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| 1 | RIP1 (ROP Interactive Partner 1)/ICR1 Marks Pollen Germination Sites and May Act in the ROP1 Pathway in the Control of Polarized Pollen Growth显示文摘Rho 家庭小 GTPases 是通用的在真核细胞的房间在房间极性的控制表明开关。他们到房间外皮的极的分发为他们的函数的执行是批评的,然而,为这分布的机制糟糕被理解。用酵母二混血儿的方法,我们识别了 RIP1 (ROP 交互搭挡 1 ) ,它属于分享与 ROP 交往的一个 C 终端区域的新奇蛋白质的五个成员的一个家庭。当在 Arabidopsis 花粉表示了时,绿荧光蛋白质标注 GFP 的 RIP1 对成熟花粉的原子核局部性。当花粉谷物在萌芽媒介是含水的时, GFP-RIP1 在未来花粉萌芽地点从原子核切换到房间外皮并且在发芽花粉和成长花粉试管的顶端的外皮被维持。RIP1 被发现在花粉试管与 ROP1 交往,并且外皮的 RIP1 本地化被 ROP1 的活动影响。RIP1 的 Overexpression 在花粉试管导致了生长去极,类似于那的显型由 ROP1 overexpression 导致了。有趣地, RIP1 overexpression 提高了 GFP-ROP1 招募到花粉试管的血浆膜(下午) 。把观察基于这些,我们假设那 RIP1 涉及 ROP1 本地化的积极反馈规定到 PM,为花粉萌芽和花粉试管生长导致一个极的地点的建立。 | Shundai Li Ying Gu An Yan Elizabeth Lord Zhen-Biao Yang | 2008 | Molecular Plant2008，1，6： | 9 |
| 2 | 试论《哈尼阿培聪坡坡》所载各迁徙阶段的历史分期显示文摘《哈尼阿培聪坡坡》是哈尼族最重要的迁徙史诗,长期以来一直为研究哈尼族的学者所重视,但是诗中所载各迁徙阶段的历史分期问题一直没有得到很好的解决。文章尝试运用新的证据为该史诗断代。据国内史学界研究,哈尼人最迟已于唐朝年间到达红河地区,这一研究成果成为笔者为该史诗断代的基点。通过史诗所述谷哈密查时期哈尼人学会'烧石化水'、'造犁铸剑'这一重要信息,结合昆明地区最早出现炼铁技术的史学研究成果,笔者初步判断哈尼人在谷哈密查的生活年代当为西汉末年到东汉末年。之后运用了三尖叉、轺车、父子连名制、南中大姓及哈尼在那妥、石七生活期间的社会氛围等相关资料为断代结果做进一步的论证,以确保断代的科学性。 | 李力路 Steven D Lord | 2008 | 红河学院学报2008，6，6： | 9 |
| 3 | 利用激光冲击波检测碳纤维材料中的粘接质量显示文摘碳纤维增强复合材料(CFRP)由于具有出色的力学性能而越来越多地受到关注,但是由于对这种材料粘接结构缺乏有效的无损检测方法而导致其应用受到了局限。发展了一种基于激光冲击波的碳纤维增强复合材料粘接质量无损检测方法。对于一个碳纤维增强复合材料粘接结构,当激光作用在样品表面时,会产生一个冲击波在其中传播,冲击波到达样品后表面时会反射一个稀疏波,并在材料内部形成拉伸。在适当的激光强度下,好的粘接质量将不会受影响;而差的粘接质量将会造成损伤。实验过程中,对样品自由面的速度历史进行了测量,该信号可以反映粘接层的内部损伤情况。这一结论也通过对回收样品的激光超声检测得到了证实。这项技术的发展将使未来碳纤维增强复合材料粘接结构的在线检测成为可能。 | 谷卓伟 Mathieu Perton Silvio E.Kruger Martin Lord Alain Blouin Jean-Pierre Monchalin | 2011 | 中国激光2011，38，3： | 8 |
| 4 | 普通法世界中的混合法系显示文摘糅合普通法系和民法法系的混合法系已经成为当今世界的一大现象。本文在介绍混合法系基本特征的基础上,描述了苏格兰的大陆法制度与英格兰地区的普通法制度的不同,包括大陆法系和普通法系在物权法和信托法等领域的不同规则,其中着重论述了苏格兰法律体系糅合大陆法系和普通法系的特征,并阐释了英国最高法院尝试包容两种法律制度的努力。文章同时指出,混合法系在全球化时代将成为法系融合的鲜明例证和重要推动力。 | 霍普勋爵(Lord Hope of Craighead) 刘晗(译) | 2012 | 清华法学2012，6，6： | 6 |
| 5 | 老年跌倒和跌倒伤害的相关定义显示文摘大量研究对老年人的跌倒发生率、发生地点和跌倒后的结局进行了描述。在进行这些描述前有必要简单讨论老年跌倒领域四个重要的方法学问题:跌倒是如何定义的?跌倒如何计数?致伤性跌倒如何定义?哪些人算是老年人? | Stephen Lord Catherine Sherrington Hylton Menz Jacqueline Close 姜玉 夏庆华 | 2015 | 伤害医学(电子版)2015，4，2： | 4 |
| 6 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 7 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 8 | Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease显示文摘Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective treatments.This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative approach.Methods:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were analyzed.Gene ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD phenotypes.Lipid species were annotated in the lipid modules associated with AD phenotypes.The associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also explored.Results:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease progression.The lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid metabolism.The five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes. | Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye Dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium | 2020 | Translational Neurodegeneration2020，9，3： | 3 |
| 9 | 主权的比较视野:宪政在英国和美国显示文摘在此次纪念詹姆斯·麦迪逊演讲中,上议院议长,欧文·莱尔格勋爵评述了美国宪法至上和司法审查体制与英国不成文宪法强调无司法审查的议会主权具有许多共同之处。尽管这两个体系经常被认为是极端对立的,欧文勋爵指出其实二者都是在民主政治的背景下运作,且殊途同归,区分并联系着,都致力于将人民主权最终引向宪政体制。 | 欧文·莱尔格勋爵(Lord Trvine of Lairg) 郭殊(译) | 2006 | 比较法研究2006，，3： | 2 |
| 10 | Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration显示文摘 | Wolfram Goessling Trista E. North Sabine Loewer Allegra M. Lord Sang Lee Cristi L. Stoick-Cooper Gilbert Weidinger Mark Puder George Q. Daley Randall T. Moon Leonard I. Zon | 2009 | Cell2009，，6： | 2 |
