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| 1 | Testicular expression of survivin and human telomerase reverse transcriptase(hTERT)associated with spermatogenic function in infertile patients显示文摘瞄准:与改变精子发生的功能在人的睾丸描绘 survivin, apoptosis (国际星际航空联合会) 的一个禁止者,和人的 telomerase 颠倒 transcriptase (hTERT ) 的 coexpression。方法:survivin mRNA 和 hTERT mRNA 的抄本层次用即时反向抄写的聚合酶链反应(RT-PCR ) 与有缺点的精子发生(n=28 ) 在正常睾丸(n=11 ) 和睾丸被决定。组织学的病情的检查根据一个修改 Johnsen 分数被执行。结果:survivin 和 hTERT 的表情在正常精子发生在 96.8 和 709 的中部的层次是最高的并且随减数分裂后精子发生的拘捕(n=10 ) 在睾丸落下到 53.3 和 534。在严重精子发生的失败( n=18 ), survivin 表示缺乏大多数标本( n=16 ),而阴囊的 hTERT 表示的至少底层在 premeiotic 精子发生的拘捕( n=7 )与 73 的规范的表情大部分是可检测的并且 45 在有 Sertoli 房间唯一的症候群( SCOS )( n=3 )的病人。survivin 和 hTERT 表情与一个进行的 Johnsen 分数(为 trend=0.001 的 P ) 增加了。结论:尽管 survivin 和 hTERT 与精子发生的功能被相关,他们在不肥沃的病人的睾丸显示出不同表示模式。这些调查结果在在 meiotically 划分生殖细胞建议 survivin 的占优势的表情的啮齿类动物睾丸从研究证实结果。 | Steffen Weikert Frank Christoph Wolfgang Schulze Hans Krause Carsten Kempkensteffen Martin Schostak Kurt Miller Mark Schrader | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 2 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 3 | Service recovery: a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，4： | 3 |
| 4 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 3 |
| 5 | Variations in zonal fruit starch concentrations of apples – a developmental phenomenon or an indication of ripening?显示文摘Patterns of starch hydrolysis in stem,equatorial,and calyx zones of‘Honeycrisp’and‘Empire’apples(Malus sylvestris(L.)Mill var.domestica(Borkh.)Mansf.)during maturation and ripening,and in‘Gala’apples in response to propylene or 1-methylcyclopropene(1-MCP)treatments after harvest,were studied.Differences in zonal starch concentrations were found for‘Empire’and‘Gala’fruits,but not for‘Honeycrisp’.During maturation and ripening of‘Empire’,the concentration of starch was highest in the calyx end and lowest in the stem region.Differences in rates of starch hydrolysis among zones were not detected.‘Honeycrisp’and‘Empire’had the highest concentration of sorbitol in the calyx region,whereas it was highest in the stem-end region in‘Gala’.The distribution differences of glucose,fructose,and sucrose were similar in all three cultivars;higher fructose and glucose concentrations in the stem region,and higher sucrose concentrations in the calyx end of the fruit.Postharvest treatment of‘Gala’with propylene did not affect the internal ethylene concentration of the fruit but 1-MCP markedly inhibited it.Starch concentrations were highest in the calyx end but gradients of starch among zones were not changed by postharvest treatment.The rate of hydrolysis was slowed by 1-MCP treatment,but was unaffected by propylene.Postharvest treatments influenced sorbitol,glucose,and fructose concentrations.Patterns of starch concentration among the zones did not confirm differences in ripening,but reflected its uneven distribution throughout the fruit during development.Therefore,measured differences in zonal starch are most likely related to starch accumulation during fruit development,rather than differences in rates of starch degradation during ripening. | Franziska C Doerflinger William B Miller Jacqueline F Nock Christopher B Watkins | 2015 | Horticulture Research2015，2，1： | 3 |
| 6 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 7 | Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites显示文摘 | Sonja Welsch Sven Miller Ines Romero-Brey Andreas Merz Christopher K.E. Bleck Paul Walther Stephen D. Fuller Claude Antony Jacomine Krijnse-Locker Ralf Bartenschlager | 2009 | Cell Host & Microbe2009，，： | 2 |
| 8 | Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial显示文摘 | Michael Miller Christopher P. Cannon Sabina A. Murphy Jie Qin Kausik K. Ray Eugene Braunwald | 2008 | Journal of the American College of Cardiology2008，，7： | 2 |
| 9 | Local Therapy with Continued EGFR Tyrosine Kinase Inhibitor Therapy as a Treatment Strategy in EGFR-Mutant Advanced Lung Cancers That Have Developed Acquired Resistance to EGFR Tyrosine Kinase Inhibitors显示文摘 | Helena A. Yu Camelia S. Sima James Huang Stephen B. Solomon Andreas Rimner Paul Paik M. Catherine Pietanza Christopher G. Azzoli Naiyer A. Rizvi Lee M. Krug Vincent A. Miller Mark G. Kris Gregory J. Riely | 2013 | Journal of Thoracic Oncology2013，，3： | 2 |
| 10 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 2 |
| 11 | Mercury Concentrations in Bicknell’s Thrush and Other Insectivorous Passerines in Montane Forests of Northeastern North America显示文摘 | Christopher C. Rimmer Kent P. McFarland David C. Evers Eric K. Miller Yves Aubry Daniel Busby Robert J. Taylor | 2005 | Ecotoxicology (-)2005，，1： | 1 |
| 12 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 1 |
| 13 | Identification of miRNA modulators to PARP inhibitor response显示文摘 | Sari Neijenhuis Ilirjana Bajrami Rowan Miller Christopher J. Lord Alan Ashworth | 2013 | DNA Repair2013，，6： | 1 |
| 14 | Service recovery:a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，18： | 1 |
| 15 | Documenting climatological data sets for GCOS: a conceptual model 显示文摘 | Christopher Miller Thomas Karl Martha Maiden | 1996 | Proceeding of the First IEEE Metadata Conference April 16-181996，，： | 1 |
| 16 | The social correlates and linguistic processes of lexical borrowing and assimilation显示文摘 | SHANA POPLACK DAVID SANKOFF CHRISTOPHER MILLER | 2009 | Linguistics2009，，1： | 1 |
| 17 | Alanine Aminotransferase Regulation by Androgens in Non-hepatic Tissues显示文摘 | Christopher Coss Matt Bauler Ramesh Narayanan Duane Miller James Dalton | 2012 | Pharmaceutical Research2012，，4： | 1 |
| 18 | A systems biology dynamical model of mammalian G1 cell cycle progression显示文摘 | Haberichter T Madge B Christopher RA Yoshioka N Dhiman A Miller R | 2007 | Mol Syst Biol2007，3，1： | 1 |
| 19 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 1 |
| 20 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘 | Wang-Xia Wang Robert J. Danaher Craig S. Miller Joseph R. Berger Vega G. Nubia Bernard S. Wilfred Janna H. Neltner Christopher M. Norris Peter T. Nelson | 2013 | Genomics, Proteomics & Bioinformatics2013，，： | 1 |
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