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| 1 | Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis显示文摘Phytoene synthase (PSY ) 是在类胡萝卜素 biosynthetic 小径的关键 plastidial 酶。然而,它的 translational 以后规定留下逃犯。同样, Clp 朊酶组成质体朊酶网络的中央部分,但是它为降级的底层不是众所周知的。在这研究,我们报导 PSY 是 Clp 朊酶的底层。PSY 被揭开身体上与各种各样的 Clp 朊酶子单元交往(即, ClpS1, ClpC1,和 ClpD ) 。在 clpc1, clpp4,和 clpr1-2 异种的 PSY 和几另外的 carotenogenic 酶蛋白质 overaccumulate 高级。overaccumulated PSY 被发现部分酶地活跃。在 clpc1 的 Clp 活动的缺陷导致 PSY 蛋白质周转的减少的率,进一步在降级的 PSY 支持 Clp 朊酶的角色蛋白质。在另一方面, ORANGE (或) 蛋白质,有 holdase 女伴活动的 PSY 的一个主要 translational 以后管理者,提高 PSY 蛋白质稳定性并且在 clpc1 增加 PSY 的酶地活跃的比例, counterbalancing 在维持 PSY 蛋白质动态平衡的调停 Clp 的解朊作用。一起,这些调查结果提供新奇卓见进质体局部性的蛋白质的质量控制并且建立迄今未辩别出的 translational 以后在在植物的 modulating 类胡萝卜素生合成的 carotenogenic 酶的规章的机制。 | Ralf Welsch Xiangjun Zhou Hui Yuan Daniel Alvarez Tianhu Sun Dennis Schlossarek Yong Yang Guoxin Shen Hong Zhang Manuel Rodriguez-Concepcion Theodore W. Thannhauser Li Li | 2018 | Molecular Plant2018，11，1： | 10 |
| 2 | The Or Gene Enhances Carotenoid Accumulation and Stability During Post-Harvest Storage of Potato Tubers显示文摘在主食庄稼的维生素原 A 类胡萝卜素不在存储期间是很稳定的,他们的损失损害营养的质量。阐明位于类胡萝卜素累积和稳定性下面的基本机制,我们调查了表示了花椰菜橘子的转基因的土豆 tubers (或) 基因。我们发现 Or transgene 不仅支持了叶红素水平的保留,而且连续地在冷存储的 5months 期间刺激了它的累积。相反,类胡萝卜素的增加的层次都没在存储的一样的时期期间在向量唯一的控制或一个黄肉的变化的 tubers 被观察。增加的类胡萝卜素累积被发现与扣押的 lipoproteincarotenoid 的形成被联系结构,以及与提高的许多 phytoene synthase,在类胡萝卜素 biosynthetic 小径的关键酶。而且,存储的维生素原 A 类胡萝卜素被显示在模仿的消化期间稳定并且为由人的肠的吸收性的房间的举起可存取。Proteomic 分析识别了蛋白质的三个主要的功能的组(即热吃惊蛋白质, glutathione-S-transferases,和糖类新陈代谢的蛋白质) 那在或调整类胡萝卜素累积是潜在地重要的。我们的结果证明类胡萝卜素隐遁能力的那条规定是类胡萝卜素稳定性被调整的重要机制。我们的调查结果建议在主食庄稼的合适的水池结构形成的那正式就职可以向庄稼提供在植物生长和收获以后的存储期间支持或稳定维生素原 A 累积的一个唯一的能力。 | Li Li Yong Yang Qiang Xu Katherine Owsiany Ralf Welsch Chureeporn Chitchumroonchokchai Shan Lu Joyce Van Eck Xiu-Xin Deng Mark Failla Theodore W. Thannhauser | 2012 | Molecular Plant2012，5，2： | 8 |
| 3 | 应用MRI形态学和T2图成像生化区域带评估并比较髌骨与股骨内侧髁关节软骨修复组织显示文摘本研究的目的是利用先进的MR技术评价并比较自体软骨细胞移植(MACT)术后髌骨与股骨内侧髁软骨的修复情况。34例MACT治疗后的病人行膝关节3TMRI检查,其中髌软骨17例,股骨内侧髁软骨17例,且年龄和术后间隔时间相匹配。形态学评估采用三维真实稳态自由进动序列对关节软骨修复组织进行MRI评分(MOCART)。生物化学评估采用多回波自旋回波方法行R图成像,并重点分析关节软骨区域带结构。应用方差分析进行统计学评估。 | G.H. Welsch T.C. Mamisch S. Quirbach L. Zak S. Marlovits S. Trattnig 刘艳杰(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 4 |
| 4 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 5 | Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites显示文摘 | Sonja Welsch Sven Miller Ines Romero-Brey Andreas Merz Christopher K.E. Bleck Paul Walther Stephen D. Fuller Claude Antony Jacomine Krijnse-Locker Ralf Bartenschlager | 2009 | Cell Host & Microbe2009，，： | 2 |
| 6 | Logistics agglomeration in the US显示文摘 | Liliana Rivera Yossi Sheffi Roy Welsch | 2014 | Transportation Research Part A2014，，： | 2 |
| 7 | Up to 70 THz bandwidth from an implanted Ge photoconductive antenna excited by a femtosecond Er:fibre laser显示文摘Phase-stable electromagnetic pulses in the THz frequency range offer several unique capabilities in time-resolved spectroscopy.However,the diversity of their application is limited by the covered spectral bandwidth.In particular,the upper frequency limit of photoconductive emitters-the most widespread technique in THz spectroscopy-reaches only up to 7 THz in the regular transmission mode due to absorption by infrared-active optical phonons.Here,we present ultrabroadband(extending up to 70 THz)THz emission from an Au-implanted Ge emitter that is compatible with mode-locked fibre lasers operating at wavelengths of 1.1 and 1.55μm with pulse repetition rates of 10 and 20 MHz,respectively.This result opens up the possibility for the development of compact THz photonic devices operating up to multi-THz frequencies that are compatible with Si CMOS technology. | Abhishek Singh Alexej Pashkin Stephan Winnerl Malte Welsch Cornelius Beckh Philipp Sulzer Alfred Leitenstorfer Manfred Helm Harald Schneider | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 8 | Structural and functional characterization of the phytoene synthase promoter from Arabidopsis thaliana显示文摘 | Ralf Welsch Joaquin Medina Giovanni Giuliano Peter Beyer Johannes von Lintig | 2003 | Planta2003，，3： | 2 |
