|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重型机动车实际排放特性与影响因素的实测研究显示文摘利用美国Sensors公司生产的SEMTECHD车载排放测试仪在上海随机选择了7辆重型柴油车开展实际道路的排放测试,该实验累积测试道路长度为186km,共取得29090个逐秒的有效工况点数据,其中城市主干道12979个,次干道12368个,快速干道3743个.给出了车辆在不同道路上的工况点分布,分析了速度、加速度对燃油消耗、尾气排放的影响.测试结果表明,在选定的城市道路上,车流的平均怠速工况比为17%,加速工况比23.6%,等速工况比为31.0%,减速工况比为28.5%.被测车辆的CO、THC、NOx平均排放因子分别为(4.41±2.46)g·km-1、(1.77±1.17)g·km-1和(6.96±1.93)g·km-1,车辆排放状况因车速、加速度等因素而不同.测试结果基本反映了目前上海道路的交通状况和柴油卡车的排放现状,同时也说明过低的车速和频繁加减速是加重机动车污染的重要原因. | 陈长虹 景启国 王海鲲 潘汉生 李莉 黄成 赵静 戴懿 黄海英 Matt Barth Nick Nikkila | 2005 | 环境科学学报2005,25,7: | 57 |
| 2 | 轻型柴油车排放特性与机动车比功率分布的实例研究显示文摘引入机动车比功率概念研究了驾驶条件(Diving Condition)对机动车排放的影响及二者间的关系.利用美国Sensors公司生产的SEMTECHD车载排放测试仪在上海选取2辆轻型柴油客货两用车开展了实际道路排放测试.测试道路包括城市快速道、主干道和次干道,2辆轻型车测试的道路全长分别为31.8和39.7 km.通过计算逐秒的比功率值,研究了实际行驶中机动车比功率(VSP)与机动车油耗、空燃比和污染物排放的关系.回归分析结果表明,比功率比加速度能够更好地反映与NOx排放之间的关系,不同道路上机动车的CO、TC、NOx排放速率和油耗的比功率区间(VSP bin)分布具有较好的一致性.实测研究中VSP bin分布于-20~20 kW·t-1的范围内,其中超过50%的数据分布在-3~1 kW·t-1之间.高排放集中在分布频率较低的高VSP区间.应用污染物排放与VSP分布的关系式和VSP bins的频率分布可以估算机动车污染物排放总量.排放速率计算式具有一定的不确定性,还有待将来进一步修正. | 潘汉生 陈长虹 景启国 黄成 黄海英 王海鲲 李莉 赵静 戴懿 蔺宏轶 王少俊 Matt Barth Nick Nikkila | 2005 | 环境科学学报2005,25,10: | 30 |
| 3 | 上海市城区典型道路行驶特征研究显示文摘对上海市城区快速干道、主干道和次于道等3种典型道路上的机动车行驶特征和交通状况进行试验和调查,得出了上海市城区各类道路上机动车行驶特征参数和交通密度。结果显示,上海市城区各类道路综合行驶特征为平均速度低,加减速频繁。其中又以主干道交通状况最差。文中的数据和结论不仅可以用于上海城市交通规划,而且对控制道路两旁机动车污染具有重要意义。 | 王海鲲 陈长虹 黄成 戴懿 赵静 Jim Lents Matt Barth Nick Nikkilia | 2005 | 交通环保2005,26,3: | 16 |
| 4 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005,11,26: | 13 |
| 5 | 气候及老化之因素显示文摘尽管大部分试验都与研究和开发有关 ,但人们从事试验的主要原因仍是为了满足客户对材料的要求。在试验期间或评估结果时可做出若干结论或决定。引起老化的三大主要因素是 :光 (日光辐射 )、水 (湿度 )和温度。但这不仅是每种因素需要多少量才能最终导致材料降解的问题 ,因为辐射波长不同、潮湿程度不同、以及实际温度的冷热循环 ,均会对曝露的材料造成很大 (甚至主要 )的影响。这些因素 (及其变化 )的共同作用导致降解。辐射能量分为直射分量和漫射分量 ,按波段不同又分为紫外部分、可见部分和红外部分。文中给出了各种辐射量的大小、定义和等式。气候在降解过程中起着关键作用。不同气候以不同方式对材料产生作用。 | Matt McGreer | 2001 | 环境技术2001,19,6: | 12 |
| 6 | 天然气增压站经济优化:压缩机运行显示文摘对于外输管道的天然气增压站,其全周期运行经济性很大程度上取决于压缩机组的运行情况。概述了影响压气站经济运行的基本要素,着重描述了管道与压气站的相互影响。通过多个典型方案的描述,指明了管道经济运行必须着重考虑负荷变化的事实。为明确管线运维中离心式压缩机的控制与运行,描述了压缩机与管道系统的内在联系,指出了影响压缩机运行点的方法。稳态运行及瞬态运行均被纳入考虑。根据给定曲线,讨论了管线输量波动情况下机组的优化,强调了驱动机选型和数量选择的重要性。 | Rainer Kurz Matt Lubomirsky | 2015 | 天然气与石油2015,33,2: | 6 |
| 7 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020,15,7: | 5 |
| 8 | Effectiveness of an employment-based smoking cessation assistance program in China显示文摘Objective:The objective of this study was to adapt an evidence-based smoking cessation intervention initially developed in the United States to the Chinese context and evaluate the ef-fectiveness of this intervention in China.Method:A smoking cessation program from United States was adapted and implemented through an Employee Assistance Program(EAP)in China.The intervention consisted of recom-mending medication and psychological counseling.Local EAP counselors received training on the program and delivered the intervention to clients.Program evaluation examined the intervention's effectiveness in helping clients quit or reduce the amount of smoking and nicotine dependence.Results:Ninety-day follow-up showed that those who had completed the program were more likely to remain abstinent,or stop smoking daily and have lower levels of nicotine dependence(p<0.05)than those who had dropped out.Conclusions:The evidence-based cessation program is effective in helping Chinese smok-ers quit or reduce the amount of smoking.Moreover,implementing such programs in an EAP setting is a practical approach to providing a wider spectrum of smokers with access to cessation assistance in China. | Peizhong Li Christopher Larrison Richard Lennox Matt Mollenhauer David ASharar | 2015 | Family Medicine and Community Health2015,3,1: | 5 |
