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| 1 | Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation显示文摘精索静脉曲张与减少的男繁殖潜力被联系了。与在 biomolecular 技术的进展,更好理解涉及精索静脉曲张挑起的阴囊的损坏的机制是可能的。尽管机制充分还没被描述了,它是可能的是 multifactorial,当前的证据在联系精索静脉曲张的男 subfertility 的致病建议反应的氧种类(ROS ) 和结果的氧化压力(OS ) 的中央角色。过多的 ROS 与精子 DNA 破碎被联系,它可以调停与精索静脉曲张有关的差的精子功能和授精结果的临床的表明。ROS/OS 和 DNA 破碎测试有潜力与常规精液分析相比提供另外的诊断、预示的信息并且可以在单个病人指导治疗学的管理策略。 | Chak-Lam Cho Sandro C Esteves Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 30 |
| 2 | Outcome of varicocele repair in men with nonobstructive azoospermia: systematic review and meta-analysis显示文摘这全身的评论的目的是评估与 nonobstructive 精子缺乏(NOA ) 在不肥沃的人修理临床的精索静脉曲张的利益。通过手术获得的精子检索率(SRR ) 和与检索阴囊的精子的使用跟随帮助繁殖技术(艺术) 的怀孕率是主要结果。第二等的结果在手术后的精液包括了可行精子的存在避免阴囊的精子检索和怀孕率(帮助并且无助) 用手术后的呼喊的精子。收集数据的电子搜索用 MEDLINE 和 EMBASE 数据库被执行直到 2015 年 4 月。十八研究在这系统的评论被包括并且说明了与 NOA 和精索静脉曲张被诊断的 468 个病人。这些病人受到也外科的精索静脉曲张修理或经皮的 embolization。评估精子检索结果的三控制研究显示在经历了 varicocelectomy 的病人,没有精索静脉曲张修理, SRR 与那些相比增加了(或:2.65;95% CI:1.69-4.14;P <0.001 ) 。尽管有阴囊的精子的使用的怀孕率赞成了 varicocelectomy 组,结果不是统计上重要的(临床的怀孕率或:2.07;95% CI:0.92-4.65;P = 0.08;实时出生率或:2.19;95% CI:0.99-4.83;P = 0.05 ) 。留下十五研究报导手术后的精液分析结果。在 43.9% 病人(变化:20.8%-55.0%) ,精子在手术后的精液被发现。怀孕率为无助、帮助(在 IVF/ICSI 以后) 分别地在有在手术后的精液的精子的人的组是 13.6% 和 18.9% 。我们的调查结果显示在有 NOA 和临床的精索静脉曲张的病人的 varicocelectomy 与改进 SRR 被联系。另外,约 44% 对待的人将有在精液的足够的精子避免精子检索。有手术后的呼喊的精子和收获阴囊的精子的怀孕结果上的有限数据预防关于在对待的个人的可能的增加的富饶潜力的任何坚挺的结论。在结论,我们的学习的结果显示有 NOA 和临床的精索静脉曲张的不肥沃的人得益于 varicocelectomy。给可得到的证据的低 / 中等的质量,医生们与精索静脉曲张的风险和好处修理的 NOA 与他们的病人讨论,是明智的。 | Sandro C Esteves Ricardo Miyaoka Matheus Roque Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 21 |
| 3 | Outcome of assisted reproductive technology in met with treated and untreated varicocele, systematic review and meta-analysis显示文摘 | Sandro C Esteves Matheus Roque Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 19 |
| 4 | Clinical management of infertile men with nonobstructive azoospermia显示文摘有寻求富饶的 nonobstructive 精子缺乏(NOA ) 的人的临床的管理同样地是为 andrologists,泌尿科医师,和繁殖的药专家的挑战。这评论在 NOA 的临床的管理上介绍一个个人观点,包括在处理这个男不孕条件的 15 年接受的教训。一个 five-consecutive-step 算法被建议管理如此的病人。首先,精子缺乏的微分诊断被做证实 / 建立 NOA 由于 spermatogenic 失败。第二,基因测试被执行不仅检测 NOA 被 Y 染色体的长手臂的 microdeletions 引起谁的男性,而且关于他们在精子检索有成功的机会建议影响病人。第三,在一次外科的检索尝试以前的任何干预是否可以被用来增加精子,被决定生产。第四,最有效、有效的检索方法被选择寻找阴囊的精子。最后, state-of-art 实验室技术在处理检索配偶子并且栽培源于精子注射的胚胎被使用。一个协调多学科的努力是关键的为最好提供与 NOA 完成一个生物后代到男性的可能的机会。 | Sandro C Esteves | 2015 | Asian Journal of Andrology2015，17，3： | 16 |
| 5 | Summary evidence on the effects of varicocele treatment to improve natural fertility in subfertile men显示文摘这评论的目的是有关精索静脉曲张处理的利益总结证据在 subfertile 男性改进自然富饶。我们也在常规精液参数和精子上分析了精索静脉曲张处理的效果功能的测试。收集数据的电子搜索用 PubMed/MEDLINE 数据库被执行直到 2015 年 7 月。从许多学习图案分享的数据显示 varicocelectomy 不管选择外科的方法与临床的精索静脉曲张和反常精液参数在对待的人的多数改进精液参数。外科的精索静脉曲张修理不仅为减轻氧化联系压力的不孕而且到是有益的改进精子原子 DNA 完整。然而,在精子 DNA 完整给效果尺寸的低大小,进一步的研究被需要阐明它的临床的意义。自然生育力上的精索静脉曲张治疗的效果上的冲突结果似乎由于异构的学习图案并且,更重要地,耐心的选择标准。当这些问题被控制时,当前的证据显示无临床症状的精索静脉曲张的治疗没被保证,当它不似乎改进富饶。相反,公平证据显示精索静脉曲张治疗应该与摸得出的精索静脉曲张和反常精液参数被提供给不肥沃的病人。这条证据支持美国 Urological 协会和泌尿学的欧洲协会发出的当前的指南,它声明精索静脉曲张治疗应该被提供给与临床的精索静脉曲张和精液参数改变为评估介绍的不肥沃的夫妇的男搭挡。 | Bruno C Tiseo Sandro C Esteves Marcello S Cocuzza | 2016 | Asian Journal of Andrology2016，18，2： | 16 |
