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| 1 | Portal vein thrombosis:Prevalence,patient characteristics and lifetime risk:A population study based on 23796 consecutive autopsies显示文摘瞄准:估计一生在一般人口的门静脉血栓形成(PVT ) 的累积发生。方法:在 1970 和 1982 之间, 23,796 具尸体,在马尔摩城市人口代表 84% 所有在里面医院死亡,被执行,用包括门静脉的检查的一个 standardised 协议。PVT 病人被描述并且在尸体的 PVT 流行,一生的表情累积发生,在高风险的疾病范畴估计了并且以机会比率和 95% CI 表示了。结果:PVT 的人口流行是 1.0% 。有 PVT 28% 的 254 个病人有肝硬化, 23% 主要并且 44% 第二等的肝胆管恶意, 10% 主要腹的传染或煽动性的疾病并且 3% 有 myeloproliferative 混乱。有肝硬化和肝的癌的病人有最高的 PVT 风险,或 17.1 (95% CI 11.1-26.4 ) 。在 14% ,没有原因被发现;仅仅,少数他们开发了 portal-hypertension-related 复杂并发症。结论:在这基于人口的研究, PVT 比由以前的临床的系列显示被发现更普通。显著地,在肝硬化和肝的癌的过量风险应该在指导干预的未来的研究可能为被考虑的这些病人保证增加的了解。 | Mats gren David Bergqvist Martin Bjrck Stefan Acosta Henry Eriksson Nils H Sternby | 2006 | World Journal of Gastroenterology2006，12，13： | 66 |
| 2 | 卵巢浆液性腺癌组织中TK1和Ki-67表达的意义显示文摘目的探讨细胞质胸苷激酶1(cytoplasmic thymidinekinas-1,TK1)、Ki-67在卵巢浆液性腺癌中表达的意义。方法回顾性研究55例经手术治疗的卵巢浆液性腺癌患者的临床病理资料,并运用免疫组化技术观察TK1、Ki-67在卵巢浆液性腺癌中的表达情况及与临床病理参数之间的意义。结果 TK1阳性表达定位于细胞质,阳性率为72.7%。TK1的表达与肿瘤的最大径、复发、pTNM分期、病理分级密切相关(P<0.05)。Ki-67阳性表达定位于细胞核,阳性率为80.0%,Ki-67的表达与肿瘤的复发、pTNM分期、病理分级有关(P<0.05)。Kappa检验显示TK1的表达与卵巢浆液性腺癌复发较一致(k=0.559,P=0.000),且判断复发比Ki-67更为优越。Kaplan-Meier检验显示pTNM分期、肿瘤复发、MDACC分级、Ki-67、TK1表达分别与预后有关(P<0.05)。COX回归多因素分析显示:肿瘤复发是影响卵巢浆液性腺癌患者的独立性预后因素。结论卵巢浆液性腺癌的复发影响患者的预后,TK1对判断卵巢浆液性腺癌是否有复发倾向具有参考价值,且优于Ki-67,初次手术后肿瘤组织免疫组化TK1高表达预示患者存在高复发的风险,提示临床要加强术后的治疗方案,并提高随访频数。 | 刘冲 郭庆 石群立 余波 马恒辉 Staffan Eriksson Ellen He Sven Skog | 2011 | 临床与实验病理学杂志2011，27，12： | 12 |
| 3 | Comparable Characterization of Nanocellulose Extracted from BleachedSoftwood and Hardwood Pulps显示文摘In this study, the characteristics of nanocellulose extracted from bleached softwood and hardwood pulps by formic acid hydrolysis followed by TEMPO-mediated oxidation were compared using transmission electron microscopy(TEM), atomic force microscopy(AFM), Fourier transform infrared analysis(FT-IR), X-ray diffraction(XRD), and thermal gravimetric analysis(TGA). The experimental results showed that the nanocellulose products derived from spruce pulp exhibited a relatively larger particle size, higher crystallinity, and higher thermal stability, compared with the corresponding products obtained from aspen pulp under the same conditions.Furthermore, the study helped establish that the properties of the nanocellulose products were highly dependent on the nature of the starting materials under identical processing conditions. | Bin Li WenYang Xu Dennis Kronlund Jan-Erik Eriksson Anni Maattanen Stefan Willfor ChunLin Xu | 2018 | Paper And Biomaterials2018，3，4： | 7 |
| 4 | 麦夸里岛毛皮海豹体内小塑料颗粒的来源和生物聚集显示文摘本文研究了从麦夸里岛上毛皮海豹(Arctocephalus spp.)粪便中发现的164个塑料颗粒(平均长度为4.1mm)。其中41个塑料颗粒的电子显微照片显示,从其形状来看,没有一个可被确定为塑料颗粒原料——通常这样的颗粒是圆柱形和球形的。而海豹粪便中的164个塑料颗粒全都是7种颜色的角形颗粒(原料颗粒通常是透明的或白色的),并可被分为两类:①沿晶体线碎裂的和可能是紫外线分解的;②被磨蚀成带有圆角的不规则形状(擦痕明显可见)。白色、棕色、绿色、黄色以及蓝色是最常见的颜色。在成分上,它们来自于5种聚合物群:聚乙烯93%;聚丙烯4%;多(1-CI-1-聚丁二烯)聚氯丁二烯2%;三聚氰胺-尿素(酚)(甲醛)树脂0.5%以及纤维素(绳纤维)0.5%。较大的群是漂浮的,比重小于海水。这些小塑料是由较大颗粒(碎片)分解而成的。它们看来是被水冲上岸的并在卵石海滩上受到研磨的塑料用品分解而成的。大多数颗粒(70%)肯定是由于经过不断的磨蚀而最后形成今天的形状。据假设,塑料颗粒被冲到海洋中,然后按其大小有选择地被一种中上层鱼——Electrona subaspera——吃掉,而这种鱼后来又被毛皮海豹吃掉。因此,这些塑料颗粒是由这种鱼和海豹在其正常的摄食过程中聚集的。 | Cecilia Eriksson Harry Burton 林宝法 | 2003 | AMBIO-人类环境杂志2003，32，6： | 7 |
