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| 1 | NO Level and Endothelial NO Synthase Gene Polymorphism (Glu298Asp) in the Patients with Coronary Artery Disease from the Turkish Population显示文摘Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene. This study was performed to investigate the relationship between the serum nitric oxide level and eNOS gene polymorphism in the Turkish population with angiographically diagnosed coronary artery disease (63.47 ± 9.10 years old, n=250) and control subjects without any history and/or risk factors of coronary artery disease (60.71 ± 9.14 years old, n=150). Griess assay and PCR-RFLP analysis were used to measure the serum nitric oxide metabolites and genotypes, respectively. It was found that Glu/Glu, Glu/Asp and Asp/ Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group. Serum nitric oxide levels were (32.56 ± 17.26) μM in controls and (29.84 ± 11.88) μM in patients. Neither the frequencies of the Glu298Asp genotypes nor the serum nitric oxide levels showed a significant difference between the groups. There was also no correlation between serum nitric oxide levels and the frequencies of the eNOS genotypes. Result showed that the coronary artery disease of the Turkish population seemed to develop without any alterations in eNOS Glu298Asp genotype frequency and the serum nitric oxide level. | Lale AFRASYAPDepartment of Biochemistry Faculty of Health Mugla University Mugla Turkey Guler OZTURK | 2004 | Acta Biochimica et Biophysica Sinica2004，36，10： | 5 |
| 2 | Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients显示文摘瞄准:为了两个都调查胃的癌症的风险是否与 Ile/Val 被联系,挑选人的表皮的生长因素 receptor-2 (HER-2 ) 的核苷酸多型性(SNP ) 在 655 上的鳕鱼和在在一个土耳其语的病人的胃的癌症案例中的 HER-2 表示的建议存在的编码域的区域组织的 transmembrane。方法:限制跟随的聚合酶链反应(PCR ) 碎裂长度多型性(RFLP ) 策略被用来在 655 上在鳕鱼分析 HER-2 SNP 的存在。c-erbB-2 表示模式被免疫组织化学分析。结果在胃的癌组和长期的胃炎组之间,以及在 clinicopathological 参数和癌之间被比较。结果:结果证明 Ile/Val 遗传型在长期的胃炎组在土耳其语的胃的癌组,和没有以内占了 20% ,并且这 genotyping 与阶段 IV 胃的癌症(P=0.04 ) 被联系。在另一方面,积极膜的 HER-2 免疫反应从长期的胃炎盒子在土耳其语的胃的癌组和没有以内占了 24% ;进一步,它与肠的类型癌(P=0.007 ) 被相关,并且上演 III-IV 癌(P=0.004 ) 。结论:这些观察暗示测试 HER-2 SNP 可以参予胃的癌症的发展和前进。在与大样品组一起证实这些结果以后,因此,在表示上的 655 SNP 或 c-erbB-2 上的 HER-2 鳕鱼可以也为胃的癌被用作差的预示的指示物。 | N Lale Satiroglu-Tufan Ferda Bir Nese Calli-Demirkan | 2006 | World Journal of Gastroenterology2006，12，20： | 4 |
| 3 | Applications of A Numerical Model to Wave Propagation on Mild Slopes显示文摘Based on the mild slope equation that has been decomposed into three equations related to wave phase function, wave amplitude and wave approach angle, a refraction-diffraction model is developed. The finite difference method has been selected as the solution method. The model results are compared with experimental results and the model is applied to coastal waters of the Fethiye Bay, which is located at the Mediterranean Sea of Turkey. | Asu INAN Lale BALAS | 2002 | China Ocean Engineering2002，17，4： | 3 |
| 4 | Agenesis of the dorsal pancreas显示文摘Developmental anomalies of the pancreas have been reported but dorsal pancreatic agenesis is an extremely rare entity. We report an asymptomatic 62-year-old woman with complete agenesis of the dorsal pancreas. Abdominal computed tomography (CT) revealed a normal pancreatic head, but pancreatic body and tail were not visualized. Magnetic resonance imaging (MRI) findings were similar to CT. At magnetic resonance cholangiopancreatography (MRCP), the major pancreatic duct was short and the dorsal pancreatic duct was not visualized. The final diagnosis was dorsal pancreatic agenesis. | Lale Pasaoglu Murat Vural Hatice Gul Hatipoglu Gokce Tereklioglu Suha Koparal | 2008 | World Journal of Gastroenterology2008，14，18： | 3 |
