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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020,30,8: | 7 |
| 2 | Five independent loci each control monogenic resistance to gummy stem blight in melon (Cucumis melo L.)显示文摘 | J. D. Frantz M. M. Jahn | 2004 | Theoretical and Applied Genetics2004,,6: | 3 |
| 3 | Genomic consequences of population decline in critically endangered pangolins and their demographic histories显示文摘Pangolins are among the most critically endangered animals due to heavy poaching and worldwide trafficking.However,their demographic histories and the genomic consequences of their recent population declines remain unknown.We generated high-quality de novo reference genomes for critically endangered Malayan(Manis javanica,MJ)and Chinese(M.pentadactyla,MP)pangolins and re-sequencing population genomic data from 74 MJs and 23 MPs.We recovered the population identities of illegally traded pangolins and previously unrecognized genetic populations that should be protected as evolutionarily distinct conservation units.Demographic reconstruction suggested environmental changes have resulted in a population size fluctuation of pangolins.Additionally,recent population size declines due to human activities have resulted in an increase in inbreeding and genetic load.Deleterious mutations were enriched in genes related to cancer/diseases and cholesterol homeostasis,which may have increased their susceptibility to diseases and decreased their survival potential to adapt to environmental changes and high-cholesterol diets.This comprehensive study provides not only high-quality pangolin reference genomes,but also valuable information concerning the driving factors of long-term population size fluctuations and the genomic impact of recent population size declines due to human activities,which is essential for pangolin conservation management and global action planning. | Jing-Yang Hu Zi-Qian Hao Laurent Frantz Shi-Fang Wu Wu Chen Yun-Fang Jiang Hong Wu Wei-Min Kuang Haipeng Li Ya-Ping Zhang Li Yu | 2020 | National Science Review2020,7,4: | 3 |
| 4 | A Contribution to Identification of Novel Regulators of Plant Response to Sulfur Deficiency: Characteristics of a Tobacco Gene UP9C, Its Protein Product and the Effects of UP9C Silencing显示文摘在植物 transcriptome 和 metabolome 的广泛的变化被众多的研究组在从最佳的条件把植物转移到硫(S) 缺乏以后观察了。尽管有集中的研究和最近的重要成就,作为对 S 缺乏的反应的一个主要 transcriptional 管理者喜欢 SLIM1/EIL3 的鉴定,有关规章的网络的另外的元素的许多问题仍然保持未答复。有编码未知功能力量的蛋白质的 S 缺乏应力调整的表示的基因的调查帮助澄清这些问题。这研究在烟草集中于 UP9C 基因和象 UP9 一样家庭。这些基因的相当或相同的事物在另外的植物种类存在,包括在 Arabidopsis thaliana (LSU1-4 ) 的未知功能的四基因的一个家庭,哪个当强烈由盐应力和硝酸盐限制由 S 赤字并且到更小的程度导致了,二被报导。预言的结构的特征的保存例如卷的卷区域或原子本地化信号,建议这些蛋白质可能可能有重要函数由和另外的蛋白质的相互作用调停了。有象 UP9 一样基因的 silenced 表示的转基因的烟草植物的分析强烈在对 S 赤字的植物反应的规定为他们的重要角色争论。尽管我们的学习证明象 UP9 一样蛋白质是如此的反应的重要部件,他们可能也在另外的压力期间被要求,他们的分子的功能仍然是一个谜。 | Matgorzata Lewandowska Anna Wawrzyhska Grzegorz Moniuszko Jolanta Lukomska Katarzyna Zientara Marta Piecho Pawel Hodurek Igor Zhukov Frantz Liszewska Victoria Nikiforova Agnieszka Sirko | 2010 | Molecular Plant2010,3,2: | 3 |
| 5 | How can we cure a heart “in flame”? A translational view on inflammation in heart failure显示文摘 | Ulrich Hofmann Stefan Frantz | 2013 | Basic Research in Cardiology2013,,4: | 2 |
| 6 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010,,2: | 2 |
| 7 | Measuring prevalence and incidence of pressure ulcers显示文摘 | Frantz R A | 1997 | Adv Wound Care1997,10,1: | 1 |
| 8 | Targeted deletion of MMP-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction显示文摘 | Ducharme A Frantz S Aikawa M | 2000 | J Clin Invest2000,106,1: | 1 |
| 9 | TLR4 expression in cardiac myocytes in normal and failing myocardium显示文摘 | Frantz S kobzik L Kim Y | 1999 | J Clin Invest1999,104,: | 1 |
| 10 | SOCS-I and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2显示文摘 | Rui LY Yuan MS Frantz D | 2002 | J Biol Chem2002,277,44: | 1 |
| 11 | The Role of SOCS3 in Leptin Signaling and Leptin Resistance显示文摘 | BJORBEAK C HASCHIMI K FRANTZ J | 1999 | J Biol Chem1999,274,30: | 1 |
| 12 | Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure显示文摘 | Frantz S Fraccarollo D Wagner H | | 0,,03: | 1 |
| 13 | Toll4 (TLR4) expressionin cardiac myocytes in normal and failing myocardium 显示文摘 | Frantz S Kobzik L Kim YD | 1999 | JClin Invest1999,104,3: | 1 |
| 14 | A murine model of experimental metastasis to bone and bone marrow显示文摘 | Arguello F Baggs RB Frantz CN | 1988 | Cancer Res1988,48,23: | 1 |
| 15 | Innate immunity and angiogenesis显示文摘 | Frantz S Vincent KA Feron O | 2005 | Circ Res2005,96,1: | 1 |
| 16 | Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction显示文摘 | Ducharme A Frantz S Aikawa M | 2000 | J Clin Invest2000,106,: | 1 |
| 17 | Physical and Chemical Properties of Municipal Solid Waste Fly Ash 显示文摘 | Hamemik J D Frantz G C | 1991 | ACI Materials Journal1991,88,3: | 1 |
| 18 | Reliable microsatellite genotyping of the Eurasian badger ( Meles meles ) using faecal DNA 显示文摘 | Frantz A C Pope L C Carpenter P J | 2003 | Molecular Ecology2003,12,6: | 1 |
| 19 | Interleukin-6 blood level is associated with circulating carciuoemhrvouic antigen and prognusis in patients with colorectal cancer显示文摘 | Belluco C NittiD Frantz M | | 0,,02: | 1 |
| 20 | Role of TLR2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes显示文摘 | Frantz S Kelly RA Bourcier T | 2001 | J Biol Chem2001,276,7: | 1 |