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| 1 | Role of genetic disorders in acute recurrent pancreatitis显示文摘There was remarkable progress in the understanding of the role genetic risk factors in chronic pancreatitis. These factors seem to be much more important than thought in the past. The rare autosomal-dominant mutations N29I and R122H of PRSS1 (cationic trypsinogen) as well as the variant N34S of SPINK1 (pancreatic secretory trypsin inhibitor) are associated to a disease onset in childhood or youth. Compared to chronic alcoholic pancreatitis the progression is slow so that for a long time only signs of acute-recurrent pancreatitis are found. Only at later time points (more than 10-15 years) there is evidence for chronic pancreatitis in the majority of patients. Acute recurrent pancreatitis may therefore be regarded as a transition state until definite signs of chronic pancreatitis are detectable. | Volker Keim | 2008 | World Journal of Gastroenterology2008，14，7： | 11 |
| 2 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 3 | Microbiome and pancreatic cancer: A comprehensive topic review of literature显示文摘AIM To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes.METHODS A comprehensive literature review was conducted by allinclusive topic review from PubM ed, MEDLINE, and Web of Science. The last search was performed in October 2016.RESULTS Diverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations.CONCLUSION Pilot study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival. | Natalie Ertz-Archambault Paul Keim Daniel Von Hoff | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 4 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 5 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 3 |
| 6 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 7 | 信息可视化与可视化数据挖掘显示文摘信息可视化与可视化数据挖掘有助于探索和分析当今大量涌现的数据和信息,文章从可视化数据类型、可视化技术和视图变换方法等三个方面对信息可视化和可视化数据挖掘技术进行了分类,并辅以实例说明。 | Daniel A. Keim 熊祥鸿(选编) | 2008 | 华东电力2008，36，9： | 2 |
| 8 | 稀土催化齐聚α-烯烃的研究显示文摘研究了三氯化镱分别和AlEt_3,AlEt_2Cl以及AlEtCl_2组成的催化体系催化烯烃齐聚反应。三氯化镱和三乙基铝组成的催化体系能齐聚和聚合乙烯,但活性较低。三氯化镱和一氯二乙基铝组成的催化体系能有效地齐聚乙烯,得到C_4-CD_8烯烃含量达到99%,且线性率高。二氯乙基铝是三种烷基铝中最有效的助催化剂,它和三氯化镱组成的体系催化乙烯齐聚的活性在80℃,Al/Yb=40的反应条件下可达3400molC_2H_4/mol Yb·h;此催化体系还能催化齐聚丙烯、丁烯-1及己烯-1。初步研究了稀土化合物的配体及不同稀土元素化合物对催化反应的影响。 | 陈忠心 沈之荃 Keim W. | 1991 | Chinese Journal of Catalysis1991，12，1： | 2 |
| 9 | Ofloxacin and Ursodeoxycholic Acid Versus Ursodeoxycholic Acid Alone to Prevent Occlusion of Biliary Stents: A Prospective, Randomized Trial显示文摘 | U. Halm I. Schiefke W. Fleig J. M?ssner V. Keim | 2001 | Endoscopy2001，，06： | 2 |
| 10 | Ionic Liquids-New 'Solution' for transition metal catalysis显示文摘 | Wassercheid W P Keim W | 2000 | Angew Chem Int Ed2000，39，： | 1 |
| 11 | Long - term clinical out come of paraneoplastic cerebellar degeneration and anti - Yo antibodies 显示文摘 | Rojas I Graus F Keime - Guibert F | 2000 | Neurology2000，55，5： | 1 |
| 12 | Fructose,weight gain,and the insulin resistance syndrome显示文摘 | Elliott SS Keim NL Stern JS | 2002 | Am J Clin Nutr2002，76，5： | 1 |
| 13 | Ionic Liquids-new 'Solution' for Transition Metalysis显示文摘 | Wasserscheid P Keim W | 2000 | Chem Int Ed2000，39，37： | 1 |
| 14 | Searching in high-dimensional spaces:index structures for improving performance of multimedia databases显示文摘 | Bohm C Berchtold S Keim D A | 2001 | ACM Computing Surveys2001，33，3： | 1 |
| 15 | Rat pancreatitisassociated protein is expressed in relation to severity of experimental pancreatitis显示文摘 | Keim V Willemer S Iovanna JL | 1994 | Pancreas1994，9，5： | 1 |
| 16 | Developmental work personality scale: an initialanalysis显示文摘 | Strauser DR Keim J | 2002 | Rehabilitation Counseling Bulletin2002，45，2： | 1 |
| 17 | Molecular evolution and di- versity in Bacillus anthraeis as detected by amplified fragment length polymorphism markers 显示文摘 | Keim P Kalif A Schupp J | 1997 | J Bacteriol1997，179，3： | 1 |
| 18 | Thrombolytic therapy for acute ischemic stroke beyond three hours显示文摘 | Carpenter CR Keim SM Milne WK | 2011 | J Emerg Med2011，40，1： | 1 |
| 19 | Arch dimension changes from successful slow maxillary expansion of unilateral posterior crossbite显示文摘 | Wong CA Sinclair PM Keim RG | 2011 | Angle Orthod2011，81，4： | 1 |
| 20 | Cancer incidence after localized therapy for prostate cancer显示文摘 | Moon K Stikenborg GJ Keim J | 2006 | Cancer2006，107，： | 1 |
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