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| 1 | 属间体细胞杂交创建甘蓝型油菜细胞质雄性不育系及其鉴定显示文摘利用原生质体融合技,获得了甘蓝型油菜品种中双4号与新疆野生油菜野油18的对称性体细胞杂种。杂种当代建成的6株植株中有2株雄性不育株。用中双4号做轮回亲本与不育株回交,不育株率随回交代数增加而升高,至BC3代大部分株系的不育株率接近100%,到BC4代不育性稳定,群体中无育性分离现象。用波里马CMS的恢复系和保持系与其测交,6个甘蓝型油菜品系均可保持该不育系的不育性,表明该雄性不育胞质与Pol不育胞质不同。 | 胡琼 李云昌 梅德圣 方小平 Lise N. Hansen Sven B. Andersen | 2004 | 中国农业科学2004，37，3： | 40 |
| 2 | 白子菜醋酸乙酯部位的化学成分研究显示文摘目的研究白子菜Gynura divaricata地上部分醋酸乙酯萃取部位的化学成分。方法采用不同柱色谱技术进行分离纯化,结合MS和NMR数据进行结构鉴定。结果从白子菜地上部分80%乙醇回流提取物的醋酸乙酯萃取部位中分离纯化得到14个化合物,分别鉴定为丁二酸(1)、丁二酸单甲酯(2)、丁二酸单乙酯(3)、丁二酸甲酯乙酯(4)、对羟基苯甲酸(5)、水杨酸(6)、异香草酸(7)、对香豆酸(8)、马栗树皮素(9)、槲皮素(10)、山柰酚(11)、异槲皮苷(12)、紫云英苷(13)、芦丁(14)。结论化合物1~4、6~9为首次从该植物中分离得到。 | 陈剑 MANGELINCKX Sven 吕寒 李维林 DEKIMPE Norbert 王峥涛 | 2013 | 中草药2013，44，5： | 22 |
| 3 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 4 | 光强和光质对底栖藻类群落影响Ⅱ.群落和种群的动态和适应模式显示文摘将原始河口底栖藻类群落移植至实验室进行培养。底栖藻类群落分别由占细胞总量 93.33%的硅藻类群、5 .4 2 %的绿藻类群和仅占 1 .2 5 %的单一蓝藻种群组成。通过对底栖藻类群落总体、不同藻类类群和单一种群在不同光照强度的白光和单色光下的适应模式和增长动态的研究发现 ,底栖藻类群落总体增长动态为弱光适应型、红光敏感型和蓝光抑制型 ,其细胞生长的敏感光照依次为 :红光 >低光强 >中光强 >高光强 >绿光 >蓝光。底栖藻类群落总体对不同光照的适应模式由底栖硅藻类群增长动态所决定。底栖绿藻类群总体增长的敏感光照依次为 :低光强 >红光 >中光强 >绿光>高光强 >蓝光 ,绿藻类群在不同的光照处理下呈现 3种适应模式。硅藻类群总体对不同光照的敏感状况与底栖藻类群落总体趋同 ,在不同光照处理下仅呈现一种适应模式。蓝藻 Oscillatoria tenuis种群的增长的敏感光照为 :红光 >白光 >绿光 >蓝光 ,其对光的适应模式有 3种。 7种绿藻种群在不同光强的白光、红光和绿光表现出 2种适应模式 ,在蓝光下基本皆呈衰退型。 2 1种硅藻种群对不同光照的适应模式可分为 4种类型 ,强竞争型、弱竞争型。 | 庄树宏 Hendrik Sven | 2001 | 生态学报2001，21，12： | 18 |
| 5 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 6 | 一种新肿瘤生长相关生物标志物胸苷激酶1临床应用进展显示文摘胸苷激酶1(TK1)是一种嘧啶补救途径的激酶,能催化脱氧胸苷磷酸化为一腺胸苷酸,与细胞周期调控和细胞增殖密切相关。多项实验证明,TK1可用于健康体检、肿瘤早期筛查、常规检测、疗效监视和预后等方面,是一种灵敏有效地评估人体肿瘤增长的标志物。本综述概述了近年关于TK1临床应用的新进展。 | 刘秀菊 周际 李远 刘森波 方聪 宇莉君 Ellen HE Sven SKOG | 2011 | 中国药理学与毒理学杂志2011，25，1： | 16 |
| 7 | 血清胸苷激酶1检测对恶性肿瘤诊断及疗效评估的意义显示文摘目的探讨血清胸苷激酶1(TK1)作为肿瘤细胞增殖标志物对恶性肿瘤诊断及疗效评估的意义。方法应用免疫印迹-增强化学发光法检测恶性肿瘤组(53例)治疗前后、体格检查组(49例)以及健康对照组(18名)的血清TK1水平。治疗前与治疗后比较用配对t检验,治疗前和后分别与健康对照组、体格检查组比较采用两独立样本均数比较t检验。结果恶性肿瘤组治疗前STK1为0.3—11.3(2.4±2.0)pmol/L;恶性肿瘤组治疗后STK1为0.3~5.0(0.9±0.8)pmol/L;体格检查组STK1为0.1~2.1(0.8±0.3)pmol/L;健康对照组STK1为0.5~1.2(0.7±0.2)pmol/L。恶性肿瘤组治疗前与治疗后之间STK1水平差异有统计学意义(t=5.257,P〈0.0001)。恶性肿瘤组治疗前与健康对照组和体格检查组STK1水平比较,差异均有统计学意义(t=3.568和5.460,P=0.001和〈0.0001),而恶性肿瘤组治疗后与健康对照组和体格检查组STK1水平比较,差异均无统计学意义(t=1.056和0.715,P均〉0.05)。结论血清TK1检测细胞增殖有较高的特异性和灵敏度,对临床监测恶性肿瘤疗效和在体格检查中进行恶性肿瘤风险筛查具有重要意义。 | 李清茹 桑士标 袁航 苏成海 吴翼伟 张旻 周际 Ellen He Sven Skog 赵久涛 | 2009 | 中华核医学杂志2009，29，4： | 16 |
| 8 | The global significance of biodiversity science in China: an overview显示文摘Biodiversity science in China has seen rapid growth over recent decades,ranging from baseline biodiversity studies to understanding the processes behind evolution across dynamic regions such as the Qinghai-Tibetan Plateau.We review research,including species catalogues;biodiversity monitoring;the origins,distributions,maintenance and threats to biodiversity;biodiversity-related ecosystem function and services;and species and ecosystems'responses to global change.Next,we identify priority topics and offer suggestions and priorities for future biodiversity research in China.These priorities include(i)the ecology and biogeography of the Qinghai-Tibetan Plateau and surrounding mountains,and that of subtropical and tropical forests across China;(ii)marine and inland aquatic biodiversity;and(iii)effective conservation and management to identify and maintain