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| 1 | 短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值显示文摘本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^2评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。 | J. Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S. Claibome Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco 李海峰 高翔(译) | 2009 | 国际脑血管病杂志2009，，9： | 86 |
| 2 | Cancer statistics, 2015显示文摘 | Rebecca L. Siegel Kimberly D. Miller Ahmedin Jemal | 2015 | CA: A Cancer Journal for Clinicians2015，，1： | 41 |
| 3 | 文化景观空间传统性评价及其整体保护格局——以江苏昆山千灯—张浦片区为例显示文摘传统地域文化景观是中国几千年文化的精华,在快速城市化背景下,城市化、工业化、商业化和现代化的发展使文化景观发生了深刻变化,传统地域文化景观正逐步因现代化而走向消失并呈现出边缘化、破碎化和孤岛化特征。针对传统文化景观空间现代化的复杂过程和众多因子影响,建立以生产空间、居住和生活空间、生态空间为主体,涉及农业、工业、商业、旅游、动力与交通、建筑与院落、村镇聚落、自然生态空间、人工生态空间和与自然环境的关系等环节共22个指标构成的文化景观空间传统性的评价体系,以江苏昆山千灯—张浦片区为典型,选取建筑空间、水系网络和农业景观3个核心因素进行传统性评价。在传统性评价的基础上,以传统文化景观空间网络为核心,探讨由传统文化景观战略点、文化景观廊道、文化景观的源与汇、踏脚石系统等构成的传统文化景观空间整体性保护的空间格局。 | 王云才 Patrick MILLER Brian KATEN | 2011 | 地理学报2011，66，4： | 40 |
| 4 | Th17 cells and their associated cytokines in liver diseases显示文摘T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune disease.The functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and IL-22.Recent studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular carcinoma.IL-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the liver.IL-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation. | Fouad Lafdil Andrew M Miller Sung Hwan Ki Bin Gao | 2010 | Cellular & Molecular Immunology2010，7，4： | 29 |
| 5 | 小麦抗白粉病基因Pm12的RFLP标记显示文摘春小麦品系Line 31携带有一个来自斯卑尔脱山羊草的显性抗白粉病基因Pm 12(Miller等,1988)。16个RFLP(restriction fragment length polymorphism)探针用于鉴定Line 31及其亲本,结果表明Line 31是一个6B/6S易位系。用5个探针所进行的连锁分析进一步揭示Pm 12位于易位染色体的着丝点附近,与6S长臂上的α-淀粉酶位点(α-Amy-S1)紧密连锁,遗传距离仅为1.1 cM。本研究结果表明RFLP技术在鉴定小麦外源染色体及外源基因上具有广阔的应用前景。 | 贾继增 T. E. Miller S. M. Reader M. D. Gale | 1993 | 中国科学(B辑)1993，23，6： | 23 |
| 6 | 神奇的数字7±2:人类信息加工能力的某些局限显示文摘我曾为一个整数所困扰。七年来,这个数既出现在我个人的实验数据中,又见之于最出名的心理学刊物,令我困惑不已,难以释怀。这个整数有种:伪装形式,有时稍大些,有时又略小些,但从未变得不可识别;由此观见,它这种令我困惑的稳定性,远不是一种随机现象。用一名知名参议员的话来说,它背后有一种谋划,有某种支配表面现象的模式。看来,这个数或者确实反映了某些异乎寻常的东西,否则就是我徒受幻造之谜的折磨了。 | G. A. Miller 陆冰章 陆丙甫 | 1983 | 心理科学进展1983，，4： | 19 |
| 7 | The use of virtual surgical planning and navigation in the treatment of orbital trauma显示文摘 | Alan Scott Herford Meagan Miller Floriana Lauritano Gabriele Cervino Fabrizio Signorino Carlo Maiorana | 2017 | Chinese Journal of Traumatology2017，20，1： | 19 |
| 8 | 小麦品种对禾谷镰刀菌毒素的抗性研究显示文摘黄化小麦芽鞘生物测定法是一种敏感的生物测定方法,可用于探测禾谷镰刀菌(Fusariumgraminearum)所产生的毒素的生物活性和不同小麦品种对这些毒素的反应。不同毒素的生物活性与不同小麦品种对毒素的反应均有显著差异,以deoxynivalenol的生物活性最强,抗赤霉品种望水白对供试7种毒素的敏感性最低。试验对毒素与品种之间的相互作用也作了初步研究。 | 王裕中 Miller J.D. | 1989 | 植物病理学报1989，19，2： | 18 |
| 9 | 团结经济:主要概念和问题显示文摘一直以来,主流经济学家都在告诉我们,以追求利润最大化为目的、不惜牺牲大多数人的利益以及生态环境为代价的资本主义经济或市场经济,是我们唯一的选择。然而,出现于上世纪80年代如今已在全球很多地方蓬勃发展的团结经济(即社会经济)却显示,一种为人民大众及其生存的环境服务的经济与社会并非是不可行的。这种新型的经济模式相信人具有非凡的创造力,可以根据自身所处的社会和生态环境找到解决经济问题的途径。而我们的任务是通过建立统一的、有力的社会运动识别他们,连接它们,从而实现另一种经济体系。因此,与其说团结经济是一种经济组织模式,不如说它是一个经济组织过程。它不是一种幻想,而是一个积极的、集体想像的过程。 | 伊桑·米勒(Ethan Miller) 罗晓旭(译) 刘亚(译) | 2012 | 开放时代2012，，6： | 17 |
| 10 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 11 | The discovery of artemisinin and the Nobel Prize in Physiology or Medicine显示文摘1 Summary The 2015 Nobel Prize in Physiology or Medicine was awarded to Professor Tu You You for her key contributions to the discovery of artemisinin.Artemisinin has saved millions of lives and represents one of the significant contributions of China to global health.Many scientists were in- | SU Xin-Zhuan MILLER Louis H. | 2015 | Science China(Life Sciences)2015，58，11： | 15 |
