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| 1 | Alcoholic disease: Liver and beyond显示文摘The harmful use of alcohol is a worldwide problem.It has been estimated that alcohol abuse represents the world’s third largest risk factor for disease and disability;it is a causal factor of 60 types of diseases and injuries and a concurrent cause of at least 200 others.Liver is the main organ responsible for metabolizing ethanol,thus it has been considered for long time the major victim of the harmful use of alcohol.Ethanol and its bioactive products,acetaldehyde-acetate,fatty acid ethanol esters,ethanol-protein adducts,have been regarded as hepatotoxins that directly and indirectly exert their toxic effect on the liver.A similar mechanism has been postulated for the alcohol-related pancreatic damage.Alcohol and its metabolites directly injure acinar cells and elicit stellate cells to produce and deposit extracellular matrix thus triggering the'necrosis-fibrosis'sequence that finally leads to atrophy and fibrosis,morphological hallmarks of alcoholic chronic pancreatitis.Even if less attention has been paid to the upper and lower gastrointestinal tract,ethanol produces harmful effects by inducing:(1)direct damaging of the mucosa of the esophagus and stomach;(2)modification of thesphincterial pressure and impairment of motility;and(3)alteration of gastric acid output.In the intestine,ethanol can damage the intestinal mucosa directly or indirectly by altering the resident microflora and impairing the mucosal immune system.Notably,disruption of the intestinal mucosal barrier of the small and large intestine contribute to liver damage.This review summarizes the most clinically relevant alcohol-related diseases of the digestive tract focusing on the pathogenic mechanisms by which ethanol damages liver,pancreas and gastrointestinal tract. | Alba Rocco Debora Compare Debora Angrisani Marco Sanduzzi Zamparelli Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，40： | 27 |
| 2 | Large Brunner's gland adenoma:Case report and literature review显示文摘Brunner 的腺腺瘤(BGA ) 是十二指肠的一个很稀罕的良性的瘤,它在内视镜检查法顺便说一下通常无征状、发现。偶尔,这损害可能大,引起上面的胃肠的出血或肠梗阻。盒子有大 Brunner 的腺腺瘤,介绍被内视镜的切除管理的│黑粪症。 | Alba Rocco PasqualeBorriello Debora Compare Patrizia DeColibus LoredanaPica GerardoNardone Alessandro Iacono | 2006 | World Journal of Gastroenterology2006，12，12： | 16 |
| 3 | 国际比较视野下的中国人力资源竞争力研究显示文摘从人力资源投入、数量、结构、质量、贡献、发展环境六个维度构建了人力资源强国发展指数,对世界44个主要国家的人力资源竞争力进行了评价,并从历史和国际比较的角度分析了中国人力资源竞争力。研究发现,21世纪头十年间,中国人力资源竞争力得到稳步提升,2010年在44个世界主要国家中排名第32位,在14个世界人口大国中排名第9位;中国在人力资源数量指数和贡献指数方面表现优异,要高于部分发达国家,但是投入、结构、质量和发展环境等四项指标表现不佳,基本上排在后5位;中国在数量、贡献、发展环境方面优于新兴市场国家平均值,投入和质量方面低于新兴市场国家平均值,但总体上要优于新兴市场国家的平均水平;中国距离世界人力资源强国之门并不遥远,只要能够继续发挥自身优势,在投入、结构、质量和发展环境上下功夫,中国在2020年进入人力资源强国行列的目标完全可以实现。 | Research Center for International Comparative Education,National Institute of Education Sciences | 2013 | 教育研究2013，34，11： | 11 |
| 4 | Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questions显示文摘Traditionally, the clonal evolution model has been used to explain gastric cancer (GC) growth dynamics. According to this model, GC cells result from multiple mutations over time resulting in a population of continually diversifying cells. This heterogeneity enables the survival of different clones under particular conditions allowing growth at metastatic locations or resistance to chemotherapeutics. Cancer stem cell (CSC) theory completely overturns this traditional understanding of cancer suggesting that only CSCs can self-renew and promote tumor growth. CSCs are relatively refractory to conventional therapies, thus explaining why anti-cancer therapies are far from curative and why relapses of cancer are frequent. The identification of the CSC component of a tumor might, thus, open new therapeutic perspective based on the selective targeting of this small population of cells. In this review we examine the current scientific evidence supporting the existence of CSC in gastric tumors and analyze the main unsolved questions of this difficult field of cancer research. | Alba Rocco Debora Compare Gerardo Nardone | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 11 |
