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| 1 | Calcium-sensing receptor in colorectal inflammation and cancer:Current insights and future perspectives显示文摘The extracellular calcium-sensing receptor(CaSR) is best known for its action in the parathyroid gland and kidneys where it controls body calcium homeostasis. However, the CaSR has different roles in the gastrointestinal tract, where it is ubiquitously expressed. In the colon, the CaSR is involved in controlling multiple mechanisms, including fluid transport, inflammation, cell proliferation and differentiation. Although the expression pattern and functions of the CaSR in the colonic microenvironment are far from being completely understood, evidence has been accumulating that the Ca SR might play a protective role against both colonic inflammation and colorectal cancer. For example, CaSR agonists such as dipeptides have been suggested to reduce colonic inflammation, while dietary calcium was shown to reduce the risk of colorectal cancer. CaSR expression is lost in colonic malignancies, indicating that the CaSR is a biomarker for colonic cancer progression. This dual anti-inflammatory and anti-tumourigenic role of the CaSR makes it especially interesting in colitisassociated colorectal cancer. In this review, we describe the clinical and experimental evidence for the role of the CaSR in colonic inflammation and colorectal cancer, the intracellular signalling pathways which are putatively involved in these actions, and the possibilities to exploit these actions of the CaSR for future therapies of colonic inflammation and cancer. | Luca Iamartino Taha Elajnaf Eniko Kallay Martin Schepelmann | 2018 | World Journal of Gastroenterology2018，24，36： | 9 |
| 2 | COX-2 as a potential biomarker and therapeutic target in melanoma显示文摘With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options.Melanoma is a model tumor in immuno-oncology.Inflammation represents an important hallmark of cancer capable of inducing and sustaining tumor development.The inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune destruction.Besides its role in proliferation,angiogenesis,and apoptosis,cyclooxygenase-2(COX-2)is a well-known promoter of immune suppression in melanoma.COX-2 inhibitors are closely involved in this condition.This review attempts to answer two controversial questions:is COX-2 a valuable prognostic factor?Among all COX-2 inhibitors,is celecoxib a suitable adjuvant in melanoma therapy? | Diana Valentina Tudor Ioana Baldea Mihai Lupu Teodor Kacso Eniko Kutasi Andreea Hopartean Roland Stretea Adriana Gabriela Filip | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 3 | Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis显示文摘 | Eniko Safrany Melinda Szabo Marta Szell Lajos Kemeny Katalin Sumegi Bela I. Melegh Lili Magyari Petra Matyas Maria Figler Agnes Weber Zsolt Tulassay Bela Melegh | 2013 | Inflammation Research2013，，2： | 3 |
| 4 | Combining extractive heterogeneous-azeotropic distillation and hydrophilic pervaporation for enhanced separation of non-ideal ternary mixtures显示文摘The separation of non-ideal mixtures using distillation can be an extremely complex process and there continues to be a need to further improve these techniques.A new method which combines extractive heterogeneous-azeotropic distillation(EHAD)and hydrophilic pervapora-tion(HPV)for the separation of non-ideal termary mixtures is demonstrated.This improved distillation method combines the benefits of heterogeneous-azeotropic and extractive distillations in one column but no added materials are needed as is usually the case with pervaporation.The separation of water-methanol-ethyl acetate and water-methanol-isopropyl acetate mixtures were investigated to demonstrate the accuracy of the combined EHAD/HPV technique.There is not currently an established treatment strategy for the separation of the second mixtures in the literature.These separation processes were rigorously modelled and optimized using a professional flowsheet.The objective functions were total cost and energy consumption and heat integration was also investigated.The verification of the process modelling was carried out using laboratory-scale measurements.Extractive heterogeneous-distillation combined with methanol dehydration was found to be more efficient than conventional distillation for the separation of these highly non-ideal mixtures. | Eniko Haaz Botond Szilagyi Daniel Fozer Andras Jozsef Toth | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 5 | Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease显示文摘AIM To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel diseases.METHODS We recruited adolescents and young adults(AYA) with inflammatory bowel diseases(IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRx ANSITION Scale? at least once during the study period(2006-2015). We used the electronic medical record to extract participants' clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition readiness.RESULTS Our sample(n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRx ANSITION Scale? scores(P < 0.01). Many healthcare transition(HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management skills.CONCLUSION This is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions. | Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 6 | Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap显示文摘阴囊的扭转可以导致严肃的局部缺血,并且生存能力取决于扭转的持续时间和 ischemia-reperfusion 的效果。