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| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | “猪地方性肺炎及其防治控制”专栏二:有关猪肺炎支原体感染诊断方法和流行病学的最新观点显示文摘猪肺炎支原体是猪地方性肺炎(Enzoodc Pneumonia,EP)的主要病原体,本病是一种主要影响肥育猪的慢性呼吸道疾病。尽管人们在控制猪肺炎支原体感染及其带来的不利影响上花费了大量的精力,但是猪地方性肺炎仍继续给全球养猪生产造成重大的经济损失。猪肺炎支原体通常是通过引进亚临床型感染的动物而侵入猪群的,或通过短距离的空气传播发生感染,但后一种情况较少。一旦侵入猪群,猪肺炎支原体可通过与受感染的母猪直接接触而将病原体传给后代或在同圈猪只之间进行传播。用于诊断猪肺炎支原体感染的“黄金标准”技术——细菌学培养非常费劲,通常很少使用。酶联免疫吸附试验和聚合酶链式反应检测方法以及以屠宰场监测或田间剖解为形式的死后检查,是用于调查猪肺炎支原体是否参与了猪呼吸道疾病的最常用技术。这些技术已被用来监测受猪地方性肺炎影响的猪群猪肺炎支原体的临床型和亚临床型感染猪群、免疫猪群或非免疫猪群以及处于不同的生产条件和管理奈件下的猪群的发生情况。猪场水平上的猪地方性肺炎临床过程差异以及猪肺炎支原体疫苗接种效果的差异表明,猪肺炎支原体的不同田间分离株的传播和毒力特性存在差异。本文综述了猪肺炎支原体感染的流行病学最新知识,包括其传播、感染和血清转化动力学,并且还比较了用来监测猪地方性肺炎的各种流行病学方法。 | Marina Sibila Maria Pieters Thomas Molitor Dominiek Maes Freddy Haesebmuck Joaquim Segal e s 沈权(译) 邵嘉佳(校) | 2009 | 国外畜牧学(猪与禽)2009，，3： | 16 |
| 4 | Prevalence of hepatitis B and C markers among refugees in Athens显示文摘AIM: To assess the prevalence of hepatitis B and C serological markers in a population of refugees living in Athens.METHODS: One hundred and thirty refugees (81 males and 49 females, mean age ±SD: 31.7±8 years) were included in the study. The hepatitis B virus surface antigen (HBsAg),the hepatitis B virus core antibody (anti-HBc) and the hepatitis C virus antibody (anti-HCV) were detected using a third-generation immunoassay.RESULTS: Twenty individuals (15.4%) were HBsAg positive and 69 (53.1%) were anti-HBc positive. The prevalence of HBsAg and anti-HBc was higher among refugees from Albania and Asia (statistical significant difference, P<0.008 and P<0.001 respectively). The prevalence of these markers was found irrelevant to age or sex. Anti-HCV was detected in the serum of 3 individuals (2.3 %). No differences among age, sex or ethnicity regarding anti-HCV prevalence were found.CONCLUSION: It can be concluded that refugees living in Athens are an immigrant population characterized by a high incidence of HBV infection. The prevalence of HBV markers is higher among refugees from Albania and Asia. It is therefore believed that the adherence to general precautions and the initiation of HBV vaccination programs will be necessary in the future, especially in these communities.Although the prevalence of HCV infection seems to be relatively low, extended epidemiological surveys are needed to provide valid results. | Anastasios Roussos Constantin Goritsas Thomas Pappas Maria Spanaki Panagiota Papadaki Angeliki Ferti | 2003 | World Journal of Gastroenterology2003，9，5： | 11 |
| 5 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 6 | Targeting leukemic fusion proteins with small interfering RNAs:recent advances and therapeutic potentials显示文摘RNA 干扰成为了一个不可缺少的研究工具在许多有机体学习基因功能。因为他们的高功效和特性, RNA 基于干扰的途径可以也翻译成新治疗学的策略治疗人的疾病。特别地,象白血病的熔化蛋白质那样的 oncogenes,从染色体 translocations 产生,为如此的基因正在答应目标因为他们只在癌症前期、癌的纸巾被表示, silencing 来临,并且因为他们为维持恶意的显型经常是不可缺少的。这评论在指向白血病特定的基因总结最近的开发并且为可能的临床的应用讨论问题和途径。 | Maria THOMAS Johann GREIL Olaf HEIDENREICH | 2006 | Acta Pharmacologica Sinica2006，27，3： | 10 |
| 7 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease显示文摘 | Uma Mahadevan Douglas C. Wolf Marla Dubinsky Antoine Cortot Scott D. Lee Corey A. Siegel Thomas Ullman Sarah Glover John F. Valentine David T. Rubin Jocelyn Miller Maria T. Abreu | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 8 | The quasiparticle band dispersion in epitaxial multilayer silicene显示文摘 | Paola De Padova Jose Avila Andrea Resta Ivy Razado-Colambo Claudio Quaresima Carlo Ottaviani Bruno Olivieri Thomas Bruhn Patrick Vogt Maria Carmen Asensio Guy Le Lay | 2013 | Journal of Physics: Condensed Matter2013，，： | 4 |