| 6 | Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor显示文摘AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPI), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. RESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPI (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPI were shown to be significantly higher (P<0.001) in the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSION: In patients with HCC treated with TACE, CT-p provides measurement of flow parameters related to residual arterial structures in viable tumor, thus helping in the assessment of therapeutic response. | Davide Ippolito Pietro Andrea Bonaff ini Laura Ratti Laura Antolini Rocco Corso Ferruccio Fazio Sandro Sironi | 2010 | World Journal of Gastroenterology2010，16，47： | 15 |
| 7 | 垃圾堆肥中重金属离子研究显示文摘通过跟踪1个快速垃圾堆肥处理过程,分析了该过程中总重金属离子浓度变化,并用连续萃取法分析了可被植物吸收和利用的金属离子浓度在垃圾堆肥处理中的变化情况.结果证明,通过垃圾堆肥过程,不可能降低重金属离子的含量。 | 蒋晓惠 Baffi Claudio Sandro Silva | 1999 | 四川师范学院学报(自然科学版)1999，20，1： | 15 |
| 8 | Colchicine reduces procollagen Ⅲ and increases pseudocholinesterase in chronic liver disease显示文摘AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the study.The patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and ascites.Patients were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory evaluation.RESULTS:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in controls.Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.CONCLUSION:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis. | Sergio Muntoni Marcos Rojkind Sandro Muntoni | 2010 | World Journal of Gastroenterology2010，16，23： | 14 |
| 9 | Caustic injury of the upper gastrointestinal tract: A comprehensive review显示文摘Prevention has a paramount role in reducing the incidence of corrosive ingestion especially in children, yet this goal is far from being reached in developing countries, where such injuries are largely unreported and their true prevalence simply cannot be extrapolated from random articles or personal experience. The specific pathophysiologic mechanisms are becoming better understood and may have a role in the future management and prevention of long-term consequences, such as esophageal strictures. Whereas the mainstay of diagnosis is considered upper gastrointestinal endoscopy, computed tomography and ultrasound are gaining a more significant role, especially in addressing the need for emergency surgery, whose morbidity and mortality remains high even in the best hands. The need to perform emergency surgery has a