阴囊的解压缩和 tunica vaginalis 拍动应用程序技术被 Kutikov 等在 2008 介绍。我们试图在一个老鼠模型在阴囊的 microcirculation 和 hemorheological 参数上检验这个方法的影响。六只成年老鼠经历了双边的阴囊的探索。睾丸的 Intravaginal 扭转被 720 ° 创造;为 2 h 的双方上的旋转。在 detorsion 以后,正确睾丸经历了 tunica albuginea 切口和 tunica vaginalis 拍动申请。阴囊的 microcirculation 被监视, hematological 参数,红血球 deformability,和聚集是坚定的。大小在扭转前后被执行,直接在 detorsion 以后,在 1 st -2 nd 和 8 th 手术后的白天。在最后采样以后,睾丸被移开为组织学的考试决定他们的体积。microcirculatory 参数表明了睾丸之间的细微差别。睾丸与中间的地区相比提高了的左(nondecompressed ) 的顶端的地区(P <0.05 ) 。在 2 nd 和 8 th 白天,睾丸的 microcirculation 使正常化然而并非同等地。红血球聚集和 deformability 由 8 th 白天。睾丸经历了萎缩和上皮的坏死,但是减压的体积更低(1.07 ±0.08 对 1.25 ±0.31 ) 。组织学地,在上皮的损坏分数在之间没有重要差别减压并且 nondecompressed 睾丸。在结论, 2-h 局部缺血两个都在阴囊的 microcirculation,在体积的减小,在 hemorheological 参数的变化和严肃的上皮的坏死导致了改变在减压并且没有显著差别的 nondecompressed 睾丸。 | Tamas Jozsat Zoltan Klarik Ferenc Kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien Magdalena Fossum Norbert Nemeth | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 7 | 体育运动与活性氧对大脑的复杂作用显示文摘活性氧(ROS)在有氧代谢中以中度水平持续产生,有利于产生氧化还原信号,但数量较大时却能引起氧化损伤和神经退行性病变。由于大脑对ROS敏感度提高,在不同类型神经细胞中保持正常氧化还原状态尤为重要。过去10年的研究充分说明:有规律的运动对大脑功能产生有益影响,并对中风、老年痴呆和帕金森症的预防和治疗起重要作用。然而,研究运动的具体影响似乎又非常复杂,包括通过神经营养因子的神经发生、毛细血管化增加、氧化损伤减少,以及通过蛋白酶和脑啡肽酶的蛋白降解增加。来自我们及其他实验室的数据表明,运动诱导的ROS水平调节对蛋白含量以及脑源性神经营养因子(BDNF)、酪氨酸激酶B(TrkB)、cAMP反应元件结合蛋白(CREB)的表达有重要作用,有利于完善脑功能、增加神经生成。因此,运动诱导的氧化还原状态调节是一种重要方式,运动能通过这一方式造福于大脑功能、增强对氧化应激的抵抗力,协助从氧化应激中恢复、减弱年龄相关的认知能力下降。 | Zsolt Radak Orsolya Marton Eniko Nagy Erika Koltai Sataro Goto | 2013 | Journal of Sport and Health Science2013，2，2： | 2 |
| 8 | Characterization of polypyrrole silver nanocomposites prepared in the presence of different dopants显示文摘 | ENIKO P RITA P TAMAS F | 2005 | J Phys Chem B2005，109，17： | 1 |
| 9 | Pretreatment of corn stover using wet oxidation to enhance enzymatic digestibility 显示文摘 | ENIKO V ANETTE S SCHMIDT K R | 2003 | Applied Biochemistry and Biotechnology2003，104，： | 1 |
| 10 | Evaluation of interfacial interaction in polypropylene/surface treated CaCO3 composites 显示文摘 | Demjén Zoltán Pukanszky Béla Foldes Eniko | 1998 | Composites Part A:Applied Science and Manufacturing1998，29，3： | 1 |
| 11 | Pathological correlates of poststroke depression in elderly patients 显示文摘 | Bozikas VP Gabriel G Eniko K | 2005 | Am J Geriatr Psychiatry2005，13，2： | 1 |
| 12 | The neuroanatomical model of post-stroke depression: Towards a change of focus? 显示文摘 | Mieaela Santos Eniko Kovari Gabriel Gold | 2009 | J Neurol Sci2009，283，12： | 1 |
| 13 | High Solid Simultaneous Saccharification and Fermentation of Wet Oxidized Corn Stover to Ethanol 显示文摘 | Eniko Varga Helene B Klinke Kati Reczey | 2004 | Biotechnol &Bioengin2004，88，5： | 1 |
| 14 | Microstructure and electrical transport properties of pulse-plated nano-crystalline nickel electrodeposits显示文摘 | Eniko toth-Kadar Imre Bakonyi Lajos Pogany | 1997 | Surface and Coatings Technology1997，，88： | 1 |
| 15 | Possible coupling reactions of functional silanes and polypropylene显示文摘 | Demjén Zoltan Pukanszky Béla Foldes Eniko | 1999 | Polymer1999，4，7： | 1 |
| 16 | The treatment of non-palpable breast tumors found during mammographic screening at our hospital显示文摘 | Henrietta B Eva S Eniko N | 2005 | Magy Seb2005，58，3： | 1 |
| 17 | Neuroprotective effects of L-camitine in a transgenic animal model of Huntington's disease 显示文摘 | ENIKO V KRISZTINA V LASZLO V | 2010 | Biomed Pharrnacother2010，64，4： | 1 |
| 18 | High solid simultaneous saccharification and fermentation of wet oxidized corn straw to ethanol显示文摘 | Eniko Varga Helene B Klinke Kati R e ciey | 2004 | Biotechnology and Bioengineering2004，88，5： | 1 |
| 19 | Micro RNA profile before and after antiviral therapy in liver transplant recipients for hepatitis C virus cirrhosis显示文摘 | Fanni Gelley Gergely Zadori Balazs Nemes Matteo Fassan Gabor Lendvai Eniko Sarvary Attila Doros Zsuzsanna Gerlei Peter Nagy Zsuzsa Schaff Andras Kiss | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 20 | Pretreatment of corn stover using wet oxidation to enhance enzymatic digestibility 显示文摘 | Eniko Varga | 2003 | Applied biochemistry and biotechnology2003，，104： | 1 |
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