| 5 | Improved Detection of Inflammatory Bowel Disease by Additional Automated Motility Analysis in Magnetic Resonance Imaging显示文摘 | Maria L. Hahnemann Felix Nensa Sonja Kinner Stefan Maderwald Lale Umutlu Guido Gerken Thomas C. Lauenstein | 2015 | Investigative Radiology2015，，2： | 2 |
| 6 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 7 | Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer’s Type Dementia?*显示文摘 | Tongabay Cumurcu Ferhat Dorak Birgul Elbozan Cumurcu Lale Gonenir Erbay Ercan Ozsoy | 2013 | Seminars in Ophthalmology2013，，4： | 1 |
| 8 | Qualitative and quantitative in situ fluorometry of citrus oil thin-layer chromatograms显示文摘 | Madsen B C Lale H W | 1970 | J Chromatogr1970，50，： | 1 |
| 9 | The CO2-bindlng by Ca-Mg-silicates in direct aqueous carbonation of oil shale ash and steel slag显示文摘 | Mai Uibu Rein kuusik Lale andreas | 2011 | Science Direct2011，4，： | 1 |
| 10 | 肿瘤18F-FDG PET/MRI全身显像专家共识(德国)显示文摘PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。 | 王洋洋 杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes Stefan Grueneisen Christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.O.Schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.Neumann D.Vorwerk | 2020 | 中华核医学与分子影像杂志2020，40，9： | 1 |
| 11 | Mucociliary transport and its assessment:a review显示文摘 | LALE A M MASON J D JONES N S | 1998 | Clin Otolaryngol Allied Sci1998，23，： | 1 |
| 12 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 13 | An HPLC method for the determination of atorvastatin and its impurities in bulk drug and tablets 显示文摘 | SIDIKA E ESRA SA LALE E | 2003 | J Pharm Biomed Anal2003，33，5： | 1 |
| 14 | Safety of high-dose intravenous immunoglobulin in systemic autoimmune diseases显示文摘 | Fatih Tufan Sevil Kamali Burak Erer Ahmet Gul Murat Inanc Lale Ocal Meral Konice Orhan Aral | 2007 | Clinical Rheumatology2007，，11： | 1 |
| 15 | Stochastic U-line balancing using genetic algorithms显示文摘 | Adil Baykaso lu Lale Ozbak r | 2007 | Adv Manuf Techno2007，，13： | 1 |
| 16 | Targeting Metastatic Prostate Cancer With Radiolabeled Monoclonal Antibody J591 to the Extracellular Domain of Prostate Specific Membrane Antigen显示文摘 | NEIL H. BANDER EDOUARD J. TRABULSI LALE KOSTAKOGLU DANIEL YAO SHANKAR VALLABHAJOSULA PETER SMITH-JONES MAUREEN A. JOYCE MATTHEW MILOWSKY DAVID M. NANUS STANLEY J. GOLDSMITH | 2003 | The Journal of Urology2003，，5： | 1 |
| 17 | Oviposition deterrent and repellent effects of products from dry chilli pepper fruits, Capsicum species on Callosobruchs maculates 显示文摘 | Lale N E S | 1992 | Postharvest Biology and Technology1992，，4： | 1 |
| 18 | Resistance status of new cowpea cultivars to a storage insect pest, Callosobruchs maculates 显示文摘 | Lale N E S Efeovbokhan S O | 1992 | Postharvest Biology and Technology1992，，2： | 1 |
| 19 | Transformational leadership, creativi- ty, and organizational innovation显示文摘 | LALE G ARZU I | 2009 | Journal of Business Research2009，，62： | 1 |
| 20 | Linking HIV and sexual and reproductive health services to enhance program outcomes显示文摘 | Manjula Lusti Narasimhan Lale Say Michael T.Mbizvo | | 0，，01： | 1 |
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