synergies between biodiversity and socio-economic development to fulfil China's vision for becoming an ecological civilization.In addition,we propose three future strategies:(i)translate advanced biodiversity science into practice for biodiversity conservation;(ii)strengthen capacity building and application of advanced technologies,including high-throughput sequencing,genomics and remote sensing;and(iii)strengthen and expand international collaborations.Based on the recent rapid progress of biodiversity research,China is well positioned to become a global leader in biodiversity research in the near future. | Xiangcheng Mi Gang Feng Yibo Hu Jian Zhang Lei Chen Richard T.Corlett Alice C.Hughes Stuart Pimm Bernhard Schmid Suhua Shi Jens-Christian Svenning Keping Ma | 2021 | National Science Review2021，8，7： | 16 |
| 9 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 10 | Modelling Hydrological Consequences of Climate Change—Progress and Challenges显示文摘The simulation of hydrological consequences of climate change has received increasing attention fromthe hydrology and land-surface modelling communities. There have been many studies of climate-changeeffects on hydrology and water resources which usually consist of three steps: (1) use of general circulationmodels (GCMs) to provide future global climate scenarios under the effect of increasing greenhouse gases,(2) use of downscaling techniques (both nested regional climate models, RCMs, and statistical methods)for 'downscaling' the GCM output to the scales compatible with hydrological models, and (3) use ofhydrologic models to simulate the effects of climate change on hydrological regimes at various scales.Great progress has been achieved in all three steps during the past few years, however, large uncertaintiesstill exist in every stage of such study. This paper first reviews the present achievements in this field andthen discusses the challenges for future studies of the hydrological impacts of climate change. | Chong-yu XU Elin WIDEN Sven HALLDIN | 2005 | Advances in Atmospheric Sciences2005，22，6： | 14 |
| 11 | The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines显示文摘AIM: There are conflicting data about p53 function on cellular sensitivity to the cytotoxic action of 5-fluorouracil (5-FU).Therefore the objective of this study was to determine the combined effects of adenovirus-mediated wild-type (wt) p53 gene transfer and 5-FU chemotherapy on pancreatic cancer cells with different p53 gene status.METHODS: Human pancreatic cancer cell lines Capan-1^p53mut,Capan-2^p53wt, FAMPAC^p53mut, PANG1^p53mut, and rat pancreatic cancer cell lines AS^p53wt and DSL6A^p53null were used for in vitro studies. Following infection with different ratios of Adp53-particles (MOI) in combination with 5-FU, proliferation of tumor cells and apoptosis were quantified by cell proliferation assay (WST-1) and FACS (PI-staining). In addition, DSL6A syngeneic pancreatic tumor cells were inoculated subcutaneously in to Lewis rats for in vivostudies.Tumor size, apoptosis (TUNEL) and survival were determined.RESULTS: Ad-p53 gene transfer combined with 5-FU significantly inhibited tumor cell proliferation and substantially enhanced apoptosis in all four cell lines with an alteration in the p53 gene compared to those two cell lines containing