persistent long-term negative impact both on survival and functional outcome. Medical or endoscopic prevention of stricture is debatable, yet esophageal stents, absorbable or not, show promising data. Dilatation is the first therapeutic option for strictures and bougies should be considered especially for long, multiple and tortuous narrowing. It is crucial to avoid malnutrition, especially in developingcountries where management strategies are influenced by malnutrition and poor clinical conditions. Late reconstructive surgery, mainly using colon transposition, offers the best results in referral centers, either in children or adults, but such a difficult surgical procedure is often unavailable in developing countries. Possible late development of esophageal cancer, though probably overemphasized, entails careful and long-term endoscopic screening. | Sandro Contini Carmelo Scarpignato | 2013 | World Journal of Gastroenterology2013，19，25： | 13 |
| 10 | Varicocele and male infertility: current concepts and Future perspectives显示文摘Andrology 的亚洲杂志的这期特刊充分被奉献给精索静脉曲张的题目的区域,它是泌尿学, Andrology,和繁殖的药的地里的最争论的期之一。作为一个临床的实体认出了为在一个世纪,从拉丁文的精索静脉曲张:静脉曲张(扩大静脉) 并且从希腊语:kele (肿瘤) 仍然在男富饶和 gonadal 功能上在可争辩的否定效果上在科学家和临床医生之中得到激烈的争论并且自从它的第一在 18 th 世纪。 | Ashok Agarwal Sandro C Esteves | 2016 | Asian Journal of Andrology2016，18，2： | 13 |
| 11 | Effect of varicocele on semen characteristics according to the new 2010 World Health Organization criteria: a systematic review and meta-analysis显示文摘这研究在不肥沃的人在精液参数上调查了精索静脉曲张的效果基于新人的精液的考试的 2010 世界健康组织实验室手册。精液分析结果(体积,精子计数,活动性,和形态学) 是主要结果。收集数据的电子搜索用 Medline/PubMed 被进行, SJU 发现,并且 Google 学者数据库。我们寻找了从 2010 出版到 2015 年 8 月的文章,即,在出版以后 2010 用手。我们包括了仅仅报导成年的不肥沃的人的实际精液参数与临床的精索静脉曲张诊断了并且包含了没与精索静脉曲张被诊断的肥沃的人或 normozoospermic 人的一个控制组的那些研究。十研究在元分析被包括,包含 1232 个人。精索静脉曲张与减少的精子计数被联系(吝啬的差别:− 44.48 ×10 6 ml −1 ;95% CI:− 61.45, − 27.51 ×10 6 ml −1 ;P <0.001 ) ,活动性(吝啬的差别:− 26.67% ;95% CI:− 34.27, − 19.08;P <0.001 ) ,并且形态学(吝啬的差别:− 19.68% ;95% CI:− 29.28, − 10.07;P <0.001 ) 然而并非精液体积(吝啬的差别:− 0.23 ml;95% CI:− 0.64, 0.17 ) 。亚群分析显示效果的大小被控制子类型影响然而并非实验室手册编辑为精液评价使用了。我们断定那精索静脉曲张是否定地在精液参数上影响精液质量,而是观察分享的效果尺寸的一个重要风险因素不似乎被 WHO 实验室手册编辑影响。在 2010 仍然为精液分析利用了 1999 手册以后,出版的研究的给定的大多数,进一步的研究被要求充分理解临床的含意 2010 在精索静脉曲张和精液参数之间的协会上的实验室手册。 | Ashok Agarwal Reecha Sharma Avi Harle Sandro C Esteves | 2016 | Asian Journal of Andrology2016，18，2： | 13 |
| 12 | Pre-illness changes in dietary habits and diet as a risk factor for inflammatory bowel disease: A case-control study显示文摘AIM: To evaluate whether symptoms of inflammatory bowel disease (IBD), before diagnosis modify dietary habits, and to investigate the pre-illness diet in patients with recent IBD in comparison with an age-matched healthy control group. METHODS: Overall, 83 new cases of IBD (41 ulcerative colitis, 42 Crohn's disease) and 160 healthy controls were studied. Portions per week of 34 foods