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| 1 | Sugar Input, Metabolism, and Signaling Mediated by Invertase: Roles in Development, Yield Potential, and Response to Drought and Heat显示文摘转化酶(INV ) 水解蔗糖进在主要新陈代谢和植物开发的葡萄糖和果糖的、从而玩的关键角色。基于他们的 pH optima 和亚 cellular 地点, INV 被分成房间墙,细胞质,并且 vacuolar 亚群,分别地作为 CWIN, CIN,和 VIN 缩短了。在植物开发和庄稼生产率的 INV 的宽广重要性和含意吸引了庞大的兴趣从多重观点检验 INV 功能和规定。这里,我们考察在最后二十年在这个区域使进展激动的一些,集中于( 1 )在在translational以后的植物开发和规定的 INV 的新或新兴的角色通过和禁止者的相互作用铺平,( 2 )在 调停INV 的糖发信号之间的串音和开发的神经质的控制,并且( 3 )对种子和水果上的干旱和热压力和他们的影响的调停糖、 调停INV 的回答设定。最后,我们讨论为解开从这新进步和轮廓未来方向产生的主要问题在植物生物工学和农业位于调停 INV 的植物开发和他们的潜在的应用下面的机制。 | Yong-Ling Ruan Ye Jin Yue-Jian Yang Guo-Jing Li John S. Boyer | 2010 | Molecular Plant2010，3，6： | 98 |
| 2 | Hepatocellular carcinoma in central Sydney :a 10yearreview of patients seen in a medical oncology department显示文摘AIM To report a single Australian oncology unit′s experience with the management of patients with hepatocellular carcinoma (HCC), in the context of a literature review of the current management issues. METHODS Retrospective case record review of 76 patients with diagnosis of HCC referred to the unit between 1984 and 1995. RESULTS Sixty three patients had adequate records for analysis. Thirty six (56%) were migrants with half from Southeast Asia. Twenty four patients had a documented viral aetiology. Nine (14%) of 51 patients with pathological confirmation of HCC had normal alpha fetoprotein levels. Median survival of the 20 patients managed palliatively was 5 weeks compared to 16 weeks for the cohort overall. Surgery in 16 patients rendered all initially disease free with a median survival of 88 weeks. Chemoembolisation induced tumor responses in 5 of the 11 patients so treated. Systemic chemotherapy and tamoxifen treatment caused tumor response in two of 12 and one of 25 respectively. CONCLUSION Prolonged survival of patients with HCC depends on early detection of small tumors suitable for surgical resection. Other active treatments are palliative in intent and have limited success. In addition to tumor response and survival duration, the toxicities of therapies and the overall quality of life of patients need to be considered as important outcomes. Viral hepatitis prevention and screening of individuals at risk are strategies that are important for HCC management in communities where the disease is endemic. | Desmond Yip 1, Michael Findlay 2, Michael Boyer 1 and Martin H. Tattersall 3 | 1999 | World Journal of Gastroenterology1999，5，6： | 17 |
| 3 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 4 | Canadian Agility and Movement Skill Assessment(CAMSA):Validity, objectivity, and reliability evidence for children 8–12 years of age显示文摘Purpose: The primary aim of this study was to develop an assessment of the fundamental, combined, and complex movement skills required to support childhood physical literacy. The secondary aim was to establish the feasibility, objectivity, and reliability evidence for the assessment.Methods: An expert advisory group recommended a course format for the assessment that would require children to complete a series of dynamic movement skills. Criterion-referenced skill performance and completion time were the recommended forms of evaluation. Children, 8–12 years of age, self-reported their age and gender and then completed the study assessments while attending local schools or day camps. Face validity was previously established through a Delphi expert(n = 19, 21% female) review process. Convergent validity was evaluated by age and gender associations with assessment performance. Inter-and