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| 1 | New generation of multi-scale NWP system (GRAPES):general scientific design显示文摘A new generation of numerical prediction system GRAPES (a short form of Global/Regional Assimilation and PrEdiction System) was set up in China Meteorological Administration (CMA). This paper focuses on the scientific design and preliminary results of the numerical prediction model in GRAPES, including basic idea and strategy of the general scientific design, multi-scale dynamic core, physical package configuration, architecture and parallelization of the codes. A series of numerical experiments using the real data with horizontal resolutions from 10 to 280 km and idealized experiments with very high resolution up to 100 m are conducted, giving encouraging results supporting the multi-scale application of GRAPES. The results of operational implementation of GRAPES model in some NWP centers are also presented with stress at evaluations of the capability to predict the main features of precipitation in China. Finally the issues to be dealt with for further development are discussed. | CHEN DeHui XUE JiShan YANG XueSheng ZHANG HongLiang SHEN XueShun HU JiangLin WANG Yu JI LiRen CHEN JiaBin | 2008 | Chinese Science Bulletin2008，53，22： | 70 |
| 2 | LA-(MC)-ICPMS U-Pb zircon geochronology and Lu-Hf isotope compositions of the Taihua complex on the southern margin of the North China Craton显示文摘Widely distributed on the southern margin of the North China Craton,the Taihua complex extends roughly in an east-west direction and the relatively complete successions are found in Lushan County,Henan Province.Like many other Archean terranes,the Taihua Complex can be divided into two major lithological units along the Dangze River,namely gneisses series and supracrustal rocks.The former is located on the north side of the river and chiefly composed of TTG gneisses and amphibolites;the latter on the south side of the river is mainly supracrustal rock.Coupled with the previous studies,the results obtained by this study show that the Taihua complex was formed in a large time span from Neoarchean to Palaeoproterozoic.The TTG gneisses and amphibolites are dated at Neoarchean (2794–2752 Ma).The 2.9 Ga and 3.1 Ga zircons in amphibolites could be xenocrysts.In the North China Craton,the 2.8–2.7 Ga old rocks crop out in several areas e.g.western Shandong Province,Jiaodong Peninsula and Lushan area of Henan Province.In addition,2.8–2.7 Ga detrital zircons or xenocryst zircons have been recognized in Huai’an,Fuping,Wutai areas of North China Craton and also reported in the Early Paleozoic diamondiferous kimberlites in Mengyin and Fuxian.All these age results indicate that the 2.8–2.7 Ga rocks may have been developed much broader region than today’s outcrops.Zircon Hf and whole rock Nd isotopes show that the 2.8–2.7 Ga tectono-thermal event represents an important period of crustal growth with minor ancient crust reworked in the North China Craton.However the formation of supracrustal rocks is limited to 2.2–2.0 Ga in the Palaeoproterozoic time,not the Archaean,as previously believed.Combined with the chronological data of aluminium-rich metamorphic rocks (Khondalite series) on the southern margin of the North China Craton and adjacent areas,it is suggested that the above areas have widely developed Paleoproterozoic passive continental margin environment. | DIWU ChunRong SUN Yong LIN CiLuan WANG HongLiang | 2010 | Chinese Science Bulletin2010，55，23： | 72 |
| 3 | Characteristics of dissolved organic matter(DOM) in leachate with different landfill ages显示文摘学习的主要目的是调查溶解有机物(DOM ) 的特征在沥滤通过化学、分光镜、元素的分析与不同垃圾堆年龄吃了。胡敏酸(哈) , fulvic (FA ) ,并且吸水(HyI ) 部分被与阳离子交换尸方法相结合的 XAD-8 树脂孤立并且净化。荧光刺激排放矩阵光谱学(EEM ) 的分析结果表明荧光山峰是为年轻垃圾堆的像蛋白质的荧光沥滤当为中等、旧的垃圾堆的荧光山峰沥滤时,吃了吃分别地是象腐殖一样和象 fulvic 一样荧光。元素的分析证明那碳,氢,和氮内容与垃圾堆年龄减少了,当氧内容增加了时。而且,在这些孤立的部分的氮内容列在后面:哈 >
HyI >
FA。元素的分析,英尺红外,和荧光 EEM 的结果也证实脂肪族的功能的组的芳香的碳和部分更充满沥滤与增加垃圾堆年龄吃了样品。 | HUO Shouliang XI Beidou YU Haichan HE Liansheng FAN Shilei LIU Hongliang | 2008 | Journal of Environmental Sciences2008，20，4： | 52 |