and beverages before onset of symptoms were recorded using a validated questionnaire. Duration of symptoms before IBD diagnosis, presence of specific symptoms and their impact on subjective changes in usual dietary habits were also recorded. The association between diet and IBD was investigated by multiple logistic regression and dietary patterns were assessed by factor analysis. RESULTS: Changes in dietary habits, due to the presence of symptoms, were reported by 38.6% of patients and were not significantly related to specific symptoms, rather to long duration of symptoms, only in Crohn's disease patients. In IBD patients who did not change dietary habits, moderate and high consumption of margarine (OR = 11.8 and OR = 21.37) was associated with ulcerative colitis, whilst high consumption of red meat (OR = 7.8) and high intake of cheese were associated with Crohn's disease. CONCLUSION: More than one third of IBD patients change dietary habits before diagnosis. Margarine, red meat and cheese increase the risk of ulcerative colitis and Crohn's disease. | Giovanni Maconi Sandro Ardizzone Claudia Cucino Cristina Bezzio Antonio Giampiero Russo Gabriele Bianchi Porro | 2010 | World Journal of Gastroenterology2010，16，34： | 10 |
| 13 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 14 | Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility显示文摘我们估计了精子检索和 intracytoplasmic 精子注射结果的率,包括构思的婴儿的新生的侧面,在有阴囊的失败的人。三 -- 经历了微解剖的阴囊的精子抽取的有阴囊的失败的 165 个人在这研究被包括。我们把他们的结果与 40 作比较为注射使用了施主精子由于的有阴囊的失败的人与妨碍的精子缺乏没有通过检索,和 146 个人经历了经皮的精子检索。在阴囊的失败的检索率是 41.4% ,并且结果比妨碍的精子缺乏低(100% ;调整机会比率:0.033;95% CI:0.007-0.164;P <0.001 ) 。在精子注射以后的实时出生率与施主精子相比在有阴囊的失败(19.9%) 的人是更低的(37.5% ;调整或:0.377 (95% CI:0.233-0.609, P <0.001 )) 并且妨碍的精子缺乏(34.2% ;调整或:0.403 (95% CI:0.241-0.676, P = 0.001 ) 。构思的婴儿的新生的参数不在这些组之中是显著地不同的。我们断定在检索上获得精子并且在 intracytoplasmic 精子注射(ICSI ) 以后完成实时出生的机会与阴囊的失败在人被减少。在精子注射不似乎被阴囊的失败否定地影响以后,婴儿的侧面怀孕了。 | Sandro C Esteves Christina Prudencio Bill Seol Sidney Verza jr Christopher Knoedler Ashok Agarwal | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 15 | 酒精对男性生殖功能有何影响?一个文献综述显示文摘酒精被广泛使用,而其对男性生殖功能的影响仍然存在争议。多年来,已经有许多研究调查了酒精对精子参数男性不育症的影响。本文综述了主要的临床前和临床证据。对实验动物进行的研究已经表明,富含乙醇的饮食会导致精子参数异常,导致很多改变,包括抑制生殖道,降低小鼠卵母细胞体外受精率。这些影响在停止酒精消费后是部分可逆的。大多数研究显示酒精对男性参数呈现负面影响。这已被报道与低睾酮症和低于正常和升高的促性腺激素水平有关,暗示着一个联合中枢的、酒精产生的睾丸损害效应。然而,饮洒似乎并没有对生育有太大的影响,无论是在体外授精过程中还是在基于人口的研究中。最后,遗传背景和其他因素,饮酒相关情况会影响睾丸损害的程度。总之,饮酒与精子参数的恶化有关,且这种恶化在停止饮酒后部分可逆。 | Sandro La Vignera Rosita A Condorelli Giancarlo Balercia Enzo Vicari Aldo E Calogero | 2013 | Asian Journal of Andrology2013，15，2： | 9 |