intra-rater(n = 53, 34% female) objectivity and test–retest(n = 60, 47% female) reliability were assessed through repeated test administration.Results: Median total score was 21 of 28 points(range 5–28). Median completion time was 17 s. Total scores were feasible for all 995 children who self-reported age and gender. Total score did not differ between inside and outside environments(95% confidence interval(CI) of difference:-0.7 to 0.6;p = 0.91) or with/without footwear(95%CI of difference:-2.5 to 1.9; p = 0.77). Older age(p < 0.001, η2= 0.15) and male gender(p < 0.001, η2= 0.02)were associated with a higher total score. Inter-rater objectivity evidence was excellent(intraclass correlation coefficient(ICC) = 0.99) for completion time and substantial for skill score(ICC = 0.69) for 104 attempts by 53 children(34% female). Intra-rater objectivity was moderate(ICC = 0.52) for skill score and excellent for completion time(ICC = 0.99). Reliability was excellent for completion time over a short(2–4 days; ICC = 0.84) or long(8–14days; ICC = 0.82) interval. Skill score reliability was moderate(ICC = 0.46) over a short interval, and substantial(ICC = 0.74) over a long interval.Conclusion: The Canadian Agility and Movement Skill Assessment is a feasible measure of selected fundamental, complex and combined movement skills, which are an important building block for childhood physical literacy. Moderate-to-excellent objectivity was demonstrated for children 8–12 years of age. Test–retest reliability has been established over an interval of at least 1 week. The time and skill scores can be accurately estimated by 1 trained examiner. | Patricia E.Longmuir Charles Boyer Meghann Lloyd Michael M.Borghese Emily Knight Travis J.Saunders Elena Boiarskaia Weimo Zhu Mark S.Tremblay | 2017 | Journal of Sport and Health Science2017，6，2： | 10 |
| 5 | 纤维蛋白相关性EBV阳性大B细胞淋巴瘤:一种不同于慢性炎症相关性弥漫大B细胞淋巴瘤而特征明显的惰性肿瘤显示文摘目前,罕见部位局限性纤维蛋白相关性EB病毒(EBV)阳性大B细胞增生淋巴瘤已有报道。本组12例患者中位年龄55.5岁,男女比为3:1。12例纤维蛋白相关性EBV阳性大B细胞增生淋巴瘤中,镜下见淋巴瘤为偶发,包含3例心房黏液瘤,3例血管内移植物相关性血栓,2例慢性血肿和4例假性囊肿。病变均为非生发中心B细胞来源, | Boyer D F McKelvie P A de Leval L 解建军 张仁亚 | 2017 | 临床与实验病理学杂志2017，33，7： | 7 |
| 6 | Record-Setting Ocean Warmth Continued in 2019显示文摘Human-emitted greenhouse gases(GHGs)have resulted in a long-term and unequivocal warming of the planet(IPCC,2019).More than 90%of the excess heat is stored within the world's oceans,where it accumulates and causes increases in ocean temperature(Rhein et al.,2013;Abram et al.,2019). | Lijing CHENG John ABRAHAM Jiang ZHU Kevin ETRENBERTH John FASULLO Tim BOYER Ricardo LOCARNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN | 2020 | Advances in Atmospheric Sciences2020，37，2： | 7 |
| 7 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 8 | IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer显示文摘In secondary lymphoid organs,mature B cells express membrane immunoglobulin(Ig)of M and D isotypes(IgM and IgD,respectively)of the same specificity through alternative splicing of a pre-mRNA encompassing the VDJ variable region and Cμand Cδheavy chain constant exons.1 After encountering antigen,B cells undergo class switch recombination(CSR)by which the Cμgene is substituted with Cγ,Cεor Cα,thereby generating IgG,IgE and IgA antibodies of the same antigenic specificity but with new effector functions.CSR requires the DNA-editing enzyme activation-induced deaminase(AID). | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2017 | Cellular & Molecular Immunology2017，14，10： | 6 |