| 4 | U–Pb ages and Hf isotopes for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southwestern margin of the North China Craton显示文摘In situ U-Pb dating and Lu-Hf isotopic analysis were carried out for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southern margin of the North China Craton (NCC). The re- sults provide further constraints on the crustal formation and evolution history of NCC. Four 207Pb/206Pb age populations were obtained from 99 analyses, with clusters at ~3.40 Ga, 2.77―2.80 Ga, ~2.50 Ga and 2.34 Ga, respectively. The 3.40 Ga old zircons have similar Hf isotopic compositions to those from Ar- chean rocks in the Jidong and Anshan areas of NCC. However, crustal remnants older than 3.6 Ga have been identified in the southern margin of NCC, the South China Craton, the northwestern part of the Qinling Orogen and its adjacent area. Thus, it is not easy to trace the source rock from which the 3.40 Ga detrital zircons were derived. It can be inferred that the crustal remnants older than 3.40 Ga might have been widely distributed in the North China Craton. The 2.77―2.80 Ga zircons make up a relatively small proportion and have the highest εHf (t) values (up to 6.1±1.6), consistent with the Hf isotopic composition of the depleted mantle at 2.83 Ga. Their single-stage Hf model age of 2.83 Ga is close to their crystallized age, suggesting that their source rocks were extracted from the contemporaneous depleted mantle. The ~2.50 Ga zircon grains constitute about 85% of the total grain population and their Hf isotopic compositions indicate major growth of juvenile crust at ~2.50 Ga but minor reworking of ancient crust. The youngest zircon dated in this study gave an U-Pb age of 2337±23 Ma, which can be considered the maximum depositional age of the formation of the Songshan Group. | DIWU ChunRong SUN Yong YUAN HongLin WANG HongLiang ZHONG XingPing LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，18： | 54 |
| 5 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 6 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 7 | ~4.1 Ga xenocrystal zircon from Ordovician volcanic rocks in western part of North Qinling Orogenic Belt显示文摘High-precision U-Pb dating by in situ LA-ICP-MS yields an age of 4079±5 Ma for a xenocrystal zircon from Ordovician volcanics of the Caotangou Group in western part of the North Qinling Orogenic Belt. As a result, the North Qinling Orogenic Belt becomes one of a few localities in the world that contain Hadean age records (4276±6 Ma and 4404±8 Ma detrital zircons from Jack Hill of the Yilgarn craton, 4016 Ma Acasta gneisses of the Wopmay Orogeny and Burang quartzite with detrital zircon of 4103 Ma in Tibet). It is also the first report of the Hadean age in Phanerozoic volcanics. The finding of the 4.1 Ga xenocrystal zircon provides not only the geochronological record of the oldest crustal materials in China, but also the condition for further search for rocks forming in the region during the early time of the Earth’s evolution. Thirty-six zircon U-Pb dates from the Ordovician volcanic rocks are subgrouped into seven generations that represent different tectono-magmatic events in the North Qinling Orogenic Belt. Among them, two periods of 0.9-1.5 Ga and 0.4-0.5 Ga are consistent with Mesoproterozoic and Early Paleozoic orogenies, respectively. | WANG HongLiang CHEN Liang SUN Yong LIU XiaoMing xu XueYi CHEN JuanLu ZHANG Hong DIWU ChunRong | 2007 | Chinese Science Bulletin2007，52，21： | 23 |
| 8 | Lightweight Design and Verification of Gantry Machining Center Crossbeam Based on Structural Bionics显示文摘 | Ling Zhao Jianfeng Ma Wuyi Chen Hongliang Guo | 2011 | Journal of Bionic Engineering2011，8，2： | 22 |
