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| 1 | 基于市场推广视角的BIM技术采纳障碍因素中意对比研究显示文摘通过国内外相关文献的阅读与分析,基于市场角度辨识和定义建筑业企业BIM技术采纳的13个障碍因素,运用ISM评价和构建了障碍因素的多级递阶结构模型。在此基础上,通过MICMAC分析明确各障碍因素的依赖性和驱动力,进而得到建筑市场中驱动力较大的关键因素。结合ISM和MICMAC分析的结果,对比研究了中国与意大利建筑市场中障碍因素的异同。结果显示,BIM的教育和培训、BIM技术人才是目前中国建筑市场驱动力最大的两个因素,而BIM标准是当前意大利建筑市场驱动力最大的因素。 | 秦旋 MANCINI Mauro TRAVAGLINI Agnese 吕坤灿 王敏 | 2016 | 管理学报2016，13，11： | 49 |
| 2 | Sarcopenia in heart failure: mechanisms and therapeutic strategies显示文摘长期的心失败(CHF ) 是一个高度流行的条件在之中老并且与可观的病态, institutionalization 和死亡被联系。在它的先进阶段, CHF 被肌肉质量和力量的损失经常伴随。Sarcopenia 是活跃地与大量不利健康结果由于它的协会在最近的年里被学习了的衰老老人症候群。这评论的目标是讨论在 CHF 和 sarcopenia 之间的关系,与分享的 pathophysiological 小径和处理的一个焦点。营养不良,全身的发炎,内分泌的不平衡,和氧化应力看起来连接 sarcopenia 和 CHF。在肌肉发达的水平, ubiquitin proteasome 系统,发信号的 myostatin,和 apoptosis 的改变在 sarcopenia 和 CHF 被描述了并且能在肌肉质量和功能的损失起一个作用。阻碍肌肉在 CHF 病人浪费的前进的可能的治疗学的策略包括变换血管收缩素的酶禁止者和 β 的蛋白质和维生素 D 补充,结构化的物理锻练,和管理; -blockers。有生长荷尔蒙,睾丸激素,和 ghrelin 的神经质的补充也作为潜在的治疗被讨论。 | Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'Angelo Alex N Sisto Francesco Landi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 25 |
| 3 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 4 | Bone alterations in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental factors.Up to 50%of IBD patients experience at least one extraintestinal manifestation;among them is the involvement of bone density which is referred to as metabolic bone disease(MBD),including osteopenia and osteoporosis.Bone alterations in IBDs population appear to have a multifactorial etiology:Decreased physical activity,inflammation-related bone resorption,multiple intestinal resections,dietary malabsorption of minerals and vitamin D deficiency,genetic factors,gut-bone immune signaling interaction,steroid treatment,microbiota and pathogenic micro-organisms interaction,and dietary malabsorption of minerals,that,all together or individually,may contribute to the alteration of bone mineral density.This review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone fragility.We also want to underline the role of the screening and prophylaxis of bone alterations in Crohn’s disease and ulcerative colitis patients and the importance of treating appropriately MBD. | Dolores Sgambato Francesca Gimigliano Cristiana De Musis Antimo Moretti Giuseppe Toro Emanuele Ferrante Agnese Miranda Domenico De Mauro Lorenzo Romano Giovanni Iolascon Marco Romano | 2019 | World Journal of Clinical Cases2019，7，15： | 8 |
| 5 | 前列腺癌的神经内分泌分化显示文摘一、良性前列腺中的神经内分泌细胞
正常前列腺主要由分泌细胞和基底细胞组成,可在HE染色下由普通显微镜分辨。另外还有散在微量的神经内分泌细胞(neuroendocfine cell,NE细胞),该细胞仅能由电镜分辨,或者通过免疫组织化学方法用特异性标记物如嗜铬粒素A(CgA)、突触素(Syn)、神经元特异性烯醇化酶(NSE)等识别。前列腺的NE细胞具有上皮性、神经性和内分泌性特征,散在分布于前列腺,但在移行区和外周区比在中心区更多见。NE细胞的这种分布,可能与前列腺增生和前列腺癌有关。 | 吴澄宇 那彦群 JorgeL.Yao P.AnthonydiSant'Agnese 黄教悌 | 2006 | 中华病理学杂志2006，35，9： | 7 |
| 6 | Eradication of Helicobacter pylori infection:Which regimen first?显示文摘Helicobacter pylori(H.pylori)is a well-known human pathogen that plays an essential role in the pathogenesis of chronic gastritis,peptic ulcer disease,and gastric malignancies.Although H.pylori is susceptible to several antimicrobials,this infection has proven challenging to cure because of the increasing prevalence of bacterial strains that are resistant to the most commonly used antimicrobials,particularly clarithromycin.An effective(i.e.,>90%)first-line therapy is mandatory for avoiding supplementary treatments and testing,and more importantly for preventing the development of secondary resistance.This study reviews the recent literature on first-line therapies forH.pylori.The eradication rates following standard triple therapy(a proton pump inhibitor plus amoxicillin and clarithromycin)for H.pylori infection are declining worldwide.Several first-line strategies have been proposed to increase the