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| 1 | Review of biosensing with whispering-gallery mode lasers显示文摘Lasers are the pillars of modern optics and sensing.Microlasers based on whispering-gallery modes(WGMs)are miniature in size and have excellent lasing characteristics suitable for biosensing.WGM lasers have been used for labelfree detection of single virus particles,detection of molecular electrostatic changes at biointerfaces,and barcode-type live-cell tagging and tracking.The most recent advances in biosensing with WGM microlasers are described in this review.We cover the basic concepts of WGM resonators,the integration of gain media into various active WGM sensors and devices,and the cutting-edge advances in photonic devices for micro-and nanoprobing of biological samples that can be integrated with WGM lasers. | Nikita Toropov Gema Cabello Mariana P.Serrano Rithvik R.Gutha Matias Rafti Frank Vollmer | 2021 | Light(Science & Applications)2021，10，3： | 12 |
| 2 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 3 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 4 | A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle显示文摘The hair follicle is a biological oscillator that alternates growth,regression,and rest phases driven by the sequential activation of the proliferation differentiation programs of resident stem cell populations.The activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling,while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity.A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling pathways.Here we have focused on the role of Endoglin(Eng),a key co-receptor for members of the Tgf-β/Bmp family of growth factors.Using an Eng haploinsufficient mouse model,we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches.We further report thatβ-catenin binds to the Eng promoter depending on Bmp signalling.Moreover,we show thatβ-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription.These observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals. | Maria I.Calvo-Sanchez Sandra Fernandez-Martos Elisa Carrasco Gema Moreno-Bueno Carmelo Bernabeu Miguel Quintanilla Jesus Espada | 2019 | Journal of Molecular Cell Biology2019，11，1： | 7 |
| 5 | Identification of SUMO Targets by a Novel Proteomic Approach in Plants显示文摘Post-translational modifications (PTMs) chemically and physically alter the properties of proteins, including their folding, subcellular localization, stability, activity, and consequently their function. In spite of their relevance, studies on PTMs in plants are still limited. Small Ubiquitin-like Modifier (SUMO) modification regulates several biological processes by affecting protein-protein interactions, or changing the subcellular localizations of the target proteins. Here, we describe a novel proteomic approach to identify SUMO targets that combines 2-D liquid chromatography, immunodetection, and mass spectrometry (MS) analyses. We have applied this approach to identify nuclear SUMO targets in response to heat shock. Using a bacterial SUMOylation system, we validated that some of the targets identified here are, in fact, labeled with SUMO1. Interestingly, we found that GIGANTEA (GI), a photoperiodic-pathway protein, is modified with SUMO in response to heat shock both in vitro and in vivo. | Gema López-Torrejón Davide Guerra Rafael Catal Julio Salinas Juan C. del Pozo | 2013 | Journal of Integrative Plant Biology2013，55，1： | 6 |
| 6 | Regulation of the New Arabidopsis Imprinted Gene AtBMI1C Requires the Interplay of Different Epigenetic Mechanisms显示文摘最近,植物包含相当或相同的事物到动物 Polycomb 压抑的建筑群,这被显示出 1 (PRC1 ) 部件 BMI1 和 RING1A/B。在 Arabidopsis,有三象 BMI1 一样基因,哪个中的二个, AtBMI1A 和 B,在 embryonic 以后植物生长期间被要求镇压胚胎的特点并且允许房间区别。然而,很少对第三象 BMI1 一样基因被知道, AtBMI1C。在这个工作,我们证明 AtBMI1C 仅仅在内乳和雄蕊开发期间被表示。AtBMI1C 是在内乳从母亲的等位基因表示,但是 biallelically 在雄蕊表示了的印的基因。我们发现 AtBMI1C 的典型表示模式是包含 CG DNA methylation,指导 RNA 的 non-CG DNA methylation (RdDM ) ,和 PcG 活动的一条复杂 epigenetic 规定的结果。我们的结果在在整个开发调整基因表示显示出不同 epigenetic 机制的安排相互影响,使为在工厂内乳印的起源和机制的当前的假设清楚些。 | Fabian Bratzel ChaoYang Alexandra Angelova Gema Lopez-Torrejon Marcus Koch Juan Carlos del Pozo Myriam Calonje | 2012 | Molecular Plant2012，5，1： | 4 |