| 5 | Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers显示文摘AIM: To elucidate the differences in somatic, psycho-logical and biochemical pattern between the subtypes of irritable bowel syndrome (IBS). METHODS: Eighty IBS patients, 30 diarrhoea pre-dominant (D-IBS), 16 constipation predominant (C-IBS) and 34 alternating IBS (A-IBS) underwent physi-otherapeutic examinations for dysfunctions in body movements and awareness and were compared to an apparently healthy control group (AHC). All groups an-swered questionnaires for gastrointestinal and psycho-logical symptoms. Biochemical variables were analysed in blood. RESULTS: The D-IBS group showed less body aware-ness, less psychological symptoms, a more normal sense of coherence and psychosocial rating as well as higher C-peptide values. C-IBS had a higher degree of body dysfunction and psychological symptoms, as well as the lowest sense of coherence compared to controls and D-IBS. They also demonstrated the most elevated prolactin levels. A-IBS had the lowest degree of body disturbance, deteriorated quality of life and affected bi-ochemical pattern. All subtypes had higher pain scores compared to controls. In addition they all had signifi -cantly increased triglycerides and elevated morning cortisol levels, however, without statistical signifi cance compared with the controls.CONCLUSION: IBS subtypes showed different pro-files in body awareness, somatic and psychological symptoms and in biochemical variables. D-IBS differed compared to the other groups by lowered body aware-ness, less psychological symptoms and a higher sense of coherence and elevated C-peptide values. C-IBS and A-IBS subtypes suffered more from depression and anxiety, associated with a lower quality of life. These differences may be important and will be taken into account in our treatment of these patients. | Elsa M Eriksson Kristina I Andrén Henry T Eriksson Gran K Kurlberg | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 6 | Aspects of the non-pharmacological treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is one of the most commonly diagnosed gastrointestinal conditions. It represents a significant healthcare burden and remains a clinical challenge. Over the years IBS has been described from a variety of different perspectives; from a strict illness of the gastrointestinal tract(medical model) to a more complex multi-symptomatic disorder of the brain-gut axis(biopsychosocial/psychosomatic model). In this article we present aspects of the pathophysiology and the non-pharmacological treatment of IBS based on current knowledge. Effects of conditioned stress and/or traumatic influences on the emotional system(top-down) as well as effects on the intestine through stressors,infection,inflammation,food and dysbiosis(bottom-up) can affect braingut communication and result in dysregulation of the autonomic nervous system(ANS),playing an important role in the pathophysiology of IBS. Conditioned stress together with dysregulation of the autonomic nervous system and the emotional system may involve reactions in which the distress inside the body is not recognized due to low body awareness. This may explain why patients have difficulty identifying their symptoms despite dysfunction in muscle tension,movement patterns,and posture and biochemical functions in addition to gastrointestinal symptoms. IBS shares many features with other idiopathic conditions,such as fibromyalgia,chronic fatigue syndrome and somatoform disorders. The key to effective treatment is a thorough examination,including a gastroenterological examination to exclude other diseases along with an assessment of body awareness by a body-mind therapist. The literature suggests that early interdisciplinary diagnostic cooperation between gastroenterologists and body-mind therapists is necessary. Re-establishing balance in the ANS is an important component of IBS treatment. This article discusses the current knowledge of body-mind treatment,addressing the topic from a practical point of view. | Elsa Maria Eriksson Kristina Ingrid Andrén Goran Karl Kurlberg Henry Ture Eriksson | 2015 | World Journal of Gastroenterology2015，21，40： | 6 |
