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| 1 | Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity. | Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 2 | 环十二烷法提取修复石铠甲显示文摘为了探索脆弱考古出土物的提取和修复方法,利用环十二烷法对一副秦陵石铠甲进行了提取和修复。环十二烷常温下是一种半透明蜡状固体,当加热至60℃以上后可以涂刷或喷涂于器物上进行加固,由于该试剂在室温下能够逐渐地挥发掉,所以可作为脆弱文物的临时性加固剂。结果表明,该方法修复后的石铠甲效果良好,与传统方法相比保留了大量原始铜丝。并可望在其它脆弱文物的保护和修复中得到应用。 | 夏寅 WEICHERT Maja 张志军 周铁 马生涛 | 2005 | 文物保护与考古科学2005，17，2： | 12 |
| 3 | Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?显示文摘 | Ulrike Heger Susanne Blank Christiane Wiecha Rupert Langer Wilko Weichert Florian Lordick Thomas Bruckner Martin Dobritz Maria Burian Christoph Springfeld Lars Grenacher J?rg-Rüdiger Siewert Markus Büchler Katja Ott | 2014 | Annals of Surgical Oncology2014，，5： | 2 |
| 4 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 5 | Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer:a retrospective analysis显示文摘 | Weichert W Roske A Gekeler V | 2008 | Lancet Oncol2008，9，： | 1 |
| 6 | Thermal simulation of switchgear显示文摘 | Paulke J Weichert H Steinhaeuser P | 2002 | IEEE Transactions on Components and Packaging Technologies2002，25，3： | 1 |
| 7 | High ex- pression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis 显示文摘 | WEICHERT W BOEHM M GEKELER V | 2007 | Br JCancer2007，97，4： | 1 |
| 8 | Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays 显示文摘 | Budczies J Weichert W Noske A | 2011 | J Histochem Cytochem2011，59，2： | 1 |
| 9 | Polo-like kinase isoforms in breast cancer:expression patterns and prognostic implications显示文摘 | Weichert W Kristiansen G Winzer KJ | | 0，，04： | 1 |
| 10 | Therapeutic management of evans syndrome in a pregnancy with maternal systemic lupus erythematosus显示文摘 | Nause SL Spiegler J Weichert J | 2015 | Z Geburtshilfe Neonatol2015，219，4： | 1 |
| 11 | Class I histone deacetylase expression has independent prognostic impact in hu- man colorectal cancer: specific role of class I histone deacety-lases in vitro and in vivo 显示文摘 | Weichert W Roske A Niesporek S | 2008 | Clin Cancer Res2008，14，6： | 1 |
| 12 | New solution for checkers working under oxidzing and reducing conditions 显示文摘 | Heilemann G Schmalenbach B Weichert T | 2007 | Ceramic Engineering and Science Proceedings2007，29，1： | 1 |
| 13 | Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation:increased expression of AKT in advanced ovarian cancer显示文摘 | Kaszubiak A Weichert W | 2007 | Cancer Lett2007，246，12： | 1 |
| 14 | Civilian vascular in- juries:a critical appraisal of three decades of management 显示文摘 | T Drapanas R L Hewitt R F Weichert | 1990 | Ann Surg1990，172，3： | 1 |
| 15 | ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival显示文摘 | WEICHERT W KNOSEL T BELLACH J | 2004 | J Clin Pathol2004，57，11： | 1 |
| 16 | Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma显示文摘 | Weichert W Denkert C Schmidt M | 2004 | Br J Cancer2004，90，4： | 1 |
| 17 | Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer显示文摘 | Noske A Kaszubiak A Weichert W | 2007 | Cancer Lett2007，246，12： | 1 |
| 18 | The MTT- assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL) 显示文摘 | Weichert H Blechschmidt I Schroder S | 1991 | Allerg Immunol (Leipz)1991，37，34： | 1 |
| 19 | High expression of RelA/p65 is associated with activation of nuclear factor kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis显示文摘 | Weichert W Boehm M Gekeler V | 2007 | Br J Cancer2007，97，4： | 1 |
| 20 | Simulation of intra-a- neurysmal blood flow by different numerical methods显示文摘 | Weichert F Walczak L Fisseler D | 2013 | Comput Math Methods Med2013，，52： | 1 |
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