| 7 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 8 | Role of hemostatic powders in the endoscopic management of gastrointestinal bleeding显示文摘Acute gastrointestinal bleeding(AGIB) is a prevalent condition with significant influence on healthcare costs. Endoscopy is essential for the management of AGIB with a pivotal role in diagnosis, risk stratification and management. Recently, hemostatic powders have been added to our endoscopic armamentarium to treat gastrointestinal(GI) bleeding. These substances are intended to control active bleeding by delivering a powdered product over the bleeding site that forms a solid matrix with a tamponade function. Local activation of platelet aggregation and coagulation cascade may be also boosted. There are currently three powders commercially available: hemostatic agent TC-325(Hemospray), EndoClotTM polysaccharide hemostatic system, and Ankaferd Bloodstopper. Although the available evidence is based on short series of cases and there is no randomized controlled trial yet, these powders seem to be effective in controlling GI bleeding from a variety of origins with a very favorable side effects profile. They can be used either as a primary therapy or a secondline treatment, and they seem to be especially indi-cated in cases of cancer-related bleeding and lesions with difficult access. In this review, we will comment on the mechanism of action, efficacy, safety and technical challenges of the use of powders in several clinical scenarios and we will try to define the main current indications of use and propose new lines of research in this area. | Marco Bustamante-Balén Gema Plumé | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 9 | Inhibition of p53 inhibitors:progress,challenges and perspectives显示文摘p53 is the major tumor suppressor and the most frequently inactivated gene in cancer.p53 could be disabled either by mutations or by upstream negative regulators,including,but not limited to MDM2 and MDMX.p53 activity is required for the prevention as well as for the eradication of cancers.Restoration of p53 activity in mouse models leads to the suppression of established tumors of different origin.These findings provide a strong support to the anti-cancer strategy aimed for p53 reactivation.In this review,we summarize recent progress in the development of small molecules,which restore the tumor suppressor function of wild-type p53 and discuss their clinical advance.We discuss different aspects of p53-mediated response,which contribute to suppression of tumors,including non-canonical p53 activities,such as regulation of immune response.While targeting p53 inhibitors is a very promising approach,there are certain limitations and concerns that the intensive research and clinical evaluation of compounds will hopefully help to overcome. | Gema Sanz Madhurendra Singh Sylvain Peuget Galina Selivanova | 2019 | Journal of Molecular Cell Biology2019，11，7： | 3 |
| 10 | Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5显示文摘Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage. | Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann | 2023 | Cellular & Molecular Immunology2023，20，4： | 2 |
| 11 | Farm-scale evaluation of the impact of CrylAb Bt maize on canopy nontarget arthropods: a 3-year study显示文摘 | Maria Arias-Martin Matias Garcia Pedro Castanera Felix Ortego Gema P. Farinos | 2018 | Insect Science2018，25，1： | 2 |
| 12 | Kriging Methods for Spatial Estimation' 显示文摘 | Calder6n Gema Ferncindez-Avil4s 'Spatial Regression Analysis vs | 2009 | International Advances in Economic Research2009，15，1： | 1 |
| 13 | Control of free AA levels by phospholipases A2 and lysophospholipid acyltransferases 显示文摘 | GEMA P C ALMA M A DAVID B | 2009 | Biochim Biophys Acta2009，1791，12： | 1 |
| 14 | Diagnosis and implications of human cytomegalovirus infection in pregnancy 显示文摘 | Revello MG Gema G | 1999 | Fet Matem Med1999，11，： | 1 |
| 15 | The risk of cardiovascular disease associated with proteinuria in renal transplant patients 显示文摘 | Gema F F Rafael E Emilio R | 2002 | Transplantation2002，73，8： | 1 |
| 16 | Solution properties of poly(diallyldimethyammonium Chloride ) (PDDA) 显示文摘 | Gema Marcelo Pilar Tarazona Enrique Saiz | 2005 | Polymer2005，46，： | 1 |
| 17 | Diagnosis and management of human cytomegalovirus infection in the mother,fetus,and newborn infect显示文摘 | Revello MG Gema G | 2002 | Clin Microbiol Rev2002，15，45： | 1 |
| 18 | Recovery of the main pear aroma compound by adsorption/desorption onto commercial granular activated carbon: Equilibrium and kinetics显示文摘 | Nazely Diban Gema Ruiz Ane Urtiaga Inmaculada Ortiz | 2007 | Journal of Food Engineering2007，，1： | 1 |
| 19 | Identification, Typing, and Phylogenetic Relationships of the Main Clinical Nocardia Species in Spain According to Their gyrB and rpoB Genes显示文摘 | Gema Carrasco Sylvia Valdezate Noelia Garrido Pilar Villalón Maria J. Medina-Pascual Juan A. Sáez-Nieto | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 20 | Bioabatement to remove inhibitors from biomass-derived sugar hydrolysates 显示文摘 | Nichols Nancy N Dienr Bruce S Guis aoo Gema M | 2005 | Apphed Biochemistry and Biotechnology2005，，： | 1 |
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