| 9 | Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis显示文摘The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor . | Gudrun Scheving Thorsteinsson Maria Magnussson Lena M Hallberg Nils Gunnar Wahlgren Fredrik Lindgren Petter Malmborg Thomas H Casswall | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 10 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 11 | m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration显示文摘线粒体的功能无所不在地取决于表示并且在内部膜的进化保存 m-AAA 朊酶。这些 ATP 依赖的 peptidases 形式 hexameric 建筑群相应子单元积聚了。AFG3L2 子单元 homo-oligomeric isoenzymes 集合进或与 SPG7 (paraplegin ) 子单元进 hetero-oligomeric 解朊的建筑群。在 AFG3L2 的变化与 Purkinje 房间的损失描绘的主导的 spinocerebellar 混乱(SCA28 ) 被联系,而在 SPG7 的变化与 cortico 针的道的马达神经原引起世袭痉挛截瘫(HSP7 ) 的一种后退的形式主要被影响。多种的功能被分到 m-AAA 朊酶,它在线粒体充当质量控制和规章的酶。m-AAA 朊酶的损失影响 mitochondrial 蛋白质合成和呼吸并且在线粒体的 axonal 运输导致 mitochondrial 破碎和缺乏。而且 m-AAA 朊酶调整 mitochondrial 钙 uniporter (MCU ) 的集会复杂。在 AFG3L2 缺乏的线粒体的 MCU 子单元 EMRE 的损害降级为导致钙的房间死亡导致 deregulated MCU 建筑群,增加的 mitochondrial 钙举起和神经原的增加的危险的形成。进 Purkinje 房间的 cytosol 的钙流入的减小在一个 AFG3L2 缺乏的老鼠模型救混乱。在这评论,我们为 neurodegeneration 讨论在 m-AAA 朊酶和 mitochondrial 钙动态平衡和它的关联之间的关系并且描述在 Purkinje 房间明确地缺乏 MCU 的一个新奇老鼠模型。我们为在线粒体集成他们的多种的功能解释联系 neurodegenerative 混乱的致病的 m-AAA 朊酶上的一个新奇看法的结果誓言。 | Maria Patron, Hans-Georg Sprenger, Thomas Langer Maria Patron, Hans-Georg Sprenger, Thomas Langer | 2018 | Cell Research2018，28，3： | 3 |
| 12 | Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the SWAT model显示文摘Land use and land cover(LULC)changes strongly affect local hydrology and sediment yields.The current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1)to perform an effective diagnosis of flow and sediment yield,(2)to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and(3)to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield series.The Soil and Water Assessment Tool(SWAT)model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow seasonality.Furthermore,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric tests.It was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment yield.According to trend and homogeneity tests,these sub-basins had break points in the time series of these variables.On the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and trendless.The current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water supply.Thus,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources. | Edivaldo Afonso de Oliveira Serrao Madson Tavares Silva Thomas Rocha Ferreira Lorena Conceiçao Paiva de Ataide Cleber Assis dos Santos Aline Maria Meiguins de Lima Vicente de Paulo Rodrigues da Silva Francisco de Assis Salviano de Sousa Denis Jose Cardoso Gomes | 2022 | International Journal of Sediment Research2022，37，1： | 3 |
| 13 | Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients With Recurrent HCV Infection Treated With Pegylated Interferon显示文摘 | Josh Levitsky Maria Isabel Fiel John P. Norvell Edward Wang Kymberly D. Watt Michael P. Curry Sumeet Tewani Timothy M. McCashland Maarouf A. Hoteit Abraham Shaked Samuel Saab Amanda C. Chi Amy Tien Thomas D. Schiano | 2012 | Gastroenterology2012，，5： | 3 |
