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| 1 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 2 | Effective UV dose and pressure shock for induction of meiotic gynogenesis in southern flounder (Paralichthys lethostigma) using black sea bass (Centropristis striata) sperm显示文摘 | ANDREW J M RYAN M CHRISTOPHER A | 2006 | Aquaculture2006，259，： | 1 |
| 3 | Effective UV dose and pressure shock for induction of meiotic gynogenesis in southern flounder (Paralichthys lethostigma) using black sea bass (Centropristis striata) sperm 显示文摘 | Andrew J M Ryan Murashige Christopher A W | 2006 | Aquaculture2006，259，： | 1 |
| 4 | Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative显示文摘BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal technique.AIM To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes.METHODS Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database.Post-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed HIPEC.RESULTS Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed HIPEC.There was no difference in re-operation or severe complications between the two groups.Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities.On multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire cohort.These findings remained consistent in the appendiceal and the colorectal subgroups.CONCLUSION In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term outcomes.HIPEC technique may be left to the discretion of the operating surgeon. | Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel E Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz | 2020 | World Journal of Gastrointestinal Oncology2020，12，7： | 1 |
| 5 | A Differentially Driven Flapping Wing Mechanism for Force Analysis and Trajectory Optimization 显示文摘 | Ryan B G Mark B C Christopher A M | 2012 | International Journal of Micro Air Vehicles2012，4，1： | 1 |
| 6 | Effects of lovastatin on cognitive function and psychological well-being ? ? Access the “Journal Club” discussion of this paper at http://gffzzf9eb861a10204708hb0qxxc60b69v65vw.ffgz.tsg.suse.edu.cn/locate/ajmselect/显示文摘 | Matthew F Muldoon Steven D Barger Christopher M Ryan Janine D Flory John P Lehoczky Karen A Matthews Stephen B Manuck | 2000 | The American Journal of Medicine2000，，7： | 1 |
| 7 | Cement channeling: how to predict and prevent 显示文摘 | LOCKYEAR Christopher F RYAN Danlel F GUNNINGHAM M M | 1990 | SPE Drilling Engineering1990，5，3： | 1 |
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