼠科的抄本的比较识别了在附睾特别地被表示的 77transcripts。这些基因的表达式被反向的抄写进一步计算 RNA from21 老鼠纸巾的聚合酶链反应(RT-PCR ) 分析。RT-PCR 分析证实了 Defensin 贝它 13 的 epididymis 特定的表示并且识别了二另外的基因,表示仅仅限制了为附睾和睾丸。在有从介绍数据库的老鼠 transcriptional 的 21 另外的纸巾的数据的老鼠附睾的 16 360 个表示抄本的比较为 theepididymis 识别了 110 抄本 specific。62 个这些抄本被 qPCR 分析进一步调查。仅仅 Defensin22 (E3 附睾的蛋白质) 被显示为附睾完全特定。另外, 14transcripts 在附睾多于 100 褶层显示出选择表示。这些基因的产品可能在附睾起重要作用或精子工作并且当避孕目标被保证,推进调查和确认。在这份报告描述的研究的结果在哺乳动物的繁殖遗传(MRG ) 数据库(http://gffzzef35f6426a0e4a47h0xpoonfbuxkq6fuv.ffgz.tsg.suse.edu.cn/) 是可得到的。 | Daniel S. Johnston Terry T. Turner Joshua N. Finger Tracy L. Owtscharuk Gregory S. Kopf Scott A. Jelinsky | 2007 | Asian Journal of Andrology2007，9，4： | 8 |
| 8 | 幔源包体和中国东部现代弧后地热标志显示文摘利用矿物学、岩石学、组构,显微构造和红外光谱的综合分析方法,研究了福建省明溪石榴石和尖晶石-石榴石二辉橄榄岩包体。根据Bertrand和Mecier温度计、Nickel和Green压力计方法,利用TEMPEST最新程序分别计算了包体平衡温度和压力,其变化范围为:1300K,1.9GPa(60km)至1500K 2.6GPa(80km)。由包体温压资料推断的明溪地区地热与实测地表热流量(70mW/m^2)一致。地热特征、包体矿物显微构造和优选方位与现代伸展弧后环境的岩石圈减薄作用是一致的。 | 金振民 H.W.Green II R.S.Borch 金淑燕 T. N. Tracy T.E.Young | 1993 | 中国科学(B辑)1993，23，4： | 8 |
| 9 | 新疆柽柳上的植食性昆虫种类调查显示文摘本文报道新疆柽柳上的植食性昆虫和螨共 7目 2 9科 1 0 5种及其分布和取食部位。其中 ,蚕食叶片有 37种 ,占 2 8 0 % ;刺吸叶片昆虫有 4 8种 ,占 36 4 % ;取食柽柳花和果实的有 2 3种 ,占 1 7 4 % ;蛀食枝干的有 1 8种 ,占 1 3 6 % ;蛀食根的有 7种 ,占 5 3%。 | 孟玲 李保平 Jack DeLoach James Tracy | 2005 | 中国生物防治2005，21，1： | 7 |
| 10 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 11 | Developing single nucleotide polymorphism(SNP)markers from transcriptome sequences for identification of longan(Dimocarpus longan)germplasm显示文摘Longan(Dimocarpus longan Lour.)is an important tropical fruit tree crop.Accurate varietal identification is essential for germplasm management and breeding.Using longan transcriptome sequences from public databases,we developed single nucleotide polymorphism(SNP)markers;validated 60 SNPs in 50 longan germplasm accessions,including cultivated varieties and wild germplasm;and designated 25 SNP markers that unambiguously identified all tested longan varieties with high statistical rigor(P<0.0001).Multiple trees from the same clone were verified and off-type trees were identified.Diversity analysis revealed genetic relationships among analyzed accessions.Cultivated varieties differed significantly from wild populations(Fst=0.300;P<0.001),demonstrating untapped genetic diversity for germplasm conservation and utilization.Within cultivated varieties,apparent differences between varieties from China and those from Thailand and Hawaii indicated geographic patterns of genetic differentiation.These SNP markers provide a powerful tool to manage longan genetic resources and breeding,with accurate and efficient genotype identification. | Boyi Wang Hua-Wei Tan Wanping Fang Lyndel W Meinhardt Sue Mischke Tracie Matsumoto Dapeng Zhang | 2015 | Horticulture Research2015，2，1： | 6 |