| 14 | High Elevation Energy and Water Balance:the Roles of Surface Albedo and Temperature显示文摘Observation and modeling of the coupled energy and water balance is the key to understand hydrospheric and cryospheric processes at high elevation.The paper summarizes the progress to address this aspect in relation with different earth system elements,from glaciers to wetlands.The energy budget of two glaciers,i.e.Xiao Dongkemadi and Parlung No.4,was studied by means of extended field measurements and a distributed model of the coupled energy and mass balance was developed and evaluated.The need for accurate characterization of surface albedo was further documented for the entire Qinghai Tibet Plateau by numerical experiments with Weather Research and Forecast(WRF)on the sensitivity of the atmospheric boundary layer to the parameterization of land surface processes.A new approach to the calibration of a coupled distributed watershed model of the energy and water balance was demonstrated by a case study on the Heihe River Basin in northwestern China.The assimilation of land surface temperature did lead to the retrieval of critical soil and vegetation properties as the soil permeability and the canopy resistance to the exchange of vapour and carbon dioxide.The retrievals of actual Evapo-Transpiration(ET)were generated by the ETMonitor system and evaluated against eddy covariance measurements at sites spread throughout Asia.As regards glacier response to climate variability,the combined findings based on satellite data and model experiments showed that the spatial variability of surface albedo and temperature is significant and controls both glacier mass balance and flow.Experiments with both atmospheric and hydrosphere-cryosphere models documented the need and advantages of using accurate retrievals of land surface albedo to capture lan-atmosphere interactions at high elevation. | Massimo MENENTI Li JIA Marco MANCINI Xin LI Francesca PELLICCIOTTI Kun YANG Jiancheng SHI Maria Jose ESCORIHUELA Chiara CORBARI Shaoting REN Chunfeng MA Chaolei ZHENG Lian LIU Thomas SHAW Baohong DING Wei YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 15 | High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin显示文摘 | Stefan Wirth Carmen Ribes-Koninckx Maria Angeles Calzado Flavia Bortolotti Lucia Zancan Paloma Jara Mark Shelton Nanda Kerkar Marcela Galoppo Alejandra Pedreira Norberto Rodriguez-Baez Mirta Ciocca Alain Lachaux Florence Lacaille Thomas Lang Ulrike Kullme | 2010 | Journal of Hepatology2010，，4： | 2 |
| 16 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 17 | Understanding bottom-up continuous hydrothermal synthesis of nanoparticles using empirical measurement and computational simulation显示文摘连续热水的合成为 nanoparticles 的生产作为一种创新技术在最近的评论被加亮。在最近的年里,是大量 nanomaterials 的合成的合适的反应媒介被显示了。许多单个、复杂的 nanomaterials 象金属,金属氧化物,做的氧化物,碳酸盐,硫化物,氢氧化物,磷酸盐,和金属那样器官的框架能用连续热水的合成技术被形成。这个工作介绍方法论试验性地并且数字地描绘连续热水的流动系统,并且为大规模生产决定一个相反当前的 supercritical 水反应堆的可伸缩性(> 1,000 T 敳 ? 潰整瑮慩??? ?? 湯敳 ? 猯'T? 漠 ?? 代嘠愠摮挠瑡污瑹捩挠牵敲瑮搠湥楳祴漠 ????? 湡 ? | Jose Sierra-Pallarest Thomas Huddle Juan Garcia-Serna Esther Alonso Fidel Mato Igor Shvets Olaf Luebben Maria Jose Cocero Edward Lester | 2016 | Nano Research2016，9，11： | 2 |
| 18 | Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?显示文摘 | Ulrike Heger Susanne Blank Christiane Wiecha Rupert Langer Wilko Weichert Florian Lordick Thomas Bruckner Martin Dobritz Maria Burian Christoph Springfeld Lars Grenacher J?rg-Rüdiger Siewert Markus Büchler Katja Ott | 2014 | Annals of Surgical Oncology2014，，5： | 2 |
| 19 | Long-term outcome in patients with apical hypertrophic cardiomyopathy显示文摘 | Maria J Eriksson Brian Sonnenberg Anna Woo Paul Rakowski Thomas G Parker E.Douglas Wigle Harry Rakowski | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 20 | Improved Detection of Inflammatory Bowel Disease by Additional Automated Motility Analysis in Magnetic Resonance Imaging显示文摘 | Maria L. Hahnemann Felix Nensa Sonja Kinner Stefan Maderwald Lale Umutlu Guido Gerken Thomas C. Lauenstein | 2015 | Investigative Radiology2015，，2： | 2 |
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