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| 1 | Antimicrobial susceptibility testing before first-line treatment for Helicobacter pylori infection in patients with dual or triple antibiotic resistance显示文摘AIM To evaluate the efficacy of antimicrobial susceptibilityguided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance.METHODS A total of 1034 patients infected by Helicobacter pylori(H. pylori) during 2013-2014 were tested for antimicrobial susceptibility. 157 of 1034(15%) patients showed resistance to two(127/1034; 12%) and to three(30/1034; 3%) antibiotics. Sixty-eight patients with dual H. pylori-resistance(clarithromycin, metronidazole or levofloxacin) were treated for 10 d with triple therapies: OAL(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and levofloxacin 500 mg b.i.d.) 43cases, OAM(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and metronidazole 500 mg b.i.d.) 12 cases and OAC(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d.) 13 cases based on the antimicrobial susceptibility testing. Twelve patients showed triple H. pylori-resistance(clarithromycin, metronidazole and levofloxacin) and received for 10 d triple therapy with OAR(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and rifabutin 150 mg b.i.d.). Eradication was confirmed by 13C-urea breath test. Adverse effects and compliance were assessed by a questionnaire. RESULTS Intention-to-treat eradication rates were: OAL(97.6%), OAM(91.6%), OAC(92.3%) and OAR(58.3%). Cure rate was significantly higher in na?ve patients treated with OAR-10 compared to patients who had two or three previous treatment failures(83% vs 33%). Adverse events rates for OAL, OAM, OAC and OAR were 22%, 25%, 23% and 17%, respectively, all of them mild-moderate. CONCLUSION Antimicrobial susceptibility-guided triple therapies during 10 d for first-line treatment leads to an eradication rate superior to 90% in patients with dual antibiotic H. pylori resistance. | Angel Cosme Milagrosa Montes Begona Ibarra Esther Tamayo Horacio Alonso Usua Mendarte Jacobo Lizasoan Marta Herreros-Villanueva Luis Bujanda | 2017 | World Journal of Gastroenterology2017，23，18： | 4 |
| 2 | Understanding bottom-up continuous hydrothermal synthesis of nanoparticles using empirical measurement and computational simulation显示文摘连续热水的合成为 nanoparticles 的生产作为一种创新技术在最近的评论被加亮。在最近的年里,是大量 nanomaterials 的合成的合适的反应媒介被显示了。许多单个、复杂的 nanomaterials 象金属,金属氧化物,做的氧化物,碳酸盐,硫化物,氢氧化物,磷酸盐,和金属那样器官的框架能用连续热水的合成技术被形成。这个工作介绍方法论试验性地并且数字地描绘连续热水的流动系统,并且为大规模生产决定一个相反当前的 supercritical 水反应堆的可伸缩性(> 1,000 T 敳 ? 潰整瑮慩??? ?? 湯敳 ? 猯'T? 漠 ?? 代嘠愠摮挠瑡污瑹捩挠牵敲瑮搠湥楳祴漠 ????? 湡 ? | Jose Sierra-Pallarest Thomas Huddle Juan Garcia-Serna Esther Alonso Fidel Mato Igor Shvets Olaf Luebben Maria Jose Cocero Edward Lester | 2016 | Nano Research2016，9，11： | 2 |
| 3 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 4 | Annexin‐A2 as predictor biomarker of recurrent disease in endometrial cancer显示文摘 | Lorena Alonso‐Alconada Maria Santacana Pablo Garcia‐Sanz Laura Muinelo‐Romay Eva Colas Cristina Mirantes Marta Monge Juan Cueva Esther Oliva Robert A Soslow Maria Angeles Lopez Jose Palacios Jaime Prat Joan Valls Camilla Krakstad Helga Salvesen Antonio Gi | 2015 | Int. J. Cancer2015，，： | 1 |
| 5 | 3D point cloud registration based on a purpose-designed similarity measure显示文摘 | Carlos Torre-Ferrero José Llata Luciano Alonso Sandra Robla Esther Sarabia | 2012 | EURASIP Journal on Advances in Signal Processing2012，，1： | 1 |
| 6 | Role of neutrophil-to-lymphocyte and platelet-tolymphocyte ratios in Peyronie’s disease: a new diagnostic approach to predict the stage of the disease?显示文摘Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of cancers.They can be assumed as markers of inflammatory imbalance.The objective of this study is to evaluate the NLR and PLR in Peyronie’s disease(PD)and to establish a comparison of its values in the acute and chronic stages.We recruited patients with PD from March 2018 to March 2019.The patients enrolled underwent medical and sexual history as well as a physical examination.The values of blood count of each patient were collected both in the acute and chronic stages.Wilcoxon test was used to compare the acute and chronic stage ratios.Kruskal-Wallis test was carried out to evaluate the impact of treatments on the ratios.To identify cutoff values,we used sensibility and specificity tables and receiver operating characteristic(ROC)curves.A total of 120 patients were enrolled.Their mean age was 55.85(range:18-77)years and the mean penile curvature was 48.43°(range:10°-100°).In the acute stage,the mean NLR was 2.35 and the mean PLR was 111.22.These ratios,in the chronic stage,were 1.57 and 100.00,respectively.Statistically significant differences between acute and stable stages for both indices were found(NLR:P<0.0001;PLR:P=0.0202).The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for PLR.According to our results,with an ordinary blood count,we could have important indications regarding the disease stage of the patient,and consequently on the most appropriate type of therapy to choose. | Esther Garda Rojo Borja Garda Gomez Rocio Santos-Perez de la Blanca Celeste Manfredi Manuel Alonso Isa Jose Medina Polo Alfredo Rodriguez Antolin Javier Romero Otero | 2021 | Asian Journal of Andrology2021，23，3： | 0 |
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