| 9 | Inside Windwows 95 操作系统崩溃测试显示文摘在上期的专题报道中,我们曾细致研究比较了Microsoft Windows3.1x、Microsoft Windows 95、IBM的OS/2 Warp Connect Version 3.0和Microsoft Windows NT Workstation3.51的强壮性和效能,其间我们采用了一套专门为此而编写的测试应用程序。在此我们将继续深入研究这些程序的内部工作情况,以便从某种程度上研究一下这些被测操作系统的体系结构。这项测试分四个部分: | Matt Pietrek 黄国胜 | 1996 | 个人电脑1996,0,1: | 4 |
| 10 | A six-gene phylogenetic overview of Basidiomycota and allied phyla with estimated divergence times of higher taxa and a phyloproteomics perspective显示文摘In this paper,we provide a phylogenetic overview of Basidiomycota and related phyla in relation to ten years of DNA based phylogenetic studies since the AFTOL publications in 2007.We selected 529 species to address phylogenetic relationships of higher-level taxa using a maximumlikelihood framework and sequence data from six genes traditionally used in fungal molecular systematics(nrLSU,nrSSU,5.8S,tef1-a,rpb1 and rpb2).These species represent 18 classes,62 orders,183 families,and 392 genera from the phyla Basidiomycota(including the newly recognized subphylum Wallemiomycotina)and Entorrhizomycota,and 13 species representing 13 classes of Ascomycota as outgroup taxa.We also conducted a molecular dating analysis based on these six genes for 116 species representing 17 classes and 54 orders of Basidiomycota and Entorrhizomycota.Finally we performed a phyloproteomics analysis from 109 Basidiomycota species and 6 outgroup taxa using amino-acid sequences retrieved from 396 orthologous genes.Recognition of higher taxa follows the criteria in Zhao et al(Fungal Divers 78:239–292,2016):(i)taxa must be monophyletic and statistically well-supported in molecular dating analyses,(ii)their respective stem ages should be roughly equivalent,and(iii)stem ages of higher taxa must be older than those of lower level taxa.The time-tree indicates that the mean of stem ages of Basidiomycota and Entorrhizomycota are ca.530 Ma;subphyla of Basidiomycota are 406–490 Ma;most classes are 358–393 Ma for those of Agaricomycotina and 245–356 Ma for those of Pucciniomycotina and Ustilaginomycotina;most orders of those subphyla split 120–290 Ma.Monophyly of most higherlevel taxa of Basidiomycota are generally supported,especially those taxa introduced in the recent ten years:phylum Entorrhizomycota,classes Malasseziomycetes,Moniliellomycetes,Spiculogloeomycetes,Tritirachiomycetes and orders Amylocorticiales,Golubeviales,Holtermanniales,Jaapiales,Lepidostromatales,Robbauerales,Stereopsidales and Trichosporonales.However,the younger divergence times of Leucosporidiales(Microbotryomycetes)indicate that its order status is not supported,thus we propose combining it under Microbotryales.On the other hand,the families Buckleyzymaceae and Sakaguchiaceae(Cystobasidiomycetes)are raised to Buckleyzymales and Sakaguchiales due to their older divergence times.Cystofilobasidiales(Tremellomycetes)has an