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| 1 | Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review显示文摘AIM To summarise the literature data on hepatitis C virus(HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk.METHODS We conducted a PubM ed search and selected all studies found with the key words 'HCV' or 'hepatitis C virus' and 'diabetes' or 'insulin resistance'. We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HCV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma(HCC)]. RESULTS HCV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of HCC development. As new antiviral therapies may offer a cure for HCV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HCV disease. The efficacy of antidiabetic treatment in improving the response toantiviral treatment and in decreasing the risk of HCC has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further studies.CONCLUSION Glucose abnormalities are strongly associated with HCV infection and show a negative impact on the main liver related outcomes. | Anne-Claire Desbois Patrice Cacoub | 2017 | World Journal of Gastroenterology2017，23，9： | 14 |
| 2 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 3 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 4 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 5 | Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis显示文摘 | Benjamin Terrier Fabrice Carrat Guillaume Geri Stanislas Pol Lionel Piroth Philippe Halfon Thierry Poynard Jean-Claude Souberbielle Patrice Cacoub | 2011 | Journal of Hepatology2011，，4： | 2 |
| 6 | Manifestations of Chronic Hepatitis C Virus Infection Beyond the Liver显示文摘 | Ira M. Jacobson Patrice Cacoub Luigino Dal Maso Stephen A. Harrison Zobair M. Younossi | 2010 | Clinical Gastroenterology and Hepatology2010，，12： | 2 |
| 7 | Extrahepatic manifestations of chronic hepatitis C virus infection显示文摘 | Patrice Cacoub Laura Gragnani Cloe Comarmond Anna Linda Zignego | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 8 | Neurological complications ofprimary Sjogren's syndrome显示文摘 | Lafitte C Amoura Z Cacoub P | 2001 | J Neurol2001，248，7： | 1 |
| 9 | Pacemaker infective endo- carditis 显示文摘 | Cacoub P Leprince P Nataf P | 1998 | Am J Cardiol1998，82，： | 1 |
| 10 | Amyloidosis and cardiac involvement 显示文摘 | CACOUB P AXLER O DE ZUTTERE D | 2000 | Ann Med Interne2000，151，： | 1 |
| 11 | Leiomyosarcoma of the inferior vena cava esperience with 7 patients and literature review显示文摘 | Cacoub P Piette JC Wechsler B | 1991 | Medicine1991，70，5： | 1 |
| 12 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Cacoub P Saadoun D Bourliere M | 2005 | J Hepatol2005，43，5： | 1 |
| 13 | Neurological complica- tions of primary Sjogren's syndrome 显示文摘 | Lafitte C Amoura Z Cacoub P | 2001 | J Neurol2001，248，： | 1 |
| 14 | Changes in Causes of Death Among Adults Infected by HIV Between 2000 and 2005: The “Mortalité 2000 and 2005” Surveys (ANRS EN19 and Mortavic)显示文摘 | Charlotte Lewden Thierry May Eric Rosenthal Christine Burty Fabrice Bonnet Dominique Costagliola Eric Jougla Caroline Semaille Philippe Morlat Dominique Salmon Patrice Cacoub Geneviève Chêne | 2008 | JAIDS Journal of Acquired Immune Deficiency Syndromes2008，，： | 1 |
| 15 | Hepatitis C virus genotypes and subtypes in patients with hepatitis C, with and without cryoglobulinemia显示文摘 | Lionel Frangeul Lucile Musset Pascale Cresta Patrice Cacoub Jean-Marie Huraux Fran?oise Lunel | 1996 | Journal of Hepatology1996，，4： | 1 |
| 16 | Pacemaker infective endocarditis显示文摘 | Cacoub P Leprince P Nataf P | 1998 | Am J Cardiol1998，82，4： | 1 |
| 17 | Antiphospholipid antibodies, antiphospholipid syndrome and infections显示文摘 | Sene D Piette JC Cacoub P | 2008 | Autoimmun Rev2008，7，4： | 1 |
| 18 | Cryoglobulinemia vasculities : an update显示文摘 | Terrier B Cacoub P | 2013 | Curr Opin Rheumato12013，25，1： | 1 |
| 19 | IFN-cl induces IL-10 production and tilt the balance between Thl and Thl7 in Beh~:et disease显示文摘 | Touzot M Cacoub P Bodaghi B | 2015 | Autoimnmn Rev2015，14，5： | 1 |
| 20 | Mixed cryoglobulinemia and hepatitis C virus显示文摘 | Cacoub P Fabiani F L Musset L | 1994 | Am J Med1994，96，： | 1 |
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