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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 3 | 饲喂果寡糖对奥尼罗非鱼Oreochromisaurea ♂×O.nilotica♀肠道菌群、成活率及生长性能的影响(英文)显示文摘本研究通过8周生长试验研究了饲喂果寡糖对奥尼罗非鱼Oreochromis aurea♂×O.nilotica♀肠道菌群、存活率及生产性能的影响。试验设计3组果寡糖水平(0、0.8及1.2 g/kg),按每天4次饱食投喂初始重为5.55 g的奥尼罗非鱼,试验系统为淡水养殖系统,试验期间平均水温为28℃,罗非鱼养殖密度40尾/箱,每组3个重复。饲喂试验结束后,试验动物整体称重并测定形态学参数。从每个养殖单元随机取出3尾试验鱼,无菌条件下取肠道通过选择性培养基分别分析副溶血性弧菌Vibrio parahaemolyticus、嗜水气单胞菌Aeromonas hydrophila、乳酸杆菌Lactobacillussp.及粪链球菌Streptococcus faecalis的数量。结果表明:随着饲喂果寡糖水平增加,奥尼罗非鱼末重(FBW,g)和特定生长率(SGR,%/d)均显著增加(P<0.10);日摄食率(FI,g/(d.只)也增加(P>0.10);饲料转化率和肝胰腺指数均降低(P>0.10);而存活率(SR,%)、屠宰率(DCY,%)及丰满度(CF,g/cm3)则不受影响。所检测的全部罗非鱼肠道菌群数量随着饲喂果寡糖水平的上升呈增加状态(P>0.10)。本研究说明,饲料中添加果寡糖对奥尼罗非鱼生产性能、饲料转化效率及肠道菌群有一定改善作用,本研究推荐奥尼罗非鱼饲料中适宜果寡糖水平为1.2 g/kg。[动物营养学报,2007,19(6):691-697] | 吕慧源 周志刚 Florence Rudeaux Frédérique Respondek | 2007 | 动物营养学报2007，19，6： | 16 |
| 4 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 5 | Rehabilitation following spinal cord injury:how animal models can help our understanding of exercise-induced neuroplasticity显示文摘Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last decades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difficult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation. | Kristina Loy Florence M.Bareyre | 2019 | Neural Regeneration Research2019，14，3： | 11 |
| 6 | Detection of Allelic Variation in Chinese Wheat (Triticum aestivum L.) Germplasm with Drought ToleranceUsing SSR Markers显示文摘Allelic variation in two domestic wheat landraces, Pingyaobaimai and Mazhamai, two cornerstone breeding materials and their derived cultivars with drought tolerance was detected by SSR (simple sequence repeat) markers. The clustering of 25 accessions showed that the similarity between Pingyaobaimai and Yanda1817, the latter was developed from the former, was 0.71, the highest one of all accessions, but the similarities were very low between these two accessions and other accessions including their derived cultivars. A similar situation was revealed between Mazhamai and its derived cultivars. Pingyaobaimai and its three derived cultivars shared three alleles at loci Xgwm526, Xgwm538 and Xgwm126 on chromosome arms 2BL, 4BL and 5AL, respectively. There were six shared alleles in Mazhamai and its derived cultivars, in order of Xgwm157,Xgwm126, Xgwm212, Xgwm626, Xgwm471 and Xgwm44 on chromosome arms 2DL, 5AL, 5DL, 6BL, 7AS and 7DC, respectively. Only one shared allele was detected between the pedigrees of Pingyaobaimai and Mazhamai. The difference of shared alleles in two cornerstone breeding materials and their derived cultivars revealed the diversity in Chinese wheat germplasm with drought tolerance and the complication in genetic basis of drought tolerance in wheat. | JING Rui-lian, CHANG Xiao-ping, Marcello Broggio and JIA Ji-zeng(Key Laboratory of Crop Germplasm and Biotechnology , Institute of Crop Germplasm Resources , Chinese Academy of Agricultural Sciences, Beijing 100081 , P. R. China Oversea Agronomic Institute, Florence 50131 , Italy) | 2002 | Agricultural Sciences in China2002，1，10： | 7 |