| 9 | The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor symptoms.Etiology is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental factors.Main body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell death.However,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause disease.Discovery of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD risk.Nevertheless,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be excluded.The lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of PD.Rare mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD risk.Heritability of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most patients.Conclusion:PD is a multifactorial disorder involving interplay of aging,genetics and environmental factors.This has implications on the development of appropriate animal models of PD which take all these factors into account.Common converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are associated with the accumulation and spread of misfoldedα-synuclein and neurodegeneration.Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course. | Shirley Yin-Yu Pang Philip Wing-Lok Ho Hui-Fang Liu Chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 10 | Expression, distribution and function of the focal adhesion kinase (pp125^(FAK)) during murine ectoplacental cone outgrowth in vitro显示文摘Mouse embryo implantation is a complex process that includes trophoblast cells derived from ectoplacental cone (EPC) adhesion to and migration through the extracellular matrix (ECM) of uterine endometrium and invasion into the decidua. At the time of implantation, fibronectin (FN) is abundant in the decidua and is distributed pericellularly around each individual stromal cell, and its receptor (integrin α-5β-1) expression on trophoblast populations is up-regulated. The focal adhesion kinase, a 125 ku protein tyrosine kinase (pp125 FAK), is tyrosine phosphorylated upon integrin engagement with its ECM ligand, and its tyrosine phosphorylation sites then serve as the binding sites which couple it with cellular proteins that contain Src SH2 or SH3 domains. Through these linkages, pp125 FAK may integrate multiple signals triggered by integrins. The model of EPC culture %in vitro% was used to study the expression, distribution and function of pp125 FAK during EPC outgrowth on FN. Results indicated that, pp125 FAK primarily expressed and distributed in cellular focal adhesions of the front edge of trophoblast outgrowth from EPC, and was localized in the peripheral region of the individual migrating trophblast cell; antibody or antisense oligodeoxynucleotide to pp125 FAK inhibited EPC attachment and outgrowth, as well as trophoblast cells spreading and migration. This experiment demonstrated that pp125 FAK as an integrin-mediated signaling molecule was involved in EPC outgrowth %in vitro%, and played an important role during trophoblast cells interaction with FN. | ZHANG Chunyu 1,2, DUAN Enkui 1*, CAO Yujing+1and ZENG Guoqing+1 1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2. Boyer Center for Molecular Medicine, Department of Genet | 1998 | Chinese Science Bulletin1998，43，17： | 5 |
| 11 | One-Year Outcomes of the DA VINCI Study of VEGF Trap-Eye in Eyes with Diabetic Macular Edema显示文摘 | Diana V. Do Quan Dong Nguyen David Boyer Ursula Schmidt-Erfurth David M. Brown Robert Vitti Alyson J. Berliner Bo Gao Oliver Zeitz Rene Ruckert Thomas Schmelter Rupert Sandbrink Jeff S. Heier | 2012 | Ophthalmology2012，，8： | 4 |
| 12 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 13 | Nitrogen Cycles: Past, Present, and Future显示文摘 | J. N. Galloway F. J. Dentener D. G. Capone E. W. Boyer R. W. Howarth S. P. Seitzinger G. P. Asner C. C. Cleveland P. A. Green E. A. Holland D. M. Karl A. F. Michaels J. H. Porter A. R. Townsend C. J. V?osmarty | 2004 | Biogeochemistry2004，，2： | 4 |