older divergence time and should be amended to a higher rank.We however,do not introduce it as new class here for Cystofilobasidiales,as DNA sequences from these taxa are not from their respective types and thus await further studies.Divergence times for Exobasidiomycetes,Cantharellales,Gomphales and Hysterangiales were obtained based on limited species sequences in molecular dating study.More comprehensive phylogenetic studies on those four taxa are needed in the future because our ML analysis based on wider sampling,shows they are not monophyletic groups.In general,the six-gene phylogenies are in agreement with the phyloproteomics tree except for the placements of Wallemiomycotina,orders Amylocorticiales,Auriculariales,Cantharellales,Geastrales,Sebacinales and Trechisporales from Agaricomycetes.These conflicting placements in the six-gene phylogeny vs the phyloproteomics tree are discussed.This leads to future perspectives for assessing gene orthology and problems in deciphering taxon ranks using divergence times. | Rui-Lin Zhao Guo-Jie Li Santiago Sanchez-Ramirez Matt Stata Zhu-Liang Yang Gang Wu Yu-Cheng Dai Shuang-Hui He Bao-Kai Cui Jun-Liang Zhou Fang Wu Mao-Qiang He Jean-Marc Moncalvo Kevin D.Hyde | 2017 | Fungal Diversity2017,,3: | 4 |
| 11 | 自然气候老化测试及应用显示文摘描述自然气候条件对材料老化的影响以及对预测材料不同应用方向等方面的影响。通过对不同地点、不同老化方法的比较 ,重点介绍了目前国际上使用的老化方法 -直接曝晒、黑板箱曝晒、间接曝晒、自然加速老化等多种标准方法的特点 ,使用的局限性以及对材料老化结果的影响 ,并详细介绍了适用于自然老化地点的选择 ,主要影响因素等等。文章在分析多种老化方法的同时 ,指出了各种方法的适用性 ,这对材料老化方面的研究有很大的参考价值和指导意义。 | Matt McGreer | 2001 | 环境技术2001,19,4: | 4 |
| 12 | Crystalline phase of Y_2O_3 :Eu particles generated in a substrate-free flame process显示文摘In this study, factors affecting the crystal structure of flame-synthesized Y 2 O 3 :Eu particles were inves- tigated, especially the particle size effect and its interaction with Eu doping concentration. Polydisperse Y 2 O 3 :Eu (size range 200 nm to 3 m) powder samples with Eu doping concentrations from 2.5 mol% to 25 mol% were generated in either H 2 /air or H 2 /O 2 substrate-free flames. The crystal structure of the powder samples was determined by powder X-ray diffraction (XRD), which was complemented by pho- toluminescence (PL) measurements. Single particle crystal structure was determined by single particle selected area electron diffraction (SAED), and for the first time, by electron backscatter diffraction (EBSD). H 2 /air flames resulted in cubic phase Y 2 O 3 :Eu particles with hollow morphology and irregular shapes. Particles from H 2 /O 2 flames had dense and spherical morphology; samples with lower Eu doping concen- trations had mixed cubic/monoclinic phases; samples with the highest Eu doping concentrations were phase-pure monoclinic. For samples generated from H 2 /O 2 flames, a particle size effect and its interaction with Eu doping concentration were found: particles smaller than a critical diameter had the monoclinic phase, and this critical diameter increased with increasing Eu doping concentration. These findings sug- gest that the formation of monoclinic Y 2 O 3 :Eu is inevitable when extremely hot substrate-free flames are used, because typical flame-synthesized Y 2 O 3 :Eu particle sizes are well below the critical diameter. However, it may be possible to generate particles with dense, spherical morphology and the desired cubic structure by using a moderately high flame temperature that enables fast sintering without melting the particles. | Bing Guoa Hoon Yim Wonjoong Hwang Matt Nowell Zhiping Luo | 2011 | Particuology2011,9,1: | 4 |