| 16 | A systematic review of clinical practice guidelines and best practice statements for the diagnosis and management of varicocele in children and adolescents显示文摘系统的评论被进行识别并且象临床的实践指南(CPG ) 和最好的建议一样的方法练习的品质上分析有关在小儿科、青春期的人口的精索静脉曲张的陈述(位/秒) 。电子搜索与 MEDLINE 被执行, EMBASE,科学直接,并且 Scielo 数据库,以及 guidelines’网络站点直到 2015 年 9 月。四个指南在质的合成被包括。一般来说,尽管有一些差距的存在, CPG/BPS 提供的建议是一致的。繁殖的药(ASRM ) 的美国 Urological 协会(AUA ) 和美国社会发出的指南没为给的建议提供基于证据的层次。大多数泌尿学(香水) 和小儿科的泌尿学(ESPU ) 的欧洲社会的欧洲协会给的建议从 nonrandomized 被导出临床的试用,回顾的研究,和专家意见。在所有 CPG/BPS 之中,仅仅明确地为小儿科的人口被设计。学习指南没承担独立划算和风险利益分析。这些指南的主要目的是把最好的证据翻译成实践并且当维持临床的自治和医生判断时,提供标准化照顾的一个框架。然而,在孩子和青少年为精索静脉曲张的诊断和管理在 CPG/BPS 识别的限制在耐心的照顾为研究和高质量的标准的未来加入显示宽大的机会。 | Matheus Roque Sandro C Esteves | 2016 | Asian Journal of Andrology2016，18，2： | 9 |
| 17 | Current status and perspectives in split liver transplantation显示文摘Growing experience with the liver splitting technique and favorable results equivalent to those of whole liver transplant have led to wider application of split liver transplantation(SLT) for adult and pediatric recipients in the last decade. Conversely, SLT for two adult recipients remains a challenging surgical procedure and outcomes have yet to improve. Differences in organ shortages together with religious and ethical issues related to cadaveric organ donation have had an impact on the worldwide distribution of SLT. Despite technical refinements and a better understanding of the complex liver anatomy, SLT remains a technically and logistically demanding surgical procedure. This article reviews the surgical and clinical advances in this field of liver transplantation focusing on the role of SLT and the issues that may lead a further expansion of this complex surgical procedure. | Andrea Lauterio Stefano Di Sandro Giacomo Concone Riccardo De Carlis Alessandro Giacomoni Luciano De Carlis | 2015 | World Journal of Gastroenterology2015，21，39： | 8 |
| 18 | Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control显示文摘这研究的目的是与糖尿病 mellitus (DM ) 和糖尿病的神经病(DN ) 评估不肥沃的病人的精囊(SV ) 的超声特征并且在与 glycaemic 控制有关的超声特征调查可能的变化。完成这,有类型 2 DM 的 45 个不肥沃的病人和征兆的 DN 被选择。有没有 DM 的自发的 oligoasthenoteratozoospermia 的二十个健康的肥沃的人和 20 个病人代表了控制组。DM 病人任意地根据 glycaemic 控制水平被划分成三个组(A=glycosylated 血色素 < 7 %在 7 % 之间的 B=glycosylated 血色素;并且 10 %C=glycosylated 血色素 > 10 %) 。病人们经历了前列腺小囊的 transrectal ultrasonography 和精子分析。下列 SV 超声参数被记录:(i) 身体 antero 以后的直径(APD ) ;(ii ) 宫底 APD;(iii ) 正确、左的 SV 的顶骨厚度;并且(iv ) 在两 SV 以内的多不的区域的数字。我们然后计算了下列参数:(i) 宫底 / 身体(F/B ) 比率;(ii ) 在权利和左 SV 之间的顶骨厚度的差别;并且(iii )pre 射精并且 ejaculatory 以后 APD 差别。所有 DM 病人与控制相比有更高的 F/B 比率(P< 0.05 ) 。组 C 与另外的 DM 组相比有更高的 F/B 比率(P< 0.05 ) 。有的所有 DM 病人一更低 pre 射精并且与控制相比的身体 SV APD 的 ejaculatory 以后差别(P< 0.05 ) 。组 A 和 B 有一类似 pre 射精并且身体 SV APD 的 ejaculatory 以后差别,而这差别在组 C 是更低的(P< 0.05 ) 。在结论,有 DN 的不肥沃的 DM 病人显示出功能的弛缓暗示的古怪 SV 超声特征,并且低 glycaemic 控制与这些特征的更大的表示被联系。 | Sandro La Vignera Rosita A Condorelli Enzo Vicari Rosario D'Agata Aldo E Calogero | 2011 | Asian Journal of Andrology2011，13，6： | 8 |
| 19 | Afterword to varicocele and male infertility: curreni concepts and future perspectives显示文摘我们总结并且评论贡献者讨论到 Andrology 的亚洲杂志的这期特刊的话题。精索静脉曲张的范围盖住一个宽系列,包括 proteomics 和 metabolomics,神经质的控制, interventional 治疗,和帮助繁殖技术(艺术) 。话题的选择证明这个题目的区域和机会研究的令人激动的宽度为两个都增加理解并且与精索静脉曲张改进男性的繁殖健康成立。 | Sandro C Esteves Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 8 |