| 5 | Four kinds of ENU-induced white spot mice and chromosome locations of the mutant genes显示文摘Phenotype-driven is the name for an ap-proach used to study gene functions through mutagenesis, location and cloning of the mutant gene. In this study, 150 male C57BL/6J(B6) mice were treated with ENU and repro-duced a total offspring of 3860. Of these descendants, 210 exhibited mutation phenotypes by screening, and more than 10 of them are hereditable. Four kinds of mutant mice, named Wbct, W-1Bao, W-2Bao, and W-3Bao, showed dominant hereditary white spot mutation with partial albinism on their belly, distal limbs and tail terminal. To map these mutant genes, 39 microsatellites, equally distributed on the mouse genome and with difference between B6 and DBA/2J (D2), were selected to scan the genome after discrimination of the white spots in the F2 mice [(B6×D2)×D2]. It is found that, the log odds score (LODS) between W-1Bao and D5Mit168 is 0.56, and the LODS of W-1Bao and D5Mit352 is 4.47. With the gradual application of microsatellites D5Mit290, D5Mit312, D5Mit308 and D5Mit356 that are close to the mutant gene, and the number of F2 mice going up to 537, the mutant W-1Bao is located between D5Mit356 and D5Mit308 on chro-mosome 5, about 42.19 cM from the centromere. In the same way, W-2Bao and W-3Bao are mapped nearby W-1Bao, and Wbct is located on chromosome 1, about 41.6 cM from the centro-mere. After searching for the mouse genome database (MGD) and performing a one-by-one study of all genes located on chromosome subregion, it is believed that the kit gene is an excellent candidate for the white spot mutations of W-1Bao, W-2Bao and W-3Bao. | WU Baojin1,2, MAO Huihua1, SHAO Yixiang1, XUE Zhengfeng1 & LI Houda1 1. Comparative Medicine Center of Yangzhou University, Yangzhou 225009, China 2. Medical College of Yangzhou University, Yangzhou 225001, China Correspondence should be addressed to Li Houda (e-mail: houdali @yahoo.com.cn) | 2003 | Chinese Science Bulletin2003，48，24： | 11 |
| 6 | Screening for and surveillance of gastric cancer显示文摘Although the prevalence of gastric cancer(GC) progressively decreased during the last decades,due to improved dietary habit,introduction of food refrigeration and recovered socio-economic level,it still accounts for 10% of the total cancer-related deaths. The best strategy to reduce the mortality for GC is to schedule appropriate screening and surveillance programs,that rises many relevant concerns taking into account its worldwide variability,natural history,diagnostic tools,therapeutic strategies,and cost-effectiveness. Intestinal-type,the most frequent GC histotype,develops through a multistep process triggered by Helicobacter pylori(H. pylori) and progressing from gastritis to atrophy,intestinal metaplasia(IM),and dysplasia. However,the majority of patients infected with H. pylori and carrying premalignant lesions do not develop GC. Therefore,it remains unclear who should be screened,when the screening should be started and how the screening should be performed. It seems reasonable that screening programs should target the general population in eastern countries,at high prevalence of GC and the high-risk subjects in western countries,at low prevalence of GC.As far as concern surveillance,currently,we are lacking of standardized international recommendations and many features have to be defined regarding the optimal diagnostic approach,the patients at higher risk,the best timing and the cost-effectiveness.Anyway,patients with corpus atrophic gastritis,extensive incomplete IM and dysplasia should enter a surveillance program.At present,screening and surveillance programs need further studies to draw worldwide reliable recommendations and evaluate the impact on mortality for GC. | Debora Compare Alba Rocco Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 7 | Prokaryote phylogeny meets taxonomy: An exhaustive comparison of composition vector trees with systematic bacteriology显示文摘We perform an exhaustive, taxon by taxon, comparison of the branchings in the composition vector trees (CVTrees) inferred from 432 prokaryotic genomes available on 31 December 2006, with the bacte-riologists' taxonomy-primarily the latest online Outline of the Bergey's Manual of Systematic Bacteri-ology. The CVTree phylogeny agrees very well with the Bergey's taxonomy in majority of fine branchings and overall structures. At the same time most of the differences between the trees and the Manual have been known to biologists to some extent and may hint at taxonomic revisions. Instead of demonstrating the overwhelming agreement this paper puts emphasis on the biological implications of the differences. | GAO Lei1,2, QI Ji1**, SUN JianDong2,3 & HAO BaiLin1,2,4 1 Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100080, China 2 T-Life Research Center, Fudan University, Shanghai 200433, China 3 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 4 Santa Fe Institute, Santa Fe, NM87501, USA Center for Comparative Genomics and Bioinformatics, Penn State University, 310 Wartik Building, University Park, PA16802, USA | 2007 | Science China(Life Sciences)2007，50，5： | 4 |