| 9 | Impact of essential oils and organic acids on the growth performance,digestive functions and immunity of broiler chickens显示文摘The aim of the experiment was to study the effects of feeding blends of sorbic acid, fumaric acid, and thymol(EOA) on growth performance, digestive functions, and immunity of broiler chickens. A total of 640 one-day-old male Cobb 500 chicks with similar BW(41.8 ± 0.6 g) were randomly divided into 4dietary treatment groups consisting of 10 replicates with 16 birds per replicate and fed a basal diet until d 42(CON) or diets with 0.15 g/kg enramycin during the grower period(AG), 0.30 g/kg EOA during the grower period(EG), or 0.30 g/kg EOA during the finisher period(EF). At d 42, the feed conversion ratio was reduced(P < 0.05) for birds in EG group compared with other groups. Birds in EG group showed a higher villus height of the duodenum and jejunum and muscular layers of the duodenum and ileum than birds in CON group(P < 0.05). Compared with other groups, crypt depth of the jejunum and ileum was markedly increased(P < 0.05) by EOA supplementation during the finisher period at d 42. The EOA supplementation during grower period increased significantly lipase, trypsin and chymotrypsin activities of the duodenum at d 21 and 42, as well as lipase and trypsin at d 21, and trypsin and chymotrypsin at d 42 in the jejunum, and trypsin and chymotrypsin activities of the ileum at d 21 compared to the control diet(P < 0.05). Birds of EG and EF groups showed a higher(P < 0.05) spleen index than birds of CON group. The level of secretory immunoglobulin A in duodenal and ileal mucosa was increased(P < 0.05) in EF group at d 42 compared with other groups. In conclusion, the results indicate that EOA can be effectively applied in broiler diets, especially during the grower phase by improving intestinal morphology and increasing digestive enzyme activity. | Xin Yang Hongliang Xin Chengbo Yang Xiaojun Yang | 2018 | Animal Nutrition2018，，4： | 20 |
| 10 | Essential oil and aromatic plants as feed additives in non-ruminant nutrition:a review显示文摘This paper summarizes the current knowledge regarding the possible modes of action and nutritional factors involved in the use of essential oils(EOs) for swine and poultry.EOs have recently attracted increased interest as feed additives to be fed to swine and poultry,possibly replacing the use of antibiotic growth promoters which have been prohibited in the European Union since 2006.In general,EOs enhance the production of digestive secretions and nutrient absorption,reduce pathogenic stress in the gut,exert antioxidant properties and reinforce the animal's immune status,which help to explain the enhanced performance observed in swine and poultry.However,the mechanisms involved in causing this growth promotion are far from being elucidated,since data on the complex gut ecosystem,gut function,in vivo oxidative status and immune system are still lacking.In addition,limited information is available regarding the interaction between EOs and feed ingredients or other feed additives(especially pro- or prebiotics and organic acids).This knowledge may help feed formulators to better utilize EOs when they formulate diets for poultry and swine. | Zhikai Zeng Sai Zhang Hongliang Wang Xiangshu Piao | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 19 |
| 11 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 12 | A model and experimental study of phosphate uptake kinetics in algae:Considering surface adsorption and P-stress显示文摘Phosphorus is an important limiting nutrient in many ecosystems.Consequently,there is increasing interest on phosphate uptake and algal growth due to the increasing frequency and magnitude of algal blooms induced by eutrophication.The co-existence of surface adsorbed and intracellular phosphorus pools indicate that phosphate uptake by phytoplankton is,to some extent,a two-stage kinetic process.However,almost all previous uptake models considered the internal uptake stage only and ignored the possible impact of surface adsorption.In this article,a two-stage kinetic uptake model considering both surface adsorption and P-stress on phosphate uptake by algae was constructed and compared to conventional one-stage models,based on experimental data on short-term uptake kinetics of a green algae S.quadricauda.Results indicated that with suitable parameters,the two-stage uptake model not only fit the experimental data better,but also gave more reasonable and realistic explanations to the phosphate uptake process.The results are meaningful as surface-adsorption of phosphate may affect the uptake process of phosphate and assist in understanding realistic phosphate uptake kinetics in phytoplankton. | Bo Yao Beidou Xi Chunming Hu Shouliang Huo Jing Su Hongliang Liu | 2011 | Journal of Environmental Sciences2011，23，2： | 15 |