| 12 | The calcium sensing receptor: from calcium sensing to signaling显示文摘The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic hypercalciuria.Compelling evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological processes.In this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated mutations.This systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling. | ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 13 | 骨密度测量中精密度的重要性显示文摘骨密度测定 ,不论采取何特殊技术 ,即使严格地按照厂家建议的操作程序 ,也常常不能达到完美的重复性。必须确定每台骨密度仪不同骨骼部位的精确度。精密度 ,如标准差平均方根或变异系数平均方根 ,被用来确定骨密度的变化 ,即精密度决定最小显著性变化值和随访需要的至少时间间隔。除非确定了精密度 ,否则就不能确定任何水平的统计可信度最小显著性变化值 。 | Sydney Lou Bonnick C.Conrad Johnston Michael Kleerekoper Robert Lindsay Paul Miller Louis Sherwood Ethel Siris 周琦 程晓光 | 2002 | 中国骨质疏松杂志2002，8，1： | 12 |
| 14 | Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology显示文摘AIM: To evaluate the completion rate and diagnostic yield of the Pill Cam SB2-ex in comparison to the Pill Cam SB2.METHODS:Two hundred cases using the 8-h Pill Cam SB2 were retrospectively compared to 200 cases using the 12 h Pill Cam SB2-ex at a tertiary academic center.Endoscopically placed capsules were excluded from the study.Demographic information,indications for capsule endoscopy,capsule type,study length,completion of exam,clinically significant findings,timestamp of most distant finding,and significant findings beyond 8 h were recorded.RESULTS:The 8 and 12 h capsule groups were well matched respectively for both age(70.90±14.19vs 71.93±13.80,P=0.46)and gender(45.5%vs48%male,P=0.69).The most common indications for the procedure in both groups were anemia and obscure gastrointestinal bleeding.Pill Cam SB2-ex had a significantly higher completion rate than Pill Cam SB2(88%vs 79.5%,P=0.03).Overall,the diagnostic yield was greater for the 8 h capsule(48.5%for SB2vs 35%for SB2-ex,P=0.01).In 4/70(5.7%)of abnormal SB2-ex exams the clinically significant findingwas noted in the small bowel beyond the 8 h mark.CONCLUSION:In our study,we found the Pill Cam SB2-ex to have a significantly increased completion rate,though without any improvement in diagnostic yield compared to the Pill Cam SB2. | Merajur Rahman Stuart Akerman Bethany De Vito Larry Miller Meredith Akerman Keith Sultan | 2015 | World Journal of Gastroenterology2015，21，18： | 12 |
| 15 | Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production. | Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler | 2009 | World Journal of Gastroenterology2009，15，12： | 12 |
| 16 | Efficacy of Bacillus subtilis MBI 600 Against Sheath Blight Caused by Rhizoctonia solani and on Growth and Yield of Rice显示文摘Rice sheath blight disease(ShB),caused by Rhizoctonia solani,gives rise to significant grain yield losses.The present study evaluated the efficacy of Integral?,the commercial liquid formulation of Bacillus subtilis strain MBI 600,against rice ShB and for plant growth promotion.In greenhouse studies,four log concentrations of Integral(from 2.2×106 to 2.2×109 cfu/mL) were used as seed treatment(ST).After 25 d,seedlings were dipped(SD) into Integral prior to transplanting.At 30 d after transplanting(DAT),leaf sheaths were inoculated with immature sclerotia of the pathogen.At 45 DAT,a foliar spray(FS) with Integral was applied to some treatments.The fungicide control was 