| 13 | Existence and uniqueness result for multidimensional BSDEs with generators of Osgood type显示文摘 | Shengjun FAN Long JIANG Matt DAVISON | 2013 | Frontiers of Mathematics in China2013,8,4: | 4 |
| 14 | Smith-Fineman-Myers综合征基因定位于Xq25显示文摘目的 定位 Smith Finem an Myers 综合征基因,为分离该基因奠定基础。方法 应用覆盖 X染色体全长的、具有多态性的短串联重复序列( S T R) 对 X 染色体进行扫查,确定致病基因所在区域和与致病基因连锁的 S T R 位点,再对该位点两侧的 S T R 位点进行分析,确定致病基因的精确位置。结果 用20个覆盖 X 染色体全长的、具有多态性的 S T R 位点对该综合征患者家系中的13 个能明确提供连锁分析信息的家系成员进行分析,发现位于 Xq25 上的 D X S1001 与致病基因紧密连锁,最大两点lods 得分为301(θ= 0) ,对 D X S1001 两侧的 S T R 分析证实,该致病基因位于 D X S1001 区域,单体型分析表明该致病基因位于 D X S8064 和 D X S8050 之间,区域为146c M。结论 Smith Finem an Myers 综合征基因,位于 Xq25 上的 D X S8064 和 D X S8050 之间的146c M 区域,该基因的定位为分离该基因奠定了基础。 | 龚瑶琴 魏建军 邵常顺 郭亦寿 陈丙玺 郭辰虹 matt warman | 1999 | 中华医学遗传学杂志1999,16,5: | 4 |
| 15 | Rates and risk factors for suicidal ideation,suicide attempts and suicide deaths in persons with HIV:a systematic review and meta-analysis显示文摘Background People living with HIV/AIDS(PLWHA)must contend with a significant burden of disease.However,current studies of this demographic have yielded wide variations in the incidence of suicidality(defined as suicidal ideation,suicide attempt and suicide deaths).Aims This systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.Methods Publications were identified from PubMed(MEDLINE),SCOPUS,OVID(MEDLINE),Joanna Briggs Institute EBP and Cochrane Library databases(from inception to before 1 February 2020).The search strategy included a combination of Medical Subject Headings associated with suicide and HIV.Researchers independently screened records,extracted outcome measures and assessed study quality.Data were pooled using a random-effects model.Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity.Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.Results A total of 185199 PLWHA were identified from 40 studies(12 cohorts,27 cross-sectional and 1 nested case-control).The overall incidence of suicide completion in PLWHA was 10.2/1000 persons(95%CI:4.5 to 23.1),translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons.The lifetime prevalence of suicide attempts was 158.3/1000 persons(95%CI:106.9 to 228.2)and of suicidal ideation was 228.3/1000 persons(95%CI:150.8 to 330.1).Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease(AIDS),the risk of suicide completion increased by 34 per 1000 persons.The quality of evidence by Grading of Recommendations,Assessment,Development and Evaluations for the suicide deaths was graded as‘moderate’quality.Conclusions The risk of suicide death is 100-fold higher in people living with HIV than in the general population.Lifetime incidence of suicidal ideation and attempts are substantially high.Suicide risk assessments should be a priority in PLWHA,especially for those with more advanced disease. | Matt Pelton Matt Ciarletta Holly Wisnousky Nicholas Lazzara Monica Manglani Djibril M Ba Vernon M Chinchillli Ping Du Anna E Ssentongo Paddy Ssentongo | 2021 | General Psychiatry2021,34,2: | 3 |
