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| 1 | 《国际功能、残疾和健康分类·足跟痛/足底筋膜炎:2014修订版》临床实践指南显示文摘美国物理治疗协会(APTA)骨科分会一直致力于为世界卫生组织国际功能、残疾与健康分类(ICF)所描述的肌肉骨骼障碍患者的骨科物理治疗管理制定循证实践指南。修订临床实践指南的目的是回顾最近的同行评议文献,并对非关节炎足跟痛作出建议。 | Roy D.ALTMAN Paul BEATTIE Mark CORNWALL Irene DAVIS John DEWITT James ELLIOTT James J.IRRGANG Sandra KAPLAN Stephen PAULSETH Leslie TORBURN James ZACHAZEWSKI 韩云峰 苟艳芸 李萌 林志刚 王芗斌 张洁 | 2019 | 康复学报2019，29，1： | 20 |
| 2 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | PCCP爆管预警的光纤声监测系统显示文摘介绍了用于PCCP爆管预警的光纤声监测系统组成及原理。对比试验及工程应用表明,该系统具有精度高、监测距离长、性能长期可靠等优点,可推广应用于长距离PCCP输水工程的实时监测,对爆管事故进行预警。 | 王五平 Jack Elliott 宋人心 傅翔 | 2009 | 水利水电技术2009，40，3： | 11 |
| 5 | 中国邻近边缘海碳通量研究现状与展望显示文摘集成分析了南海、东黄渤海等中国邻近边缘海(简称中国边缘海)海-气界面CO_2通量及其所表征的CO_2源汇格局,简析海-气CO_2通量的主要控制因素;总结了河-海界面、边缘海与大洋的交换界面及输出真光层的碳通量,进而初步构架了简化的中国边缘海碳收支;并与世界其他陆架边缘海碳的源汇格局和通量作了比对,最后对边缘海碳循环研究进行了展望.从周年尺度上看,中国边缘海是大气CO_2的源,全年向大气的释放量为(9.5±53)Tg C;河流经过河口输送至中国边缘海的总碳量为(59.6±6.4)Tg Ca^(-1);中国境内河口释放CO_2的总量为(0.74±0.02)Tg Ca^(-1);西太平洋每年输入中国边缘海的总碳量为2.5Pg Ca^(-1),可见,西北太平洋输入中国边缘海的碳通量巨大.中国边缘海上层海洋颗粒有机碳输出通量为(240±80)Tg Ca^(-1). | 刘茜 郭香会 尹志强 周宽波 Elliott Gareth ROBERTS 戴民汉 | 2018 | 中国科学:地球科学2018，48，11： | 11 |
| 6 | Self-management of coronary heart disease in older patients after elective percutaneous transluminal coronary angioplasty显示文摘 | Susan Dawkes Graeme D Smith Lawrie Elliott Robert Raeside Jayne H Donaldson | 2016 | Journal of Geriatric Cardiology2016，13，5： | 10 |
| 7 | 多元PCR在黑鲍(Haliotis rubra)微卫星遗传研究中的应用显示文摘根据D03等11个微卫星引物单位点PCR扩增时优化的扩增条件(退火温度、MgCl2等)和11个微卫星引物所带有的荧光颜色、等位基因大小变异范围及反应的灵敏度,可将11个微卫星引物分成A组(D03、G04、B04和H08)、B组(A09、H11、A08和G01)和C组(CmrHr1.24、CmrHr2.30和CmrHr2.23)进行多元PCR扩增,结果显示各组内位点之间的分离清晰,这表明多元PCR可以大大提高微卫星检测仪器的使用效率和提高实验效果,在微卫星研究中是一种快速便捷的方法。 | 黎中宝 Appleyard Sharon A Elliott Nicholas G | 2005 | 海洋与湖沼2005，36，4： | 8 |
| 8 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 9 | 羊鲍(Haliotis ovina)和耳鲍(H.asinina)MtDNA COⅠ和COⅡ基因片段序列的比较研究显示文摘采用基因测序的方法,对我国海南产的羊鲍和耳鲍两个自然种群的COⅠ和COⅡ基因片段进行了PCR扩增和测序。结果表明,羊鲍和耳鲍COⅠ基因片段的核苷酸序列均为193bp,4种碱基组成非常相似,且其A+T的含量也非常相似,分别为45.08%和45.60%。羊鲍和耳鲍COⅠ基因片段的核苷酸序列之间有29bp的差异,其中有8处发生碱基颠换,21处发生碱基转换,差异为15.03%,同源性为84.97%;羊鲍和耳鲍COⅡ基因片段的核苷酸序列均为157bp,羊鲍和耳鲍4种碱基组成差异较大,且其A+T的含量也不同,分别为59.24%和55.41%。羊鲍和耳鲍COⅡ基因片段的核苷酸序列之间有19bp的差异,其中3处发生碱基颠换,16处发生碱基转换,达到12.10%的差异,同源性为87.90%。分子变异分析表明羊鲍和耳鲍物种间的变异组成为0.50,变异百分数为100.00,羊鲍和耳鲍物种间的遗传分化显著(FST=1,P<0.001)。 | 黎中宝 Appleyard Sharon A. Elliott Nicholas G. | 2008 | 海洋与湖沼2008，39，2： | 8 |
| 10 | 大口径输水管道自由浮游式检漏系统显示文摘介绍自由浮游式检漏系统的工作原理、分析方法以及工程实例。该系统的核心技术是可随管道内水流自由浮游的智能球。由于智能球直接经过漏点,可以清楚地接收由漏水引起的声信号,具有高精度、高效率,不受管材、管径及管道埋深影响等优点。自由浮游式检漏系统克服了传统音听检漏法的不足,特别适合大口径输水管道检漏。 | 王五平 Jack Elliott | 2009 | 给水排水2009，35，7： | 8 |
| 11 | Determining the trade–environment composition effect: the role of capital, labor and environmental regulations显示文摘 | Matthew A. Cole Robert J.R. Elliott | 2003 | Journal of Environmental Economics and Management2003，，3： | 7 |
| 12 | 改进医疗服务质量、确保病人安全的教学方法显示文摘提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如何安全有效地在团队中工作,如何在实践中教授和学习病人安全知识,如何根据认可的伦理原则服务公众。 | Merrilyn M Walton Bruce H Barraclough Samantha A Van Staalduinen Susan L Elliott 段玉蓉(译) 张鸣明(审校) | 2009 | 中国循证医学杂志2009，9，9： | 7 |
| 13 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 14 | Recent advances in connected and automated vehicles显示文摘Connected and automated vehicle(CAV) is a transformative technology that has great potential to change our daily life. Therefore, CAV related research has been advanced significantly in recent years. This paper does a comprehensive review on five selected subjects that lie in the heart of CAV research:(i) inter-CAV communications;(ii) security of CAVs;(iii) intersection control for CAVs;(iv) collision-free navigation of CAVs; and(v)pedestrian detection and protection. It is believed that these topics are essential to ensure the success of CAVs and need to be better understood. For inter-CAV communications, this paper focuses on both Dedicated Short Range Communications(DSRC) and the future 5 G cellular technologies; for security of CAVs, this paper discusses both passive and active attacks and the existing solutions; for intersection control, this paper summarizes the pros and cons of both centralized and decentralized approaches; for collision avoidance, this paper concentrates on four subareas: maneuverability, vehicle networking, control confliction, and motorcycles; for pedestrian detection, this paper covers sensor, radar, and computer vision based approaches. Under each topic, this paper not only shows the stateof-the-art, but also unveils potential future research directions. By establishing connections among these subjects, this paper shows how they interact with each other and how they can be integrated into a seamless user experience. It is believed that the literature covered and conclusions drawn in this paper are very helpful to CAV researchers, application engineers, and policy makers. | David Elliott Walter Keen Lei Miao | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，2： | 7 |