wt-p53. In vivo experiments showed the most effective tumor regression in animals treated with Ad-p53 plus 5-FU. Both in vitroand in vivoanalyses revealed that a sublethal dose of Ad-p53 augmented the apoptotic response induced by 5-FU.CONCLUSION: Our results suggest that Ad-p53 may synergistically enhance 5-FU-chemosensitivity most strikingly in pancreatic cancer cells lacking p53 function. These findings illustrate that the anticancer efficacy of this combination treatment is dependent on the p53 gene status of the target tumor cells. | Sven Eisold Michael Linnebacher EduardRyschich DaliborAntolovic UlfHinz Ernst Klar Jan Schmidt | 2004 | World Journal of Gastroenterology2004，10，24： | 14 |
| 12 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 13 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 14 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 15 | 光照强度和波长对底栖藻类种群生长的影响(Ⅰ)——光合色素的变化显示文摘在自然水体中首先让底栖藻类在透明人造丝膜附着装置上定居着生5周,然后移至实验室培养.测定初始的叶绿素a和脱镁叶绿素后,对底栖藻类进行3个不同光照强度的全光照处理(29.1,11.0和5.5W/m2)和3种不同光照波长的处理(红光、蓝光和绿光).处理期间温度和水流保持一致.在所有光照处理下底栖藻类体内叶绿素a的含量表现出稳定增长的趋势,在第二周末达到最高值,在第三周开始急剧下降.研究发现,光照强度与底栖藻类的生长呈负相关,这与高光照强度对藻类细胞内光合色素的破坏有关.在不同光照强度的全色光下,叶绿素a的含量的变化是由于所研究的底栖藻类对光照强度的反应存在着“小球藻型”“小环藻型”和过渡类型所致.强光引发的藻类细胞的“失绿”亦是由于叶绿素a含量减少的原因.由于红光能增加光合作用的效率,促进藻类细胞叶绿素a的合成等生物合成过程,在红光的处理下藻类细胞内叶绿素a的含量达到最大值.而在绿光下底栖藻类种群的生长速度居中. | 庄树宏 Hendrik Sven | 1999 | 烟台大学学报(自然科学与工程版)1999，12，2： | 12 |
| 16 | 卵巢浆液性腺癌组织中TK1和Ki-67表达的意义显示文摘目的探讨细胞质胸苷激酶1(cytoplasmic thymidinekinas-1,TK1)、Ki-67在卵巢浆液性腺癌中表达的意义。方法回顾性研究55例经手术治疗的卵巢浆液性腺癌患者的临床病理资料,并运用免疫组化技术观察TK1、Ki-67在卵巢浆液性腺癌中的表达情况及与临床病理参数之间的意义。结果 TK1阳性表达定位于细胞质,阳性率为72.7%。TK1的表达与肿瘤的最大径、复发、pTNM分期、病理分级密切相关(P<0.05)。Ki-67阳性表达定位于细胞核,阳性率为80.0%,Ki-67的表达与肿瘤的复发、pTNM分期、病理分级有关(P<0.05)。Kappa检验显示TK1的表达与卵巢浆液性腺癌复发较一致(k=0.559,P=0.000),且判断复发比Ki-67更为优越。Kaplan-Meier检验显示pTNM分期、肿瘤复发、MDACC分级、Ki-67、TK1表达分别与预后有关(P<0.05)。COX回归多因素分析显示:肿瘤复发是影响卵巢浆液性腺癌患者的独立性预后因素。结论卵巢浆液性腺癌的复发影响患者的预后,TK1对判断卵巢浆液性腺癌是否有复发倾向具有参考价值,且优于Ki-67,初次手术后肿瘤组织免疫组化TK1高表达预示患者存在高复发的风险,提示临床要加强术后的治疗方案,并提高随访频数。 | 刘冲 郭庆 石群立 余波 马恒辉 Staffan Eriksson Ellen He Sven Skog | 2011 | 临床与实验病理学杂志2011，27，12： | 12 |
| 17 | Big Earth Data science:an information framework for a sustainable planet显示文摘The digital transformation of our society coupled with the increasing exploitation of natural resources makes sustainability challenges more complex and dynamic than ever before.These changes will unlikely stop or even decelerate in the near future.There is an urgent need for a new scientific approach and an advanced form of evidence-based decisionmaking towards the benefit of society,the economy,and the environment.To understand the impacts and interrelationships between humans as a society and natural Earth system processes,we propose a new engineering discipline,Big Earth Data science.This science is called to provide the methodologies and tools to generate knowledge from diverse,numerous,and complex data sources necessary to ensure a sustainable human society essential for the preservation of planet Earth.Big Earth Data science aims at utilizing data from Earth observation and social sensing and develop theories for understanding the mechanisms of how such a social-physical system operates and evolves.The manuscript introduces the universe of discourse characterizing this new science,its foundational paradigms and methodologies,and a possible technological framework to be implemented by applying an ecosystem approach.CASEarth and GEOSS are presented as examples of international implementation attempts.Conclusions discuss important challenges and collaboration opportunities. | Huadong Guo Stefano Nativi Dong Liang Max Craglia Lizhe Wang Sven Schade Christina Corban Guojin He Martino Pesaresi Jianhui Li Zeeshan Shirazi Jie Liu Alessandro Annoni | 2020 | International Journal of Digital Earth2020，13，7： | 12 |