| 11 | Colonic lesion characterization in inflammatory bowel disease:A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease(IBD), using optical imaging techniques, including virtual chromoendoscopy(VCE), dye-based chromoendoscopy(DBC), magnification endoscopy and confocal laser endomicroscopy(CLE). METHODS We searched Medline, Embase and the Cochrane library. We performed a bivariate meta-analysis to calculate the pooled estimate sensitivities, specificities, positive and negative likelihood ratios(+LHR,-LHR), diagnostic odds ratios(DOR), and area under the SROC curve(AUSROC) for each technology group. A subgroup analysis was performed to investigate differences in real-time nonmagnified Kudo pit patterns(with VCE and DBC) and real-time CLE.RESULTS We included 22 studies [1491 patients; 4674 polyps, of which 539(11.5%) were neoplastic]. Real-time CLE had a pooled sensitivity of 91%(95%CI: 66%-98%), specificity of 97%(95%CI: 94%-98%), and an AUSROC of 0.98(95%CI: 0.97-0.99). Magnification endoscopy had a pooled sensitivity of 90%(95%CI: 77%-96%)and specificity of 87%(95%CI: 81%-91%). VCE had a pooled sensitivity of 86%(95%CI: 62%-95%) and specificity of 87%(95%CI: 72%-95%). DBC had a pooled sensitivity of 67%(95%CI: 44%-84%) and specificity of 86%(95%CI: 72%-94%). CONCLUSION Real-time CLE is a highly accurate technology for differentiating neoplastic from non-neoplastic lesions in patients with colonic IBD. However, most CLE studies were performed by single expert users within tertiary centres, potentially confounding these results. | Richard Lord Nicholas E Burr Noor Mohammed Venkataraman Subramanian | 2018 | World Journal of Gastroenterology2018，24，10： | 2 |
| 12 | Preferential Attachment of Peritoneal Tumor Metastases to Omental Immune Aggregates and Possible Role of a Unique Vascular Microenvironment in Metastatic Survival and Growth显示文摘 | Scott A. Gerber Viktoriya Y. Rybalko Chad E. Bigelow Amit A. Lugade Thomas H. Foster John G. Frelinger Edith M. Lord | 2006 | The American Journal of Pathology2006，，5： | 2 |
| 13 | Applications of solid-phase microextraction in food analysis显示文摘 | Hiroyuki Kataoka Heather L Lord Janusz Pawliszyn | 2000 | Journal of Chromatography A2000，，1： | 2 |
| 14 | p53-dependent and independent apoptosis induced by ionizing radiation in murine bone marrow cells显示文摘APOPTOSIS or programmed cell death is a model of cell death, along with typical morphological and biochemical changes. The cell death, occurring during embryonic development, T and B cell maturation and endocrine-induced atrophy, is a physiological apoptosis which controls the amount of cells in the body. Apoptosis can also be induced by various factors, such as ionizing radiation and anti-tumour agents which damage DNA, and has been proposed to be a consequence of the induced expression of some tumour-related genes or increase of the proteins sta- | Cui, YF Zhou, PK Lord, BI Hendry, JH | 1997 | Chinese Science Bulletin1997，42，2： | 2 |
| 15 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 16 | Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus显示文摘 | Reginald V.N. Lord Ji Min Park Kumari Wickramasinghe Steven R. DeMeester Stefan Oberg Dennis Salonga Jon Singer Jeffrey H. Peters Kathleen D. Danenberg Tom R. DeMeester Peter V. Danenberg | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 17 | Improved recoverability of microbial colonies from marine sponge samples显示文摘 | Olson J B Lord C C McCarthy P J | 2000 | Microbial Ecology2000，40，： | 1 |
| 18 | Finite element modeling of magnetic field/defect interactions 显示文摘 | Hwang J H Lord W | 1975 | Journal of Testing & Evaluation (S0090-3973)1975，3，1： | 1 |
| 19 | Percutaneous sclerotherapy for lymphatic malformations:a retrospective analysis of patient-evaluated improvement显示文摘 | Alomari A I Karian V E Lord D J | 2006 | J Vasc Interv Radiol2006，17，10： | 1 |
| 20 | Madigan prostatectomy显示文摘 | Dixon AR Lord PH Madigan MR | 1990 | J Urol1990，144，： | 1 |
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