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| 1 | Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells显示文摘AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC.METHODS: BMSCs were obtained from patients under-going total hip arthroplasty and ADSC from human adi-pose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver develop-ment using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differ-entiation was RT-PCR-assessed and liver-marker genes were immunohistochemically analysed. RESULTS: BMSC and ADSC exhibited a fibroblastic mor-phology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thy1 de-creased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to in-creased liver-enriched transcription factors (C/EBPβ and HNF4α), as demonstrated by adenoviral expression vec-tors.CONCLUSION: Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation ca-pacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing. | Raquel Taléns-Visconti Ana Bonora Ramiro Jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José Gómez-Lechón | 2006 | World Journal of Gastroenterology2006，12，36： | 35 |
| 2 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes显示文摘 | Anna Zampetaki Stefan Kiechl Ignat Drozdov Peter Willeit Ursula Mayr Marianna Prokopi Agnes Mayr Siegfried Weger Friedrich Oberhollenzer Enzo Bonora Ajay Shah Johann Willeit Manuel Mayr | 2010 | Circulation Research2010，，6： | 3 |
| 3 | EIS study of organic coating on zinc surface pretreated with environmentally friendly products显示文摘 | F. Deflorian S. Rossi L. Fedrizzi P.L. Bonora | 2004 | Progress in Organic Coatings2004，，4： | 2 |
| 4 | Design of a kJ-class HiLASE laser as a driver for inertial fusion energy显示文摘We present the results of performance modeling of a diode-pumped solid-state HiLASE laser designed for use in inertial fusion energy power plants. The main amplifier concept is based on a He-gas-cooled multi-slab architecture similar to that employed in Mercury laser system. Our modeling quantifies the reduction of thermally induced phase aberrations and average depolarization in Yb3+:YAG slabs by a combination of helium cryogenic cooling and properly designed(doping/width) cladding materials. | Antonio Lucianetti Magdalena Sawicka Ondrej Slezak Martin Divoky Jan Pilar Venkatesan Jambunathan Stefano Bonora Roman Antipenkov Tomas Mocek | 2014 | High Power Laser Science and Engineering2014，2，2： | 2 |
| 5 | Design of deformable mirrors for high power lasers显示文摘We present the workflow of the design, realization and testing of deformable mirrors suitable for high power diode pumped solid-state lasers. It starts with the study of the aberration to be corrected, and then it continues with the design of the actuators position and characteristic. In this paper, we present and compare three deformable mirrors realized for multi-J level laser facilities. We show that with the same design concept it is possible to realize deformable mirrors for other types of lasers. As an example, we report the realization of a deformable mirror for femtosecond lasers and for a CW CO_2 laser. | Stefano Bonora Jan Pilar Antonio Lucianetti Tomas Mocek | 2016 | High Power Laser Science and Engineering2016，4，2： | 2 |
| 6 | Prevalence of insulin resistance in metabolic disorders: the Bruneck Study显示文摘 | Bonora E Kiechl S Willeit J | 1998 | Diabetes1998，47，10： | 2 |
| 7 | Preparation and investigation of nanostructured SiC-nickel layers by electrodeposition显示文摘 | Benea L Bonora P L Borello A | 2002 | Solid State Ionics2002，151，： | 2 |
| 8 | Corrosion behaviour of stressed magnesium alloys显示文摘 | BONORA L ANDREI M EIEZER A | 2002 | Corrosion Science2002，44，4： | 1 |
| 9 | The metabolic syndrome and cardiovascular disease 显示文摘 | Bonora E | 2006 | Ann Mad2006，38，1： | 1 |
| 10 | Mechanical and anticorrosive properties of copper matrix micro- and nano-composite coatings 显示文摘 | LEKKA M KOUMOULiS D KOULOUMBI N BONORA P L | 2009 | Electrochemica Acta2009，54，： | 1 |
| 11 | The Chronic Kidney Disease Epidemiology Collaboration ( CKD- EPI ) e- quation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease( MDRD)Study formula in subjects with type 2 dia- betes显示文摘 | PUGLIESE G SOLINI A BONORA E | 2011 | Atherosclerosis2011，218，1： | 1 |
| 12 | p53 at the endo- plasmie reticulum regulates apoptosis in a Ca^2+ -dependent manner显示文摘 | Giorgi C Bonora M Sorrentino G | 2015 | Proc Natl Acad Sci U S A2015，112，6： | 1 |
| 13 | Corrosion behaviour of fluotitanate pretreated and painted alurrdnium sheets显示文摘 | Fedrizzi L Deflorian F Bonora P L | 1997 | Eleetrochimica Acta1997，42，6： | 1 |
| 14 | Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM 显示文摘 | BONNADONA R C PRATD S D BONORA E | 1996 | Diabetes1996，45，7： | 1 |
| 15 | Human mesenchymal stem cells from adipose tissue: differentiation into hepatic lineage显示文摘 | R TALENS - VISCONTI A BONORA R JOVER | 2007 | Toxicol In Vitro2007，21，： | 1 |
| 16 | Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease显示文摘 | Targher G Day CP Bonora E | 2010 | N Engl J Med2010，363，： | 1 |
| 17 | Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients:the Verona Diabetes Study显示文摘 | Muggeo M Zoppini G Bonora E | 2000 | Diabetes Care2000，23，1： | 1 |
| 18 | Homeostasis model assess- ment closely mirrors the glucose clamp technique in the assessment of in- sulin sensitivity : studies in subjects with various degrees of glucose toler- ance and insulin sensitivity 显示文摘 | Bonora E Targher G Alberiche M | 2000 | Diabetes Care2000，23，： | 1 |
| 19 | Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity显示文摘 | Bonora E Targher G Alberiche M | 2000 | Diabetes Care2000，23，1： | 1 |
| 20 | Plasma glucose levels throughout the day and HbA1C interrelationships in type 2 diabetes:implications for treatment and monitoring of metabolic control显示文摘 | Bonora E Calcaterra F Lombardi S | 2001 | Diabetes Care2001，24，12： | 1 |
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