| 18 | A concept for multiterawatt fibre lasers based on coherent pulse stacking in passive cavities显示文摘Since the advent of femtosecond lasers,performance improvements have constantly impacted on existing applications and enabled novel applications.However,one performance feature bearing the potential of a quantum leap for high-field applications is still not available:the simultaneous emission of extremely high peak and average powers.Emerging applications such as laser particle acceleration require exactly this performance regime and,therefore,challenge laser technology at large.On the one hand,canonical bulk systems can provide pulse peak powers in the multi-terawatt to petawatt range,while on the other hand,advanced solid-state-laser concepts such as the thin disk,slab or fibre are well known for their high efficiency and their ability to emit high average powers in the kilowatt range with excellent beam quality.In this contribution,a compact laser system capable of simultaneously providing high peak and average powers with high wall-plug efficiency is proposed and analysed.The concept is based on the temporal coherent combination(pulse stacking)of a pulse train emitted from a high-repetition-rate femtosecond laser system in a passive enhancement cavity.Thus,the pulse energy is increased at the cost of the repetition rate while almost preserving the average power.The concept relies on a fast switching element for dumping the enhanced pulse out of the cavity.The switch constitutes the key challenge of our proposal.Addressing this challenge could,for the first time,allow the highly efficient dumping of joule-class pulses at megawatt average power levels and lead to unprecedented laser parameters. | Sven Breitkopf Tino Eidam Arno Klenke Lorenz von Grafenstein Henning Carstens Simon Holzberger Ernst Fill Thomas Schreiber Ferenc Krausz Andreas Tunnermann Ioachim Pupeza Jens Limpert | 2014 | Light(Science & Applications)2014，3，1： | 11 |
| 19 | 血清胸苷激酶1对癌前疾病的癌变风险筛查的意义显示文摘目的研究血清胸苷激酶1(STK1)对癌前疾病癌变风险筛查的意义。方法吉林油田总医院对8869例不同工种人群进行常规健康体检,包括平行检测STK1。该项目检测方法是采用高灵敏度点印迹免疫增强发光检测系统来检测STK1的浓度。依据STK1检测结果将人群分类讨论。结果正常绀8355例,STK1≤2pmol/L,平均值(0.6±0.5)pmol/L;其中仅124例每项体检项目都正常占1.4%。风险组514例,STK1〉2pmol/L,平均值(3.8±2.2)pmol/L,风险率为5.8%。癌前相关疾病可能恶变风险人数为85.2%(包括胆/肾息肉样病变增生,疑肝或肺恶瘤病灶,贫血疾病,肥胖,胆/肝/肺良性肿瘤,脂肪肝和乙肝阳性并伴有肝功能异常)。发现STK1风险率升降与职业有一定相关性,第一类是长期、直接进行油田操作(钻井,运输,地质),总人数4333例,风险率7.8%;第二类是钻井前技术准备和服务(钻服,物探,钻技和测井),总人数4536例,风险率为3.9%,两类比较,第一类人群风险率有明显的升高(x^2=55.53,P〈0.05),特别是息肉样病变增生和疑恶瘤病灶者主要发现在第一类,可能与直接、长期接触油田污染物有关。结论胸苷激酶1是很有前景的血清标志物之一,它真实地反映了细胞异常增殖状况,使早期评估癌前疾病的癌变风险成为可能。 | 张兴华 杨金荣 付筱英 秦蕾 刘海燕 汪海霞 云霞 宋波 张旻 Ellen He Sven Skog | 2010 | 中华健康管理学杂志2010，4，1： | 10 |
