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| 1 | Role of Akt signaling in resistance to DNA-targeted therapy显示文摘The Akt signal transduction pathway controls most hallmarks of cancer. Activation of the Akt cascade promotes a malignant phenotype and is also widely implicated in drug resistance. Therefore, the modulation of Akt activity is regarded as an attractive strategy to enhance the efficacy of cancer therapy and irradiation. This pathway consists of phosphatidylinositol 3 kinase(PI3K), mammalian target of rapamycin, and the transforming serine-threonine kinase Akt protein isoforms, also known as protein kinase B. DNA-targeted agents, such as platinum agents, taxanes, and antimetabolites, as well as radiation have had a significant impact on cancer treatment by affecting DNA replication, which is aberrantly activated in malignancies. However, the caveat is that they may also trigger the activation of repairing mechanisms, such as upstream and downstream cascade of Akt survival pathway. Thus, each target can theoretically be inhibited in view of improving the potency of conventional treatment. Akt inhibitors, e.g., MK-2206 and perifosine, or PI3K modulators, e.g., LY294002 and Wortmannin, have shown some promising results in favor of sensitizing the cancer cells to the therapy in vitro and in vivo, which have provided the rationale for incorporation of these novel agents into multimodality treatment of different malignancies. Nevertheless, despite the acceptable safety profile of some of these agents in the clinical studies, with regard to the efficacy, the results are still too preliminary. Hence, we need to wait for the upcoming data from the ongoing trials before utilizing them into the standard care of cancer patients. | Abolfazl Avan Ravi Narayan Elisa Giovannetti Godefridus J Peters | 2016 | World Journal of Clinical Oncology2016，7，5： | 12 |
| 2 | Association of a genetic variant in AKT1 gene with features of the metabolic syndrome显示文摘Metabolic syndrome(MetS)is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 diabetes.There is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and obesity.We aimed to investigate the association between MetS and its components with the genetic polymorphism in AKT1,rs1130233(T>C).Total of 618 participants,recruited from Mashhad stroke and heart atherosclerosis disorder cohort(MASHAD study).Patients with MetS were defined by using international diabetes federation(IDF)criteria(n Z 326)and those without MetS(n Z 261)were recruited.Anthropometric and biochemical parameters were measured in all subjects.Genetic analysis for the rs1130233 polymorphism was performed,using the ABI-StepOne instruments with SDS version-2.0 software.Individuals with MetS had a significantly higher levels of BMI,waistcircumference,total cholesterol,triglyceride,high sensitivity-c reactive protein(hs-CRP)and blood-pressure,and lower concentrations of high density lipoprotein(HDL-C),compared to non-MetS individuals(P<0.05).The association between the rs1130233 and MetS was not significant.Subjects with a CC or CT genotypes had a significantly higher serum hs-CRP-level(OR:1.5;95%CI(1.05e2.1),P Z 0.02).Additionally,subjects who carried the TC genotype had a higher BMI compared to the CC genotype(p value Z 0.045).Our findings demonstrated that AKT1,rs1130233(T>C)polymorphism was associated with major components of MetS such as hs-CRP,and BMI,indicating further investigation in a multi-center setting to explore its value as an emerging biomarker of risk stratification marker. | Fateme Sadat Eshaghi Hamideh Ghazizadeh Sakine Kazami-Nooreini Ameneh Timar Habibollah Esmaeily Mehrane Mehramiz Amir Avan Majid Ghayour-Mobarhan | 2019 | Genes & Diseases2019，6，3： | 6 |