| 7 | 粮食生产系统中的镉:对敏感人群的健康威胁显示文摘本文概述了瑞典农业系统中镉的状况以及镉的人类暴露状况。农业土壤(耕层)中的镉每年增加0.03%~0.05%。饲料是当地农业系统中镉增加的重要原因。当前暴露水平下已经有一些测量表明人体肾功能受到影响。如果粮食中的水平达到欧盟允许的最大限度,那么10%~25%的瑞典人群暴露的镉水平将超过暂时可容忍的每周摄入量(PTWI,7μg Cd/kg体重)。人群中的敏感者是那些低铁状况(主要是女性)和肾紊乱的个体。最近的研究表明镉对骨质疏松症有影响,但还需要进一步的研究来辨别镉是否在早期发展阶段毒害神经。必须采取坚决行动来阻止农业土壤中镉含量进一步增加。本文给出了预防及采取措施的建议。 | Ing-Marie Olsson Jan Eriksson Ingrid born Staffan Skerfving Agneta Oskarsson 王中英 | 2005 | AMBIO-人类环境杂志2005，34，4： | 6 |
| 8 | How Off-farm Employment Affects Technical Efficiency of China's Farms" The Case of Jiangsu显示文摘 | Linxiu Zhang Weiliang Su Tor Eriksson Chengfang Liu | 2016 | China & World Economy2016，24，3： | 6 |
| 9 | 大型植物对湿地中硝酸盐持留的作用显示文摘湿地中硝酸盐的有效持留取决于脱氮作用(反硝化作用)。大型植物通过提供有机碳来支持脱氮作用。可被脱氮细菌利用的有机碳是由大型植物活体和死地被物释放的。大型植物为附生植物(它们也生产有机物质)和脱氮细菌提供附着表面。挺出水面的大型植物一般比浸于水中的大型植物更具生产力,但是浸水大型植物具有较多的附生植物,而且在水柱中为脱氮细菌提供了较大的附着面积。挺水型和浸水型植被在释放有机碳方面具有不同的季节特征。我们认为。对于具富硝酸盐地表径流的湿地脱氮而言,挺水型和浸水型大型植物的混合结构可能是有利的,植被对湿地水力学的影响也必须考虑。沿着水流,在较深处配置浸水型大型植物,而在较浅处,配置挺水型大型植物,这种交错的湿地设计有助于脱氮进程并改善水流的分布。 | Stefan Weisner Peder Eriksson WilhelmGranéli Lars Leonardson 朱志辉 | 1994 | 人类环境杂志1994，23，6： | 6 |
| 10 | Contribution of precursor compounds to the release of per-and polyfluoroalkyl substances(PFASs) from waste water treatment plants(WWTPs)显示文摘Per-and polyfluoroalkyl substances(PFASs) are ubiquitous in sludge and water from waste water treatment plants, as a result of their incorporation in everyday products and industrial processes. In this study, we measured several classes of persistent PFASs,precursors, transformation intermediates, and newly identified PFASs in influent and effluent sewage water and sludge from three municipal waste water treatment plants in Sweden, sampled in 2015. For sludge, samples from 2012 and 2014 were analyzed as well.Levels of precursors in sludge exceeded those of perfluoroalkyl acids and sulfonic acids(PFCAs and PFSAs), in 2015 the sum of polyfluoroalkyl phosphoric acid esters(PAPs) were 15–20 ng/g dry weight, the sum of fluorotelomer sulfonic acids(FTSAs) was 0.8–1.3 ng/g,and the sum of perfluorooctane sulfonamides and ethanols ranged from non-detected to 3.2 ng/g. Persistent PFSAs and PFCAs were detected at 1.9–3.9 ng/g and 2.4–7.3 ng/g dry weight, respectively. The influence of precursor compounds was further demonstrated by an observed substantial increase for a majority of the persistent PFCAs and PFSAs in water after waste water treatment. Perfluorohexanoic acid(PFHxA), perfluorooctanoic acid(PFOA), perfluorohexane sulfonic acid(PFHxS), and perfluorooctane sulfonic acid(PFOS)had a net mass increase in all WWTPs, with mean values of 83%, 28%, 37% and 58%,respectively. The load of precursors and intermediates in influent water and sludge combined with net mass increase support the hypothesis that degradation of precursor compounds is a significant contributor to PFAS contamination in the environment. | Ulrika Eriksson Peter Haglund Anna K?rrman | 2017 | Journal of Environmental Sciences2017，29，11： | 5 |
