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| 1 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 2 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 3 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 4 | Colorectal cancer显示文摘 | David Cunningham Wendy Atkin Heinz-Josef Lenz Henry T Lynch Bruce Minsky Bernard Nordlinger Naureen Starling | 2010 | The Lancet2010，，9719： | 3 |
| 5 | Colorectal cancer显示文摘 | David Cunningham Wendy Atkin Heinz-Josef Lenz Henry T Lynch Bruce Minsky Bernard Nordlinger Naureen Starling | 2010 | The Lancet2010，，9719： | 2 |
| 6 | Colorectal cancer显示文摘 | David Cunningham Wendy Atkin Heinz-Josef Lenz Henry T Lynch Bruce Minsky Bernard Nordlinger Naureen Starling | 2010 | The Lancet . 2010 (9719)2010，，9719： | 2 |
| 7 | 贵金属Ag中光学和磁光性质的实验研究显示文摘用椭圆偏振光谱仪和磁光谱仪研究了热蒸发和溅射法制备的Ag膜的光学和磁光性质 .在 1 0T的外磁场作用下 ,贵金属Ag在 3 9eV附近具有可观的磁光效应 .分析发现主要来源于两个方面 :1)自由电子在外磁场中回旋共振引起小的非对角元 ;2 )Ag本身在 3 9eV附近的光学性质 .数值计算表明磁光克尔效应θK 和εK 的峰值随ωc 的增加而增大 .对磁光实验数据拟合的有效质量与光学的相应数值基本相符 ,这为自由电子有效质量的测量提供了一种新方法 . | 邓世虎 王松有 李晶 刘铸 陈岳立 杨月梅 陈良尧 刘辉 张西祥 DAVID LYNCH | 2001 | 物理学报2001，50，1： | 2 |
| 8 | Serum Albumin Level as a Predictor of Outcome in Traumatic Brain Injury: Potential for Treatment显示文摘 | Francis Bernard Yahia Z. Al-Tamimi Doris Chatfield Andrew G. Lynch Basil F. Matta David K. Menon | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，4： | 1 |
| 9 | Mapping Levels of Palliative Care Development: A Global Update显示文摘 | Thomas Lynch Stephen Connor David Clark | 2013 | Journal of Pain and Symptom Management2013，，6： | 1 |
| 10 | Lung disease related to collagen vascular disease显示文摘 | David A Lynch MB | 2009 | J Thorac Imaging2009，24，4： | 1 |
| 11 | Group project work and student-centred active learning: two different experiences显示文摘 | Livingstone David & Kenneth Lynch | 2000 | Studies in Higher Education2000，25，3： | 1 |
| 12 | Estimating respiration of roots in soil: Interactions with soil CO2, soil temperature and soil water content显示文摘 | Tjeerd J. Bouma Kai L. Nielsen David M. Eissenstat Jonathan P. Lynch | 1997 | Plant and Soil1997，，2： | 1 |
| 13 | Occurrence of fastidious Campylobacter spp. in fresh meat and poultry using an adapted cultural protocol显示文摘 | órla A. Lynch Claire Cagney David A. McDowell Geraldine Duffy | 2011 | International Journal of Food Microbiology2011，，2： | 1 |
| 14 | Lipid and Lipoprotein Biomarkers and the Risk of Ischemic Stroke in Postmenopausal Women显示文摘 | Jeffrey S. Berger Aileen P. McGinn Barbara V. Howard Lewis Kuller JoAnn E. Manson Jim Otvos J. David Curb Charles B. Eaton Robert C. Kaplan John K. Lynch Daniel M. Rosenbaum Sylvia Wassertheil-Smoller | 2012 | Stroke2012，，4： | 1 |
| 15 | Colorectal cancer显示文摘 | David Cunningham Wendy Atkin Heinz-Josef Lenz Henry T Lynch Bruce Minsky Bernard Nordlinger Naureen Starling | 2010 | The Lancet2010，，9719： | 1 |
| 16 | Conversion of VOC13 to VOCI/ in liq- uid TiC14 显示文摘 | Lynch David C | 2002 | Acta Mechanica Slovaca2002，2，33： | 1 |
| 17 | High -resolution computed tomography in idiopathic pulmonary fibrosis显示文摘 | David A Lynch J David G | 2005 | American Journal of Respiratory and Critical Care Medicine2005，172，： | 1 |
| 18 | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo 显示文摘 | Jesse J Smith Renee Deehan Kenney David J Gagne Brian P Frushour William Ladd Heidi L Galonek Kristine Israelian Jeffrey Song Giedre Razvadauskaite Amy V Lynch David P Carney Robin J Johnson Siva Lavu Andre Iffland Peter J Elliott Philip D Lambert Keith O Elliston Michael R Jirousek Jill C Milne and Olivier Boss | 2009 | BMC Systems Biology2009，284，27： | 1 |
| 19 | Effect of biomaterial surface properties on fibronectin– α 5 β 1 integrin interaction and cellular attachment显示文摘 | Mark H. Lee Paul Ducheyne Laura Lynch David Boettiger Russell J. Composto | 2005 | Biomaterials2005，，9： | 1 |
| 20 | Quantitative Computed Tomography Detects Air Trapping due to Asthma显示文摘 | David A Lynch Lee S Newman | 1994 | Chest1994，106，1： | 1 |
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