eradication rate,including extending the treatment duration to 14 d,the use of a four-drug regimen(bismuth-containing quadruple,sequential,and concomitant treatments),and the use of novel antibiotics,such as fluoroquinolones.However,the ef5ficacy of these regimens is controversial.A first-line eradication regimen should be based on what works best in a defined geographical area and must take into account the prevalence of antimicrobial resistance in that region. | Alessandro Federico Antonietta Gerarda Gravina Agnese Miranda Carmela Loguercio Marco Romano | 2014 | World Journal of Gastroenterology2014，20，3： | 6 |
| 7 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 8 | Efficacy of 5-Day Levofloxacin-Containing Concomitant Therapy in Eradication of Helicobacter pylori Infection显示文摘 | Alessandro Federico Gerardo Nardone Antonietta G. Gravina Maria Rosaria Iovene Agnese Miranda Debora Compare Paola A. Pilloni Alba Rocco Luigi Ricciardiello Riccardo Marmo Carmelina Loguercio Marco Romano | 2012 | Gastroenterology2012，，1： | 3 |
| 9 | Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis显示文摘 | Eniko Safrany Melinda Szabo Marta Szell Lajos Kemeny Katalin Sumegi Bela I. Melegh Lili Magyari Petra Matyas Maria Figler Agnes Weber Zsolt Tulassay Bela Melegh | 2013 | Inflammation Research2013，，2： | 3 |
| 10 | Transforaminal Posterolateral Endoscopic Discectomy With or Without the Combination of a Low-Dose Chymopapain: A Prospective Randomized Study in 280 Consecutive Cases显示文摘 | Thomas Hoogland Michael Schubert Boris Miklitz Agnes Ramirez | 2006 | Spine2006，，24： | 3 |
| 11 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes显示文摘 | Anna Zampetaki Stefan Kiechl Ignat Drozdov Peter Willeit Ursula Mayr Marianna Prokopi Agnes Mayr Siegfried Weger Friedrich Oberhollenzer Enzo Bonora Ajay Shah Johann Willeit Manuel Mayr | 2010 | Circulation Research2010，，6： | 3 |
| 12 | Amyloid positron emission tomography and cognitive reserve显示文摘Alzheimer's disease(AD) is characterized by a nonlinear progressive course and several aspects influence the relationship between cerebral amount of AD pathology and the clinical expression of the disease. Brain cognitive reserve(CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. CR phenomenon contributed to explain the disjunction between the degree of neurodegeneration and the clinical phenotype of AD. The possibility to track brain amyloidosis(Aβ) in vivo has huge relevance for AD diagnosis and new therapeutic approaches. The clinical repercussions of positron emission tomography(PET)-assessed Aβ load are certainly mediated by CR thus potentially hampering the prognostic meaning of amyloid PET in selected groups of patients. Similarly, amyloid PET and cerebrospinal fluid amyloidosis biomarkers have recently provided new evidence for CR. The present review discusses the concept of CR in the framework of available neuroimaging studies and specifically deals with the reciprocal influences between amyloid PET and CR in AD patients and with the potential consequent interventional strategies for AD. | Matteo Bauckneht Agnese Picco Flavio Nobili Silvia Morbelli | 2015 | World Journal of Radiology2015，7，12： | 3 |
| 13 | Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity显示文摘AIM: To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal cancer.METHODS: From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy(IMRT) and concurrent chemotherapy for anal canal squamous cell carcinoma at our center. Radiotherapy was delivered via simultaneous integrated boost(SIB) technique by helical tomotherapy, and doses were adapted to two clinical target volumes according to the tumor-nodemetastasis(TNM) stage: 50.6 Gy and 41.4 Gy in 23 fractions in T1N0, 52.8 Gy and 43.2 Gy in 24 fractionsin T2N0, and 55 Gy and 45 Gy in 25 fractions in