| 11 | Latest development of double perovskite electrode materials for solid oxide fuel cells:a review显示文摘Recently,the development and fabrication of electrode component of the solid oxide fuel cell(SOFC)have gained a significant importance,especially after the advent of electrode supported SOFCs.The function of the electrode involves the facilitation of fuel gas diffusion,oxidation of the fuel,transport of electrons,and transport of the byproduct of the electrochemical reaction.Impressive progress has been made in the development of alternative electrode materials with mixed conducting properties and a few of the other composite cermets.During the operation of a SOFC,it is necessary to avoid carburization and sulfidation problems.The present review focuses on the various aspects pertaining to a potential electrode material,the double perovskite,as an anode and cathode in the SOFC.More than 150 SOFCs electrode compositions which had been investigated in the literature have been analyzed.An evaluation has been performed in terms of phase,structure,diffraction pattern,electrical conductivity,and power density.Various methods adopted to determine the quality of electrode component have been provided in detail.This review comprises the literature values to suggest possible direction for future research. | Shammya AFROZE AfizulHakem KARIM Quentin CHEOK Sten ERIKSSON Abul K.AZAD | 2019 | Frontiers in Energy2019，13，4： | 5 |
| 12 | Regulation of the permeability transition pore skeletal muscle mitochondria显示文摘 | Fontaine E Eriksson O Ichas F | 1998 | J Bid Chem1998，273，12： | 3 |
| 13 | 脑胶质瘤组织中胸腺嘧啶核苷激酶1的表达和意义及其与细胞增殖抗原Ki67表达的关系显示文摘目的研究脑胶质瘤组织中胸腺嘧啶核苷激酶1(TK1)的表达和意义,以及其与细胞增殖抗原Ki67表达的关系。方法 202例脑胶质瘤患者,经病理检查进行脑胶质瘤病理分级及组织类型分型。采用免疫组化染色法检测脑胶质瘤组织中TK1和Ki67的表达。比较不同级别及类型患者脑胶质瘤组织中TK1表达的阳性率;分析TK1与Ki67表达的关系。结果本组患者脑胶质瘤按WHO分级:Ⅰ级12例,Ⅱ级85例,Ⅲ级60例,Ⅳ级45例;组织类型分型:少突胶质细胞瘤28例,星形胶质细胞瘤174例。本组患者TK1阳性119例(58.9%);其中良性组(WHOⅠ级)患者无TK1阳性,低度恶性组(WHOⅡ级)阳性31例(36.5%),高度恶性组(WHOⅢ、Ⅳ级)阳性88例(83.8%);三组间TK1阳性率比较差异均有统计学意义(P<0.05~0.001)。星形胶质细胞瘤及复发患者的TK1阳性率分别显著高于少突胶质细胞瘤和初发的患者(均P<0.05)。TK1与Ki67的表达水平呈正相关(r=0.711,P<0.01)。结论恶性程度高、星形胶质细胞瘤及复发的脑胶质瘤患者瘤组织中TK1的表达增高;提示TK1表达可作为脑胶质瘤病理分级、分型及复发的重要参考指标。TK1与Ki67正相关,提示TK1亦可反映脑胶质瘤细胞的增殖情况。 | 朱海青 宋坤 王娟 张巧全 周金宝 石群立 Staffan Eriksson Ellen He Sven Skog | 2012 | 临床神经病学杂志2012，25，5： | 3 |
| 14 | Microbial mat-related structures shared by both siliciclastic and carbonate formations显示文摘Microbiota has always been the dominant life form,records of which are preserved in delicate forms within siliciclastic rocks.More pronounced record in the form of stromatolites possibly obscured the fact that many of the same delicate structures may be recognizable within carbonate rocks too.The Neoproterozoic Bhander Limestone in central India bears many such structures that are quintessentially similar to microbial mat-related structures reported from the Paleoproterozoic Chorhat Sandstone preserved within the same,Vindhyan Basin.Extensive microscopic,ultramicroscopic,and geochemical studies address the apprehension that such bedding plane structures in carbonate rocks could be merely weathering products.Trapping,binding and stabilitization of sediment by microbial mats are all evident.Preferred pyritization along the inferred,predefined microbial mats confirmed on the basis of EPMA(Electron Probe Microanalysis) results,and the enhanced carbon content along these mats layers and within suspected mat chips associated with them,are revealing.Raman spectroscopy,indeed,evinces enhanced kerogen content within both mats and mat chips.Interestingly,these microbial mat layers are recognized selectively within the lower of the two tiers of the Bhander Limestone.The lagoonal carbonate of the lower tier of the Bhander Limestone is muddy and contains a substantial proportion of silt-sized quartz grains that possibly impeded stromatolite growth.Stromatolites abound in the wave agitated upper tier of the Bhander Limestone which is dominated by oosparite.This paper provides evidence that the delicate microbial mat-related structures reported so far only from siliciclastic rocks can also be recognized within carbonate formations,and hopes to stimulate the search for additional such features,more preferably within carbonates originated in shallow and quiet water. | Subir Sarkar Adrita Choudhuri Sunipa Mandal Patrick G. Eriksson | 2016 | Journal of Palaeogeography2016，5，3： | 3 |