| 13 | Critical illness polyneuropathy and myopathy:a systematic review显示文摘Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles,respectively.Clinically,they manifest as limb and respiratory muscle weakness.Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation.Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event.Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy.Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population.The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical,diagnostic,differentiating,and treatment information for this debilitating neurological disease. | Chunkui Zhou Limin Wu Fengming Ni Wei Ji Jiang Wu Hongliang Zhang | 2014 | Neural Regeneration Research2014，9，1： | 15 |
| 14 | Changes in soil properties and erodibility of gully heads induced by vegetation restoration on the Loess Plateau, China显示文摘Soil erosion on the Loess Plateau of China is effectively controlled due to the implementation of several ecological restoration projects that improve soil properties and reduce soil erodibility. However, few studies have examined the effects of vegetation restoration on soil properties and erodibility of gully head in the gully regions of the Loess Plateau. The objectives of this study were to quantify the effects of vegetation restoration on soil properties and erodibility in this region. Specifically, a control site in a slope cropland and 9 sites in 3 restored land-use types(5 sites in grassland, 3 in woodland and 1 in shrubland) in the Nanxiaohegou watershed of a typical gully region on the Loess Plateau were selected, and soil and root samples were collected to assess soil properties and root characteristics. Soil erodibility factor was calculated by the Erosion Productivity Impact Calculator method. Our results revealed that vegetation restoration increased soil sand content, soil saturated hydraulic conductivity, organic matter content and mean weight diameter of water-stable aggregate but decreased soil silt and clay contents and soil disintegration rate. A significant difference in soil erodibility was observed among different vegetation restoration patterns or land-use types. Compared with cropland, soil erodibility decreased in the restored lands by 3.99% to 21.43%. The restoration patterns of Cleistogenes caespitosa K. and Artemisia sacrorum L. in the grassland showed the lowest soil erodibility and can be considered as the optimal vegetation restoration pattern for improving soil anti-erodibility of the gully heads. Additionally, the negative linear change in soil erodibility for grassland with restoration time was faster than those of woodland and shrubland. Soil erodibility was significantly correlated with soil particle size distribution, soil disintegration rate, soil saturated hydraulic conductivity, water-stable aggregate stability, organic matter content and root characteristics(including root average diameter, root length density, root surface density and root biomass density), but it showed no association with soil bulk density and soil total porosity. These findings indicate that although vegetation destruction is a short-term process, returning the soil erodibility of cropland to the level of grassland, woodland and shrubland is a long-term process(8–50 years). | GUO Mingming WANG Wenlong KANG Hongliang YANG Bo | 2018 | Journal of Arid Land2018，10，5： | 14 |
| 15 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 16 | Verification of GRAPES unified global and regional numerical weather prediction model dynamic core显示文摘During the past few years, most of the new developed numerical weather prediction models adopt the strategy of multi-scale technique. Therefore, China Meteorological Administration has devoted to developing a new generation of global and regional multi-scale model since 2003. In order to validate the performance of the GRAPES (Global and Regional Assimilation and PrEdiction System) model both for its scientific design and program coding, a suite of idealized tests has been proposed and conducted, which includes the density flow test, three-dimensional mountain wave and the cross-polar flow test. The density flow