| 8 | Efficacy of 5-Day Levofloxacin-Containing Concomitant Therapy in Eradication of Helicobacter pylori Infection显示文摘 | Alessandro Federico Gerardo Nardone Antonietta G. Gravina Maria Rosaria Iovene Agnese Miranda Debora Compare Paola A. Pilloni Alba Rocco Luigi Ricciardiello Riccardo Marmo Carmelina Loguercio Marco Romano | 2012 | Gastroenterology2012，，1： | 3 |
| 9 | Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease显示文摘 | D. Compare P. Coccoli A. Rocco O.M. Nardone S. De Maria M. Cartenì G. Nardone | 2012 | Nutrition Metabolism and Cardiovascular Diseases2012，，6： | 3 |
| 10 | Ibsen’s Plays in China And Their Ethical Value:A Speech at the Closing Ceremony of the Third International Ibsen Conference in China显示文摘This is a speech delivered at the closing ceremony of The Third International Ibsen Conference in China, which introduces some people and their studies on Ibsen in China, and takes A Doll’s House as an example for an ethical analysis. The speech chooses Professor Wang Zhongxiang, Professor Kwok-kan Tam, Professor Knut Brynhildsvoll and others for an evaluation of their studies as the evidence of achievements in the Ibsen studies in the New Period in China. The speech, from the perspective of ethical literary criticism, also analyses A Doll’s House as a moral play to raise moral questions and concludes that Ibsen’s so-called social problem plays are ethical problem ones. | Nie Zhenzhaois professor of English literature and comparative literature at CentralChinaNormalUniversity. He is also chief editor of Foreign Literature Studies(FLS), vice presi-dent of China Foreign LiteratureAssociation, and fellow of China NationalFunds forPhilosophyand SocialSciences | 2005 | 外国文学研究2005，27，5： | 2 |
| 11 | Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease显示文摘 | D. Compare P. Coccoli A. Rocco O.M. Nardone S. De Maria M. Cartenì G. Nardone | 2012 | Nutrition, Metabolism and Cardiovascular Diseases2012，，6： | 2 |
| 12 | The Acute Respiratory Distress Syndrome Network显示文摘 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome | 2000 | N Engl J Med2000，342，18： | 1 |
| 13 | Fragmin and fast revascularization during instability in coronary disease investigators 显示文摘 | Invasive compareal with non - invasive treatment in unstable coronary artery disease: FRISC Ⅱ prospective randomized mulficenter study | 1999 | Lancet1999，354，9180： | 1 |
| 14 | Phase plus fluorouracil to paeJitaxel,cisplatin,and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer 显示文摘 | Hitt R Lopez-Pousa A Martinez study comparing cisplatin -Tmfero J | 2005 | J Clin Oncol2005，23，34： | 1 |
| 15 | The International Neonatal Network 显示文摘 | The CRIB (clinical risk index for babies) score: a tool for asses- sing initial neonatal risk and comparing performance of neonatal intensive care units | 1993 | Lancet1993，342，8865： | 1 |
| 16 | The GUSTO investigators显示文摘 | An international randomized trial comparing four thrombolytic strate gies for acute myocardial infarction | 1993 | N Engl JM ed1993，329，10： | 1 |
| 17 | Ten year results of a a conservative treatment to mastectomy in early breast cancer显示文摘 | Sarrazin D Le MG Arriagada randomised trial comparing R | 1989 | Radiother Oncol1989，14，3： | 1 |
| 18 | ]'IS score as a predictor of survival after hepatectomy for hepatocellular carcinoma显示文摘 | Luo KZ Itamoto T Amano H Comparative study of the Japan Integrated Stage (JIS) and modified | 2008 | J Gastroenterol2008，43，5： | 1 |
| 19 | UK Prospective Diabetes Group显示文摘 | Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes | 1998 | Lancet1998，352，9131： | 1 |
| 20 | Metaanalysis Group In Cancer 显示文摘 | Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer | 1998 | J Clin Oncol1998，16，1： | 1 |
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