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| 1 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 2 | Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction显示文摘 | Anna Zampetaki Peter Willeit Lindsey Tilling Ignat Drozdov Marianna Prokopi Jean-Marie Renard Agnes Mayr Siegfried Weger Georg Schett Ajay Shah Chantal M. Boulanger Johann Willeit Philip J. Chowienczyk Stefan Kiechl Manuel Mayr | 2012 | Journal of the American College of Cardiology2012，，： | 2 |
| 3 | Osteoprotegerin Is a Risk Factor for Progressive Atherosclerosis and Cardiovascular Disease显示文摘 | Stefan Kiechl Georg Schett Gregor Wenning Kurt Redlich Martin Oberhollenzer Agnes Mayr Peter Santer Josef Smolen Werner Poewe Johann Willeit | 2004 | Circulation: Journal of the American Heart Association2004，，18： | 2 |
| 4 | Osteoprotegerin is a risk factor for progressive atherosclemsis and cardiovascular disease显示文摘 | Kiechl S Schett G Wenning G | 2004 | Circulation2004，109，18： | 1 |
| 5 | Relationship between diurnal blood ressure, renal hemodynamic function, and the rennin angiotensin sys2tem in type 1 diabetes 显示文摘 | Miller J A Curtis J R Schett E B | 2003 | Diabetes2003，52，7： | 1 |
| 6 | RANKL in- hibition by osteoprotegerin prevents bone loss with- out affecting local orsystemic inflammation parame- ters in two rat arthritis models~ comparison with- anti-TNFalpha or anti-IL-1 therapies 显示文摘 | Stolina M Schett G Dwyer D | 2009 | Arthritis Res Ther2009，11，6： | 1 |
| 7 | The chloride cell: definitive identification as the salt-secretory cell in teleosts显示文摘 | Foskett J K Schett C | 1982 | Science1982，215，： | 1 |
| 8 | Oral apremilast in the treatment of active psoriatic arthritis: results of a multicenter, randomized, double-blind, placebo-controlled study 显示文摘 | Schett G Wollenhaupt J Papp K | 2012 | Arthritis Rheum2012，64，10： | 1 |
| 9 | The ups and downs of bone in health and rheumatic disease显示文摘 | Ulrike Harre Beorg Schett | 2013 | Rheumatol2013，9，： | 1 |
| 10 | Serum soluble heatshock protein 60 is elevated in subjects with atherosclerosis in ageneral population显示文摘 | XU Q SCHETT G PERSCHINKA H | 2000 | Circulation2000，102，1： | 1 |
| 11 | Osteoprotegerin is a risk factorfor progressive atherosclerosis and cardiovascular disease 显示文摘 | Kiechl S Schett G Wenning G | 2004 | Circulation2004，109，： | 1 |
| 12 | The pathogenesis of rheumatoid arthritis显示文摘 | McInnes IB Schett G | 2011 | N Engl J Med2011，365，23： | 1 |
| 13 | Activation,differential localization and regulation of the stress-activated protein kinases,extracellular signal-regulated kinase,c-Jun N-terminal kinase,and P38 mitogen-activated protein kinase,in synovial tissue and cells in rheumatoid arthritis显示文摘 | Schett G Tohidast-Akrad M Smolen JS | 2000 | Arthritis Rheum2000，43，11： | 1 |
| 14 | Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease显示文摘 | Kiechl S Schett G Wenning G | | 0，，18： | 1 |
| 15 | Gytokines in the pathogenesis of rheumatoid arehritis显示文摘 | Mcinnes IB Schett G | 2007 | Nature Reviews Immunology2007，7，6： | 1 |
| 16 | New insights in the mechanism of bone loss in arthritis 显示文摘 | Schett Georg Smolen Josef S | 2005 | Curr Pharm Des2005，11，23： | 1 |
| 17 | Mechanisms of disease: thelink between RANKL and arthritic bone disease 显示文摘 | Schett G Hayer S Zwerina J | 2005 | NatureClinical Practice Rheumatology2005，1，1： | 1 |
| 18 | Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease 显示文摘 | Kiechl S Schett G Wenning G etal | 2004 | Circulation2004，109，18： | 1 |
| 19 | The pathogenesis of rheumatoid arthritis显示文摘 | McInnes I B Schett G | | 0，，23： | 1 |
| 20 | The pathogenesis of rheumatoid arthritis 显示文摘 | Mclnnes IB Schett G | 2011 | N Engl J Med2011，365，11： | 1 |
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