| 12 | The price of protection:a defensive endosymbiont impairs nymph growth in the bird cherry-oat aphid,Rhopalosiphum padi显示文摘Bacterial endosymbionts have enabled aphids to adapt to a range of stressors,but their effects in many aphid species remain to be established.The bird cherry-oat aphid,Rhopalosiphum padi(Linnaeus),is an important pest of cereals worldwide and has been reported to form symbiotic associations with Serratia symbiotica and Sitobion miscanthi L-type symbiont endobacteria,although the resulting aphid phenotype has not been described.This study presents the first report of R.padi infection with the facultative bacterial endosymbiont Hamiltonella defensa.Individuals of R.padi were sampled from populations in Eastern Scotland,UK,and shown to represent seven R.padi genotypes based on the size of polymorphic microsatellite markers;two of these genotypes harbored H.defensa.In parasitism assays,survival of H.defensa-infected nymphs following attack by the parasitoid wasp Aphidius colemani(Viereck)was 5 fold higher than for uninfected nymphs.Aphid genotype was a major determinant of aphid performance on two Hordeum species,a modern cultivar of barley H.vulgare and a wild relative H.spontaneum,although aphids infected with H.defensa showed 16%lower nymph mass gain on the partially resistant wild relative compared with uninfected individuals.These findings suggest that deploying resistance traits in barley will favor the fittest R.padi genotypes,but symbiontinfected individuals will be favored when parasitoids are abundant,although these aphids will not achieve optimal performance on a poor quality host plant. | Daniel J.Leyboume Jorunn I.B.Bos Tracy A.Valentine Alison J.Karley | 2020 | Insect Science2020，27，1： | 5 |
| 13 | 《日常谈话:身份建构与身份映现》述介显示文摘语言与身份的研究近年来引起了语用学与话语研究的极大关注。最近几年的语用学和话语研究方面的专业期刊也都不定期刊发身份建构方面的研究论文,相关专著也陆续出版。2013年由Tracy与Robles撰写的第二版《日常谈话:身份建构与身份映现》(Everyday Talk:Building and Reflecting Identities)代表了该类研究的最新进展。本文拟对该书进行介绍和简要评价。 | 袁周敏 金梅 Karen Tracy Jessica S.Robles | 2015 | 现代外语2015，38，1： | 5 |
| 14 | Clinical Performance of an Automated Stool DNA Assay for Detection of Colorectal Neoplasia显示文摘 | Graham P. Lidgard Michael J. Domanico Janelle J. Bruinsma James Light Zubin D. Gagrat Rebecca L. Oldham-Haltom Keith D. Fourrier Hatim Allawi Tracy C. Yab Julie A. Simonson Mary Devens Russell I. Heigh David A. Ahlquist Barry M. Berger | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 5 |
| 15 | 恐怖主义犯罪学研究:前沿观点与未来发展显示文摘本文第一部分主要是对关于恐怖主义犯罪学研究的文章进行文献综述,介绍这类文章的主要内容与学术观点,并希望能够引起更多学者对恐怖主义犯罪学研究的关注。同时,本文着重介绍面向公众的恐怖主义数据库以及数据库的特点与数据内容,并结合全球恐怖主义数据库信息对未来恐怖主义犯罪学研究方向进行分析。 | Paul E Tracy 宋虹 | 2014 | 犯罪研究2014，，1： | 5 |
| 16 | 不同叶龄拟南芥荧光参数分析及对强光的响应显示文摘采用叶绿素荧光图像分析系统,研究了野生型拟南芥(Wild Arabidopsis thaliana)Col-0不同叶龄叶片的荧光参数变化及对强光的响应。结果表明,随叶片趋于成熟或衰老,20 min暗适应的最大PSⅡ光化学量子效率(Fv/Fm),稳定作用光下的PSⅡ有效和实际光化学效率(Fv′/Fm′和ΦPSⅡ)以及光化学猝灭系数(q P)均呈降低趋势,而非光化学猝灭系数(NPQ)增加;但短期5 d的处理期间其变化都不明显。与低光强相比,强光处理时Fv/Fm,ΦPSⅡ,Fv′/Fm′和q P呈降低趋势而NPQ明显升高。说明不同发育阶段的叶片具有明显差异的光化学反应特性,强光下光抑制现象明显;NPQ增加说明拟南芥能通过非辐射的热能耗散途径消耗过多的激发能,从而能避免光合机构的继续伤害。 | 师生波 Neil Baker Tracy Lawson 张德罡 | 2011 | 草原与草坪2011，31，4： | 4 |
| 17 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 18 | Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease显示文摘 | Paul M. Ridker Mary Cushman Meir J. Stampfer Russell P. Tracy Charles H. Hennekens | 1998 | Circulation1998，，5： | 3 |
| 19 | POSITIVE PSYCHOLOGY IN CLINICAL PRACTICE显示文摘 | Angela Lee Duckworth Tracy A. Steen Martin E.P. Seligman | 2005 | Annual Review of Clinical Psychology (2005)2005，，： | 3 |
| 20 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
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