| 3 | Turbulent heat transfer with phase change material suspensions显示文摘 | Sanjay K Roy Branko L Avanic | 2001 | International Journal of Heat and Mass Transfer2001，，12： | 2 |
| 4 | Coronary artery diameterrelated to calcium scores and coronary risk factors as measuredwith multidetector computed tomography : a substudy of the ACCU-RACY trial显示文摘 | Hamirani YS Nasir K Avanes E | 2013 | Tex Heart Inst J2013，40，3： | 1 |
| 5 | Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study显示文摘 | Daniel Baylis Georgia Ntani Mark H. Edwards Holly E. Syddall David B. Bartlett Elaine M. Dennison Carmen Martin-Ruiz Thomas Zglinicki Diana Kuh Janet M. Lord Avan Aihie Sayer Cyrus Cooper | 2014 | Calcified Tissue International2014，，1： | 1 |
| 6 | Therapeutic potential of interferon-γ and its antagonists in autoimqammation: Lessons from murine models of systemic juvenile idiopathic arthritis and maerophage activation syndrome 显示文摘 | Avan A Matthys P | 2015 | Pharmaceuticals ( Basel)2015，8，4： | 1 |
| 7 | Physical and psychomotor development of 1799 children born after second trimesteamniocentesis for maternal serum positive triple test screening annormalprenatal karyotype 显示文摘 | I Witters P Moerman AVan Assche J - P Fryns | 2002 | J Med Genet2002，39，： | 1 |
| 8 | Protective effect of heat shock pretreatment with heat shock protein induction before hepatic warm ischemic injury caused by pringle's maneuver显示文摘 | Saad S Kanai M Avane M | 1995 | Surgery1995，118，3： | 1 |
| 9 | Cochlear ischemia: from funda- mental data to clinical hope 显示文摘 | Morn T Gilain L Avan P | 2008 | Ann Otolaryngol Chir Cervicofac2008，125，6： | 1 |
| 10 | Piezoelectric sensors to monitor lubricant film thickness at piston-cylinder contacts in a fired engine 显示文摘 | Mills R S Avan E Y Dwyer-Joyce R S | 2013 | Proceedings of the Institution of Mechanical Engineers Part J: Journal of Engineering Tribology2013，227，2： | 1 |
| 11 | Multiple primary tumors in patients diagnosed with hypopharygneal cancer显示文摘 | RAG H AVAN U F QURAISH I S F BRADLEY P J | 2003 | Otolaryngol Head Neck Surg2003，128，： | 1 |
| 12 | Metoprolol,a beta-1 selective blocker,can be used safely in coronary artery disease patients with chronic obstructive pulmonary disease显示文摘 | Camsari A Arikan S Avan C | 2003 | Heart Vessels2003，18，4： | 1 |
| 13 | Cross-functional dynamics in new product development显示文摘 | Avan R J Hemant C S | 2000 | Research Technology Management2000，43，1： | 1 |
| 14 | Characteristics of transi- i ent--evoked otoacoustic emissions (TEOAEs) in neonates 显示文摘 | Aidan D Lestang P Avan P | 1997 | ActaOtolaryngol1997，117，： | 1 |
| 15 | Quantitative assessment of human cochlear function by evoked otoacoustic emissions显示文摘 | Avan P Bonfils P Loth D | 1991 | Hear Res1991，52，： | 1 |
| 16 | Adaptive Workilow Scheduling Under Resource Al- location Constraints and Network Dynamics 显示文摘 | Avanes A | 2008 | Proceedings of the VLDB Endowment2008，1，2： | 1 |
| 17 | Functional anatomy of auditory brainstem nuclei:application to the anatomical basis of brainstem auditory evoked potentials显示文摘 | Biacabe B Chevallier J M Avan P | 2001 | Auris Nasus Larynx2001，28，： | 1 |
| 18 | Functional anatomy of auditory brainstem nuclei: application to the anatomical basis of brainstem auditory evoked potentials显示文摘 | Bernard Biacabe Jean Marc Chevallier Paul Avan | 2001 | Auris Nasus Larynx2001，28，1： | 1 |
| 19 | Cochlear ischemia:from fundamental data to clinical hope显示文摘 | Mom T Gilain L Avan P | 2008 | Ann-Otolaryngol-Chir-Cervicofac2008，125，6： | 1 |
| 20 | Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry显示文摘 | Danny Avan Elswijk Otto Diefenbach Sonja van der Berg | 2003 | Journal of Chromatography A2003，1020，： | 1 |
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