50% carbendazim at 1.0 g/L,and a nontreated control was also included.Overall,there were 10 treatments,each with five replications.ShB severity was rated at 52 DAT,and seedling height and number of tillers per plant were rated at 60 DAT.In 2009,two field trials evaluated Integral at 2.2×108 and 2.2×109 cfu/mL.Integral was applied as ST,and seedlings were produced in a nursery bed.After 32 d,seedlings were treated with Integral as SD and transplanted into 10 m2 blocks.Foliar sprays were given at 45 and 60 DAT.There were seven treatments,each with eight replications arranged as a factorial randomized complete block design.At 20 DAT,the plots were broadcast inoculated with R.solani produced on rice grains.Seedling height before transplanting,ShB severity at 90 DAT,and grain yield at harvest were recorded.Integral at 2.2×109 cfu/mL provided significant increase of seedling heights over other treatments under greenhouse conditions.The Integral treatments of ST + SD + FS at 2.2×109 cfu/mL significantly suppressed ShB over other treatments.In field studies,Integral provided significant increase of seedling height in nursery,and number of tillers per plant,compared with the control.ShB severity was significantly suppressed with higher concentrations of Integral compared to lower concentrations.Grain yield were the highest at an Integral concentration of 2.2×109 cfu/mL.Overall,Integral significantly reduced ShB severity,enhanced seedling growth,number of tillers per plant and grain yield as ST + SD + FS at the concentration of 2.2×109 cfu/mL under the conditions evaluated. | K. VIJAY KRISHNA KUMAR S. KR. YELLAREDDYGARI M. S. REDDY J. W. KLOEPPER K. S. LAWRENCE X. G. ZHOU H. SUDINI D. E. GROTH S. KRISHNAM RAJU M. E. MILLER | 2012 | Rice science2012，19，1： | 11 |
| 17 | 青蒿素的发现与诺贝尔生理学或医学奖显示文摘屠呦呦研究员因发现青蒿素这一杰出的贡献获得了2015年诺贝尔生理学或医学奖.青蒿素挽救了数百万人的生命,它的发现被认为是中国对全球人类健康所作出的最重要的贡献之一.先前集众多科学家参与和协作的"523项目"鲜为人知,诺贝尔奖颁给个人也因此引起了许多争议.本文概述了"523项目"的几个关键节点, | 苏新专 MILLER Louis H. 李剑 | 2015 | 中国科学:生命科学2015，45，11： | 10 |
| 18 | Probiotic supplementation decreases intestinal transit time: Meta-analysis of randomized controlled trials显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time (ITT) and to identify factors that influence these outcomes. METHODS: A systematic review of randomized controlled trials (RCTs) of probiotic supplementation that measured ITT in adults was conducted by searching MEDLINE and EMBASE using relevant combinations. Main search limits included RCTs of probiotic supplementation in healthy or constipated adults that measured ITT. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference (SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses were conducted to examine the impact of moderator variables on ITT SMD. RESULTS: A total of 11 clinical trials with 13 treatment effects representing 464 subjects were included in this analysis. Probiotic supplementation was associated with decreased ITT in relation to controls, with an SMD of 0.40 (95%CI: 0.20-0.59, P < 0.001). Constipation (r 2 = 39%, P = 0.01), higher mean age (r 2 = 27%, P = 0.03), and higher percentage of female subjects (r 2 = 23%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation and in older vs younger subjects [both SMD: 0.59 (95%CI: 0.39-0.79) vs 0.17 (95%CI: -0.08-0.42), P = 0.01]. Medium to large treatment effects were identified with Bifidobacterium Lactis (B. lactis ) HN019 (SMD: 0.72, 95%CI: 0.27-1.18, P < 0.01) and B. lactis DN-173 010 (SMD: 0.54, 95%CI: 0.15-0.94, P < 0.01) while other single strains and combination products yielded small treatment effects. CONCLUSION: Overall, short-term probiotic supplementation decreases ITT with consistently greater treatment effects identified in constipated or older adults and with certain probiotic strains. | Larry E Miller Arthur C Ouwehand | 2013 | World Journal of Gastroenterology2013，19，29： | 9 |
