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| 1 | Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect. | Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol | 2016 | World Journal of Hepatology2016，8，21： | 5 |
| 2 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 3 | HCV direct‐acting antiviral agents: the best interferon‐free combinations显示文摘 | Raymond Schinazi Philippe Halfon Patrick Marcellin Tarik Asselah | 2014 | Liver Int2014，，： | 2 |
| 4 | Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis显示文摘 | Benjamin Terrier Fabrice Carrat Guillaume Geri Stanislas Pol Lionel Piroth Philippe Halfon Thierry Poynard Jean-Claude Souberbielle Patrice Cacoub | 2011 | Journal of Hepatology2011，，4： | 2 |
| 5 | Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation显示文摘AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective 'Fibroscore Study' in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as 'fast fi brosers' and 116 as 'slow fi brosers'; 13% of the 'fast fi brosers' carried the PT20210 mutation as compared with 5.5% of the 'slow fi brosers', with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for 'fast' liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients. | Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 6 | Antioxidant potential and phenolic constituents of Salvia cedronella显示文摘 | YESILYURT V HALFON B OZTURK M et a1 | 2008 | Food Chemistry2008，108，： | 1 |
| 7 | Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C显示文摘 | Shlomai A Halfon P Goldiner l | 2013 | J Viral Hepat2013，20，2： | 1 |
| 8 | Meta - analyses of FibroTest diagnostic value in chronic liver disease 显示文摘 | Poynard T Morra R Halfon P | 2007 | BMC Gastroenterol2007，7，： | 1 |
| 9 | Control of seed-borne Penicillium oxalicum in sweet corn by seed treatment显示文摘 | Halfon Meiri A | 1989 | Zpflanzenkr Pelanzenschutz1989，96，6： | 1 |
| 10 | Drug-resistance genotyping in HIV-1 therapy:the VIRADAPT randomised controlled trial显示文摘 | Durant J Clevenbergh P Halfon P | 1999 | Lancet1999，353，： | 1 |
| 11 | Autocatalytic activa- tion of human legumain at aspartic acid residues显示文摘 | HALFON S PATEL S VEGA F | 1998 | FEBS Let- ters1998，438，12： | 1 |
| 12 | Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fi- brosis stages显示文摘 | Poynard T Halfon P Castera L | 2007 | Clin Chem2007，53，9： | 1 |
| 13 | Triage of women with minor abnormal cervical cytology: meta-analysis of the accuracy of an assay targeting messenger ribonucleic acid of 5 high-risk human papillomavirus types显示文摘 | Verdoodt F Szarewski A Halfon P | 2013 | Cancer Cyto- pathol2013，121，12： | 1 |
| 14 | Drug resistance genotyging in HIV-1 therapy: the VIRADAPT randomised controlled trial 显示文摘 | Durant J Clevenbergh P Halfon P | 1999 | Lancet1999，353，： | 1 |
| 15 | Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus 显示文摘 | HALFON P BOURLIERE M PENARANDA G | 2005 | Comp Hepatol2005，4，6： | 1 |
| 16 | Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging显示文摘 | Halfon S Abramov N Grinblat B | 2011 | Stem Cells Dev2011，20，1： | 1 |
| 17 | Hepatitis C virus resistance to protease inhibitors显示文摘 | Halfon P Locamini S | 2011 | J Hepatol2011，55，1： | 1 |
| 18 | Comparison of the clinical performance of carcinogenic HPV typing of the Linear Array and Papillocheck HPV-screening assay显示文摘 | Halfon P Benmoura D Khiri H | 2010 | J Clin Virol2010，47，1： | 1 |
| 19 | Multicentre study of hepatitis B virus genotypes in France:correlation with liver fibrosis and hepatitis B e antigen status显示文摘 | Halfon P Bourliere M Pol S | | 0，，： | 1 |
| 20 | Hepatitis C virus is a weak inducer of interferon alpha in plasmacytoid dendritic cells in comparison with influenza and human herpesvirus type-1显示文摘 | GONDOIS R F DENTAL C HALFON P | 2009 | PLoS One2009，4，2： | 1 |
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