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| 1 | Long-term outcome in patients with apical hypertrophic cardiomyopathy显示文摘 | Maria J Eriksson Brian Sonnenberg Anna Woo Paul Rakowski Thomas G Parker E.Douglas Wigle Harry Rakowski | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 2 | 应用酵母双杂交技术筛选转录因子MEOX2的相互作用蛋白显示文摘目的研究同源盒基因Meox2所编码的转录因子MEOX2在心肌细胞内与哪些蛋白质存在相互作用。方法应用酵母双杂交技术对人心脏cDNA文库进行筛选。(1)通过PCR方法扩增编码组氨酸/谷氨酸(H/Q)富含区缺失的MEOX2蛋白质(Meox2ΔHQ)的DNA片断,并克隆进入pGBKT7载体,从而构建“诱饵”质粒pGBKT7Meox2ΔHQ;(2)将“诱饵”质粒pGBKT7Meox2ΔHQ转化酵母菌AH109,然后从被转化的酵母菌中提取蛋白质,应用抗C Myc单克隆抗体进行免疫印迹分析,检测“诱饵”蛋白的表达;(3)将被“诱饵'质粒转化的AH109分别涂布于SD/Trp、SD/Trp/His、SD/Trp/Ade和SD/Trp/XαGAL平板上,以观察“诱饵”蛋白自我激活报告基因与否;(4)将已被“诱饵”质粒转化的AH109与人心脏cDNA文库进行杂交,筛选阳性克隆,分离阳性克隆中的cDNA,并测序。结果Meox2ΔHQ与pGBKT7中的Gal4DNA结合域及C myc在同一读框,并稳定表达融合蛋白“Gal4DNA结合域C myc Meox2ΔHQ”,“诱饵”蛋白不会自我激活报告基因,筛选得到11个准阳性克隆。结论同源盒基因Meox2所编码的转录因子MEOX2可能与心肌细胞中的多种蛋白质存在相互作用,并参与这些蛋白质表达的调控。 | 林吉进 李玉光 梁庆 Jeffrey Wigle | 2005 | 中国分子心脏病学杂志2005，5，2： | 2 |
| 3 | Endoscopic and Surgical Treatment of Mucosal (T1a) Esophageal Adenocarcinoma in Barrett’s Esophagus显示文摘 | Ganapathy A. Prasad Tsung Teh Wu Dennis A. Wigle Navtej S. Buttar Louis–Michel Wongkeesong Kelly T. Dunagan Lori S. Lutzke Lynn S. Borkenhagen Kenneth K. Wang | 2009 | Gastroenterology2009，，： | 2 |
| 4 | Annual review of advances in lung cancer clinical research:a report for the year2009显示文摘 | Stinchcombe TE Bogart J Wigle DA | 2010 | J Thorac Oncol2010，5，7： | 1 |
| 5 | Proxl function is required for the development of the murine lymphatic system显示文摘 | Wigle JT Oliver G | 1999 | Cell1999，98，6： | 1 |
| 6 | The 50-Year History, Controversy, and Clinical Implications of Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy显示文摘 | Barry J. Maron Martin S. Maron E. Douglas Wigle Eugene Braunwald | 2009 | Journal of the American College of Cardiology2009，，3： | 1 |
| 7 | Residential pesticides and childhood leukemia: a systematic review and Meta-analysis 显示文摘 | Turner MC Wigle DT Krewski D | 2011 | Ciencia & Saude Coletiva2011，16，3： | 1 |
| 8 | Functional topology in a network of protein interactions 显示文摘 | PRZULJ N WIGLE D A JURISICA I | 2004 | Bioinformatics2004，20，3： | 1 |
| 9 | Nonspecificpleuritis:optimaldurationoffollow-up显示文摘 | DepewZS VermaA WigleD etal | 2014 | AnnThoracSurg2014，97，6： | 1 |
| 10 | Proxl function is required for the development of the murine lymphatic system 显示文摘 | Wigle JT Oliver G | 1999 | Cell1999，98，6： | 1 |
| 11 | Hypertrophic cardiomyopathy: clinical spectrum and treatment显示文摘 | Wigle ED Rakowski H Kimball BP | 1995 | Circulation1995，92，： | 1 |
| 12 | Preoperative pulmonary rehabilitation before lung cancer resection= Results from two randomized studies 显示文摘 | Benzo R Wigle D Novotny P | 2011 | Lung cancer2011，74，3： | 1 |
| 13 | Morponhology of a pro- lalsed ostmio milral valve leatlet显示文摘 | Trenl R Ade nan AG Wigle ED | 1970 | Am Heart J1970，79，4： | 1 |
| 14 | Role of Hormonal and Other Factors in Human Prostate Cancer显示文摘 | Donald T. Wigle Michelle C. Turner James Gomes Marie-Elise Parent | 2008 | Journal of Toxicology and Environmental Health, Part B . 2008 (3-4)2008，，3： | 1 |
| 15 | Prox-1 function is required for the development of the murine lymphatic system显示文摘 | Wigle JT Oliver G | 1999 | Cell1999，98，2： | 1 |
| 16 | An essential role for Proxl in the induction of the lymphatic endothelial cell phenotype显示文摘 | Wigle JT Harvey N Detmar M | 2002 | Embo Journal2002，21，7： | 1 |
| 17 | Mitral regurgitation in hypertrophic obstructive cardiomyopathy: relationship to obstruction and relief with myectomy显示文摘 | Yu EH Omran AS Wigle ED | 2006 | Am Coll Cardiol2006，36，7： | 1 |
| 18 | Residential pesticides and childhood leukemia:a systematic review and meta-analysis显示文摘 | Turner M C Wigle D T Krewski D | | 0，，01： | 1 |
| 19 | Proxl function is required for the development of the murine lymphatic system显示文摘 | Wigle JT Oliver G | 1999 | Cell1999，98，6： | 1 |
| 20 | Hypertrophic cardiomyopathy:clinical spectrum and treatment显示文摘 | Wigle ED Rakowski H Kimball BP | 1995 | Circulation1995，92，7： | 1 |
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