experiment indicates that the dynamic core has the ability to simulate the fine scale nonlinear flow structures and its transient features. While the three-dimensional mountain wave test shows that the model can reproduce the horizontal and vertical propagation of internal gravity waves quite well. Cross-polar flow test demonstrates the rationality of both for the semi-Lagrangian departure point calculation and the discretization of the model near the poles. The real case forecasts reveal that the model has the ability to predict the large-scale weather regimes in summer such as the subtropical high, and to capture the major synoptic patterns in the mid and high latitudes. | YANG XueSheng HU JiangLin CHEN DeHui ZHANG HongLiang SHEN XueShun CHEN JiaBin JI LiRen | 2008 | Chinese Science Bulletin2008，53，22： | 14 |
| 17 | Study on Graphene Oxide Modified Inorganic Phase Change Materials and Their Packaging Behavior显示文摘We prepared the nano-inorganic phase-change 'alloy' materials through the modification of Na_2SO_4·10H_2O using Na_2HPO_4·12H_2O and GO nano-nucleating agent, and further investigated their thermophysical properties such as melting/solidification temperatures and enthalpies via differential scanning calorimetry. When the weight ratio of Na_2SO_4·10H_2O and Na_2HPO_4·12H_2O was 8:2 and the weight ratio of graphene oxide was 0.5% of phase change material, the phase change 'alloy' material showed excellent performances, specifically, the melting temperature and latent heat were found to be 22 ℃ and 190 J/g with a degree of subcooling decreased from 8.6℃ to 2.1℃. In order to extend the application of the phase change 'alloy' material to building energy saving field, it was adsorbed on expanded glass beads under vacuum and further covered with diatomite. When the adsorption rate of EGB(volume) and PCAM(weight) was 2.5:1, the particle size of diatomaceous earth was found to be 3.6μm, while the best packaging result was obtained with the melting temperature and latent heat being 21℃ and 135 J/g, and no leakage was observed. | 肖力光 ZHAO Mingyue HU Hongliang | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 14 |
| 18 | Formability of AA 2219-O sheet under quasi-static,electromagnetic dynamic,and mechanical dynamic tensile loadings显示文摘The mechanism by which electromagnetic forming(EMF)enhances the formability of metals is unclear owing to the coupling effect of multi-physics fields.In the present work,the associated formability improvement mechanisms were qualitatively categorized and illustrated.This was realized by comparing the formability of fully annealed 2219 aluminum alloy(AA 2219-O)sheet under quasi-static(QS),electromagnetic dynamic(EM),and mechanical dynamic(MD)tensile loadings.It was found that the forming limit of AA 2219-O sheet under EM tensile loading was significantly(45.4%)higher than that under QS tensile loading,and was marginally(3.7%–4.3%)higher than that under MD tensile loading.In addition,the forming limit of AA 2219-O sheet demonstrated a negative dependency on the strain rate within the range of the dynamic tensile tests conducted.The deformation conditions common to EM and MD tensile loadings were responsible for the significant formability improvement compared with QS tensile loading.In particular,the inertial effect was dominant.The different deformation conditions that distinguish EM tensile loading from MD tensile loading resulted in the marginal improvement in formability.This was caused by the absence of a sustaining contact force at the later deformation stage and the lower strain rate.The body force exerted little influence on the formability improvement,and the thermal effect under the two dynamic tensile loadings was negligible. | Hongliang Su Liang Huang Jianjun Li Wang Xiao Hui Zhu Fei Feng Hongwei Li Siliang Yan | 2021 | Journal of Materials Science & Technology2021，，11： | 13 |
| 19 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 20 | A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis cell condition显示文摘 | Weichao Yue Xiaofang Chen Weihua Gui Yongfang Xie Hongliang Zhang | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 13 |
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