| 19 | Preliminary examination of electrochemical and spectroscopic features of trithiocarbonate collectors for sulfide mineral flotation显示文摘The redox potentials of xanthate/dixanthogen (dithiocarbonate/di dithiocarbonate, DTC/(DTC) 2) and trithiocarbonate/di trithiocarbonate (TTC/(TTC) 2) couples have been measured for the potassium salts. The spectroscopic characteristics of these sulfide mineral collectors were determined by FTIR and UV analysis. Electrochemically controlled contact angle measurements at a pyrite surface provided the basis to analyze the effect of the functional group ( O CS 2 versus S CS 2) on the hydrophobic surface state. Results from this preliminary examination are discussed with respect to the nature of collector adsorption and the pyrite flotation response. | R. Du Plessis 1, J.D. Miller 1, J.C.Davidtz 2 1. Department of Metallurgical Engineering, University of Utah, Salt Lake City, Utah 84102, USA 2. Department of Materials Science and Metallurgical Engineering, University of Pretoria, Pretoria 0002 | 2000 | 中国有色金属学会会刊:英文版2000，10，S1： | 9 |
| 20 | Risk of New-Onset Atrial Fibrillation in Elderly Patients with the Overlap Syndrome: A Retrospective Cohort Study显示文摘Background Co-existence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is referred to as overlap syndrome. Overlap patients have greater degree of hypoxia and pulmonary hypertension than patients with OSA or COPD alone. Studies showed that elderly patients with OSA alone do not have increased risk of atrial fibrillation (AF) but it is not known if overlap patients have higher risk of AF. Objective To determine whether elderly patients with overlap syndrome have an increased risk of AF. Methods In this single center, community-based retrospective cohort analysis, data were collected on 2,873 patients > 65 years of age without AF, presenting in the year 2006. Patients were divided into OSA group (n = 60), COPD group (n = 416), overlap syndrome group (n = 28) and group with no OSA or COPD(n = 2369). The primary endpoint was incidence of new-onset AF over the following two years. Logistic regression was performed to adjust for heart failure (HF), coronary artery disease, hypertension (HTN), cerebrovascular disease, cardiac valve disorders, diabetes mellitus, hyperlipidemia, chronic kidney disease (CKD) and obesity. Results The incidence of AF was 10% in COPD group, 6% in OSA group and 21% in overlap syndrome group (P < 0.05). After adjusting for age, sex, HF, CKD, and HTN, patientswith overlap syndrome demonstrated a significant association with new-onset AF (OR = 3.66, P = 0.007). HF, CKD and HTNwere also significantly associated with new-onset AF (P < 0.05). Conclusion Among elderly patients, the presence of overlap syndrome is associatedwith a marked increase in risk of new-onset AF as compared to the presence of OSA or COPDalone. | Harsha V. Ganga Sanjeev U. Nair Venkata K. Puppala Wayne L. Miller | 2013 | Journal of Geriatric Cardiology2013，10，2： | 9 |
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