| 15 | In-situ characterization of metal nanoparticles and their organic coatings using laser-vaporization aerosol mass spectrometry显示文摘方法的发展很快正在进行经由喷雾器线路与唯一的性质生产 nanoparticles。典型描述技术为随后的离线的分析从合成过程提取粒子,它可以改变粒子特征。在这个工作,我们与 70-eV 电子电离使用激光蒸发喷雾器团 spectrometry (LVbe ) 为即时,在原处 nanoparticle 描述。粒子特征为各种各样的喷雾器合成方法被检验, sintering 的度,并且为器官的材料到的控制冷凝作用模仿表面 coating/functionalization。LVbe 被用来描绘金属 nanoparticles (Ag, Au, Pd, PdAg, Fe, Ni,和 Cu ) 的几种类型。Fe 和 Ni nanoparticles 的氧化的度被发现与增加的 sintering 温度增加,当时表面金属粒子的器官杂质的内容与增加的 sintering 温度减少。为总数金属粒子,器官杂质的内容被发现类似于单层的。由比较不同相等直径的大小,我们证明 LVbe 能与一个微分活动性分析器一起被使用决定综合金属粒子的紧密,在 sintering 期间并且在为表面 functionalization 的材料增加期间。进一步,供应到粒子生产的材料发电机被发现作为沾染物到达发电机的粒子下游地排队。为这的能力在原处观察是重要的,当它在粒子生产以内便于快速的反应到不希望得到的行为,处理。这研究表明实用程序即时,在原处描绘从合成进程直接获得的金属 nanoparticles 的度谱的大小衬里包括他们的化学作文,形状,和污染,为进程操作的有效优化提供潜力的喷雾器质量参数。 | Patrik T. Nilsson Axel C. Eriksson Linus Ludvigsson Maria E. Messing Erik Z. Nordin Anders Gudmundsson Bengt O. Meuller Knut Deppert Edward C. Fortner Timothy B. Onasch Joakim H. Pagels | 2015 | Nano Research2015，8，12： | 2 |
| 16 | Recruitment in species-rich grasslands: the effects of functional traits and propagule pressure显示文摘Aims The assembly of plant communities is a complex process which combines impacts from the species pool,dispersal and propagule pressure,niche requirements of colonizing species and the niche structure of the community.Recent theory development has incorporated all these aspects,e.g.in‘stochastic niche theory’.We investigated recruitment into a species-rich grassland community,using an experimental approach where we manipulated the trait composition of the community and examined the success of colonizing species entering with various propagule pressure.Specifically,we examined two predictions:(i)colonization success increases with increasing difference between traits of the colonizing species and the trait profile of the community and(ii)colonization success increases with increasing propagule pressure.Methods The examined communities were species-rich semi-natural grasslands located in southern Sweden.After a careful documentation of the composition of the plant communities at the experimental sites,we manipulated the trait profile of species-rich grassland plots based on the plant functional trait specific leaf area(SLA),which is correlated with several key life history functions.In addition to SLA,seed mass was also used to describe the trait profile of grassland plots.Seeds of 12 plant species from the regional species pool,varying in SLA and seed mass,were sown into plots using four different levels of propagule pressure.Recruitment was examined after 1 year.We also planted juvenile‘plug plants’of the same species which allowed us to examine survivorship and growth beyond the seedling stage.Important Findings Overall we found very limited evidence for relationships between the traits of the colonizing species and the trait profile of the community and for recruitment after sowing these relationships were contrary to the prediction.Survival of plug plants after two seasons of growth was high irrespective of the trait profile of the community,but growth of plug plants was affected by the trait profile of the surrounding community.For four of the species there was a positive effect of increased propagule pressure on colonization.The