| 20 | Multi-scale phylogenetic structure in coastal dune plant communities across the globe显示文摘Aims Studies integrating phylogenetic history and large-scale community assembly are few,and many questions remain unanswered.Here,we use a global coastal dune plant data set to uncover the important factors in community assembly across scales from the local filtering processes to the global long-term diversification and dispersal dynamics.Coastal dune plant communities occur worldwide under a wide range of climatic and geologic conditions as well as in all biogeographic regions.However,global patterns in the phylogenetic composition of coastal dune plant communities have not previously been studied.Methods The data set comprised vegetation data from 18463 plots in New Zealand,South Africa,South America,North America and Europe.The phylogenetic tree comprised 2241 plant species from 149 families.We calculated phylogenetic clustering(Net Relatedness Index,NRI,and Nearest Taxon Index,NTI)of regional dune floras to estimate the amount of in situ diversification relative to the global dune species pool and evaluated the relative importance of land and climate barriers for these diversification patterns by geographic analyses of phylogenetic similarity.We then tested whether dune plant communities exhibit similar patterns of phylogenetic structure within regions.Finally,we calculated NRI for local communities relative to the regional species pool and tested for an association with functional traits(plant height and seed mass)thought to vary along sea–inland gradients.Important Findings Regional species pools were phylogenetically clustered relative to the global pool,indicating regional diversification.NTI showed stronger clustering than NRI pointing to the importance of especially recent diversifications within regions.The species pools grouped phylogenetically into two clusters on either side of the tropics suggesting greater dispersal rates within hemispheres than between hemispheres.Local NRI plot values confirmed that most communities were also phylogenetically clustered within regions.NRI values decreased with increasing plant height and seed mass,indicating greater phylogenetic clustering in communities with short maximum height and good dispersers prone to wind and tidal disturbance as well as salt spray,consistent with environmental filtering along sea–inland gradients.Height and seed mass both showed significant phylogenetic signal,and NRI tended to correlate negatively with both at the plot level.Low NRI plots tended to represent coastal scrub and forest,whereas high NRI plots tended to represent herb-dominated vegetation.We conclude that regional diversification processes play a role in dune plant community assembly,with convergence in local phylogenetic community structure and local variation in community structure probably reflecting consistent coastal-inland gradients.Our study contributes to a better understanding of the globally distributed dynamic coastal ecosystems and the structuring factors working on dune plant communities across spatial scales and regions. | Ane Kirstine Brunbjerg Jeannine Cavender-Bares Wolf L.Eiserhardt Rasmus Ejrnæs Lonnie W.Aarssen Hannah L.Buckley Estelle Forey Florian Jansen Jens Kattge Cynthia Lane Roy A.Lubke Angela T.Moles Ana Laura Monserrat Robert K.Peet Julissa Roncal Louise Wootton Jens-Christian Svenning | 2014 | Journal of Plant Ecology2014，7，2： | 9 |
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