| 7 | Portopulmonary hypertension and hepatopulmonary syndrome显示文摘Portopulmonary hypertension(POPH) and hepatopulmonary syndrome(HPS) are two frequent complications of liver disease, with prevalence among liver transplant candidates of 6% and 10%, respectively. Both conditions result from a lack of hepatic clearance of vasoactive substances produced in the splanchnic territory. Subsequently, these substances cause mainly pulmonary vascular remodeling and some degree of vasoconstriction in POPH with resulting elevated pulmonary pressure and right ventricular dysfunction. In HPS the vasoactive mediators cause intrapulmonary shunts with hypoxemia. Medical treatment is disappointing overall. Whereas liver transplantation(LT) results in the disappearance of HPS within six to twelve months, its effect on POPH is highly unpredictable. Modern strategies in managing HPS and POPH rely on a thorough screening and grading of the disease's severity, in order to tailor the appropriate therapy and select only the patients who will benefit from LT. The anesthesiologist plays a central role in managing these high-risk patients. Indeed, the important hemodynamic and respiratory modifications of the perioperative period mustbe avoided through continuation of the preoperatively initiated drugs, appropriate intraoperative monitoring and proper hemodynamic and respiratory therapies. | Florence Aldenkortt Marc Aldenkortt Laurence Caviezel Jean Luc Waeber Anne Weber Eduardo Schiffer | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 8 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 9 | 不同针头设计的预灌封注射器用于预防接种的对比研究显示文摘目的探讨5切面27G与3切面25G两种针头设计的预灌封注射器在受试者的疼痛感、接种护士的穿刺阻力以及注射部位不良事件等预防接种实践中的差异。方法采用随机双盲平行对照临床试验。将604例受试者随机分为2组,试验组299例使用5切面27G预灌封注射器,对照组305例使用3切面25G预灌封注射器接种甲肝疫苗,同时2组均使用3切面25G预灌封注射器接种乙肝疫苗作为自身对照。比较受试者疼痛与穿刺阻力,并比较受试者注射部位皮肤不良反应情况。结果采用视觉模拟量表(VAS)和疼痛程度语言等级量表中文版(C-PIVRS)评分法对甲肝疫苗穿刺时的疼痛感进行分级评价,试验组中等及以上疼痛比例分别为7.02%、16.55%;对照组分别为15.73%、20.32%,组间差异有统计学意义(均P≤0.001)。对照组注射甲肝时穿刺皮肤阻力VAS评分显著高于试验组(P<0.001)。试验组注射部位皮肤不良反应发生率低于对照组,分别为47.49%和65.25%(P<0.001)。结论5切面27G预灌封注射器用于疫苗接种时,受试者的疼痛度、针头的穿刺阻力以及注射部位不良事件发生率显著低于3切面25G针头设计的预灌封注射器。 | 吕敏 白霜 高培 王怀 富继业 史如晶 董琳 Florence Schwarzenbach Cecile Berteau 吴疆 | 2019 | 中华全科医学2019，17，11： | 6 |
| 10 | The Involvement of Lipids in Alzheimer's Disease显示文摘It has been estimated that Alzheimer's disease(AD), the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined.Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the ε4 variant of apolipoprotein E(APOE).Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD. | Wei Ling Florence Lim Ian James Martins Ralph Nigel Martins | 2014 | Journal of Genetics and Genomics2014，41，5： | 6 |
| 11 | Temporomandibular joint damage in K/BxN arthritic mice显示文摘Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood. | Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert | 2020 | International Journal of Oral Science2020，12，1： | 6 |
| 12 | Galectin-1-mediated biochemical controls of melanoma and glioma aggressive behavior显示文摘Gliomas and melanomas are associated with dismal prognosis because of their marked intrinsic resistance to proapoptotic stimuli,such as conventional chemotherapy and radiotherapy,as well as their ability to escape immune cell attacks.In addition,gliomas and melanomas display pronounced neoangiogenesis.Galectin-1 is a hypoxia-sensitive protein,which is abundantly secreted by glioma and melanoma cells,which displays marked proangiogenic effects.It also provides immune tolerogenic environments to melanoma and glioma cells through the killing of activated T cells that attack these tumor cells.Galectin-1 protects glioma and melanoma cells against cytotoxic insults(including chemotherapy and radiotherapy) through a direct role in the unfolded protein response.Altogether,these facts clearly point to galectin-1 as an important target to be combated in gliomas and melanomas in order to:(1) weaken the defenses of these two types of cancers against radiotherapy,chemotherapy and immunotherapy/vaccine therapy;and(2) reinforce antiangiogenic therapies.In the present article,we review the biochemical and molecular biology-related pathways controlled by galectin-1,which are actually beneficial for melanoma and glioma cells,and therefore detrimental for melanoma and glioma patients. | Florence Lefranc Véronique Mathieu Robert Kiss | 2011 | World Journal of Biological Chemistry2011，2，9： | 6 |