| 9 | Ultrastructure and function of follicle cell in the ovary of Branchiostoma belcheri显示文摘The ultrastructure of follicle cells in the ovary at different developmental stages of Branchiostoma has been observed in detail with a transmission electron microscope. The results indicate that only one kind of follicle cell exists with structural features related to steroid hormone biosynthesis: (i) oval or round mitochondria with tubules; (ii) smooth surfaced endoplasmic reticulum; (iii) several large lipid droplets in the cytoplasm; (iv) a well de-veloped Golgi complex and tubular rough surfaced endoplasmic reticulum, as can be found in mammalian theca interna cells. In addition, as steroid hormone synthesizing cells, they obviously play an important role in the phagocytosis of relict gametes and cellular debris and may have a nutritive function for the oocytes. They can produce abundant secre-tory granules in stages III-IV ovaries. In mature ovaries they transform into flat epithelial cells with numerous micro-filaments which may play a role in ovulation. | Ulrich Welsch 方永强 | 1997 | Science China(Life Sciences)1997，40，1： | 2 |
| 10 | Corruption, Growth, and the Environment: A Cross-country Analysis 显示文摘 | Welsch H | 2004 | Environment and Development Economics2004，9，： | 1 |
| 11 | Surgery for pancreatic cancer 显示文摘 | Welsch T Buchler MW Schmidt J | 2008 | Z Gastroenterol2008，46，12： | 1 |
| 12 | The high temperature deform- ation in cycle loading of a single crystal nickel-base superalloy 显示文摘 | GABB T P WELSCH G | 1989 | Acta Metallurgica1989，37，： | 1 |
| 13 | Family business research: The evolution of an academic field显示文摘 | Bird B Welsch H Astrachan J H and Pistrui D | 2002 | Family Business Review2002，15，4： | 1 |
| 14 | Cartilage T2 assessment at 3T MR imaging:in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures-initial experience显示文摘 | Welsch GH Mamisch TC Domayer SE | 2008 | Radiolo- gy2008，247，1： | 1 |
| 15 | Organizational absorptive capacity and responsiveness: An empirical investigation of growth-oriented SMEs 显示文摘 | LiaoJ Welsch H StoicaM | 2003 | Entrepreneuship Theory and Practice2003，8，4： | 1 |
| 16 | Results of extralevator abdominoperineal resection for low rectal cancer including quality of life and long-term wound complications 显示文摘 | Welsch T Mategakis V Contin P | 2013 | Int J Colorectal Dis2013，28，4： | 1 |
| 17 | The low cycle fatigue deformation response of a single-crystal superalloy at 650 ℃ 显示文摘 | GABB T P WELSCH G MINER R V | 1989 | Materials Science and Engi- neering1989，0，： | 1 |
| 18 | Chlamydia pneumoniae in coronary plaques:Increased detection with acute coronary syndrome显示文摘 | Barriedel G Welsch U Likungu J A | 1999 | Dtsch Med Wochenschr1999，124，： | 1 |
| 19 | Venture Gesta- tion Paths of Nascent Entrepreneurs: Exploring the Temporal Patterns显示文摘 | LIAO J WELSCH H TAN W L | 2005 | Journal of High Technology Management Research2005，16，1： | 1 |
| 20 | Diagnosis and definition of anastomotic leakage from the surgeon' s perspective 显示文摘 | Welsch T yon Frankenberg M Schmidt J | 2011 | Chirnrg2011，82，1： | 1 |
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