| 16 | 中国人工智能兴起的原因及其经济意义显示文摘中国在扮演了将近四十年世界工厂的角色之后,正逐渐成为人工智能创新应用的中心。预计至2030年,人工智能将为全球创造15.7万亿美元的财富,其中7万亿美元的财富将由中国创造。为何中国能在人工智能领域迅速跻身国际先进国家行列?这将对中国甚至全球经济产生怎样的影响?本文将从以下三个方面进行回答:人工智能最新进展的本质. | 李开复 Matt Sheehan | 2019 | 智慧中国2019,0,4: | 3 |
| 17 | In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts显示文摘核黄素(Rf ) 受体绑并且 translocate Rf 和它的 phosphorylated 形式(例如黄素 mononucleotide,黄素单核甘酸) 进他们调停的房间各种各样的细胞的新陈代谢的小径。以前,我们证明黄素单核甘酸涂的 ultrasmall superparamagnetic 氧化铁(FLUSPIO ) nanoparticles 对在 vitro 把新陈代谢地活跃的癌症和 endothelial 房间标记合适。在这研究,我们集中了于在里面用前列腺癌症异种皮移植的 FLUSPIO 的 vivo 申请。FLUSPIO 的尺寸,充电,和化学作文被评估。我们探索了在里面为它用磁性的回声成像(MRI ) 和染色的普鲁士的蓝色的细胞的受体的 FLUSPIO 的 vitro 特性。竞争有约束力的实验被在过量注射免费黄素单核甘酸在 vivo 执行。FLUSPIO 的简历分发被用比色的试金在机关和肿瘤估计铁内容决定。AFM 分析和希腊语的第六个字母潜力大小揭示了微粒形态学在尺寸和一个否定希腊语的第六个字母潜力的近似 20-40 nm (-24.23 ??????????? | Jabadurai Jayapaul Susanne Ares Matt Bunker Marek Weiler Sandra Rutherford Peter Comba Fabian Kiessling | 2016 | Nano Research2016,9,5: | 3 |
| 18 | The community structure and microbial linkage of rumen protozoa and methanogens in response to the addition of tea seed saponins in the diet of beef cattle显示文摘Background: This study investigated changes in rumen protozoal and methanogenic communities, along with the correlations among microbial taxa and methane(CH_4) production of six Belmont Red Composite beef steers fed tea seed saponins(TSS). Animals were fed in three consecutive feeding periods, a high-grain basal diet for 14 d(BD period) then a period of progressive addition of TSS to the basal diet up to 30 g/d for 20 d(TSS period), followed by the basal diet for 13 d without TSS(BDP post-control period).Results: The study found that TSS supplementation decreased the amount of the protozoal genus Entodinium and increased Polyplastron and Eudiplodinium genera. During BDP period, the protozoa community of steers did not return to the protozoal profiles observed in BD period, with higher proportions of Metadinium and Eudiplodinium and lower Isotricha. The addition of TSS was found to change the structure of methanogen community at the subgenus level by decreasing the abundance of methanogens in the SGMT clade and increasing the abundance of methanogens in the RO clade. The correlation analysis indicated that the abundance of SGMT clade methanogens were positively correlated with Isotricha, and Isotricha genus and SGMT clade methanogens were positively correlated with CH_4 production. While RO clade were positively correlated with the proportion of Metadinium genus, which was negatively correlated with CH_4 emission.Conclusions: These results suggest that different genera of rumen protozoa ciliates appear to be selectively inhibited by TSS, and the change in methanogen community at the subgenus level may be due to the mutualistic relationships between methanogens and rumen ciliates. | Cui Tan Carlos A.Ramírez-Restrepo Ali Mujtaba Shah Rui Hu Matt Bell Zhisheng Wang Chris McSweeney | 2021 | Journal of Animal Science and Biotechnology2021,12,1: | 3 |
| 19 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010,,3: | 3 |
| 20 | Automatic reconstruction of tree skeletal structures from point clouds显示文摘 | Yotam Livny Feilong Yan Matt Olson Baoquan Chen Hao Zhang Jihad El-Sana | 2010 | ACM Transactions on Graphics (TOG)2010,,6: | 3 |