all patients with N positive and/or ≥ T3, respectively, to planning target volumes 1 and 2. The most common chemotherapy regimen was 5-fluorouracil and mitomycin-based. Human papilloma virus(HPV) p16 expression was performed by immunohistochemistry and evaluated in the majority of patients. Acute and late toxicity was scored according to CTCAe v 3.0 and RTOG scales.RESULTS: The median follow-up was 30 mo(range:12-71). Median age was 63 years(range 32-84). The stage of disease was: stage Ⅰ in 2 patients, stage Ⅱin 13 patients, stage ⅢA in 12 patients, and stage ⅢB in 14 patients, respectively. Two patients were known to be HIV positive(4.9%). HPV p16 expression status was positive in 29/34(85.3%) patients. The 4-year progression-free survival and overall survival in HPVpositive patients were 78% and 92%, respectively.Acute grade 3 skin and gastrointestinal toxicities were reported in 5% and 7.3% of patients, respectively;patients' compliance to the treatment was good due to a low occurrence of severe acute toxicity, although treatment interruptions due to toxicity were required in 7.3% of patients. At 6 mo from end of treatment,36/40(90%) patients obtained complete response;during follow-up, 5(13.8%) patients presented with disease progression(local or systemic).CONCLUSION: In our experience, intensified SIBIMRT with chemotherapy is very feasible in clinical practice, with excellent results in terms of overall survival and local control. | Liliana Belgioia Stefano Vagge Dario Agnese Stefania Garelli Roberto Murialdo Giuseppe Fornarini Silvana Chiara Fabio Gallo Almalina Bacigalupo Renzo Corvò | 2015 | World Journal of Gastroenterology2015，21，37： | 2 |
| 14 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 15 | Accumulation of heavy metals from contaminated soil to plants and evaluation of soil remediation by vermiculite显示文摘 | Mery Malandrino Ornella Abollino Sandro Buoso Agnese Giacomino Carmela La Gioia Edoardo Mentasti | 2010 | Chemosphere2010，，2： | 2 |
| 16 | High rates of HBsAg seroconversion in HBeAg-positive chronic hepatitis B patients responding to interferon: A long-term follow-up study显示文摘 | Rami Moucari Anneke Korevaar Olivier Lada Michelle Martinot-Peignoux Nathalie Boyer Vincent Mackiewicz Agnes Dauvergne Ana C. Cardoso Tarik Asselah Marie-Hélène Nicolas-Chanoine Michel Vidaud Dominique Valla Pierre Bedossa Patrick Marcellin | 2009 | Journal of Hepatology2009，，6： | 2 |
| 17 | Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction显示文摘 | Anna Zampetaki Peter Willeit Lindsey Tilling Ignat Drozdov Marianna Prokopi Jean-Marie Renard Agnes Mayr Siegfried Weger Georg Schett Ajay Shah Chantal M. Boulanger Johann Willeit Philip J. Chowienczyk Stefan Kiechl Manuel Mayr | 2012 | Journal of the American College of Cardiology2012，，： | 2 |
| 18 | Osteoprotegerin Is a Risk Factor for Progressive Atherosclerosis and Cardiovascular Disease显示文摘 | Stefan Kiechl Georg Schett Gregor Wenning Kurt Redlich Martin Oberhollenzer Agnes Mayr Peter Santer Josef Smolen Werner Poewe Johann Willeit | 2004 | Circulation: Journal of the American Heart Association2004，，18： | 2 |
| 19 | Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1显示文摘 | Dolkun Rahmutula Gregory M. Marcus Emily E. Wilson Chun-Hua Ding Yuanyuan Xiao Agnes C. Paquet Rebecca Barbeau Andrea J. Barczak David J. Erle Jeffrey E. Olgin | 2013 | Cardiovascular Research2013，，4： | 2 |
| 20 | Liver Transplantation in Alcoholic Patients: Impact of an Alcohol Addiction Unit Within a Liver Transplant Center显示文摘 | Giovanni Addolorato Antonio Mirijello Lorenzo Leggio Anna Ferrulli Cristina D’Angelo Gabriele Vassallo Anthony Cossari Giovanni Gasbarrini Raffaele Landolfi Salvatore Agnes Antonio Gasbarrini | 2013 | Alcohol Clin Exp Res2013，，9： | 2 |
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