| 13 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 14 | 成人语音特征与9种体质的相关性研究显示文摘目的:探索多种语音特征与现代中医9种体质的相关性。方法:根据40位女性和10位男性18岁~38岁受试者的语音特征参数和9种体质参数所做的相关性统计和回归分析,每种体质都与多个语音特征相关,个别结果与理论有差异。结论:通过34个语音参数的线性回归能够非常好的建立模型、预测39位女性受试者的体质参数:测定系数R2很高,模型p值分很低:平和R-squared=0.8114,p=0.022,其他8种体质(气虚、阳虚、阴虚、痰湿、湿热、血瘀、气郁、特禀)R2>0.9,p≤0.022。 | Reclus Florence(孙乡) 杨学智 李海燕 朱庆文 牛欣 | 2012 | 中国中医基础医学杂志2012，18，4： | 5 |
| 15 | Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension显示文摘 | Ian R. Wanless Florence Wong Lawrence M. Blendis Paul Greig E.Jenny Heathcote Gary Levy | 1995 | Hepatology1995，，5： | 4 |
| 16 | The management of ascites in cirrhosis: Report on the consensus conference of the International Ascites Club显示文摘 | Kevin P. Moore Florence Wong Pere Gines Mauro Bernardi Andreas Ochs Francesco Salerno Paolo Angeli Michael Porayko Richard Moreau Guadelupe Garcia-Tsao Wladimiro Jimenez Ramon Planas Vicente Arroyo | 2003 | Hepatology2003，，1： | 4 |
| 17 | Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy显示文摘BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria.More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor cells.AIM To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after NAC.METHODSFrom January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt TRG.Based on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were performed.RESULTS Seventy-four patients were classified as responders and 76 as non-responders.The postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological response.Three were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 yr.The factors contributing to a poor prognosis for disease-free survival were: No histological response after NAC, largest metastasis > 3 cm, more than three preoperative metastases, R1 resection, and the use of a targeted therapy with NAC(P < 0.005).CONCLUSION A non-radiological response and a number of NAC sessions > 7 are the two most pertinent predictive factors of non-histological response(TRG 4 or 5). | Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 4 |
| 18 | 电化学氢压缩和纯化与竞争技术的对比:Ⅱ.电催化的挑战显示文摘在未来的几十年里,氢将成为世界能源政策的基础,因为它的脱碳性质,至少在可再生能源生产时是如此.目前,氢基本上仍然是从化石原料中生产出来的(在某种程度上来自于生物质);因此,目前市场上的氢气含有不可忽略的杂质,这些杂质阻碍了氢气立即用于特殊化学或作为燃料电池的能量载体,例如在运输应用(汽车、公共汽车、火车、船只等)中逐渐扩散到地球上.因此,氢气必须具有足够的纯度,但也必须充分压缩(在高压下,通常为70 MPa),这使得氢气循环中不可避免存在净化和压缩步骤.如本文第一部分'电化学氢压缩和净化与竞争技术的对比--第一部分:优缺点'所示,电化学氢压缩机(EHCs)能够实现氢净化和压缩,具有比它们相应的机械设备更多的理论(热力学)和实际(动力学)的优越性.然而,为了具有竞争力, EHCs必须在非常密集的条件下运行(高电流密度和低电池电压),只有在其核心材料(如膜和电极/电催化剂)经过优化后才能达到.本文将特别关注电催化剂在EHCs中必须表现出的特性:在杂质存在的情况下它们应促进(非常)快速的氢氧化反应(HOR),这意味着它们对毒物也具有(非常)耐受性.这包括操作氢气净化压缩所用的EHC阳极的先决条件,而大量低温燃料电池文献中为耐受毒性而开发的材料可能并不总是满足这两个标准,正如本综述所阐述的. | Marine Tregaro Maha Rhandi Florence Druart Jonathan Deseure Marian Chatenet | 2020 | Chinese Journal of Catalysis2020，41，5： | 4 |
| 19 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 20 | 猪圆环病毒的复制显示文摘猪圆环病毒是环状的单链DNA病毒,可以感染家猪和野猪。猪圆环病毒有两种型。猪圆环病毒2型可以引起断奶后多系统衰竭综合征,与此相反,猪圆环病毒1型没有致病性。猪圆环病毒DNA通过滚环复制机制进行复制。另有研究显示,质粒和单链病毒有类似的滚环复制机制,如双生病毒。滚环复制中重要的3种元件:①编码启动蛋白的基因;②双链起始位点;③单链起始位点。但是病毒与质粒之间以及不同的病毒之间存在着不同。猪圆环病毒的复制是采用融合型滚环复制机制,而不是交叉型滚环复制机制。作者对当前有关以猪圆环病毒复制作为圆环病毒属模型的研究进展进行了总结。通过多方面的研究,确定了影响复制的因素,并对复制不同时期的机制进行了描述或提出了假设。 | Florence Faurez 邱文英 | 2009 | 中国畜牧兽医2009，36，10： | 4 |
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