results suggest that species assembly in species-rich grasslands is not strongly dependent on the niche structure of the community.However,the finding that colonization of only a third of the species responded positively to increased propagule pressure indicates that there might be niche-related effects that were not captured by our treatments.Overall,our results indicate that the factors determining colonization in this community are species specific.Some species are able to colonize irrespective of niche relationships,provided that the propagule pressure is sufficiently high to overcome stochastic mortality after seed arrival.For other species,however,we cannot exclude that niche assembly occurred,but we failed to identify the relevant niche factor. | MathiasÖster Ove Eriksson | 2012 | Journal of Plant Ecology2012，5，3： | 2 |
| 17 | Chemical/Physical Retting of Flax Using Detergent and Oxalic Acid at High Ph显示文摘 | Gunnar Henriksson Karl-Erik L Eriksson | 1998 | Textile Res J1998，68，： | 2 |
| 18 | Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance显示文摘 | Tuomilehto J Lindstrom J Eriksson JG | | 0，，： | 2 |
| 19 | Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding显示文摘 | Guillaume Paré Niclas Eriksson Thorsten Lehr Stuart Connolly John Eikelboom Michael D. Ezekowitz Tomas Axelsson Sebastian Haertter Jonas Oldgren Paul Reilly Agneta Siegbahn Ann-Christine Syvanen Claes Wadelius Mia Wadelius Heike Zimdahl-Gelling Salim Yusu | 2013 | Circulation2013，，13： | 2 |
| 20 | 多奈哌齐治疗重度阿尔茨海默病患者:双盲、平行分组、安慰剂对照研究显示文摘Background: The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer’s disease. Its efficacy in severe dementia has not been assessed and is controversial. Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer’s disease, by focusing primarily on cognition and activities of daily living. Methods: We did a 6-month, double-blind, parallel-group, placebo-controlled study in 248 patients with severe Alzheimer‘s disease (mini mental state examination score 1-10) who were living in assisted care nursing homes ran by trained staff in Sweden. We assigned patients oral donepezil (5 mg per day for 30 days then up to 10 mg per day thereafter, n=128) or matched placebo (n=120). Our primary endpoints were change from baseline to month 6 in the severe impairment battery (SIB) and modified Alzheimer’s Disease Cooperative Study activities of daily living inventory for severe Alzheimer’s disease (ADCS-ADL-severe). We analysed outcomes for patients with data at baseline and at one or more other timepoints (modified intent-to-treat population) with last observation carried forward used to replace missing data. Findings: 95 patients assigned donepezil and 99 patients assigned placebo completed the study. Patients treated with donepezil improved more in SIB scores and declined less in ADCS-ADL-severe scores at 6 months after initiation of treatment compared with baseline than did controls (least squares [LS] mean difference, 5.7, 95%CI 1.5-9.8; p=0.008, and 1.7, 0.2-3.2; p=0.03, respectively). The incidence of adverse events was comparable between groups (donepezil 82%[n=105] vs placebo 76%[n=91]), with most being transient and mild or moderate in severity. More patients discontinued treatment because of adverse events in the donepezil group (n=20) than in the placebo group (n=8). Interpretation: Donepezil improves cognition and preserves function in individuals with severe Alzheimer’s disease who live in nursing homes. | Winblad B. Kilander L. Eriksson S. 周永(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 2 |
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