| 14 | A Floating Island Treatment System for the Removal of Phosphorus from Surface Waters显示文摘本研究旨在设计、建造和测试一个中试规模的浮动模块化处理系统,并用以对美国佛罗里达州中部富营养化湖泊中的总磷(TP)进行去除。该处理系统由生物和物理-化学处理模块组成。用多种底物和水生大型植物组合构建了13种不同的中宇宙实验(mesocosm),分别测试了总磷(TP)和正磷(PO_4^(3-))的去除率及潜在的区域去除率。此外本研究对7种吸附介质进行了小型杯罐实验和柱实验,并对3种商业树脂进行了吸附能力的测试。完成这些独立的测试过程后,在佛罗里达中部的一个湖泊中,设计了一个浮岛处理系统(FITS)并运行了8个月。中宇宙实验对磷的平均去除率为40%~50%,平均去除量为5.0 g·m^(–2)·a^(–1)。其中沉水植物(SAV)系统和藻类洗涤器(AGS)效果最好,分别去除了20 mg·m^(–2)·d^(–1)和50 mg·m^(–2)·d^(–1)的磷,它们对磷的平均去除量分别为5.5 g·m^(–2)·a^(–1)和12.0 g·m^(–2)·a^(–1)。在吸附介质中,明矾渣(AR)的性能最佳,接触5 min后,PO_4^(3-)浓度降低了75%左右。在所测试的商品树脂中,PhosX树脂的去除效果最好,在30 min后去除了约40%的磷,60 min后去除了约60%的磷。在基线运行条件下展开实验,FITS对PO_4^(3-)的平均去除率为53%;使用PO_4^(3-)去除率的第50百分位和第90百分位以及FITS的环境足迹进行评价,结果表明系统的去除率分别为56%和86%;区域磷去除率在8.9~16.5 g·m^(–2)·a^(–1)之间。 | Mark T. Brown Treavor Boyer R.J. Sindelar Sam Arden Amar Persaud Sherry Brandt-Williams | 2018 | Engineering2018，4，5： | 4 |
| 15 | Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: Incidence and survival in hepatitis C patients with advanced fibrosis显示文摘 | Ana-Carolina Cardoso Rami Moucari Claudio Figueiredo-Mendes Marie-Pierre Ripault Nathalie Giuily Corinne Castelnau Nathalie Boyer Tarik Asselah Michelle Martinot-Peignoux Sarah Maylin Roberto J. Carvalho-Filho Dominique Valla Pierre Bedossa Patrick Marcel | 2010 | Journal of Hepatology2010，，5： | 3 |
| 16 | Hydrothermal Synthesis and Characterization of Europium-doped Barium Titanate Nanocrystallites显示文摘Barium titanate nanocrystallites were synthesized by a hydrothermal technique from barium chloride and tetrabutyl titanate. Single-crystalline cubic perovskite Ba TiO_3 consisting of spherical particles with diameters ranging from 10 to 30 nm was easily achieved by this route. In order to study the influence of the synthesis process on the morphology and the optical properties, barium titanate was also prepared by a solid-state reaction. In this case, only the tetragonal phase which crystallizes above 900 was observed. High-temperature X-ray diffraction measurements were performed to investigate the crystallization temperatures as well as the particle sizes via the Scherrer formula. The lattice vibrations were evidenced by infrared spectroscopy. Eu^(3+)was used as a structural probe, and the luminescence properties recorded from Ba TiO_3 :Eu^(3+)and elaborated by a solid-state reaction and hydrothermal process were compared. The reddish emission of the europium is increased by the nanometric particles. | Margarita García-Hernndez Geneviève Chadeyron Damien Boyer Antonieta García-Murillo Felipe Carrillo-Romo Rachid Mahiou | 2013 | Nano-Micro Letters2013，5，1： | 3 |
| 17 | A fast string searching algorithm显示文摘 | Robert S. Boyer J. Strother Moore | 1977 | Communications of the ACM1977，，10： | 3 |
| 18 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 3 |
| 19 | A fast string searching algorithm显示文摘 | BOYER RS MOORE JS | 1977 | Communications of ACM1977，20，10： | 3 |
| 20 | Upper Ocean Temperatures Hit Record High in 2020显示文摘The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variations and secular trends,which the ocean records extremely well(Hansen et al., 2011;IPCC, 2013;Rhein et al., 2013;Trenberth et al., 2016;Abram et al., 2019). | Lijing CHENG John ABRAHAM Kevin ETRENBERTH John FASULLO Tim BOYER Ricardo LOCARNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Jiang ZHU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
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