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| 1 | Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications显示文摘Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics. | Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh | 2014 | World Journal of Orthopedics2014，5，4： | 17 |
| 2 | Presepsin teardown- pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis显示文摘AIM To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein(CRP) and procalcitonin(PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality.RESULTS Present 34.7 of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without(median, 1002 pg/m L vs 477 pg/m L, P < 0.001), increasing with the severity of infection [organ failure(OF): Yes vs No, 2358 pg/m L vs 710 pg/m L, P < 0.001]. Diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP(AUC-ROC: 0.85, 0.85 and 0.66, respectively, P = NS for presepsin vs PCT and P < 0.01 for presepsin vs CRP). At the optimal cut-off value of presepsin > 1206 pg/m L sensitivity, specificity, positive predictive values and negative predictive values were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-d mortality rate was higher among patients with > 1277 pg/m L compared to those with ≤ 1277 pg/m L(46.9% vs 11.6%, P < 0.001). In a binary logistic regression analysis, however, only PCT(OR = 1.81, 95%CI: 1.09-3.01, P = 0.022) but neither presepsin nor CRP were independent risk factor for 28-d mortality after adjusting with MELD score and leukocyte count.CONCLUSION Presepsin is a valuable new biomarker for defining severe infections in cirrhosis, proving same efficacy as PCT. However, it is not a useful marker of short-term mortality. | Maria Papp Tamas Tornai Zsuzsanna Vitalis Istvan Tornai David Tornai Tamas Dinya Andrea Sumegi Peter Antal-Szalmas | 2016 | World Journal of Gastroenterology2016，22，41： | 9 |
| 3 | Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility显示文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals.Genetic markers are associated with disease phenotype and long-term evolution,but their value in everyday clinical practice is limited at the moment.IBD has a clear immunological background and interleukins play key role in the process.Almost130 original papers were revised including meta-analysis.It is clear these data are very important for understanding the base of the disease,especially in terms of clinical utility and validity,but text often do not available for the doctors use these in the clinical practice nowadays.We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD,performing an electronic search of PubMed Database from publications of the last 10 years,and used the following medical subject heading terms and/or text words:IBD,CD,UC,interleukins and polymorphisms. | Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy Katalin Sumegi Bela Melegh | 2014 | World Journal of Gastroenterology2014，20，12： | 8 |
| 4 | Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis显示文摘 | Eniko Safrany Melinda Szabo Marta Szell Lajos Kemeny Katalin Sumegi Bela I. Melegh Lili Magyari Petra Matyas Maria Figler Agnes Weber Zsolt Tulassay Bela Melegh | 2013 | Inflammation Research2013，，2： | 3 |
| 5 | Correlation of mutations of the SH2D1A gene and Epstein-Barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease 显示文摘 | Sumegi J Huang D Lanyi A et d | 2000 | Blood2000，96，9： | 1 |
| 6 | Isolation and sequence analysis of a eDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot - Leyden Crystal protein 显示文摘 | Than NG Sumegi B Than GN | 1999 | Placenta1999，20，： | 1 |
| 7 | 26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster显示文摘 | Sumegi M Hunyadi-Gulyas E Medzihradszky KF | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 8 | Correlation of mutations of the SH2D1A gene and epstein-barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease显示文摘 | Sumegi J Huang D Lanyi A | 2000 | Blood2000，96，9： | 1 |
| 9 | Analysis of components of the CD14/TLR system on leukocytes of patients with atopic dermatitis显示文摘 | Sumegi A Szegedi A Gal M | 2007 | Int Arch Allergy Immunol2007，143，3： | 1 |
| 10 | Identification of a Novel, Recurrent SLC44A1‐PRKCA Fusion in Papillary Glioneuronal Tumor显示文摘 | Julia A. Bridge Xiao‐qiong Liu Janos Sumegi Marilu Nelson Christine Reyes Leslie A. Bruch Marc Rosenblum Mark J. Puccioni Bradley S. Bowdino Rodney D. McComb | 2012 | Brain Pathology2012，，2： | 1 |
| 11 | Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma显示文摘 | Yasuda T Nishio J Sumegi J | 2009 | Mod Pathol2009，22，11： | 1 |
| 12 | Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma显示文摘 | Yasuda T Nishio J Sumegi J | 2009 | Mod Patho12009，22，11： | 1 |
| 13 | A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses显示文摘 | Sumegi J Seemayer TA Huang D | 2002 | Leuk Lymphoma2002，43，6： | 1 |
| 14 | The Relationship between Insurance and Economic Growth in Europe:A Theoreti- cal and Empirical Analysis 显示文摘 | Haiss Peter Sumegi Kjell | 2008 | Empirica2008，35，4： | 1 |
| 15 | Correlation of mutations of the SH2DI A gene and Epstein-Barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease 显示文摘 | Sumegi J Huang D Lanyi A | 2000 | Blood2000，96，9： | 1 |
| 16 | Does soil change cause vegetation change or viceversa? A temporal perspec- tive from Hungray显示文摘 | Willis K J Braun M Sumegi P | 1997 | Ecology1997，78，： | 1 |
| 17 | Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis显示文摘 | Sumegi J Barnes MG Nestheide SV | 2011 | Blood2011，117，15： | 1 |
| 18 | Mitochondria, oxidative stress and aging显示文摘 | Szarka A Banhegyi G Sumegi B | 2014 | Orv Hetil2014，155，12： | 1 |
| 19 | High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis显示文摘 | Maria Papp Nora Sipeki Zsuzsanna Vitalis Tamas Tornai Istvan Altorjay Istvan Tornai Miklos Udvardy Kai Fechner Silvia Jacobsen Bianca Teegen Andrea Sumegi Gabor Veres Peter Laszlo Lakatos Janos Kappelmayer Peter Antal-Szalmas | 2013 | Journal of Hepatology2013，，： | 1 |
| 20 | Lipid droplet and milk lipid globule membrane associated placental protein 17b ( PP17 b) is involved in apoptotie and differentiation processes of human epithelial cervical carcinoma cells显示文摘 | Than NG Sumegi B Bellyei S | 2003 | Eur J Biochem2003，270，6： | 1 |
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