| 15 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 16 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 17 | Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples显示文摘Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the environment.Hg^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater samples.Herein,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water samples.In a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the bare-AuNPs.This activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water matrices.To overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from 1-14.Interestingly,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg amalgamation.This novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water samples.The approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices. | Natasha Logan Claire McVey Christopher Elliott Cuong Cao | 2020 | Nano Research2020，13，4： | 6 |
| 18 | Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker显示文摘Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control. | Claire McVey Natasha Logan Nguyen T. K. Thanh Christopher Elliott Cuong Cao | 2019 | Nano Research2019，12，3： | 5 |
| 19 | An Internal State Variable Model for the Low Temperature Tempering of Low Alloy Steels显示文摘An internal state variable (ISV) framework is used to predict the rate and degree of strain relaxation associated with the stage I, low temperature tempering of martensite. A single variable tracks the change in volume between the tempered an untempered structures. The rate at which this occurs is taken to be a function of martensite fraction, temperature, degree of tempering, and carbon concentration. Experimental dilatometty data is used to both fit and validate the model. | Mark T. Lusk, Young-Kook Lee, Herng-Jeng Jou, William H. Elliott, Gerard M Ludtka 1.Materials Science Program, Division of Engineering, Colorado School of Mines, Golden, CO. U.S. 80401 2.Questek Innovations LCC, 1801 Maple Avenue, Evanston, IL, U.S. 602 | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 5 |
| 20 | Expression and Chromosomal Mapping of Mouse Gpx2 Gene Encoding the Gastrointestinal Form of Glutathione Peroxidase, GPX-GI显示文摘GPX-GI is a cytosolic tetrameric Se-dependent glutathione peroxidase, similar in properties to GPX-1. Unlike the almost ubiquitous GPX-1, GPX-GI is mainly expressed in the epithelium of gastrointestinal tract. GPX-GI contributes to at least fifty percent of GPX activity in rodent small intestmal epithelium. The total GPX activity consists of at least 70% of selenium-dependent GPX activity in this compartment.By analyzing a panel of mouse mterspecies DNA from the Jackson Laboratory’s backcross resource,we mapped Gpx2 gene to mouse chromosome 12 between D12Mit4 and D12Mit5, near the Ccs1 locus which contains a colon cancer susceptibility gene. A pseudogene, Gpx2-ps is mapped to mouse chromosome 7.Comparison of Gpx2 gene expression in three pairs of C57BL/6Ha and ICR/Ha mice which are respectively resistant and sensitive to dimethylhydrazine-induced colon cancer, we found a higher Gpx2 mRNA level in C57BL/6Ha colon than ICR/Ha colon. Interestingly, a lower level of GPX activity is found in the resistant strain of mice. Because GPX-1 has three times higher specific activity than GPX GI, our data suggest that the decreased GPX activity may result from a higher level of Gpx2 gene expression in those cells co-express GPx1 | FONG-FONG CHU R. STEVEN ESWORTHY YE SHIH HO MARGIT BERMEISTER KRISTINE SWIDEREK AND ROSEMARY W. ELLIOTT(Department of Medical Oncology, City of Hope Midical Center, Duarte,CA91010, USA Department of Psychiatry and Human Genetics,Mintal Health Research | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
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