| 20 | Rectal cancer staging: Multidetector-row computed tomography diagnostic accuracy in assessment of mesorectal fascia invasion显示文摘AIM: To assess the diagnostic accuracy of multidetectorrow computed tomography(MDCT) as compared with conventional magnetic resonance imaging(MRI), in identifying mesorectal fascia(MRF) invasion in rectal cancer patients.METHODS: Ninety-one patients with biopsy proven rectal adenocarcinoma referred for thoracic and abdominal CT staging were enrolled in this study. The contrast-enhanced MDCT scans were performed on a 256 row scanner(ICT, Philips) with the following acquisition parameters: tube voltage 120 KV, tube current 150-300 m As. Imaging data were reviewed as axial and as multiplanar reconstructions(MPRs) images along the rectal tumor axis. MRI study, performed on 1.5 T with dedicated phased array multicoil, included multiplanar T2 and axial T1 sequences and diffusion weighted images(DWI). Axial and MPR CT images independently were compared to MRI and MRF involvement was determined. Diagnostic accuracy of both modalities was compared and statistically analyzed.RESULTS: According to MRI, the MRF was involved in 51 patients and not involved in 40 patients. DWI allowed to recognize the tumor as a focal mass with high signal intensity on high b-value images, compared with the signal of the normal adjacent rectal wall or with the lower tissue signal intensity background. The number of patients correctly staged by the native axial CT images was 71 out of 91(41 with involved MRF; 30 with not involved MRF), while by using the MPR 80 patients were correctly staged(45 with involved MRF; 35 with not involved MRF). Local tumor staging suggested by MDCT agreed with those of MRI, obtaining for CT axial images sensitivity and specificity of 80.4% and 75%, positive predictive value(PPV) 80.4%, negative predictive value(NPV) 75% and accuracy 78%; while performing MPR the sensitivity and specificity increased to 88% and 87.5%, PPV was 90%, NPV 85.36% and accuracy 88%. MPR images showed higher diagnostic accuracy, in terms of MRF involvement, than native axial images, as compared to the reference magnetic resonance images. The difference in accuracy was statistically significant(P = 0.02). CONCLUSION: New generation CT scanner, using high resolution MPR images, represents a reliable diagnostic tool in assessment of loco-regional and whole body staging of advanced rectal cancer, especially in patients with MRI contraindications. | Davide Ippolito Silvia Girolama Drago Cammillo Talei Franzesi Davide Fior Sandro Sironi | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
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